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Items: 44

1.

Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes.

Brunette GJ, Jamalruddin MA, Baldock RA, Clark NL, Bernstein KA.

Proc Natl Acad Sci U S A. 2019 Sep 9. pii: 201906559. doi: 10.1073/pnas.1906559116. [Epub ahead of print]

PMID:
31501324
2.

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.

Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ.

Mol Cell. 2019 Aug 7. pii: S1097-2765(19)30500-3. doi: 10.1016/j.molcel.2019.06.043. [Epub ahead of print]

PMID:
31400850
3.

The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.

Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA.

Nat Commun. 2019 Aug 5;10(1):3515. doi: 10.1038/s41467-019-11374-8.

4.

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ.

Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032.

5.

RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.

Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA.

DNA Repair (Amst). 2019 Apr;76:99-107. doi: 10.1016/j.dnarep.2019.02.008. Epub 2019 Feb 23.

PMID:
30836272
6.

RAD-ical New Insights into RAD51 Regulation.

Sullivan MR, Bernstein KA.

Genes (Basel). 2018 Dec 13;9(12). pii: E629. doi: 10.3390/genes9120629. Review.

7.

The global role for Cdc13 and Yku70 in preventing telomere resection across the genome.

Westmoreland JW, Mihalevic MJ, Bernstein KA, Resnick MA.

DNA Repair (Amst). 2018 Feb;62:8-17. doi: 10.1016/j.dnarep.2017.11.010. Epub 2017 Nov 29.

8.

Predictors of venous thromboembolism in patients with primary sarcoma of bone.

Kaiser CL, Freehan MK, Driscoll DA, Schwab JH, Bernstein KA, Lozano-Calderon SA.

Surg Oncol. 2017 Dec;26(4):506-510. doi: 10.1016/j.suronc.2017.09.007. Epub 2017 Sep 27.

PMID:
29113671
9.

Pib2 and the EGO complex are both required for activation of TORC1.

Varlakhanova NV, Mihalevic MJ, Bernstein KA, Ford MGJ.

J Cell Sci. 2017 Nov 15;130(22):3878-3890. doi: 10.1242/jcs.207910. Epub 2017 Oct 9.

10.

Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.

Zacchi LF, Dittmar JC, Mihalevic MJ, Shewan AM, Schulz BL, Brodsky JL, Bernstein KA.

Dis Model Mech. 2017 Sep 1;10(9):1129-1140. doi: 10.1242/dmm.029926. Epub 2017 Aug 2.

11.

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.

Kondrashova O, Nguyen M, Shield-Artin K, Tinker AV, Teng NNH, Harrell MI, Kuiper MJ, Ho GY, Barker H, Jasin M, Prakash R, Kass EM, Sullivan MR, Brunette GJ, Bernstein KA, Coleman RL, Floquet A, Friedlander M, Kichenadasse G, O'Malley DM, Oza A, Sun J, Robillard L, Maloney L, Bowtell D, Giordano H, Wakefield MJ, Kaufmann SH, Simmons AD, Harding TC, Raponi M, McNeish IA, Swisher EM, Lin KK, Scott CL; AOCS Study Group.

Cancer Discov. 2017 Sep;7(9):984-998. doi: 10.1158/2159-8290.CD-17-0419. Epub 2017 Jun 6.

12.

Improved local control with an aggressive strategy of preoperative (with or without intraoperative) radiation therapy combined with radical surgical resection for retroperitoneal sarcoma.

Hull MA, Molina G, Niemierko A, Haynes AB, Jacobson A, Bernstein KA, Chen YL, DeLaney TF, Mullen JT.

J Surg Oncol. 2017 May;115(6):746-751. doi: 10.1002/jso.24557. Epub 2017 Jan 27.

PMID:
28127762
13.

Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process.

Kong M, Liu L, Chen X, Driscoll KI, Mao P, Böhm S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, Min JH, Van Houten B.

Mol Cell. 2016 Oct 20;64(2):376-387. doi: 10.1016/j.molcel.2016.09.005. Epub 2016 Oct 6.

14.

The Shu complex is a conserved regulator of homologous recombination.

Martino J, Bernstein KA.

FEMS Yeast Res. 2016 Sep;16(6). pii: fow073. Epub 2016 Sep 1.

15.

The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products.

Godin SK, Zhang Z, Herken BW, Westmoreland JW, Lee AG, Mihalevic MJ, Yu Z, Sobol RW, Resnick MA, Bernstein KA.

Nucleic Acids Res. 2016 Sep 30;44(17):8199-215. doi: 10.1093/nar/gkw535. Epub 2016 Jun 13.

16.

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication.

Godin SK, Sullivan MR, Bernstein KA.

Biochem Cell Biol. 2016 Oct;94(5):407-418. Epub 2016 Mar 31. Review.

17.

Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans.

McClendon TB, Sullivan MR, Bernstein KA, Yanowitz JL.

Genetics. 2016 May;203(1):133-45. doi: 10.1534/genetics.115.185827. Epub 2016 Mar 2.

18.

Tryptophan biosynthesis is important for resistance to replicative stress in Saccharomyces cerevisiae.

Godin SK, Lee AG, Baird JM, Herken BW, Bernstein KA.

Yeast. 2016 May;33(5):183-9. doi: 10.1002/yea.3150. Epub 2016 Mar 21.

19.

The Budding Yeast Ubiquitin Protease Ubp7 Is a Novel Component Involved in S Phase Progression.

Böhm S, Szakal B, Herken BW, Sullivan MR, Mihalevic MJ, Kabbinavar FF, Branzei D, Clark NL, Bernstein KA.

J Biol Chem. 2016 Feb 26;291(9):4442-52. doi: 10.1074/jbc.M115.671057. Epub 2016 Jan 6.

20.

Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.

Gaines WA, Godin SK, Kabbinavar FF, Rao T, VanDemark AP, Sung P, Bernstein KA.

Nat Commun. 2015 Jul 28;6:7834. doi: 10.1038/ncomms8834.

21.

DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination.

Wei L, Nakajima S, Böhm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3495-504. doi: 10.1073/pnas.1507105112. Epub 2015 Jun 22.

22.

Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens.

Godin SK, Meslin C, Kabbinavar F, Bratton-Palmer DS, Hornack C, Mihalevic MJ, Yoshida K, Sullivan M, Clark NL, Bernstein KA.

Genetics. 2015 Apr;199(4):1023-33. doi: 10.1534/genetics.114.173518. Epub 2015 Feb 5.

23.

Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells.

Böhm S, Mihalevic MJ, Casal MA, Bernstein KA.

DNA Repair (Amst). 2015 Feb;26:1-14. doi: 10.1016/j.dnarep.2014.12.004. Epub 2014 Dec 26.

24.

The role of post-translational modifications in fine-tuning BLM helicase function during DNA repair.

Böhm S, Bernstein KA.

DNA Repair (Amst). 2014 Oct;22:123-32. doi: 10.1016/j.dnarep.2014.07.007. Epub 2014 Aug 24. Review.

25.

Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.

Fu Q, Chow J, Bernstein KA, Makharashvili N, Arora S, Lee CF, Person MD, Rothstein R, Paull TT.

Mol Cell Biol. 2014 Mar;34(5):778-93. doi: 10.1128/MCB.00963-13. Epub 2013 Dec 16. Erratum in: Mol Cell Biol. 2014 Nov 15;34(22):4213.

26.

Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae.

Bernstein KA, Mimitou EP, Mihalevic MJ, Chen H, Sunjaveric I, Symington LS, Rothstein R.

Genetics. 2013 Dec;195(4):1241-51. doi: 10.1534/genetics.113.157370. Epub 2013 Oct 4.

27.

The Shu complex regulates Rad52 localization during rDNA repair.

Bernstein KA, Juanchich A, Sunjevaric I, Rothstein R.

DNA Repair (Amst). 2013 Sep;12(9):786-90. doi: 10.1016/j.dnarep.2013.05.003. Epub 2013 Jun 19.

28.

The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.

Godin S, Wier A, Kabbinavar F, Bratton-Palmer DS, Ghodke H, Van Houten B, VanDemark AP, Bernstein KA.

Nucleic Acids Res. 2013 Apr;41(8):4525-34. doi: 10.1093/nar/gkt138. Epub 2013 Mar 4.

29.

From yeast to mammals: recent advances in genetic control of homologous recombination.

Karpenshif Y, Bernstein KA.

DNA Repair (Amst). 2012 Oct 1;11(10):781-8. doi: 10.1016/j.dnarep.2012.07.001. Epub 2012 Aug 11. Review.

30.

The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase.

Bernstein KA, Reid RJ, Sunjevaric I, Demuth K, Burgess RC, Rothstein R.

Mol Biol Cell. 2011 May;22(9):1599-607. doi: 10.1091/mbc.E10-08-0691. Epub 2011 Mar 3.

31.

HDACs link the DNA damage response, processing of double-strand breaks and autophagy.

Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein KA, Rothstein R, Botrugno OA, Parazzoli D, Oldani A, Minucci S, Foiani M.

Nature. 2011 Mar 3;471(7336):74-79. doi: 10.1038/nature09803.

32.

The RecQ DNA helicases in DNA repair.

Bernstein KA, Gangloff S, Rothstein R.

Annu Rev Genet. 2010;44:393-417. doi: 10.1146/annurev-genet-102209-163602. Review.

33.

At loose ends: resecting a double-strand break.

Bernstein KA, Rothstein R.

Cell. 2009 May 29;137(5):807-10. doi: 10.1016/j.cell.2009.05.007. Review.

34.

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.

Bernstein KA, Shor E, Sunjevaric I, Fumasoni M, Burgess RC, Foiani M, Branzei D, Rothstein R.

EMBO J. 2009 Apr 8;28(7):915-25. doi: 10.1038/emboj.2009.28. Epub 2009 Feb 12.

35.

Ribosome biogenesis is sensed at the Start cell cycle checkpoint.

Bernstein KA, Bleichert F, Bean JM, Cross FR, Baserga SJ.

Mol Biol Cell. 2007 Mar;18(3):953-64. Epub 2006 Dec 27.

36.

Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis.

Bernstein KA, Granneman S, Lee AV, Manickam S, Baserga SJ.

Mol Cell Biol. 2006 Feb;26(4):1195-208.

37.

Comprehensive mutational analysis of yeast DEXD/H box RNA helicases required for small ribosomal subunit synthesis.

Granneman S, Bernstein KA, Bleichert F, Baserga SJ.

Mol Cell Biol. 2006 Feb;26(4):1183-94.

38.

The small-subunit processome is a ribosome assembly intermediate.

Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ.

Eukaryot Cell. 2004 Dec;3(6):1619-26.

39.

The small subunit processome is required for cell cycle progression at G1.

Bernstein KA, Baserga SJ.

Mol Biol Cell. 2004 Nov;15(11):5038-46. Epub 2004 Sep 8.

40.

Intravenous butyrate and healing of colonic anastomoses in the rat.

Rolandelli RH, Buckmire MA, Bernstein KA.

Dis Colon Rectum. 1997 Jan;40(1):67-70.

PMID:
9102264
41.

Murine lupus glomerulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism.

Di Valerio R, Bernstein KA, Varghese E, Lefkowith JB.

J Immunol. 1995 Aug 15;155(4):2258-68.

PMID:
7636272
42.

Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex.

Bernstein KA, Valerio RD, Lefkowith JB.

J Immunol. 1995 Mar 1;154(5):2424-33.

PMID:
7868908
43.
44.

Serum glomerular binding activity is highly correlated with renal disease in MRL/lpr mice.

Bernstein KA, Bolshoun D, Lefkowith JB.

Clin Exp Immunol. 1993 Sep;93(3):418-23.

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