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Items: 1 to 50 of 179

1.

ATP release drives heightened immune responses associated with hypertension.

Zhao TV, Li Y, Liu X, Xia S, Shi P, Li L, Chen Z, Yin C, Eriguchi M, Chen Y, Bernstein EA, Giani JF, Bernstein KE, Shen XZ.

Sci Immunol. 2019 Jun 28;4(36). pii: eaau6426. doi: 10.1126/sciimmunol.aau6426.

2.

The Plethora of Angiotensin-Converting Enzyme-Processed Peptides in Mouse Plasma.

Semis M, Gugiu GB, Bernstein EA, Bernstein KE, Kalkum M.

Anal Chem. 2019 May 21;91(10):6440-6453. doi: 10.1021/acs.analchem.8b03828. Epub 2019 May 7.

3.

Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.

Khan Z, Cao DY, Giani JF, Bernstein EA, Veiras LC, Fuchs S, Wang Y, Peng Z, Kalkum M, Liu GY, Bernstein KE.

J Biol Chem. 2019 Mar 22;294(12):4368-4380. doi: 10.1074/jbc.RA118.006275. Epub 2019 Jan 22.

PMID:
30670595
4.

The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease.

Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

J Am Soc Nephrol. 2018 Oct;29(10):2546-2561. doi: 10.1681/ASN.2018030323. Epub 2018 Sep 5.

PMID:
30185469
5.

Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by down-regulating Smad and TGF-β-activated kinase 1 (TAK1) pathways in mice.

Tan WQ, Fang QQ, Shen XZ, Giani JF, Zhao TV, Shi P, Zhang LY, Khan Z, Li Y, Li L, Xu JH, Bernstein EA, Bernstein KE.

Br J Pharmacol. 2018 Nov;175(22):4239-4252. doi: 10.1111/bph.14489. Epub 2018 Oct 8.

PMID:
30153328
6.

Angiotensin-converting enzyme in innate and adaptive immunity.

Bernstein KE, Khan Z, Giani JF, Cao DY, Bernstein EA, Shen XZ.

Nat Rev Nephrol. 2018 May;14(5):325-336. doi: 10.1038/nrneph.2018.15. Epub 2018 Mar 26. Review.

7.

Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.

O'Reilly PJ, Ding Q, Akthar S, Cai G, Genschmer KR, Patel DF, Jackson PL, Viera L, Roda M, Locy ML, Bernstein EA, Lloyd CM, Bernstein KE, Snelgrove RJ, Blalock JE.

JCI Insight. 2017 Nov 16;2(22). pii: 91923. doi: 10.1172/jci.insight.91923. eCollection 2017 Nov 16.

8.

Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy.

Eriguchi M, Lin M, Yamashita M, Zhao TV, Khan Z, Bernstein EA, Gurley SB, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F531-F542. doi: 10.1152/ajprenal.00523.2017. Epub 2017 Nov 29.

9.

Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation.

Li Y, Shen XZ, Li L, Zhao TV, Bernstein KE, Johnson AK, Lyden P, Fang J, Shi P.

Stroke. 2017 Sep;48(9):2557-2564. doi: 10.1161/STROKEAHA.117.017370. Epub 2017 Jul 11.

10.

Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils.

Khan Z, Shen XZ, Bernstein EA, Giani JF, Eriguchi M, Zhao TV, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE.

Blood. 2017 Jul 20;130(3):328-339. doi: 10.1182/blood-2016-11-752006. Epub 2017 May 17.

11.

Angiotensin-converting enzyme affects the presentation of MHC class II antigens.

Zhao T, Bernstein KE, Fang J, Shen XZ.

Lab Invest. 2017 Jul;97(7):764-771. doi: 10.1038/labinvest.2017.32. Epub 2017 Apr 10.

12.

Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity.

Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA.

Kidney Int. 2017 Apr;91(4):856-867. doi: 10.1016/j.kint.2016.10.007. Epub 2016 Dec 15.

13.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 1. No abstract available.

14.

Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response.

Bernstein KE, Khan Z, Giani JF, Zhao T, Eriguchi M, Bernstein EA, Gonzalez-Villalobos RA, Shen XZ.

F1000Res. 2016 Mar 23;5. pii: F1000 Faculty Rev-393. doi: 10.12688/f1000research.7508.1. eCollection 2016. Review.

15.

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.

Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG.

Circ Res. 2016 Apr 15;118(8):1233-43. doi: 10.1161/CIRCRESAHA.115.308111. Epub 2016 Mar 17.

16.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Jan;126(1):50-67. doi: 10.1172/JCI80761. Epub 2015 Nov 23. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1607.

17.

Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension.

Shah KH, Shi P, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE, Shen XZ.

Circ Res. 2015 Oct 23;117(10):858-69. doi: 10.1161/CIRCRESAHA.115.306539. Epub 2015 Aug 20.

18.

Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme.

Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA.

Hypertension. 2015 Sep;66(3):534-42. doi: 10.1161/HYPERTENSIONAHA.115.05320. Epub 2015 Jul 6.

19.

Microglia participate in neurogenic regulation of hypertension.

Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P, Shi P.

Hypertension. 2015 Aug;66(2):309-16. doi: 10.1161/HYPERTENSIONAHA.115.05333. Epub 2015 Jun 8.

20.

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.

Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML.

Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R71-8. doi: 10.1152/ajpregu.00039.2015. Epub 2015 Apr 29.

21.

The intrarenal generation of angiotensin II is required for experimental hypertension.

Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE.

Curr Opin Pharmacol. 2015 Apr;21:73-81. doi: 10.1016/j.coph.2015.01.002. Epub 2015 Jan 21. Review.

22.

DC isoketal-modified proteins activate T cells and promote hypertension.

Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J 2nd, Harrison DG.

J Clin Invest. 2014 Oct;124(10):4642-56. doi: 10.1172/JCI74084. Epub 2014 Sep 17.

23.

Renal generation of angiotensin II and the pathogenesis of hypertension.

Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA.

Curr Hypertens Rep. 2014 Sep;16(9):477. doi: 10.1007/s11906-014-0477-1. Review.

24.

Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition.

Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough AA, Gonzalez-Villalobos RA.

J Am Soc Nephrol. 2014 Dec;25(12):2752-63. doi: 10.1681/ASN.2013091030. Epub 2014 Jul 10.

25.

ACE overexpression in myelomonocytic cells: effect on a mouse model of Alzheimer's disease.

Koronyo-Hamaoui M, Shah K, Koronyo Y, Bernstein E, Giani JF, Janjulia T, Black KL, Shi PD, Gonzalez-Villalobos RA, Fuchs S, Shen XZ, Bernstein KE.

Curr Hypertens Rep. 2014 Jul;16(7):444. doi: 10.1007/s11906-014-0444-x. Review.

26.

Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response.

Bernstein KE, Gonzalez-Villalobos RA, Giani JF, Shah K, Bernstein E, Janjulia T, Koronyo Y, Shi PD, Koronyo-Hamaoui M, Fuchs S, Shen XZ.

Biol Chem. 2014 Oct;395(10):1173-8. doi: 10.1515/hsz-2013-0295. Review.

27.

Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells.

Shen XZ, Okwan-Duodu D, Blackwell WL, Ong FS, Janjulia T, Bernstein EA, Fuchs S, Alkan S, Bernstein KE.

Lab Invest. 2014 May;94(5):536-44. doi: 10.1038/labinvest.2014.41. Epub 2014 Mar 10.

28.

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline.

Bernstein KE, Koronyo Y, Salumbides BC, Sheyn J, Pelissier L, Lopes DH, Shah KH, Bernstein EA, Fuchs DT, Yu JJ, Pham M, Black KL, Shen XZ, Fuchs S, Koronyo-Hamaoui M.

J Clin Invest. 2014 Mar;124(3):1000-12.

29.

Renal angiotensin-converting enzyme and blood pressure control.

Bernstein KE, Giani JF, Shen XZ, Gonzalez-Villalobos RA.

Curr Opin Nephrol Hypertens. 2014 Mar;23(2):106-12. doi: 10.1097/01.mnh.0000441047.13912.56. Review.

30.

Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.

Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell WL, Shah KH, Shi PD, Fuchs S, Bernstein KE.

J Mol Med (Berl). 2013 Oct;91(10):1143-54. doi: 10.1007/s00109-013-1051-z. Epub 2013 May 18. Review.

31.

The absence of intrarenal ACE protects against hypertension.

Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA.

J Clin Invest. 2013 May;123(5):2011-23. doi: 10.1172/JCI65460. Epub 2013 Apr 24.

32.

Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry.

Grobe N, Weir NM, Leiva O, Ong FS, Bernstein KE, Schmaier AH, Morris M, Elased KM.

Am J Physiol Cell Physiol. 2013 May 15;304(10):C945-53. doi: 10.1152/ajpcell.00346.2012. Epub 2013 Feb 7.

33.

A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme.

Bernstein KE, Ong FS, Blackwell WL, Shah KH, Giani JF, Gonzalez-Villalobos RA, Shen XZ, Fuchs S, Touyz RM.

Pharmacol Rev. 2012 Dec 20;65(1):1-46. doi: 10.1124/pr.112.006809. Print 2013 Jan. Review. Erratum in: Pharmacol Rev. 2013;65(1):544.

34.

The M694V mutation in Armenian-Americans: a 10-year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA.

Ong FS, Vakil H, Xue Y, Kuo JZ, Shah KH, Lee RB, Bernstein KE, Rimoin DL, Getzug T, Das K, Deignan JL, Rotter JI, Grody WW.

Clin Genet. 2013 Jul;84(1):55-9. doi: 10.1111/cge.12029. Epub 2012 Nov 7.

35.

Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing.

Ong FS, Das K, Wang J, Vakil H, Kuo JZ, Blackwell WL, Lim SW, Goodarzi MO, Bernstein KE, Rotter JI, Grody WW.

Expert Rev Mol Diagn. 2012 Jul;12(6):593-602. doi: 10.1586/erm.12.59. Review.

36.

Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation.

Ong FS, Deignan JL, Kuo JZ, Bernstein KE, Rotter JI, Grody WW, Das K.

Pharmacogenomics. 2012 Mar;13(4):465-75. doi: 10.2217/pgs.12.2. Review.

37.

Nontraditional roles of angiotensin-converting enzyme.

Shen XZ, Ong FS, Bernstein EA, Janjulia T, Blackwell WL, Shah KH, Taylor BL, Gonzalez-Villalobos RA, Fuchs S, Bernstein KE.

Hypertension. 2012 Apr;59(4):763-8. doi: 10.1161/HYPERTENSIONAHA.111.188342. Epub 2012 Feb 21. Review. No abstract available.

38.

Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity.

Ong FS, Lin CX, Campbell DJ, Okwan-Duodu D, Chen X, Blackwell WL, Shah KH, Gonzalez-Villalobos RA, Shen XZ, Fuchs S, Bernstein KE.

Hypertension. 2012 Feb;59(2):283-90. doi: 10.1161/HYPERTENSIONAHA.111.180844. Epub 2011 Dec 27.

39.

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death.

Sovari AA, Iravanian S, Dolmatova E, Jiao Z, Liu H, Zandieh S, Kumar V, Wang K, Bernstein KE, Bonini MG, Duffy HS, Dudley SC.

J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. doi: 10.1016/j.jacc.2011.07.048.

40.

The carboxypeptidase ACE shapes the MHC class I peptide repertoire.

Shen XZ, Billet S, Lin C, Okwan-Duodu D, Chen X, Lukacher AE, Bernstein KE.

Nat Immunol. 2011 Oct 2;12(11):1078-85. doi: 10.1038/ni.2107.

41.

Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43.

Iravanian S, Sovari AA, Lardin HA, Liu H, Xiao HD, Dolmatova E, Jiao Z, Harris BS, Witham EA, Gourdie RG, Duffy HS, Bernstein KE, Dudley SC Jr.

J Mol Med (Berl). 2011 Jul;89(7):677-87. doi: 10.1007/s00109-011-0761-3. Epub 2011 May 7.

42.

The peptide network regulated by angiotensin converting enzyme (ACE) in hematopoiesis.

Shen XZ, Bernstein KE.

Cell Cycle. 2011 May 1;10(9):1363-9. Epub 2011 May 1. Review.

43.

Angiotensin-converting enzyme is required for normal myelopoiesis.

Lin C, Datta V, Okwan-Duodu D, Chen X, Fuchs S, Alsabeh R, Billet S, Bernstein KE, Shen XZ.

FASEB J. 2011 Apr;25(4):1145-55. doi: 10.1096/fj.10-169433. Epub 2010 Dec 9.

44.

Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE).

Bernstein KE, Shen XZ, Gonzalez-Villalobos RA, Billet S, Okwan-Duodu D, Ong FS, Fuchs S.

Curr Opin Pharmacol. 2011 Apr;11(2):105-11. doi: 10.1016/j.coph.2010.11.001. Epub 2010 Dec 2. Review.

45.

Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion.

Gonzalez-Villalobos RA, Billet S, Kim C, Satou R, Fuchs S, Bernstein KE, Navar LG.

J Am Soc Nephrol. 2011 Mar;22(3):449-59. doi: 10.1681/ASN.2010060624. Epub 2010 Nov 29.

46.

Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus.

Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, Bernstein KE.

J Biol Chem. 2010 Dec 10;285(50):39051-60. doi: 10.1074/jbc.M110.163782. Epub 2010 Oct 11.

47.

Angiotensin-converting enzyme N-terminal inactivation alleviates bleomycin-induced lung injury.

Li P, Xiao HD, Xu J, Ong FS, Kwon M, Roman J, Gal A, Bernstein KE, Fuchs S.

Am J Pathol. 2010 Sep;177(3):1113-21. doi: 10.2353/ajpath.2010.081127. Epub 2010 Jul 22.

48.

Angiotensin II and JAK2 put on the pressure.

Bernstein KE, Fuchs S.

Nat Med. 2010 Feb;16(2):165-6. doi: 10.1038/nm0210-165. No abstract available.

49.

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction.

Silberman GA, Fan TH, Liu H, Jiao Z, Xiao HD, Lovelock JD, Boulden BM, Widder J, Fredd S, Bernstein KE, Wolska BM, Dikalov S, Harrison DG, Dudley SC Jr.

Circulation. 2010 Feb 2;121(4):519-28. doi: 10.1161/CIRCULATIONAHA.109.883777. Epub 2010 Jan 18.

50.

Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice.

Weiss D, Bernstein KE, Fuchs S, Adams J, Synetos A, Taylor WR.

Atherosclerosis. 2010 Apr;209(2):352-8. doi: 10.1016/j.atherosclerosis.2009.09.069. Epub 2009 Oct 6.

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