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Items: 1 to 50 of 83

1.

Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis.

Chollet A, Stigliani JL, Pasca MR, Mori G, Lherbet C, Constant P, Quémard A, Bernadou J, Pratviel G, Bernardes-Génisson V.

Chem Biol Drug Des. 2016 Nov;88(5):740-755. doi: 10.1111/cbdd.12804. Epub 2016 Jul 16.

PMID:
27301022
2.

Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.

Chollet A, Mourey L, Lherbet C, Delbot A, Julien S, Baltas M, Bernadou J, Pratviel G, Maveyraud L, Bernardes-Génisson V.

J Struct Biol. 2015 Jun;190(3):328-37. doi: 10.1016/j.jsb.2015.04.008. Epub 2015 Apr 17.

PMID:
25891098
3.

Isoniazid: an update on the multiple mechanisms for a singular action.

Bernardes-Génisson V, Deraeve C, Chollet A, Bernadou J, Pratviel G.

Curr Med Chem. 2013;20(35):4370-85. Review.

PMID:
23931278
4.

Cross-docking study on InhA inhibitors: a combination of Autodock Vina and PM6-DH2 simulations to retrieve bio-active conformations.

Stigliani JL, Bernardes-Génisson V, Bernadou J, Pratviel G.

Org Biomol Chem. 2012 Aug 21;10(31):6341-9. doi: 10.1039/c2ob25602a. Epub 2012 Jun 29.

PMID:
22751934
5.

Preliminary investigations of the effect of lipophilic analogues of the active metabolite of isoniazid toward bacterial and plasmodial strains.

Delaine T, Bernardes-Génisson V, Quémard A, Constant P, Cosledan F, Meunier B, Bernadou J.

Chem Biol Drug Des. 2012 Jun;79(6):1001-6. doi: 10.1111/j.1747-0285.2012.01374.x. Epub 2012 Apr 10.

PMID:
22405039
6.

Chemical synthesis, biological evaluation and structure-activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as potential antimycobacterial agents.

Deraeve C, Dorobantu IM, Rebbah F, Le Quéméner F, Constant P, Quémard A, Bernardes-Génisson V, Bernadou J, Pratviel G.

Bioorg Med Chem. 2011 Nov 1;19(21):6225-32. doi: 10.1016/j.bmc.2011.09.017. Epub 2011 Sep 14.

PMID:
21975068
7.

Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy.

Poiroux G, Pitié M, Culerrier R, Lafont E, Ségui B, Van Damme EJ, Peumans WJ, Bernadou J, Levade T, Rougé P, Barre A, Benoist H.

PLoS One. 2011;6(8):e23315. doi: 10.1371/journal.pone.0023315. Epub 2011 Aug 17.

8.

Morniga G: a plant lectin as an endocytic ligand for photosensitizer molecule targeting toward tumor-associated T/Tn antigens.

Poiroux G, Pitié M, Culerrier R, Ségui B, Van Damme EJ, Peumans WJ, Bernadou J, Levade T, Rougé P, Barre A, Benoist H.

Photochem Photobiol. 2011 Mar-Apr;87(2):370-7. doi: 10.1111/j.1751-1097.2010.00858.x. Epub 2010 Dec 8.

PMID:
21143236
9.

Development of isoniazid-NAD truncated adducts embedding a lipophilic fragment as potential bi-substrate InhA inhibitors and antimycobacterial agents.

Delaine T, Bernardes-Génisson V, Quémard A, Constant P, Meunier B, Bernadou J.

Eur J Med Chem. 2010 Oct;45(10):4554-61. doi: 10.1016/j.ejmech.2010.07.016. Epub 2010 Jul 15.

PMID:
20696503
10.

Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection.

Gordien JB, Pigneux A, Vigouroux S, Tabrizi R, Accoceberry I, Bernadou JM, Rouault A, Saux MC, Breilh D.

J Pharm Biomed Anal. 2009 Dec 5;50(5):932-8. doi: 10.1016/j.jpba.2009.06.030. Epub 2009 Jun 24.

PMID:
19608374
11.

Quantitative and qualitative control of cytotoxic preparations by HPLC-UV in a centralized parenteral preparations unit.

Delmas A, Gordien JB, Bernadou JM, Roudaut M, Gresser A, Malki L, Saux MC, Breilh D.

J Pharm Biomed Anal. 2009 Jul 12;49(5):1213-20. doi: 10.1016/j.jpba.2009.03.007. Epub 2009 Mar 20.

PMID:
19362442
12.

Binding of the tautomeric forms of isoniazid-NAD adducts to the active site of the Mycobacterium tuberculosis enoyl-ACP reductase (InhA): a theoretical approach.

Stigliani JL, Arnaud P, Delaine T, Bernardes-Génisson V, Meunier B, Bernadou J.

J Mol Graph Model. 2008 Nov;27(4):536-45. doi: 10.1016/j.jmgm.2008.09.006. Epub 2008 Sep 17.

PMID:
18955002
13.

Synthesis of the isonicotinoylnicotinamide scaffolds of the naturally occurring isoniazid-NAD(P) adducts.

Delaine T, Bernardes-Génisson V, Meunier B, Bernadou J.

J Org Chem. 2007 Jan 19;72(2):675-8.

PMID:
17221997
14.

The first chemical synthesis of the core structure of the benzoylhydrazine-NAD adduct, a competitive inhibitor of the Mycobacterium tuberculosis enoyl reductase.

Broussy S, Bernardes-Génisson V, Quémard A, Meunier B, Bernadou J.

J Org Chem. 2005 Dec 9;70(25):10502-10.

PMID:
16323864
15.

1H and 13C NMR characterization of pyridinium-type isoniazid-NAD adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis.

Broussy S, Bernardes-Génisson V, Coppel Y, Quémard A, Bernadou J, Meunier B.

Org Biomol Chem. 2005 Feb 21;3(4):670-3. Epub 2005 Jan 21.

PMID:
15703806
16.

Studies on the 4-benzoylpyridine-3-carboxamide entity as a fragment model of the Isoniazid-NAD adduct.

Broussy S, Bernardes-Génisson V, Gornitzka H, Bernadou J, Meunier B.

Org Biomol Chem. 2005 Feb 21;3(4):666-9. Epub 2005 Jan 13.

PMID:
15703805
17.

Determination of linezolid in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method.

Toutain J, Boselli E, Djabarouti S, Allaouchiche B, Xuereb F, Bernadou JM, Ba B, Saux MC, Breilh D.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):145-50.

PMID:
15556527
18.

In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid.

Ducasse-Cabanot S, Cohen-Gonsaud M, Marrakchi H, Nguyen M, Zerbib D, Bernadou J, Daffé M, Labesse G, Quémard A.

Antimicrob Agents Chemother. 2004 Jan;48(1):242-9.

19.

Determination of levofloxacin in plasma, bronchoalveolar lavage and bone tissues by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method.

Djabarouti S, Boselli E, Allaouchiche B, Ba B, Nguyen AT, Gordien JB, Bernadou JM, Saux MC, Breilh D.

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 5;799(1):165-72.

PMID:
14659449
20.
21.

Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.

Nguyen M, Quémard A, Broussy S, Bernadou J, Meunier B.

Antimicrob Agents Chemother. 2002 Jul;46(7):2137-44.

22.

A fast and efficient metal-mediated oxidation of isoniazid and identification of isoniazid-NAD(H) adducts.

Nguyen M, Claparols C, Bernadou J, Meunier B.

Chembiochem. 2001 Dec 3;2(12):877-83.

PMID:
11948876
23.

[The mechanism of action of isoniazid. A chemical model of activation].

Bernadou J, Nguyen M, Meunier B.

Ann Pharm Fr. 2001 Sep;59(5):331-7. French.

PMID:
11787427
24.

Characterization of a 5'-aldehyde terminus resulting from the oxidative attack at C5' of a 2-deoxyribose on DNA.

Angeloff A, Dubey I, Pratviel G, Bernadou J, Meunier B.

Chem Res Toxicol. 2001 Oct;14(10):1413-20.

PMID:
11599933
25.

False teeth of the Roman world.

Crubézy E, Murail P, Girard L, Bernadou JP.

Nature. 1998 Jan 1;391(6662):29. No abstract available.

PMID:
9422504
26.

Origin of the Oxygen Atom in C-H Bond Oxidations Catalyzed by a Water-Soluble Metalloporphyrin.

Balahura RJ, Sorokin A, Bernadou J, Meunier B.

Inorg Chem. 1997 Jul 30;36(16):3488-3492.

PMID:
11670027
27.
28.
29.

Selective DNA cleavage by metalloporphyrin derivatives.

Pratviel G, Bernadou J, Meunier B.

Met Ions Biol Syst. 1996;33:399-426. Review. No abstract available.

PMID:
8742850
30.
32.
33.

Mechanism of DNA cleavage mediated by photoexcited non-steroidal antiinflammatory drugs.

Artuso T, Bernadou J, Meunier B, Piette J, Paillous N.

Photochem Photobiol. 1991 Aug;54(2):205-13.

PMID:
1838196
34.
35.

31P NMR characterization of terminal phosphates induced on DNA by the artificial nuclease 'Mn-TMPyP/KHSO5' in comparison with DNases I and II.

Gasmi G, Pasdeloup M, Pratviel G, Pitié M, Bernadou J, Meunier B.

Nucleic Acids Res. 1991 Jun 11;19(11):2835-9.

36.
37.
38.

On the chemical nature of DNA and RNA modification by a hemin model system.

Van Atta RB, Bernadou J, Meunier B, Hecht SM.

Biochemistry. 1990 May 22;29(20):4783-9.

PMID:
1694683
39.

DNA strand breaks photosensitized by benoxaprofen and other non steroidal antiinflammatory agents.

Artuso T, Bernadou J, Meunier B, Paillous N.

Biochem Pharmacol. 1990 Feb 1;39(3):407-13.

PMID:
2137692
40.
41.

Magnesium monoperoxophtalate: an efficient single oxygen atom donor in DNA cleavage catalyzed by metalloporphyrin.

Pratviel G, Bernadou J, Ricci M, Meunier B.

Biochem Biophys Res Commun. 1989 May 15;160(3):1212-8.

PMID:
2525035
42.

[1'-carbon hydroxylation of deoxyribose as the mechanism of cleavage of poly(dA) by manganese porphyrin combined with potassium monopersulfate].

Bernadou J, Lauretta B, Pratviel G, Meunier B.

C R Acad Sci III. 1989;309(10):409-14. French.

PMID:
2514966
43.

Evidence for high-valent iron-oxo species active in the DNA breaks mediated by iron-bleomycin.

Pratviel G, Bernadou J, Meunier B.

Biochem Pharmacol. 1989 Jan 1;38(1):133-40.

PMID:
2462877
44.
45.

The biooxidation of cytotoxic ellipticine derivatives: a key to structure-activity relationship studies?

Meunier G, De Montauzon D, Bernadou J, Grassy G, Bonnafous M, Cros S, Meunier B.

Mol Pharmacol. 1988 Jan;33(1):93-102.

PMID:
3336351
46.
47.
48.

Oxidative biotransformation of the antitumour agent elliptinium acetate: Structural characterization of its human and rat urinary metabolites.

Monsarrat B, Maftouh M, Meunier G, Bernadou J, Armand JP, Paoletti C, Meunier B.

J Pharm Biomed Anal. 1987;5(4):341-51.

PMID:
16867503
49.
50.

Excretion of doxifluridine catabolites in human bile assessed by 19F NMR spectrometry.

Martino R, Bernadou J, Malet-Martino MC, Roché H, Armand JP.

Biomed Pharmacother. 1987;41(2):104-6.

PMID:
2955816

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