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Items: 32


ATP release drives heightened immune responses associated with hypertension.

Zhao TV, Li Y, Liu X, Xia S, Shi P, Li L, Chen Z, Yin C, Eriguchi M, Chen Y, Bernstein EA, Giani JF, Bernstein KE, Shen XZ.

Sci Immunol. 2019 Jun 28;4(36). pii: eaau6426. doi: 10.1126/sciimmunol.aau6426.


The Plethora of Angiotensin-Converting Enzyme-Processed Peptides in Mouse Plasma.

Semis M, Gugiu GB, Bernstein EA, Bernstein KE, Kalkum M.

Anal Chem. 2019 May 21;91(10):6440-6453. doi: 10.1021/acs.analchem.8b03828. Epub 2019 May 7.


Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.

Khan Z, Cao DY, Giani JF, Bernstein EA, Veiras LC, Fuchs S, Wang Y, Peng Z, Kalkum M, Liu GY, Bernstein KE.

J Biol Chem. 2019 Mar 22;294(12):4368-4380. doi: 10.1074/jbc.RA118.006275. Epub 2019 Jan 22.


The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease.

Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

J Am Soc Nephrol. 2018 Oct;29(10):2546-2561. doi: 10.1681/ASN.2018030323. Epub 2018 Sep 5.


Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by down-regulating Smad and TGF-β-activated kinase 1 (TAK1) pathways in mice.

Tan WQ, Fang QQ, Shen XZ, Giani JF, Zhao TV, Shi P, Zhang LY, Khan Z, Li Y, Li L, Xu JH, Bernstein EA, Bernstein KE.

Br J Pharmacol. 2018 Nov;175(22):4239-4252. doi: 10.1111/bph.14489. Epub 2018 Oct 8.


Angiotensin-converting enzyme in innate and adaptive immunity.

Bernstein KE, Khan Z, Giani JF, Cao DY, Bernstein EA, Shen XZ.

Nat Rev Nephrol. 2018 May;14(5):325-336. doi: 10.1038/nrneph.2018.15. Epub 2018 Mar 26. Review.


Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.

O'Reilly PJ, Ding Q, Akthar S, Cai G, Genschmer KR, Patel DF, Jackson PL, Viera L, Roda M, Locy ML, Bernstein EA, Lloyd CM, Bernstein KE, Snelgrove RJ, Blalock JE.

JCI Insight. 2017 Nov 16;2(22). pii: 91923. doi: 10.1172/jci.insight.91923. eCollection 2017 Nov 16.


Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy.

Eriguchi M, Lin M, Yamashita M, Zhao TV, Khan Z, Bernstein EA, Gurley SB, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F531-F542. doi: 10.1152/ajprenal.00523.2017. Epub 2017 Nov 29.


Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils.

Khan Z, Shen XZ, Bernstein EA, Giani JF, Eriguchi M, Zhao TV, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE.

Blood. 2017 Jul 20;130(3):328-339. doi: 10.1182/blood-2016-11-752006. Epub 2017 May 17.


Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity.

Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA.

Kidney Int. 2017 Apr;91(4):856-867. doi: 10.1016/j.kint.2016.10.007. Epub 2016 Dec 15.


Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response.

Bernstein KE, Khan Z, Giani JF, Zhao T, Eriguchi M, Bernstein EA, Gonzalez-Villalobos RA, Shen XZ.

F1000Res. 2016 Mar 23;5. pii: F1000 Faculty Rev-393. doi: 10.12688/f1000research.7508.1. eCollection 2016. Review.


Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension.

Shah KH, Shi P, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE, Shen XZ.

Circ Res. 2015 Oct 23;117(10):858-69. doi: 10.1161/CIRCRESAHA.115.306539. Epub 2015 Aug 20.


The intrarenal generation of angiotensin II is required for experimental hypertension.

Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE.

Curr Opin Pharmacol. 2015 Apr;21:73-81. doi: 10.1016/j.coph.2015.01.002. Epub 2015 Jan 21. Review.


Renal generation of angiotensin II and the pathogenesis of hypertension.

Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA.

Curr Hypertens Rep. 2014 Sep;16(9):477. doi: 10.1007/s11906-014-0477-1. Review.


Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells.

Shen XZ, Okwan-Duodu D, Blackwell WL, Ong FS, Janjulia T, Bernstein EA, Fuchs S, Alkan S, Bernstein KE.

Lab Invest. 2014 May;94(5):536-44. doi: 10.1038/labinvest.2014.41. Epub 2014 Mar 10.


Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline.

Bernstein KE, Koronyo Y, Salumbides BC, Sheyn J, Pelissier L, Lopes DH, Shah KH, Bernstein EA, Fuchs DT, Yu JJ, Pham M, Black KL, Shen XZ, Fuchs S, Koronyo-Hamaoui M.

J Clin Invest. 2014 Mar;124(3):1000-12.


Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.

Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell WL, Shah KH, Shi PD, Fuchs S, Bernstein KE.

J Mol Med (Berl). 2013 Oct;91(10):1143-54. doi: 10.1007/s00109-013-1051-z. Epub 2013 May 18. Review.


Nontraditional roles of angiotensin-converting enzyme.

Shen XZ, Ong FS, Bernstein EA, Janjulia T, Blackwell WL, Shah KH, Taylor BL, Gonzalez-Villalobos RA, Fuchs S, Bernstein KE.

Hypertension. 2012 Apr;59(4):763-8. doi: 10.1161/HYPERTENSIONAHA.111.188342. Epub 2012 Feb 21. Review. No abstract available.


Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus.

Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, Bernstein KE.

J Biol Chem. 2010 Dec 10;285(50):39051-60. doi: 10.1074/jbc.M110.163782. Epub 2010 Oct 11.


ATP-loaded liposomes for targeted treatment in models of myocardial ischemia.

Levchenko TS, Hartner WC, Verma DD, Bernstein EA, Torchilin VP.

Methods Mol Biol. 2010;605:361-75. doi: 10.1007/978-1-60327-360-2_25.


ATP-loaded liposomes for treatment of myocardial ischemia.

Hartner WC, Verma DD, Levchenko TS, Bernstein EA, Torchilin VP.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Sep-Oct;1(5):530-9. doi: 10.1002/wnan.46. Review.


New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice.

Shen XZ, Xiao HD, Li P, Lin CX, Billet S, Okwan-Duodu D, Adams JW, Bernstein EA, Xu Y, Fuchs S, Bernstein KE.

J Mol Med (Berl). 2008 Jun;86(6):679-84. doi: 10.1007/s00109-008-0325-3. Epub 2008 Apr 29. Review.


Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy.

Xiao HD, Fuchs S, Bernstein EA, Li P, Campbell DJ, Bernstein KE.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H659-67. Epub 2007 Nov 21.


ATP-loaded liposomes effectively protect the myocardium in rabbits with an acute experimental myocardial infarction.

Verma DD, Hartner WC, Levchenko TS, Bernstein EA, Torchilin VP.

Pharm Res. 2005 Dec;22(12):2115-20. Epub 2005 Nov 5.


ATP-loaded liposomes effectively protect mechanical functions of the myocardium from global ischemia in an isolated rat heart model.

Verma DD, Levchenko TS, Bernstein EA, Torchilin VP.

J Control Release. 2005 Nov 28;108(2-3):460-71. Epub 2005 Oct 17.


Stability of insulin lispro in insulin infusion systems.

Lougheed WD, Zinman B, Strack TR, Janis LJ, Weymouth AB, Bernstein EA, Korbas AM, Frank BH.

Diabetes Care. 1997 Jul;20(7):1061-5.


Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion.

Bernstein EA, Eberli FR, Silverman AM, Horowitz GL, Apstein CS.

Cardiovasc Drugs Ther. 1996 May;10(2):167-78.


Granulocyte sequestration and early failure in the autoperfused heart-lung preparation.

Genco CM, Connolly RJ, Peterson MB, Bernstein EA, Ramberg K, Zhang X, Cleveland RJ, Diehl JT.

Ann Thorac Surg. 1992 Feb;53(2):217-26.


Leukocyte redistribution and eicosanoid changes during the autoperfused working heart-lung preparation.

Genco CM, Bernstein EA, Connolly RJ, Peterson MB, Zhang X, Somerville K, Cleveland RJ, Diehl JT.

J Invest Surg. 1991;4(4):477-85.


Mouse angiotensin-converting enzyme is a protein composed of two homologous domains.

Bernstein KE, Martin BM, Edwards AS, Bernstein EA.

J Biol Chem. 1989 Jul 15;264(20):11945-51.


The isolation of angiotensin-converting enzyme cDNA.

Bernstein KE, Martin BM, Bernstein EA, Linton J, Striker L, Striker G.

J Biol Chem. 1988 Aug 15;263(23):11021-4.

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