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Items: 1 to 50 of 274

1.

Monitoring of Systemic Lupus Erythematosus Pregnancies: A Systematic Literature Review.

McDonald EG, Bissonette L, Ensworth S, Dayan N, Clarke AE, Keeling S, Bernatsky S, Vinet E.

J Rheumatol. 2018 Jul 15. pii: jrheum.171023. doi: 10.3899/jrheum.171023. [Epub ahead of print]

2.

Risk of Childhood Rheumatic and Non-Rheumatic Autoimmune Diseases in Children Born to Women with Systemic Lupus Erythematosus.

Couture J, Bernatsky S, Scott S, Pineau CA, Vinet E.

Arthritis Rheumatol. 2018 May 23. doi: 10.1002/art.40570. [Epub ahead of print]

PMID:
29790298
3.

Serious infections in rheumatoid arthritis offspring exposed to tumour necrosis factor α inhibitors: cohort study.

Vinet É, De Moura C, Pineau CA, Abrahamowicz M, Curtis JR, Bernatsky S.

Arthritis Rheumatol. 2018 May 17. doi: 10.1002/art.40536. [Epub ahead of print]

PMID:
29771477
4.

Treatment Discontinuation and Clinical Events in Type 2 Diabetes Patients Treated with Dipeptidyl Peptidase-4 Inhibitors or NPH Insulin as Third-Line Therapy.

Moura CS, Rosenberg ZB, Abrahamowicz M, Bernatsky S, Behlouli H, Pilote L.

J Diabetes Res. 2018 Mar 11;2018:4817178. doi: 10.1155/2018/4817178. eCollection 2018.

5.

Effectiveness and safety of tofacitinib in rheumatoid arthritis: a cohort study.

Machado MAÁ, Moura CS, Guerra SF, Curtis JR, Abrahamowicz M, Bernatsky S.

Arthritis Res Ther. 2018 Mar 23;20(1):60. doi: 10.1186/s13075-018-1539-6.

6.

Causes of death in rheumatoid arthritis: How do they compare to the general population?

Widdifield J, Paterson JM, Huang A, Bernatsky S.

Arthritis Care Res (Hoboken). 2018 Mar 7. doi: 10.1002/acr.23548. [Epub ahead of print]

PMID:
29512334
7.

Glucocorticoid use and factors associated with variability in this use in the Systemic Lupus International Collaborating Clinics Inception Cohort.

Little J, Parker B, Lunt M, Hanly JG, Urowitz MB, Clarke AE, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Buyon J, Isenberg DA, Rahman A, Ginzler EM, Petri M, Dooley MA, Fortin P, Gladman DD, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Mackay M, Alarcón GS, Manzi S, Nived O, Jönsen A, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Sam Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Sanchez-Guerrero J, Bruce IN.

Rheumatology (Oxford). 2018 Apr 1;57(4):677-687. doi: 10.1093/rheumatology/kex444.

PMID:
29361147
8.

Risk of preterm birth following late pregnancy exposure to NSAIDs or COX-2 inhibitors.

Bérard A, Sheehy O, Girard S, Zhao JP, Bernatsky S.

Pain. 2018 May;159(5):948-955. doi: 10.1097/j.pain.0000000000001163.

PMID:
29351170
9.

Smoking Is the Most Significant Modifiable Lung Cancer Risk Factor in Systemic Lupus Erythematosus.

Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin PR, Yelin EH, Ginzler E, Hanly JG, Peschken C, Gordon C, Nived O, Aranow C, Bae SC, Isenberg D, Rahman A, Hansen JE, Pierre YS, Clarke AE.

J Rheumatol. 2018 Mar;45(3):393-396. doi: 10.3899/jrheum.170652. Epub 2018 Jan 15.

PMID:
29335347
10.

Cerebrovascular Events in Systemic Lupus Erythematosus.

Hanly JG, Li Q, Su L, Urowitz MB, Gordon C, Bae SC, Romero-Diaz J, Sanchez-Guerrero J, Bernatsky S, Clarke AE, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin P, Gladman DD, Bruce IN, Petri M, Ginzler EM, Dooley MA, Steinsson K, Ramsey-Goldman R, Zoma AA, Manzi S, Nived O, Jonsen A, Khamashta MA, Alarcón GS, Chatham W, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Ramos-Casals M, Lim SS, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Theriault C, Farewell V.

Arthritis Care Res (Hoboken). 2018 Jan 5. doi: 10.1002/acr.23509. [Epub ahead of print]

PMID:
29316357
11.

Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study.

Ferreira I, Croca S, Raimondo MG, Matharu M, Miller S, Giles I, Isenberg D, Ioannou Y, Hanly JG, Urowitz MB, Anderson N, Aranow C, Askanase A, Bae SC, Bernatsky S, Bruce IN, Buyon J, Clarke AE, Dooley MA, Fortin P, Ginzler E, Gladman D, Gordon C, Inanc M, Jacobsen S, Kalunian K, Kamen D, Khamashta M, Lim S, Manzi S, Merrill J, Nived O, Peschken C, Petri M, Ramsey-Goldman R, Ruiz-Irastorza G, Sanchez-Guerrero J, Steinson K, Sturfelt GK, van Vollenhoven R, Wallace DJ, Zoma A, Rahman A.

Arthritis Res Ther. 2017 Dec 22;19(1):287. doi: 10.1186/s13075-017-1495-6.

12.

A comparison of health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARDs).

Greenfield J, Hudson M, Vinet E, Fortin PR, Bykerk V, Pineau CA, Wang M, Bernatsky S, Baron M; Canadian Scleroderma Research Group and Canadian Inflammatory Myopathy Study Group.

PLoS One. 2017 Dec 19;12(12):e0189840. doi: 10.1371/journal.pone.0189840. eCollection 2017.

13.

A review on SLE and malignancy.

Choi MY, Flood K, Bernatsky S, Ramsey-Goldman R, Clarke AE.

Best Pract Res Clin Rheumatol. 2017 Jun;31(3):373-396. doi: 10.1016/j.berh.2017.09.013. Epub 2017 Nov 10. Review.

PMID:
29224679
14.

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.

Bernatsky S, Velásquez García HA, Spinelli JJ, Gaffney P, Smedby KE, Ramsey-Goldman R, Wang SS, Adami HO, Albanes D, Angelucci E, Ansell SM, Asmann YW, Becker N, Benavente Y, Berndt SI, Bertrand KA, Birmann BM, Boeing H, Boffetta P, Bracci PM, Brennan P, Brooks-Wilson AR, Cerhan JR, Chanock SJ, Clavel J, Conde L, Cotenbader KH, Cox DG, Cozen W, Crouch S, De Roos AJ, de Sanjose S, Di Lollo S, Diver WR, Dogan A, Foretova L, Ghesquières H, Giles GG, Glimelius B, Habermann TM, Haioun C, Hartge P, Hjalgrim H, Holford TR, Holly EA, Jackson RD, Kaaks R, Kane E, Kelly RS, Klein RJ, Kraft P, Kricker A, Lan Q, Lawrence C, Liebow M, Lightfoot T, Link BK, Maynadie M, McKay J, Melbye M, Molina TJ, Monnereau A, Morton LM, Nieters A, North KE, Novak AJ, Offit K, Purdue MP, Rais M, Riby J, Roman E, Rothman N, Salles G, Severi G, Severson RK, Skibola CF, Slager SL, Smith A, Smith MT, Southey MC, Staines A, Teras LR, Thompson CA, Tilly H, Tinker LF, Tjonneland A, Turner J, Vajdic CM, Vermeulen RCH, Vijai J, Vineis P, Virtamo J, Wang Z, Weinstein S, Witzig TE, Zelenetz A, Zeleniuch-Jacquotte A, Zhang Y, Zheng T, Zucca M, Clarke AE.

Lupus Sci Med. 2017 Nov 12;4(1):e000187. doi: 10.1136/lupus-2016-000187. eCollection 2017.

15.

Economic evaluation of lupus nephritis in the Systemic Lupus International Collaborating Clinics inception cohort using a multistate model approach.

Barber MRW, Hanly JG, Su L, Urowitz MB, Pierre YS, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Fortin PR, Gladman DD, Sanchez-Guerrero J, Ramsey-Goldman R, Khamashta MA, Aranow C, Mackay M, Alarcón GS, Manzi S, Nived O, Jönsen A, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Sam Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Theriault C, Farewell V, Clarke AE.

Arthritis Care Res (Hoboken). 2017 Nov 28. doi: 10.1002/acr.23480. [Epub ahead of print]

PMID:
29193883
16.

Comment on: Cumulative immunosuppressant exposure is associated with diversified cancer risk among 14 832 patients with systemic lupus erythematosus.

Bernatsky S, Clarke AE, Ramsey-Goldman R.

Rheumatology (Oxford). 2017 Oct 1;56(10):1823-1824. doi: 10.1093/rheumatology/kex255. No abstract available.

PMID:
28957560
17.

Temporal trends in prevalence, incidence, and mortality for rheumatoid arthritis in Quebec, Canada: a population-based study.

Jean S, Hudson M, Gamache P, Bessette L, Fortin PR, Boire G, Bernatsky S.

Clin Rheumatol. 2017 Dec;36(12):2667-2671. doi: 10.1007/s10067-017-3796-1. Epub 2017 Aug 21.

PMID:
28828712
18.

Antiretroviral combination use during pregnancy and the risk of major congenital malformations.

Bérard A, Sheehy O, Zhao JP, Abrahamowicz M, Loutfy M, Boucoiran I, Bernatsky S.

AIDS. 2017 Oct 23;31(16):2267-2277. doi: 10.1097/QAD.0000000000001610.

PMID:
28806195
19.

Malignancy in Pediatric-onset Systemic Lupus Erythematosus.

Bernatsky S, Clarke AE, Zahedi Niaki O, Labrecque J, Schanberg LE, Silverman ED, Hayward K, Imundo L, Brunner HI, Haines KA, Cron RQ, Oen K, Wagner-Weiner L, Rosenberg AM, O'Neil KM, Duffy CM, von Scheven E, Joseph L, Lee JL, Ramsey-Goldman R.

J Rheumatol. 2017 Oct;44(10):1484-1486. doi: 10.3899/jrheum.170179. Epub 2017 Aug 1.

PMID:
28765255
20.

Comparative effectiveness of antihypertensive drugs in nondiabetic patients with hypertension: A population-based study.

Machado MAÁ, de Moura CS, Wang Y, Danieli C, Abrahamowicz M, Bernatsky S, Behlouli H, Pilote L.

J Clin Hypertens (Greenwich). 2017 Oct;19(10):999-1009. doi: 10.1111/jch.13055. Epub 2017 Jul 29.

21.

Clinically Apparent Arterial Thrombosis in Persons with Systemic Vasculitis.

Tsoukas A, Bernatsky S, Joseph L, Buckeridge DL, Bélisle P, Pineau CA.

Int J Rheumatol. 2017;2017:3572768. doi: 10.1155/2017/3572768. Epub 2017 Jun 21.

22.

Breast cancer in systemic lupus erythematosus (SLE): receptor status and treatment.

Chan K, Clarke AE, Ramsey-Goldman R, Foulkes W, Tessier Cloutier B, Urowitz MB, Gladman D, Nived O, Romero-Diaz J, Petri M, Ginzler E, Fortin PR, Bae SC, Wallace DJ, Yelin EH, Bernatsky S.

Lupus. 2018 Jan;27(1):120-123. doi: 10.1177/0961203317713146. Epub 2017 Jun 8.

PMID:
28595511
23.

Application of pharmacogenomics to investigate adverse drug reactions to the disease-modifying treatments for multiple sclerosis: a case-control study protocol for dimethyl fumarate-induced lymphopenia.

Kowalec K, Kingwell E, Carruthers R, Marrie RA, Bernatsky S, Traboulsee A, Ross CJD, Carleton B, Tremlett H.

BMJ Open. 2017 Jun 2;7(5):e016276. doi: 10.1136/bmjopen-2017-016276.

24.

Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies.

Bernatsky S, Smargiassi A, Joseph L, Awadalla P, Colmegna I, Hudson M, Fritzler MJ.

Environ Res. 2017 Aug;157:60-63. doi: 10.1016/j.envres.2017.04.035. Epub 2017 May 17.

PMID:
28525857
25.

Postpartum complications in new mothers with juvenile idiopathic arthritis: a population-based cohort study.

Ehrmann Feldman D, Vinet É, Sylvestre MP, Hazel B, Duffy C, Bérard A, Meshefedjian G, Bernatsky S.

Rheumatology (Oxford). 2017 Aug 1;56(8):1378-1385. doi: 10.1093/rheumatology/kex168.

PMID:
28460079
26.

The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients.

Choi MY, Clarke AE, St Pierre Y, Hanly JG, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin P, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Manzi S, Nived O, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Buyon J, Mahler M, Fritzler MJ.

Lupus. 2017 Sep;26(10):1051-1059. doi: 10.1177/0961203317692437. Epub 2017 Feb 23.

PMID:
28420054
27.

Outcomes in Children Born to Women with Rheumatic Diseases.

Vinet É, Bernatsky S.

Rheum Dis Clin North Am. 2017 May;43(2):263-273. doi: 10.1016/j.rdc.2016.12.006. Epub 2017 Mar 14. Review.

PMID:
28390568
28.

Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients.

Isenberg D, Sturgess J, Allen E, Aranow C, Askanase A, Sang-Cheol B, Bernatsky S, Bruce I, Buyon J, Cervera R, Clarke A, Dooley MA, Fortin P, Ginzler E, Gladman D, Hanly J, Inanc M, Jacobsen S, Kamen D, Khamashta M, Lim S, Manzi S, Nived O, Peschken C, Petri M, Kalunian K, Rahman A, Ramsey-Goldman R, Romero-Diaz J, Ruiz-Irastorza G, Sanchez-Guerrero J, Steinsson K, Sturfelt G, Urowitz M, van Vollenhoven R, Wallace DJ, Zoma A, Merrill J, Gordon C.

Arthritis Care Res (Hoboken). 2018 Jan;70(1):98-103. doi: 10.1002/acr.23252. Epub 2017 Dec 8.

29.

Novel insights into systemic autoimmune rheumatic diseases using shared molecular signatures and an integrative analysis.

Hudson M, Bernatsky S, Colmegna I, Lora M, Pastinen T, Klein Oros K, Greenwood CMT.

Epigenetics. 2017 Jun 3;12(6):433-440. doi: 10.1080/15592294.2017.1303581. Epub 2017 Apr 7.

30.

Risk of Allergic Conditions in Children Born to Women With Systemic Lupus Erythematosus.

Couture J, Ben-Shoshan M, Pineau CA, Scott S, Clarke AE, Bernatsky S, Vinet E.

Arthritis Care Res (Hoboken). 2018 Feb;70(2):315-319. doi: 10.1002/acr.23251. Epub 2018 Jan 22.

PMID:
28382783
31.

Risk of Autism Spectrum Disorders in Children Born to Mothers With Rheumatoid Arthritis: A Systematic Literature Review.

Wojcik S, Bernatsky S, Platt RW, Pineau CA, Clarke AE, Fombonne É, Bérard A, Vinet É.

Arthritis Care Res (Hoboken). 2017 Dec;69(12):1926-1931. doi: 10.1002/acr.23235. Epub 2017 Nov 7. Review.

PMID:
28319657
32.

Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus.

Demirci FY, Wang X, Morris DL, Feingold E, Bernatsky S, Pineau C, Clarke A, Ramsey-Goldman R, Manzi S, Vyse TJ, Kamboh MI.

J Med Genet. 2017 Jun;54(6):381-389. doi: 10.1136/jmedgenet-2016-104247. Epub 2017 Mar 13.

33.

Disease characterization of systemic lupus erythematosus (SLE) patients in Quebec.

Ng R, Bernatsky S, Rahme E.

Lupus. 2017 Aug;26(9):1005-1011. doi: 10.1177/0961203317692435. Epub 2017 Feb 8.

PMID:
28178878
34.

The spectrum of rheumatic in-patient diagnoses at a pediatric hospital in Kenya.

Migowa A, Colmegna I, Hitchon C, Were E, Ng'ang'a E, Ngwiri T, Wachira J, Bernatsky S, Scuccimarri R.

Pediatr Rheumatol Online J. 2017 Jan 14;15(1):4. doi: 10.1186/s12969-016-0131-3.

35.

Primary Care Screening and Comorbidity Management in Rheumatoid Arthritis in Ontario, Canada.

Widdifield J, Ivers NM, Bernatsky S, Jaakkimainen L, Bombardier C, Thorne JC, Ahluwalia V, Paterson JM, Young J, Wing L, Tu K.

Arthritis Care Res (Hoboken). 2017 Oct;69(10):1495-1503. doi: 10.1002/acr.23178. Epub 2017 Aug 22.

PMID:
27998044
36.

SSRI and SNRI use during pregnancy and the risk of persistent pulmonary hypertension of the newborn.

Bérard A, Sheehy O, Zhao JP, Vinet É, Bernatsky S, Abrahamowicz M.

Br J Clin Pharmacol. 2017 May;83(5):1126-1133. doi: 10.1111/bcp.13194. Epub 2017 Jan 18.

37.

Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review.

Sun G, Hazlewood G, Bernatsky S, Kaplan GG, Eksteen B, Barnabe C.

Int J Rheumatol. 2016;2016:5356307. Epub 2016 Oct 25. Review.

38.

Brief Report: Risk of Gastrointestinal Perforation Among Rheumatoid Arthritis Patients Receiving Tofacitinib, Tocilizumab, or Other Biologic Treatments.

Xie F, Yun H, Bernatsky S, Curtis JR.

Arthritis Rheumatol. 2016 Nov;68(11):2612-2617. doi: 10.1002/art.39761.

39.

Breast cancer in systemic lupus.

Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin PF, Ginzler E, Romero-Diaz J, Peschken C, Jacobsen S, Hanly JG, Gordon C, Nived O, Yelin EH, Isenberg D, Rahman A, Bae SC, Joseph L, Witte T, Ruiz-Irastorza G, Aranow C, Kamen D, Sturfeldt G, Foulkes WD, Hansen JE, St Pierre Y, Raymer PC, Tessier-Cloutier B, Clarke AE.

Lupus. 2017 Mar;26(3):311-315. doi: 10.1177/0961203316664595. Epub 2016 Sep 30.

40.

Treatment persistence in patients with rheumatoid arthritis and ankylosing spondylitis.

Machado MA, Moura CS, Ferré F, Bernatsky S, Rahme E, Acurcio Fde A.

Rev Saude Publica. 2016 Aug 22;50:50. doi: 10.1590/S1518-8787.2016050006265. English, Portuguese.

41.

Health-selective migration among patients with rheumatoid arthritis in Québec: a cohort study using administrative data.

Labrecque JA, Kyle RP, Joseph L, Bernatsky S.

Rheumatol Int. 2016 Sep;36(9):1275-9. doi: 10.1007/s00296-016-3540-1. Epub 2016 Jul 26.

PMID:
27460818
42.

Hospitalization for musculoskeletal disorders in rheumatoid arthritis patients: a population-based study.

Machado MA, Bernatsky S, Bessette L, Nedjar H, Rahme E.

BMC Musculoskelet Disord. 2016 Jul 19;17:298. doi: 10.1186/s12891-016-1142-4.

43.

Cancer and autoimmunity: Harnessing longitudinal cohorts to probe the link.

Egiziano G, Bernatsky S, Shah AA.

Best Pract Res Clin Rheumatol. 2016 Feb;30(1):53-62. doi: 10.1016/j.berh.2016.03.001. Epub 2016 Apr 9. Review.

44.

Wait times to rheumatology care for patients with rheumatic diseases: a data linkage study of primary care electronic medical records and administrative data.

Widdifield J, Bernatsky S, Thorne JC, Bombardier C, Jaakkimainen RL, Wing L, Paterson JM, Ivers N, Butt D, Lyddiatt A, Hofstetter C, Ahluwalia V, Tu K.

CMAJ Open. 2016 May 11;4(2):E205-12. doi: 10.9778/cmajo.20150116. eCollection 2016 Apr-Jun.

45.

Standardised incidence ratios (SIRs) for cancer after renal transplant in systemic lupus erythematosus (SLE) and non-SLE recipients.

Ramsey-Goldman R, Brar A, Richardson C, Salifu MO, Clarke A, Bernatsky S, Stefanov DG, Jindal RM.

Lupus Sci Med. 2016 Jun 6;3(1):e000156. doi: 10.1136/lupus-2016-000156. eCollection 2016.

46.

Inflammatory Arthritis Prevalence and Health Services Use in the First Nations and Non-First Nations Populations of Alberta, Canada.

Barnabe C, Jones CA, Bernatsky S, Peschken CA, Voaklander D, Homik J, Crowshoe LF, Esdaile JM, El-Gabalawy H, Hemmelgarn B.

Arthritis Care Res (Hoboken). 2017 Apr;69(4):467-474. doi: 10.1002/acr.22959. Epub 2017 Mar 9.

47.

Development of the Lupus Interactive Navigator as an Empowering Web-Based eHealth Tool to Facilitate Lupus Management: Users Perspectives on Usability and Acceptability.

Neville C, Da Costa D, Rochon M, Peschken CA, Pineau CA, Bernatsky S, Keeling S, Avina-Zubieta A, Lye E, Eng D, Fortin PR.

JMIR Res Protoc. 2016 May 30;5(2):e44. doi: 10.2196/resprot.4219.

48.

Malignancy incidence in 5294 patients with juvenile arthritis.

Zahedi Niaki O, Clarke AE, Ramsey-Goldman R, Yeung R, Hayward K, Oen K, Duffy CM, Rosenberg A, O'Neil KM, von Scheven E, Schanberg L, Labrecque J, Tse SM, Hasija R, Lee JL, Bernatsky S.

RMD Open. 2016 May 2;2(1):e000212. doi: 10.1136/rmdopen-2015-000212. eCollection 2016.

49.

Brief Report: Causes of Stillbirths in Women With Systemic Lupus Erythematosus.

Vinet É, Genest G, Scott S, Pineau CA, Clarke AE, Platt RW, Bernatsky S.

Arthritis Rheumatol. 2016 Oct;68(10):2487-91. doi: 10.1002/art.39742.

50.

An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies.

McGregor K, Bernatsky S, Colmegna I, Hudson M, Pastinen T, Labbe A, Greenwood CM.

Genome Biol. 2016 May 3;17:84. doi: 10.1186/s13059-016-0935-y.

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