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Items: 1 to 50 of 266


The History of Armand Trousseau and Cancer-Associated Thrombosis.

Metharom P, Falasca M, Berndt MC.

Cancers (Basel). 2019 Jan 31;11(2). pii: E158. doi: 10.3390/cancers11020158.


EPHB2 regulates platelet activation.

Berndt MC, Andrews RK.

Blood. 2018 Nov 8;132(19):2002-2004. doi: 10.1182/blood-2018-09-876086. No abstract available.


Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment.

Abdol Razak NB, Jones G, Bhandari M, Berndt MC, Metharom P.

Cancers (Basel). 2018 Oct 11;10(10). pii: E380. doi: 10.3390/cancers10100380. Review.


The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance.

Elaskalani O, Falasca M, Moran N, Berndt MC, Metharom P.

Cancers (Basel). 2017 Oct 24;9(10). pii: E142. doi: 10.3390/cancers9100142.


Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2017 Aug 30;8:16125. doi: 10.1038/ncomms16125.


Targeting Platelets for the Treatment of Cancer.

Elaskalani O, Berndt MC, Falasca M, Metharom P.

Cancers (Basel). 2017 Jul 22;9(7). pii: E94. doi: 10.3390/cancers9070094. Review.


Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.

Deng W, Xu Y, Chen W, Paul DS, Syed AK, Dragovich MA, Liang X, Zakas P, Berndt MC, Di Paola J, Ware J, Lanza F, Doering CB, Bergmeier W, Zhang XF, Li R.

Nat Commun. 2016 Sep 27;7:12863. doi: 10.1038/ncomms12863.


14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2016 Sep 27;7:12862. doi: 10.1038/ncomms12862. Erratum in: Nat Commun. 2017 Aug 30;8:16125.


Liver-mediated shedding of platelet GPVI.

Berndt MC, Andrews RK.

Blood. 2016 Aug 11;128(6):751-2. doi: 10.1182/blood-2016-07-723973. No abstract available.


Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.

Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC, Metharom P.

Redox Biol. 2015 Dec;6:640-647. doi: 10.1016/j.redox.2015.10.009. Epub 2015 Oct 28.


COMP: an endogenous thrombin inhibitor.

Metharom P, Berndt MC.

Blood. 2015 Aug 13;126(7):831-2. doi: 10.1182/blood-2015-06-650846.


Current state and novel approaches of antiplatelet therapy.

Metharom P, Berndt MC, Baker RI, Andrews RK.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1327-38. doi: 10.1161/ATVBAHA.114.303413. Epub 2015 Apr 2. Review.


Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation.

Carrim N, Walsh TG, Consonni A, Torti M, Berndt MC, Metharom P.

PLoS One. 2014 Nov 21;9(11):e113679. doi: 10.1371/journal.pone.0113679. eCollection 2014.


The functional role of platelets in the regulation of angiogenesis.

Walsh TG, Metharom P, Berndt MC.

Platelets. 2015;26(3):199-211. doi: 10.3109/09537104.2014.909022. Epub 2014 May 15. Review.


Primary haemostasis: newer insights.

Berndt MC, Metharom P, Andrews RK.

Haemophilia. 2014 May;20 Suppl 4:15-22. doi: 10.1111/hae.12427. Review.


The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.

Walsh TG, Berndt MC, Carrim N, Cowman J, Kenny D, Metharom P.

Redox Biol. 2014 Jan 13;2:178-86. doi: 10.1016/j.redox.2013.12.023. eCollection 2014.


Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.

Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R.

J Thromb Haemost. 2013 Dec;11(12):2155-62. doi: 10.1111/jth.12425.


Bernard-Soulier syndrome: an update.

Andrews RK, Berndt MC.

Semin Thromb Hemost. 2013 Sep;39(6):656-62. doi: 10.1055/s-0033-1353390. Epub 2013 Aug 8. Review.


LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis.

Estevez B, Stojanovic-Terpo A, Delaney MK, O'Brien KA, Berndt MC, Ruan C, Du X.

Blood. 2013 May 30;121(22):4586-94. doi: 10.1182/blood-2012-12-470765. Epub 2013 Apr 25.


Platelet hem-immunoreceptor tyrosine-based activation motif receptors: at least one required.

Berndt MC, Andrews RK.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):884-5. doi: 10.1161/ATVBAHA.113.301400. No abstract available.


Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.

Mazharian A, Wang YJ, Mori J, Bem D, Finney B, Heising S, Gissen P, White JG, Berndt MC, Gardiner EE, Nieswandt B, Douglas MR, Campbell RD, Watson SP, Senis YA.

Sci Signal. 2012 Oct 30;5(248):ra78. doi: 10.1126/scisignal.2002936.


The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.

Delaney MK, Liu J, Zheng Y, Berndt MC, Du X.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2761-8. doi: 10.1161/ATVBAHA.112.254920. Epub 2012 Sep 20.


An acquired defect associated with abnormal signaling of the platelet collagen receptor glycoprotein VI.

Qiao J, Arthur JF, Collecutt M, Shen Y, Mu FT, Berndt MC, Davis AK, Andrews RK, Gardiner EE.

Acta Haematol. 2012;128(4):233-41. doi: 10.1159/000340048. Epub 2012 Aug 24.


Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood.

Jung SM, Moroi M, Soejima K, Nakagaki T, Miura Y, Berndt MC, Gardiner EE, Howes JM, Pugh N, Bihan D, Watson SP, Farndale RW.

J Biol Chem. 2012 Aug 24;287(35):30000-13. doi: 10.1074/jbc.M112.359125. Epub 2012 Jul 6.


Cadherin 6 has a functional role in platelet aggregation and thrombus formation.

Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, Newman PJ, Ni H, Kenny D.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1724-31. doi: 10.1161/ATVBAHA.112.250464. Epub 2012 Apr 26.


ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways.

Arthur JF, Qiao J, Shen Y, Davis AK, Dunne E, Berndt MC, Gardiner EE, Andrews RK.

J Thromb Haemost. 2012 Jun;10(6):1133-41. doi: 10.1111/j.1538-7836.2012.04734.x.


Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels.

Al-Tamimi M, Tan CW, Qiao J, Pennings GJ, Javadzadegan A, Yong AS, Arthur JF, Davis AK, Jing J, Mu FT, Hamilton JR, Jackson SP, Ludwig A, Berndt MC, Ward CM, Kritharides L, Andrews RK, Gardiner EE.

Blood. 2012 May 3;119(18):4311-20. doi: 10.1182/blood-2011-10-386607. Epub 2012 Mar 19.


Platelet receptor shedding.

Gardiner EE, Al-Tamimi M, Andrews RK, Berndt MC.

Methods Mol Biol. 2012;788:321-39. doi: 10.1007/978-1-61779-307-3_22. Review.


Bernard-Soulier syndrome.

Berndt MC, Andrews RK.

Haematologica. 2011 Mar;96(3):355-9. doi: 10.3324/haematol.2010.039883. No abstract available.


Thrombotic thrombocytopenic purpura: reducing the risk?

Berndt MC, Andrews RK.

J Clin Invest. 2011 Feb;121(2):522-4. doi: 10.1172/JCI46091. Epub 2011 Jan 25.


Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa.

Al-Tamimi M, Grigoriadis G, Tran H, Paul E, Servadei P, Berndt MC, Gardiner EE, Andrews RK.

Blood. 2011 Apr 7;117(14):3912-20. doi: 10.1182/blood-2010-08-301523. Epub 2011 Jan 20.


An event of shear importance.

Andrews RK, Berndt MC.

Blood. 2011 Jan 6;117(1):5-7. doi: 10.1182/blood-2010-10-312116. No abstract available.


Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke.

Al-Tamimi M, Gardiner EE, Thom JY, Shen Y, Cooper MN, Hankey GJ, Berndt MC, Baker RI, Andrews RK.

Stroke. 2011 Feb;42(2):498-500. doi: 10.1161/STROKEAHA.110.602532. Epub 2010 Dec 30.


High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction.

Cranmer SL, Ashworth KJ, Yao Y, Berndt MC, Ruggeri ZM, Andrews RK, Jackson SP.

Blood. 2011 Mar 3;117(9):2718-27. doi: 10.1182/blood-2010-07-296194. Epub 2010 Dec 14.


TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.

Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC.

J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. Erratum in: J Thromb Haemost. 2011 Dec;9(12):2523. Murphy, D [added].


Arterial thrombosis: going, gone!

Gardiner EE, Berndt MC.

Blood. 2010 Sep 30;116(13):2201-2. doi: 10.1182/blood-2010-06-291492. No abstract available.


Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha.

Mo X, Nguyen NX, Mu FT, Yang W, Luo SZ, Fan H, Andrews RK, Berndt MC, Li R.

J Biol Chem. 2010 Oct 15;285(42):32096-104. doi: 10.1074/jbc.M110.111864. Epub 2010 Aug 17.


GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events.

Gardiner EE, Arthur JF, Shen Y, Karunakaran D, Moore LA, Am Esch JS 2nd, Andrews RK, Berndt MC.

Platelets. 2010;21(4):244-52. doi: 10.3109/09537101003695339.


Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI.

Wijeyewickrema LC, Gardiner EE, Gladigau EL, Berndt MC, Andrews RK.

J Biol Chem. 2010 Apr 16;285(16):11793-9. doi: 10.1074/jbc.M110.100479. Epub 2010 Feb 17.


Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpura.

Gardiner EE, Thom JY, Al-Tamimi M, Hughes A, Berndt MC, Andrews RK, Baker RI.

Br J Haematol. 2010 May;149(4):625-8. doi: 10.1111/j.1365-2141.2010.08092.x. Epub 2010 Feb 8. No abstract available.


Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex.

Mu FT, Cranmer SL, Andrews RK, Berndt MC.

J Thromb Haemost. 2010 Feb;8(2):324-30. doi: 10.1111/j.1538-7836.2009.03672.x. Epub 2009 Oct 30.


Reducing intra-individual variation in platelet aggregation: implications for platelet function testing.

Peace AJ, Egan K, Kavanagh GF, Tedesco AF, Foley DP, Dicker P, Berndt MC, Kenny D.

J Thromb Haemost. 2009 Nov;7(11):1941-3. doi: 10.1111/j.1538-7836.2009.03593.x. Epub 2009 Aug 19. No abstract available.


Presence of platelet-associated anti-glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency.

Akiyama M, Kashiwagi H, Todo K, Moroi M, Berndt MC, Kojima H, Kanakura Y, Tomiyama Y.

J Thromb Haemost. 2009 Aug;7(8):1373-83. doi: 10.1111/j.1538-7836.2009.03510.x. Epub 2009 Jun 9.


Recent advances in vascular biology: selected highlights from IVBM 2008.

Khachigian LM, Peter K, Berndt MC.

Thromb Haemost. 2009 Jun;101(6):997-8. No abstract available.


Measuring soluble platelet glycoprotein VI in human plasma by ELISA.

Al-Tamimi M, Mu FT, Moroi M, Gardiner EE, Berndt MC, Andrews RK.

Platelets. 2009 May;20(3):143-9. doi: 10.1080/09537100802710286.


Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding.

Al-Tamimi M, Mu FT, Arthur JF, Shen Y, Moroi M, Berndt MC, Andrews RK, Gardiner EE.

Platelets. 2009 Mar;20(2):75-82. doi: 10.1080/09537100802645029.


Systems biology meets platelet biology.

Berndt MC, Andrews RK.

Blood. 2008 Nov 15;112(10):3920-1. doi: 10.1182/blood-2008-07-170225. No abstract available.


Dual antiplatelet therapy unmasks distinct platelet reactivity in patients with coronary artery disease.

Peace AJ, Tedesco AF, Foley DP, Dicker P, Berndt MC, Kenny D.

J Thromb Haemost. 2008 Dec;6(12):2027-34. doi: 10.1111/j.1538-7836.2008.03157.x. Epub 2008 Sep 23.


Microparticles facilitate neutrophil/platelet crosstalk.

Andrews RK, Berndt MC.

Blood. 2008 Sep 15;112(6):2174-5. doi: 10.1182/blood-2008-06-163063. No abstract available.


Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.

Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK.

J Thromb Haemost. 2008 Nov;6(11):1915-22. doi: 10.1111/j.1538-7836.2008.03135.x. Epub 2008 Aug 22.

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