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Initial characterization of transgenic mice overexpressing human histamine H2 receptors.

Gergs U, Bernhardt G, Buchwalow I, Edler H, Froeba J, Keller M, Kirchhefer U, Koehler F, Misslinger N, Wache H, Neumann J.

J Pharmacol Exp Ther. 2019 Feb 6. pii: jpet.118.255711. doi: 10.1124/jpet.118.255711. [Epub ahead of print]


A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells.

Littmann T, Ozawa T, Hoffmann C, Buschauer A, Bernhardt G.

Sci Rep. 2018 Nov 21;8(1):17179. doi: 10.1038/s41598-018-35615-w.


The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study.

Frings-Meuthen P, Bernhardt G, Buehlmeier J, Baecker N, May F, Heer M.

Osteoporos Int. 2018 Sep 25. doi: 10.1007/s00198-018-4703-6. [Epub ahead of print]


Septic Revision Total Knee Arthroplasty: Treatment of Metaphyseal Bone Defects Using Metaphyseal Sleeves.

Klim SM, Amerstorfer F, Bernhardt GA, Sadoghi P, Gruber G, Radl R, Leithner A, Glehr M.

J Arthroplasty. 2018 Dec;33(12):3734-3738. doi: 10.1016/j.arth.2018.08.017. Epub 2018 Aug 24.


Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators.

Peña-Solórzano D, Scholler M, Bernhardt G, Buschauer A, König B, Ochoa-Puentes C.

ACS Med Chem Lett. 2018 Jul 25;9(8):854-859. doi: 10.1021/acsmedchemlett.8b00289. eCollection 2018 Aug 9.


In Search of NPY Y4R Antagonists: Incorporation of Carbamoylated Arginine, Aza-Amino Acids, or d-Amino Acids into Oligopeptides Derived from the C-Termini of the Endogenous Agonists.

Kuhn KK, Littmann T, Dukorn S, Tanaka M, Keller M, Ozawa T, Bernhardt G, Buschauer A.

ACS Omega. 2017 Jul 31;2(7):3616-3631. doi: 10.1021/acsomega.7b00451. Epub 2017 Jul 14.


Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity.

She X, Pegoli A, Mayr J, Hübner H, Bernhardt G, Gmeiner P, Keller M.

ACS Omega. 2017 Oct 31;2(10):6741-6754. doi: 10.1021/acsomega.7b01085. Epub 2017 Oct 16.


Fibrinogen - A Practical and Cost Efficient Biomarker for Detecting Periprosthetic Joint Infection.

Klim SM, Amerstorfer F, Gruber G, Bernhardt GA, Radl R, Leitner L, Leithner A, Glehr M.

Sci Rep. 2018 Jun 11;8(1):8802. doi: 10.1038/s41598-018-27198-3.


Coming of Age: CD96 Emerges as Modulator of Immune Responses.

Georgiev H, Ravens I, Papadogianni G, Bernhardt G.

Front Immunol. 2018 May 17;9:1072. doi: 10.3389/fimmu.2018.01072. eCollection 2018. Review.


CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity.

Roman Aguilera A, Lutzky VP, Mittal D, Li XY, Stannard K, Takeda K, Bernhardt G, Teng MWL, Dougall WC, Smyth MJ.

Oncoimmunology. 2018 Feb 1;7(5):e1424677. doi: 10.1080/2162402X.2018.1424677. eCollection 2018.


Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches.

Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots GG, Förster R, Bernhardt G.

Front Immunol. 2018 Apr 9;9:714. doi: 10.3389/fimmu.2018.00714. eCollection 2018.


Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.

Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B.

Nature. 2018 Apr;556(7702):520-524. doi: 10.1038/s41586-018-0046-x. Epub 2018 Apr 18.


Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.

Jackson SM, Manolaridis I, Kowal J, Zechner M, Taylor NMI, Bause M, Bauer S, Bartholomaeus R, Bernhardt G, Koenig B, Buschauer A, Stahlberg H, Altmann KH, Locher KP.

Nat Struct Mol Biol. 2018 Apr;25(4):333-340. doi: 10.1038/s41594-018-0049-1. Epub 2018 Apr 2.


Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies.

Georgiev H, Ravens I, Papadogianni G, Malissen B, Förster R, Bernhardt G.

Eur J Immunol. 2018 Jun;48(6):1078-1081. doi: 10.1002/eji.201747420. Epub 2018 Mar 23.


Perioperative, Spatiotemporally Coordinated Activation of T and NK Cells Prevents Recurrence of Pancreatic Cancer.

Brooks J, Fleischmann-Mundt B, Woller N, Niemann J, Ribback S, Peters K, Demir IE, Armbrecht N, Ceyhan GO, Manns MP, Wirth TC, Kubicka S, Bernhardt G, Smyth MJ, Calvisi DF, Gürlevik E, Kühnel F.

Cancer Res. 2018 Jan 15;78(2):475-488. doi: 10.1158/0008-5472.CAN-17-2415. Epub 2017 Nov 27.


Expression of CD226 is associated to but not required for NK cell education.

Wagner AK, Kadri N, Snäll J, Brodin P, Gilfillan S, Colonna M, Bernhardt G, Höglund P, Kärre K, Chambers BJ.

Nat Commun. 2017 May 31;8:15627. doi: 10.1038/ncomms15627.


Like or Dislike? Impact of Facebook on Ewing Sarcoma Treatment.

Ruckenstuhl P, Schippinger M, Liebmann P, Leithner A, Bernhardt G.

JMIR Cancer. 2016 Aug 25;2(2):e11. doi: 10.2196/cancer.5367.


Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor.

Pegoli A, She X, Wifling D, Hübner H, Bernhardt G, Gmeiner P, Keller M.

J Med Chem. 2017 Apr 27;60(8):3314-3334. doi: 10.1021/acs.jmedchem.6b01892. Epub 2017 Apr 17.


Fluorescence- and Radiolabeling of [Lys4,Nle17,30]hPP Yields Molecular Tools for the NPY Y4 Receptor.

Dukorn S, Littmann T, Keller M, Kuhn K, Cabrele C, Baumeister P, Bernhardt G, Buschauer A.

Bioconjug Chem. 2017 Apr 19;28(4):1291-1304. doi: 10.1021/acs.bioconjchem.7b00103. Epub 2017 Apr 5.


Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma.

Keller M, Maschauer S, Brennauer A, Tripal P, Koglin N, Dittrich R, Bernhardt G, Kuwert T, Wester HJ, Buschauer A, Prante O.

ACS Med Chem Lett. 2017 Feb 21;8(3):304-309. doi: 10.1021/acsmedchemlett.6b00467. eCollection 2017 Mar 9.


Label-free versus conventional cellular assays: Functional investigations on the human histamine H1 receptor.

Lieb S, Littmann T, Plank N, Felixberger J, Tanaka M, Schäfer T, Krief S, Elz S, Friedland K, Bernhardt G, Wegener J, Ozawa T, Buschauer A.

Pharmacol Res. 2016 Dec;114:13-26. doi: 10.1016/j.phrs.2016.10.010. Epub 2016 Oct 15.


Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the H1R, H4R, 5-HT2AR and other selected GPCRs.

Naporra F, Gobleder S, Wittmann HJ, Spindler J, Bodensteiner M, Bernhardt G, Hübner H, Gmeiner P, Elz S, Strasser A.

Pharmacol Res. 2016 Nov;113(Pt A):610-625. doi: 10.1016/j.phrs.2016.09.042. Epub 2016 Sep 30.


Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets.

Georgiev H, Ravens I, Benarafa C, Förster R, Bernhardt G.

Nat Commun. 2016 Oct 10;7:13116. doi: 10.1038/ncomms13116.


[The Effect of Intraoperative Screw Monitoring (Root Monitoring) with the INS-1 System (NUVASIVE) on the Radiological Outcome of Dorsal Instrumentation of the Lumbar Spine].

Bernhardt G, Awiszus F, Meister U, Heyde CE, Böhm H.

Z Orthop Unfall. 2016 Jun;154(3):269-74. doi: 10.1055/s-0042-100816. Epub 2016 Jun 28. German.


High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling.

Kuhn KK, Ertl T, Dukorn S, Keller M, Bernhardt G, Reiser O, Buschauer A.

J Med Chem. 2016 Jul 14;59(13):6045-58. doi: 10.1021/acs.jmedchem.6b00309. Epub 2016 Jun 22.


Label-free analysis of GPCR-stimulation: The critical impact of cell adhesion.

Lieb S, Michaelis S, Plank N, Bernhardt G, Buschauer A, Wegener J.

Pharmacol Res. 2016 Jun;108:65-74. doi: 10.1016/j.phrs.2016.04.026. Epub 2016 Apr 28.


Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.

Smith LE, Olszewski MA, Georgoudaki AM, Wagner AK, Hägglöf T, Karlsson MC, Dominguez-Villar M, Garcia-Cozar F, Mueller S, Ravens I, Bernhardt G, Chambers BJ.

J Leukoc Biol. 2016 Oct;100(4):781-789. Epub 2016 Mar 31.


Exploring miniature insect brains using micro-CT scanning techniques.

Smith DB, Bernhardt G, Raine NE, Abel RL, Sykes D, Ahmed F, Pedroso I, Gill RJ.

Sci Rep. 2016 Feb 24;6:21768. doi: 10.1038/srep21768.


BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells.

Edalat L, Stegen B, Klumpp L, Haehl E, Schilbach K, Lukowski R, Kühnle M, Bernhardt G, Buschauer A, Zips D, Ruth P, Huber SM.

Oncotarget. 2016 Mar 22;7(12):14259-78. doi: 10.18632/oncotarget.7423.


The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation.

Kraus AK, Chen J, Edenhofer I, Ravens I, Gaspert A, Cippà PE, Mueller S, Wuthrich RP, Segerer S, Bernhardt G, Fehr T.

PLoS One. 2016 Feb 3;11(2):e0147951. doi: 10.1371/journal.pone.0147951. eCollection 2016.


Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.

Keller M, Kuhn KK, Einsiedel J, Hübner H, Biselli S, Mollereau C, Wifling D, Svobodová J, Bernhardt G, Cabrele C, Vanderheyden PM, Gmeiner P, Buschauer A.

J Med Chem. 2016 Mar 10;59(5):1925-45. doi: 10.1021/acs.jmedchem.5b01495. Epub 2016 Feb 11.


Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy.

Blake SJ, Stannard K, Liu J, Allen S, Yong MC, Mittal D, Aguilera AR, Miles JJ, Lutzky VP, de Andrade LF, Martinet L, Colonna M, Takeda K, Kühnel F, Gurlevik E, Bernhardt G, Teng MW, Smyth MJ.

Cancer Discov. 2016 Apr;6(4):446-59. doi: 10.1158/2159-8290.CD-15-0944. Epub 2016 Jan 19.


Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.

Obreque-Balboa JE, Sun Q, Bernhardt G, König B, Buschauer A.

Eur J Med Chem. 2016 Feb 15;109:124-33. doi: 10.1016/j.ejmech.2015.12.010. Epub 2015 Dec 13.


CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation.

Georgiev H, Ravens I, Shibuya A, Förster R, Bernhardt G.

Eur J Immunol. 2016 Apr;46(4):993-1003. doi: 10.1002/eji.201546073. Epub 2016 Jan 20.


N(ω)-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([(3)H]UR-MK299) with Extended Residence Time.

Keller M, Weiss S, Hutzler C, Kuhn KK, Mollereau C, Dukorn S, Schindler L, Bernhardt G, König B, Buschauer A.

J Med Chem. 2015 Nov 25;58(22):8834-49. doi: 10.1021/acs.jmedchem.5b00925. Epub 2015 Nov 4.


Histamine H(1)- and H(4)-receptor signaling cooperatively regulate MAPK activation.

Beermann S, Bernhardt G, Seifert R, Buschauer A, Neumann D.

Biochem Pharmacol. 2015 Dec 1;98(3):432-9. doi: 10.1016/j.bcp.2015.09.011. Epub 2015 Sep 15.


Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver.

Schreder A, Moschovakis GL, Halle S, Schlue J, Lee CW, Schippers A, David S, Bernhardt G, Ganser A, Pabst O, Förster R, Koenecke C.

Biol Blood Marrow Transplant. 2015 Dec;21(12):2069-2078. doi: 10.1016/j.bbmt.2015.08.038. Epub 2015 Sep 5.


Esters of Bendamustine Are by Far More Potent Cytotoxic Agents than the Parent Compound against Human Sarcoma and Carcinoma Cells.

Huber S, Huettner JP, Hacker K, Bernhardt G, König J, Buschauer A.

PLoS One. 2015 Jul 21;10(7):e0133743. doi: 10.1371/journal.pone.0133743. eCollection 2015.


CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.

Yamashita-Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.

J Immunol. 2015 Jun 15;194(12):5644-53. doi: 10.4049/jimmunol.1401942. Epub 2015 May 13.


Topotecan-induced ABCG2 expression in MCF-7 cells is associated with decreased CD24 and EpCAM expression and a loss of tumorigenicity.

Huber S, Wege AK, Bernhardt G, Buschauer A, Brockhoff G.

Cytometry A. 2015 Aug;87(8):707-16. doi: 10.1002/cyto.a.22675. Epub 2015 Apr 17.


Toward Labeled Argininamide-Type NPY Y1 Receptor Antagonists: Identification of a Favorable Propionylation Site in BIBO3304.

Keller M, Schindler L, Bernhardt G, Buschauer A.

Arch Pharm (Weinheim). 2015 Jun;348(6):390-8. doi: 10.1002/ardp.201400427. Epub 2015 Apr 17.


High performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) for the sensitive determination of hyaluronan oligosaccharides.

Rothenhöfer M, Grundmann M, Bernhardt G, Matysik FM, Buschauer A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:106-15. doi: 10.1016/j.jchromb.2015.02.027. Epub 2015 Feb 25.


Targeting CD226/DNAX accessory molecule-1 (DNAM-1) in collagen-induced arthritis mouse models.

Elhai M, Chiocchia G, Marchiol C, Lager F, Renault G, Colonna M, Bernhardt G, Allanore Y, Avouac J.

J Inflamm (Lond). 2015 Feb 8;12:9. doi: 10.1186/s12950-015-0056-5. eCollection 2015.


M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding.

Keller M, Tränkle C, She X, Pegoli A, Bernhardt G, Buschauer A, Read RW.

Bioorg Med Chem. 2015 Jul 15;23(14):3970-90. doi: 10.1016/j.bmc.2015.01.015. Epub 2015 Jan 14.


Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists.

Kagermeier N, Werner K, Keller M, Baumeister P, Bernhardt G, Seifert R, Buschauer A.

Bioorg Med Chem. 2015 Jul 15;23(14):3957-69. doi: 10.1016/j.bmc.2015.01.012. Epub 2015 Jan 14.


The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity.

Wifling D, Bernhardt G, Dove S, Buschauer A.

PLoS One. 2015 Jan 28;10(1):e0117185. doi: 10.1371/journal.pone.0117185. eCollection 2015. Erratum in: PLoS One. 2015;10(3):e0122162.


Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: kinetic investigations by HPLC.

Huber S, Antoni F, Schickaneder C, Schickaneder H, Bernhardt G, Buschauer A.

J Pharm Biomed Anal. 2015 Feb;104:137-43. doi: 10.1016/j.jpba.2014.11.038. Epub 2014 Nov 27.


Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice.

Nagumo Y, Iguchi-Manaka A, Yamashita-Kanemaru Y, Abe F, Bernhardt G, Shibuya A, Shibuya K.

PLoS One. 2014 Nov 10;9(11):e112415. doi: 10.1371/journal.pone.0112415. eCollection 2014.


[(3) H]UR-DE257: development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist.

Baumeister P, Erdmann D, Biselli S, Kagermeier N, Elz S, Bernhardt G, Buschauer A.

ChemMedChem. 2015 Jan;10(1):83-93. doi: 10.1002/cmdc.201402344. Epub 2014 Oct 15.


Quality of life after volar locked plating: a 10-year follow-up study of patients with intra-articular distal radius fractures.

Ruckenstuhl P, Bernhardt GA, Sadoghi P, Glehr M, Holzer LA, Leithner A, Wolf M, Gruber G.

BMC Musculoskelet Disord. 2014 Jul 24;15:250. doi: 10.1186/1471-2474-15-250.

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