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Items: 1 to 50 of 71

1.

Glucose stimulates microRNA-199 expression in murine pancreatic β-cells.

Werneck-de-Castro JP, Blandino-Rosano M, Hilfiker-Kleiner D, Bernal-Mizrachi E.

J Biol Chem. 2019 Dec 27. pii: jbc.RA119.010356. doi: 10.1074/jbc.RA119.010356. [Epub ahead of print]

2.

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.

Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG.

Sci Signal. 2019 Dec 3;12(610). pii: eaax0715. doi: 10.1126/scisignal.aax0715.

PMID:
31796630
3.

Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to a diet rich in high fat and branched-chain amino acids.

Sadagurski M, Debarba LK, Werneck-de-Castro JP, Ali Awada A, Baker TA, Bernal-Mizrachi E.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E526-E534. doi: 10.1152/ajpendo.00183.2019. Epub 2019 Jul 30.

PMID:
31361548
4.

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.

Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A.

J Clin Invest. 2019 Jul 2;130:4124-4137. doi: 10.1172/JCI127021.

5.

Steroid-Free Immune Suppression Impairs Glycemic Control in a Healthy Cynomolgus Monkey.

Berman DM, Ruiz P Jr, Blandino-Rosano M, Bernal-Mizrachi E, Kenyon NS.

Cell Transplant. 2019 Mar;28(3):262-268. doi: 10.1177/0963689718823505. Epub 2019 Jan 24.

6.

Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse.

Riahi Y, Israeli T, Yeroslaviz R, Chimenez S, Avrahami D, Stolovich-Rain M, Alter I, Sebag M, Polin N, Bernal-Mizrachi E, Dor Y, Cerasi E, Leibowitz G.

Elife. 2018 Nov 9;7. pii: e38472. doi: 10.7554/eLife.38472.

7.

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.

Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NH, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F.

JCI Insight. 2018 Jun 21;3(12). pii: 98607. doi: 10.1172/jci.insight.98607. eCollection 2018 Jun 21.

8.

Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring.

Gregg BE, Botezatu N, Brill JD, Hafner H, Vadrevu S, Satin LS, Alejandro EU, Bernal-Mizrachi E.

Sci Rep. 2018 Apr 10;8(1):5745. doi: 10.1038/s41598-018-23965-4.

9.

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.

10.

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.

Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E.

Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014.

11.

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC.

Cell Metab. 2017 Jun 6;25(6):1362-1373.e5. doi: 10.1016/j.cmet.2017.05.011.

12.

Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development.

Elghazi L, Blandino-Rosano M, Alejandro E, Cras-Méneur C, Bernal-Mizrachi E.

Mol Metab. 2017 Mar 28;6(6):560-573. doi: 10.1016/j.molmet.2017.03.010. eCollection 2017 Jun.

13.

Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.

Alejandro EU, Bozadjieva N, Blandino-Rosano M, Wasan MA, Elghazi L, Vadrevu S, Satin L, Bernal-Mizrachi E.

Diabetes. 2017 Aug;66(8):2150-2162. doi: 10.2337/db16-1349. Epub 2017 May 25.

14.

Early pancreatic islet fate and maturation is controlled through RBP-Jκ.

Cras-Méneur C, Conlon M, Zhang Y, Pasca Di Magliano M, Bernal-Mizrachi E.

Sci Rep. 2016 May 31;6:26874. doi: 10.1038/srep26874.

15.

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.

Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A, Liu M, Rui L, Sonenberg N, Bernal-Mizrachi E.

Diabetes. 2016 Aug;65(8):2235-48. doi: 10.2337/db15-1443. Epub 2016 May 23.

16.

Noninvasive in vivo imaging of embryonic β-cell development in the anterior chamber of the eye.

Cras-Méneur C, Elghazi L, Fort P, Bernal-Mizrachi E.

Islets. 2016 Mar 3;8(2):35-47. doi: 10.1080/19382014.2016.1148236.

17.

Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.

Alejandro EU, Bozadjieva N, Kumusoglu D, Abdulhamid S, Levine H, Haataja L, Vadrevu S, Satin LS, Arvan P, Bernal-Mizrachi E.

Cell Rep. 2015 Dec 22;13(11):2527-2538. doi: 10.1016/j.celrep.2015.11.020. Epub 2015 Dec 8.

18.

S6K1 controls pancreatic β cell size independently of intrauterine growth restriction.

Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschöp MH, Thomas G, Kozma SC.

J Clin Invest. 2015 Jul 1;125(7):2736-47. doi: 10.1172/JCI77030. Epub 2015 Jun 15.

19.

Human β-cell proliferation and intracellular signaling: part 3.

Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN.

Diabetes. 2015 Jun;64(6):1872-85. doi: 10.2337/db14-1843. Review.

20.

Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice.

Sadagurski M, Landeryou T, Cady G, Bartke A, Bernal-Mizrachi E, Miller RA.

Physiol Rep. 2015 Apr;3(4). pii: e12379. doi: 10.14814/phy2.12379.

21.

Molecular aspects of pancreatic beta cell failure and diabetes.

Arvan P, Bernal-Mizrachi E, Liu M, Pietropaolo M, Satin L, Schnell S, Soleimanpour SA.

Mol Aspects Med. 2015 Apr;42:1-2. doi: 10.1016/j.mam.2015.01.002. Epub 2015 Jan 14. No abstract available.

PMID:
25596327
22.

Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells.

Jiménez-Palomares M, López-Acosta JF, Villa-Pérez P, Moreno-Amador JL, Muñoz-Barrera J, Fernández-Luis S, Heras-Pozas B, Perdomo G, Bernal-Mizrachi E, Cózar-Castellano I.

Am J Physiol Endocrinol Metab. 2015 Mar 15;308(6):E450-9. doi: 10.1152/ajpendo.00260.2014. Epub 2015 Jan 6.

23.

Natural history of β-cell adaptation and failure in type 2 diabetes.

Alejandro EU, Gregg B, Blandino-Rosano M, Cras-Méneur C, Bernal-Mizrachi E.

Mol Aspects Med. 2015 Apr;42:19-41. doi: 10.1016/j.mam.2014.12.002. Epub 2014 Dec 24. Review.

24.

Fractalkine signaling in regulation of insulin secretion.

Gregg B, Lumeng CN, Bernal-Mizrachi E.

Islets. 2014;6(1):e27861. doi: 10.4161/isl.27861.

25.

Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors.

Gregg B, Elghazi L, Alejandro EU, Smith MR, Blandino-Rosano M, El-Gabri D, Cras-Méneur C, Bernal-Mizrachi E.

Diabetologia. 2014 Dec;57(12):2566-75. doi: 10.1007/s00125-014-3379-5. Epub 2014 Sep 24.

26.

Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.

Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E.

J Clin Invest. 2014 Oct;124(10):4395-410. doi: 10.1172/JCI74237. Epub 2014 Sep 2.

27.

Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis.

Sadagurski M, Landeryou T, Blandino-Rosano M, Cady G, Elghazi L, Meister D, See L, Bartke A, Bernal-Mizrachi E, Miller RA.

Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1305-14. doi: 10.1152/ajpendo.00031.2014. Epub 2014 Apr 15.

28.

Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.

Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A.

Diabetes. 2014 Mar;63(3):819-31. doi: 10.2337/db13-1146. Review.

29.

Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females.

Parlee SD, Simon BR, Scheller EL, Alejandro EU, Learman BS, Krishnan V, Bernal-Mizrachi E, MacDougald OA.

Endocrinology. 2014 Apr;155(4):1313-26. doi: 10.1210/en.2013-1995. Epub 2014 Jan 23.

30.

Importance of β-Catenin in glucose and energy homeostasis.

Elghazi L, Gould AP, Weiss AJ, Barker DJ, Callaghan J, Opland D, Myers M, Cras-Méneur C, Bernal-Mizrachi E.

Sci Rep. 2012;2:693. Epub 2012 Sep 25.

31.

mTORC1 signaling and regulation of pancreatic β-cell mass.

Blandino-Rosano M, Chen AY, Scheys JO, Alejandro EU, Gould AP, Taranukha T, Elghazi L, Cras-Méneur C, Bernal-Mizrachi E.

Cell Cycle. 2012 May 15;11(10):1892-902. doi: 10.4161/cc.20036. Epub 2012 May 15. Review.

32.

Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip.

Blandino-Rosano M, Alejandro EU, Sathyamurthy A, Scheys JO, Gregg B, Chen AY, Rachdi L, Weiss A, Barker DJ, Gould AP, Elghazi L, Bernal-Mizrachi E.

Diabetologia. 2012 May;55(5):1380-9. doi: 10.1007/s00125-012-2465-9. Epub 2012 Feb 12.

33.

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

Tanabe K, Liu Y, Hasan SD, Martinez SC, Cras-Méneur C, Welling CM, Bernal-Mizrachi E, Tanizawa Y, Rhodes CJ, Zmuda E, Hai T, Abumrad NA, Permutt MA.

PLoS One. 2011 Apr 26;6(4):e18146. doi: 10.1371/journal.pone.0018146.

34.

Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ.

Diabetes. 2010 Dec;59(12):3090-8. doi: 10.2337/db10-0624. Epub 2010 Aug 29.

35.

Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.

Bernal-Mizrachi E, Cras-Méneur C, Ye BR, Johnson JD, Permutt MA.

PLoS One. 2010 Aug 3;5(8):e11969. doi: 10.1371/journal.pone.0011969.

36.

Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells.

Elghazi L, Balcazar N, Blandino-Rosano M, Cras-Méneur C, Fatrai S, Gould AP, Chi MM, Moley KH, Bernal-Mizrachi E.

Diabetes. 2010 Oct;59(10):2390-9. doi: 10.2337/db09-0851. Epub 2010 Jul 9.

37.

Akt and PTEN: beta-cell mass and pancreas plasticity.

Elghazi L, Bernal-Mizrachi E.

Trends Endocrinol Metab. 2009 Jul;20(5):243-51. doi: 10.1016/j.tem.2009.03.002. Epub 2009 Jun 21. Review.

38.

mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability.

Balcazar N, Sathyamurthy A, Elghazi L, Gould A, Weiss A, Shiojima I, Walsh K, Bernal-Mizrachi E.

J Biol Chem. 2009 Mar 20;284(12):7832-42. doi: 10.1074/jbc.M807458200. Epub 2009 Jan 14.

39.

Regulation of pancreas plasticity and malignant transformation by Akt signaling.

Elghazi L, Weiss AJ, Barker DJ, Callaghan J, Staloch L, Sandgren EP, Gannon M, Adsay VN, Bernal-Mizrachi E.

Gastroenterology. 2009 Mar;136(3):1091-103. doi: 10.1053/j.gastro.2008.11.043. Epub 2008 Nov 27.

40.

Beta-cell failure as a complication of diabetes.

Chang-Chen KJ, Mullur R, Bernal-Mizrachi E.

Rev Endocr Metab Disord. 2008 Dec;9(4):329-43. doi: 10.1007/s11154-008-9101-5. Review.

41.

Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

Rachdi L, Balcazar N, Osorio-Duque F, Elghazi L, Weiss A, Gould A, Chang-Chen KJ, Gambello MJ, Bernal-Mizrachi E.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9250-5. doi: 10.1073/pnas.0803047105. Epub 2008 Jun 27.

42.

Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination.

Elghazi L, Weiss AJ, Gould AP, Hegedus B, Gutmann DH, Bernal-Mizrachi E.

Genesis. 2008 May;46(5):256-64. doi: 10.1002/dvg.20388.

43.

Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.

Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH.

Cell Stem Cell. 2007 Oct 11;1(4):443-57. doi: 10.1016/j.stem.2007.07.008.

44.

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA.

PLoS Biol. 2008 Feb;6(2):e37. doi: 10.1371/journal.pbio.0060037.

45.

Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.

Liu Z, Tanabe K, Bernal-Mizrachi E, Permutt MA.

Diabetologia. 2008 Apr;51(4):623-31. doi: 10.1007/s00125-007-0914-7. Epub 2008 Jan 25.

PMID:
18219478
46.

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.

Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2008 Apr;57(4):846-59. doi: 10.2337/db07-0595. Epub 2008 Jan 3.

47.

Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway.

Elghazi L, Rachdi L, Weiss AJ, Cras-Méneur C, Bernal-Mizrachi E.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:147-57. Review.

PMID:
17919189
48.

Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.

McDunn JE, Muenzer JT, Rachdi L, Chang KC, Davis CG, Dunne WM, Piwnica-Worms D, Bernal-Mizrachi E, Hotchkiss RS.

FASEB J. 2008 Feb;22(2):561-8. Epub 2007 Sep 13.

49.

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.

Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19575-80. Epub 2006 Dec 8.

50.

Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life.

Rachdi L, Balcazar N, Elghazi L, Barker DJ, Krits I, Kiyokawa H, Bernal-Mizrachi E.

Diabetes. 2006 Dec;55(12):3520-8.

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