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Type V Secretion in Gram-Negative Bacteria.

Bernstein HD.

EcoSal Plus. 2019 Feb;8(2). doi: 10.1128/ecosalplus.ESP-0031-2018.


The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding.

Kudva R, Tian P, Pardo-Avila F, Carroni M, Best RB, Bernstein HD, von Heijne G.

Elife. 2018 Nov 26;7. pii: e36326. doi: 10.7554/eLife.36326.


Identification of a novel post-insertion step in the assembly of a bacterial outer membrane protein.

Peterson JH, Hussain S, Bernstein HD.

Mol Microbiol. 2018 Oct;110(1):143-159. doi: 10.1111/mmi.14102. Epub 2018 Sep 28.


The Bam complex catalyzes efficient insertion of bacterial outer membrane proteins into membrane vesicles of variable lipid composition.

Hussain S, Bernstein HD.

J Biol Chem. 2018 Feb 23;293(8):2959-2973. doi: 10.1074/jbc.RA117.000349. Epub 2018 Jan 8.


Folding of a bacterial integral outer membrane protein is initiated in the periplasm.

Sikdar R, Peterson JH, Anderson DE, Bernstein HD.

Nat Commun. 2017 Nov 3;8(1):1309. doi: 10.1038/s41467-017-01246-4.


Selective pressure for rapid membrane integration constrains the sequence of bacterial outer membrane proteins.

Peterson JH, Plummer AM, Fleming KG, Bernstein HD.

Mol Microbiol. 2017 Dec;106(5):777-792. doi: 10.1111/mmi.13845. Epub 2017 Oct 16.


Genomic Diversity of Enterotoxigenic Strains of Bacteroides fragilis.

Pierce JV, Bernstein HD.

PLoS One. 2016 Jun 27;11(6):e0158171. doi: 10.1371/journal.pone.0158171. eCollection 2016.


Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids.

In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O.

Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):48-62.e3.


Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria.

Wilson MM, Bernstein HD.

Trends Microbiol. 2016 Mar;24(3):198-208. doi: 10.1016/j.tim.2015.11.006. Epub 2015 Dec 17. Review.


An In Vitro Assay for Outer Membrane Protein Assembly by the BAM Complex.

Roman-Hernandez G, Bernstein HD.

Methods Mol Biol. 2015;1329:203-13. doi: 10.1007/978-1-4939-2871-2_16.


Looks can be deceiving: recent insights into the mechanism of protein secretion by the autotransporter pathway.

Bernstein HD.

Mol Microbiol. 2015 Jul;97(2):205-15. doi: 10.1111/mmi.13031. Epub 2015 May 15. Review.


Analysis of the outer membrane proteome and secretome of Bacteroides fragilis reveals a multiplicity of secretion mechanisms.

Wilson MM, Anderson DE, Bernstein HD.

PLoS One. 2015 Feb 6;10(2):e0117732. doi: 10.1371/journal.pone.0117732. eCollection 2015.


Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion.

Drobnak I, Braselmann E, Chaney JL, Leyton DL, Bernstein HD, Lithgow T, Luirink J, Nataro JP, Clark PL.

Mol Microbiol. 2015 Jan;95(1):1-16. doi: 10.1111/mmi.12838. Epub 2014 Nov 24. Review.


Reconstitution of bacterial autotransporter assembly using purified components.

Roman-Hernandez G, Peterson JH, Bernstein HD.

Elife. 2014 Sep 2;3:e04234. doi: 10.7554/eLife.04234.


Monitoring the assembly of a secreted bacterial virulence factor using site-specific crosslinking.

Pavlova O, Ieva R, Bernstein HD.

J Vis Exp. 2013 Dec 17;(82):e51217. doi: 10.3791/51217.


Stepwise folding of an autotransporter passenger domain is not essential for its secretion.

Kang'ethe W, Bernstein HD.

J Biol Chem. 2013 Dec 6;288(49):35028-38. doi: 10.1074/jbc.M113.515635. Epub 2013 Oct 28.


Charge-dependent secretion of an intrinsically disordered protein via the autotransporter pathway.

Kang'ethe W, Bernstein HD.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):E4246-55. doi: 10.1073/pnas.1310345110. Epub 2013 Oct 21.


Mutations in the Escherichia coli ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor.

Yap MN, Bernstein HD.

J Bacteriol. 2013 Jul;195(13):2991-9. doi: 10.1128/JB.00211-13. Epub 2013 Apr 26.


Mechanistic link between β barrel assembly and the initiation of autotransporter secretion.

Pavlova O, Peterson JH, Ieva R, Bernstein HD.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E938-47. doi: 10.1073/pnas.1219076110. Epub 2013 Feb 19.


Cell biology: All clear for ribosome landing.

Bernstein HD.

Nature. 2012 Dec 13;492(7428):189-91. doi: 10.1038/492189a. No abstract available.


Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter.

Barnard TJ, Gumbart J, Peterson JH, Noinaj N, Easley NC, Dautin N, Kuszak AJ, Tajkhorshid E, Bernstein HD, Buchanan SK.

J Mol Biol. 2012 Jan 6;415(1):128-42. doi: 10.1016/j.jmb.2011.10.049. Epub 2011 Nov 7.


Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain.

Ieva R, Tian P, Peterson JH, Bernstein HD.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):E383-91. doi: 10.1073/pnas.1103827108. Epub 2011 Jun 6.


The translational regulatory function of SecM requires the precise timing of membrane targeting.

Yap MN, Bernstein HD.

Mol Microbiol. 2011 Jul;81(2):540-53. doi: 10.1111/j.1365-2958.2011.07713.x. Epub 2011 Jun 3.


The double life of a bacterial lipoprotein.

Bernstein HD.

Mol Microbiol. 2011 Mar;79(5):1128-31. doi: 10.1111/j.1365-2958.2011.07538.x. Epub 2011 Jan 23.


Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment.

Peterson JH, Tian P, Ieva R, Dautin N, Bernstein HD.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17739-44. doi: 10.1073/pnas.1009491107. Epub 2010 Sep 27.


The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding.

Peterson JH, Woolhead CA, Bernstein HD.

Mol Microbiol. 2010 Oct;78(1):203-17. doi: 10.1111/j.1365-2958.2010.07325.x. Epub 2010 Aug 20.


Type V Secretion: the Autotransporter and Two-Partner Secretion Pathways.

Bernstein HD.

EcoSal Plus. 2010 Sep;4(1). doi: 10.1128/ecosalplus.4.3.6.


Molecular basis for the structural stability of an enclosed β-barrel loop.

Tian P, Bernstein HD.

J Mol Biol. 2010 Sep 17;402(2):475-89. doi: 10.1016/j.jmb.2010.07.035. Epub 2010 Jul 23.


Sequential translocation of an Escherchia coli two-partner secretion pathway exoprotein across the inner and outer membranes.

Choi PS, Bernstein HD.

Mol Microbiol. 2010 Jan;75(2):440-51. doi: 10.1111/j.1365-2958.2009.06993.x. Epub 2009 Dec 4.


Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane.

Ieva R, Bernstein HD.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19120-5. doi: 10.1073/pnas.0907912106. Epub 2009 Oct 22.


The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.

Yap MN, Bernstein HD.

Mol Cell. 2009 Apr 24;34(2):201-11. doi: 10.1016/j.molcel.2009.04.002.


Identification of a post-targeting step required for efficient cotranslational translocation of proteins across the Escherichia coli inner membrane.

Tian P, Bernstein HD.

J Biol Chem. 2009 Apr 24;284(17):11396-404. doi: 10.1074/jbc.M900375200. Epub 2009 Feb 11.


Cotranslational translocation of proteins into canine rough microsomes.

Bernstein HD.

Curr Protoc Cell Biol. 2001 May;Chapter 11:Unit 11.4. doi: 10.1002/0471143030.cb1104s00.


Incorporation of a polypeptide segment into the beta-domain pore during the assembly of a bacterial autotransporter.

Ieva R, Skillman KM, Bernstein HD.

Mol Microbiol. 2008 Jan;67(1):188-201. Epub 2007 Nov 27.


Autotransporter structure reveals intra-barrel cleavage followed by conformational changes.

Barnard TJ, Dautin N, Lukacik P, Bernstein HD, Buchanan SK.

Nat Struct Mol Biol. 2007 Dec;14(12):1214-20. Epub 2007 Nov 11.


Are bacterial 'autotransporters' really transporters?

Bernstein HD.

Trends Microbiol. 2007 Oct;15(10):441-7.


Protein secretion in gram-negative bacteria via the autotransporter pathway.

Dautin N, Bernstein HD.

Annu Rev Microbiol. 2007;61:89-112. Review.


Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism.

Dautin N, Barnard TJ, Anderson DE, Bernstein HD.

EMBO J. 2007 Apr 4;26(7):1942-52. Epub 2007 Mar 8.


Characterization of a novel two-partner secretion system in Escherichia coli O157:H7.

Choi PS, Dawson AJ, Bernstein HD.

J Bacteriol. 2007 May;189(9):3452-61. Epub 2007 Feb 23.


The surprising complexity of signal sequences.

Hegde RS, Bernstein HD.

Trends Biochem Sci. 2006 Oct;31(10):563-71. Epub 2006 Aug 21. Review.


Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.

Woolhead CA, Johnson AE, Bernstein HD.

Mol Cell. 2006 Jun 9;22(5):587-98.


Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter.

Skillman KM, Barnard TJ, Peterson JH, Ghirlando R, Bernstein HD.

Mol Microbiol. 2005 Nov;58(4):945-58.


An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter.

Szabady RL, Peterson JH, Skillman KM, Bernstein HD.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):221-6. Epub 2004 Dec 22.


Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain.

Huck L, Scherrer A, Terzi L, Johnson AE, Bernstein HD, Cusack S, Weichenrieder O, Strub K.

Nucleic Acids Res. 2004 Sep 21;32(16):4915-24. Print 2004.


Basic amino acids in a distinct subset of signal peptides promote interaction with the signal recognition particle.

Peterson JH, Woolhead CA, Bernstein HD.

J Biol Chem. 2003 Nov 14;278(46):46155-62. Epub 2003 Aug 29.


Signal recognition particle (SRP)-mediated targeting and Sec-dependent translocation of an extracellular Escherichia coli protein.

Sijbrandi R, Urbanus ML, ten Hagen-Jongman CM, Bernstein HD, Oudega B, Otto BR, Luirink J.

J Biol Chem. 2003 Feb 14;278(7):4654-9. Epub 2002 Dec 3.


DnaK promotes the selective export of outer membrane protein precursors in SecA-deficient Escherichia coli.

Qi HY, Hyndman JB, Bernstein HD.

J Biol Chem. 2002 Dec 27;277(52):51077-83. Epub 2002 Oct 25.


Trigger factor retards protein export in Escherichia coli.

Lee HC, Bernstein HD.

J Biol Chem. 2002 Nov 8;277(45):43527-35. Epub 2002 Aug 29.

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