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Items: 1 to 50 of 101

1.

Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia.

Ceccato A, Panagiotarakou M, Ranzani OT, Martin-Fernandez M, Almansa-Mora R, Gabarrus A, Bueno L, Cilloniz C, Liapikou A, Ferrer M, Bermejo-Martin JF, Torres A.

J Clin Med. 2019 Jun 13;8(6). pii: E843. doi: 10.3390/jcm8060843.

2.

Impact of Lymphocyte and Neutrophil Counts on Mortality Risk in Severe Community-Acquired Pneumonia with or without Septic Shock.

Güell E, Martín-Fernandez M, De la Torre MC, Palomera E, Serra M, Martinez R, Solsona M, Miró G, Vallès J, Fernández S, Cortés E, Ferrer V, Morales M, Yébenes JC, Almirall J, Bermejo-Martin JF.

J Clin Med. 2019 May 27;8(5). pii: E754. doi: 10.3390/jcm8050754.

3.

Composed endotypes to guide antibiotic discontinuation in sepsis.

Bermejo-Martin JF, Andaluz-Ojeda D, Martin-Fernandez M, Aldecoa C, Almansa R.

Crit Care. 2019 Apr 24;23(1):140. doi: 10.1186/s13054-019-2439-0.

4.

Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality.

Méndez R, Menéndez R, Amara-Elori I, Feced L, Piró A, Ramírez P, Sempere A, Ortega A, Bermejo-Martín JF, Torres A.

J Infect. 2019 Jun;78(6):423-431. doi: 10.1016/j.jinf.2019.04.006. Epub 2019 Apr 6.

PMID:
30965065
5.

Author Correction: Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients.

Almansa R, Martín S, Martin-Fernandez M, Heredia-Rodríguez M, Gómez-Sánchez E, Aragón M, Andrés C, Calvo D, Rico-Feijoo J, Esteban-Velasco MC, Vaquero-Roncero LM, Ortega A, Gómez-Pesquera E, Lorenzo-López M, de Cenarruzabeitia IL, Benavides D, López-Sanchez J, Doncel C, González-Sanchez C, Zarca E, Ríos-Llorente A, Diaz A, Sanchez-Barrado E, de Heredia JB, Calvo-Vecino JM, Muñoz-Bellvís L, Gomez-Herreras JI, Aldecoa C, Tamayo E, Bermejo-Martin JF.

Sci Rep. 2019 Feb 27;9(1):3426. doi: 10.1038/s41598-019-39976-8.

6.

Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia.

Almansa R, Nogales L, Martín-Fernández M, Batlle M, Villareal E, Rico L, Ortega A, López-Campos G, Andaluz-Ojeda D, Ramírez P, Socias L, Tamayo L, Vallés J, Bermejo-Martín JF, Martín-Loeches I.

Ann Transl Med. 2018 Nov;6(21):415. doi: 10.21037/atm.2018.05.12.

7.

Lymphopenic hospital acquired sepsis (L-HAS): An immunological phenotype conferring higher risk of mortality.

López-Mestanza C, Andaluz-Ojeda D, Gómez-López JR, Bermejo-Martín JF.

Med Intensiva. 2018 Nov 5. pii: S0210-5691(18)30277-8. doi: 10.1016/j.medin.2018.09.015. [Epub ahead of print] English, Spanish. No abstract available.

PMID:
30409680
8.

Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease).

Bermejo-Martin JF, Martín-Fernandez M, López-Mestanza C, Duque P, Almansa R.

J Clin Med. 2018 Oct 30;7(11). pii: E400. doi: 10.3390/jcm7110400. Review.

9.

Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients.

Almansa R, Martín S, Martin-Fernandez M, Heredia-Rodríguez M, Gómez-Sánchez E, Aragón M, Andrés C, Calvo D, Rico-Feijoo J, Esteban-Velasco MC, Vaquero-Roncero LM, Ortega A, Gómez-Pesquera E, Lorenzo-López M, de Cenarruzabeitia IL, Benavides D, López-Sanchez J, Doncel C, González-Sanchez C, Zarca E, Ríos-Llorente A, Diaz A, Sanchez-Barrado E, de Heredia JB, Calvo-Vecino JM, Muñoz-Bellvís L, Gomez-Herreras JI, Aldecoa C, Tamayo E, Bermejo-Martin JF.

Sci Rep. 2018 Aug 10;8(1):11999. doi: 10.1038/s41598-018-30505-7. Erratum in: Sci Rep. 2019 Feb 27;9(1):3426.

10.

New Organ Failure as an Alternative Endpoint to Develop Diagnostic Criteria for Sepsis.

Bermejo-Martin JF, Almansa R, Yebenes JC.

Chest. 2018 May;153(5):1278. doi: 10.1016/j.chest.2017.11.046. No abstract available.

PMID:
29731039
11.

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

Sweeney TE, Azad TD, Donato M, Haynes WA, Perumal TM, Henao R, Bermejo-Martin JF, Almansa R, Tamayo E, Howrylak JA, Choi A, Parnell GP, Tang B, Nichols M, Woods CW, Ginsburg GS, Kingsmore SF, Omberg L, Mangravite LM, Wong HR, Tsalik EL, Langley RJ, Khatri P.

Crit Care Med. 2018 Jun;46(6):915-925. doi: 10.1097/CCM.0000000000003084.

12.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

13.

Immunological profiling to assess disease severity and prognosis in community-acquired pneumonia.

Bermejo-Martin JF, Almansa R, Martin-Fernandez M, Menendez R, Torres A.

Lancet Respir Med. 2017 Dec;5(12):e35-e36. doi: 10.1016/S2213-2600(17)30444-7. No abstract available.

PMID:
29185421
14.

Pre-sepsis: A necessary concept to complete the SEPSIS-3 picture?

Bermejo-Martin JF, Martín-Fernandez M, Almansa R.

J Crit Care. 2018 Apr;44:148. doi: 10.1016/j.jcrc.2017.10.041. Epub 2017 Oct 29. No abstract available.

PMID:
29121586
15.

Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection.

Almansa R, Martínez-Orellana P, Rico L, Iglesias V, Ortega A, Vidaña B, Martínez J, Expósito A, Montoya M, Bermejo-Martin JF.

PeerJ. 2017 Oct 11;5:e3915. doi: 10.7717/peerj.3915. eCollection 2017.

16.

Lymphopenic Community Acquired Pneumonia (L-CAP), an Immunological Phenotype Associated with Higher Risk of Mortality.

Bermejo-Martin JF, Cilloniz C, Mendez R, Almansa R, Gabarrus A, Ceccato A, Torres A, Menendez R; NEUMONAC group.

EBioMedicine. 2017 Oct;24:231-236. doi: 10.1016/j.ebiom.2017.09.023. Epub 2017 Sep 21.

17.

Clinical factors influencing mortality risk in hospital-acquired sepsis.

López-Mestanza C, Andaluz-Ojeda D, Gómez-López JR, Bermejo-Martín JF.

J Hosp Infect. 2018 Feb;98(2):194-201. doi: 10.1016/j.jhin.2017.08.022. Epub 2017 Sep 5.

PMID:
28882641
18.

Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients.

Almansa R, Ortega A, Ávila-Alonso A, Heredia-Rodríguez M, Martín S, Benavides D, Martín-Fernandez M, Rico L, Aldecoa C, Rico J, López de Cenarruzabeitia I, Beltrán de Heredia J, Gomez-Sanchez E, Aragón M, Andrés C, Calvo D, Andaluz-Ojeda D, Liu P, Blanco-Antona F, Blanco L, Gómez-Herreras JI, Tamayo E, Bermejo-Martin JF.

Ann Surg. 2019 Mar;269(3):545-553. doi: 10.1097/SLA.0000000000002406.

PMID:
28692472
19.

The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure.

Martin-Loeches I, Muriel-Bombín A, Ferrer R, Artigas A, Sole-Violan J, Lorente L, Andaluz-Ojeda D, Prina-Mello A, Herrán-Monge R, Suberviola B, Rodriguez-Fernandez A, Merino P, Loza AM, Garcia-Olivares P, Anton E, Tamayo E, Trapiello W, Blanco J, Bermejo-Martin JF; GRECIA group.

Ann Intensive Care. 2017 Dec;7(1):44. doi: 10.1186/s13613-017-0268-3. Epub 2017 Apr 20.

20.

Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity.

Andaluz-Ojeda D, Nguyen HB, Meunier-Beillard N, Cicuéndez R, Quenot JP, Calvo D, Dargent A, Zarca E, Andrés C, Nogales L, Eiros JM, Tamayo E, Gandía F, Bermejo-Martín JF, Charles PE.

Ann Intensive Care. 2017 Dec;7(1):15. doi: 10.1186/s13613-017-0238-9. Epub 2017 Feb 10.

21.

Characterizing Systemic Immune Dysfunction Syndrome to Fill in the Gaps of SEPSIS-2 and SEPSIS-3 Definitions.

Bermejo-Martin JF, Tamayo E, Andaluz-Ojeda D, Martín-Fernández M, Almansa R.

Chest. 2017 Feb;151(2):518-519. doi: 10.1016/j.chest.2016.11.047. No abstract available.

PMID:
28183496
22.

IgG2 as an independent risk factor for mortality in patients with community-acquired pneumonia.

de la Torre MC, Palomera E, Serra-Prat M, Güell E, Yébenes JC, Bermejo-Martín JF, Almirall J.

J Crit Care. 2016 Oct;35:115-9. doi: 10.1016/j.jcrc.2016.05.005. Epub 2016 May 13.

PMID:
27481745
23.

Postbooster Antibodies from Humans as Source of Diphtheria Antitoxin.

Bermejo-Martin JF, Avila-Alonso A, González-Rivera M, Tamayo E, Eiros JM, Almansa R.

Emerg Infect Dis. 2016 Jul;22(7):1265-7. doi: 10.3201/eid2207.151670.

24.

Impact of ventilator-associated pneumonia on mortality and epidemiological features of patients with secondary peritonitis.

Heredia-Rodríguez M, Peláez MT, Fierro I, Gómez-Sánchez E, Gómez-Pesquera E, Lorenzo M, Álvarez-González FJ, Bustamante-Munguira J, Eiros JM, Bermejo-Martin JF, Gómez-Herreras JI, Tamayo E.

Ann Intensive Care. 2016 Dec;6(1):34. doi: 10.1186/s13613-016-0137-5. Epub 2016 Apr 18.

25.

Probable Hospital Cluster of H7N9 Influenza Infection.

Farooqui A, Liu W, Zeng T, Liu Y, Zhang L, Khan A, Wu X, Wu R, Wu S, Huang L, Cai Y, Kelvin AA, Paquette SG, Hu K, Zheng N, Chen H, Xu S, Lin C, Sun P, Yao Z, Wang J, Ma H, Zhu Z, Lin P, Chen W, Fang X, Bermejo-Martin JF, Leon AJ, Kelvin DJ; H7N9 Shantou Working Group.

N Engl J Med. 2016 Feb 11;374(6):596-8. doi: 10.1056/NEJMc1505359. No abstract available.

26.

Procalcitonin cannot be used as a biomarker of infection in heart surgery patients with acute kidney injury.

Heredia-Rodríguez M, Bustamante-Munguira J, Fierro I, Lorenzo M, Jorge-Monjas P, Gómez-Sánchez E, Álvarez FJ, Bergese SD, Eiros JM, Bermejo-Martin JF, Gómez-Herreras JI, Tamayo E.

J Crit Care. 2016 Jun;33:233-9. doi: 10.1016/j.jcrc.2016.01.015. Epub 2016 Jan 15.

PMID:
26861073
27.

Defining immunological dysfunction in sepsis: A requisite tool for precision medicine.

Bermejo-Martin JF, Andaluz-Ojeda D, Almansa R, Gandía F, Gómez-Herreras JI, Gomez-Sanchez E, Heredia-Rodríguez M, Eiros JM, Kelvin DJ, Tamayo E.

J Infect. 2016 May;72(5):525-36. doi: 10.1016/j.jinf.2016.01.010. Epub 2016 Feb 3. Review.

PMID:
26850357
28.

Predicting cardiac surgery-associated acute kidney injury: The CRATE score.

Jorge-Monjas P, Bustamante-Munguira J, Lorenzo M, Heredia-Rodríguez M, Fierro I, Gómez-Sánchez E, Hernandez A, Álvarez FJ, Bermejo-Martin JF, Gómez-Pesquera E, Gómez-Herreras JI, Tamayo E.

J Crit Care. 2016 Feb;31(1):130-8. doi: 10.1016/j.jcrc.2015.11.004. Epub 2015 Nov 6.

PMID:
26700607
29.

Endogenous immunoglobulins and sepsis: New perspectives for guiding replacement therapies.

Bermejo-Martin JF, Giamarellos-Bourboulis EJ.

Int J Antimicrob Agents. 2015 Dec;46 Suppl 1:S25-8. doi: 10.1016/j.ijantimicag.2015.10.013. Epub 2015 Nov 3. Review.

30.

Preventing sepsis.

Bermejo-Martin JF, Andaluz-Ojeda D, Almansa R, Eiros JM, Tamayo E.

Lancet Infect Dis. 2015 Nov;15(11):1259-60. doi: 10.1016/S1473-3099(15)00374-6. No abstract available.

PMID:
26531031
31.

Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis.

Sanchez-Antolín G, Almohalla-Alvarez C, Bueno P, Almansa R, Iglesias V, Rico L, Ortega A, Muñoz-Conejero E, García-Pajares F, Bermejo-Martin JF.

PLoS One. 2015 Aug 28;10(8):e0137128. doi: 10.1371/journal.pone.0137128. eCollection 2015.

32.

Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis.

Shankar-Hari M, Culshaw N, Post B, Tamayo E, Andaluz-Ojeda D, Bermejo-Martín JF, Dietz S, Werdan K, Beale R, Spencer J, Singer M.

Intensive Care Med. 2015 Aug;41(8):1393-401. doi: 10.1007/s00134-015-3845-7. Epub 2015 May 14. Review.

PMID:
25971390
33.

The original sins of clinical trials with intravenous immunoglobulins in sepsis.

Almansa R, Tamayo E, Andaluz-Ojeda D, Nogales L, Blanco J, Eiros JM, Gomez-Herreras JI, Bermejo-Martin JF.

Crit Care. 2015 Feb 26;19:90. doi: 10.1186/s13054-015-0793-0.

34.

Improvement of fatigue in multiple sclerosis by physical exercise is associated to modulation of systemic interferon response.

Mulero P, Almansa R, Neri MJ, Bermejo-Martin JF, Archanco M, Arenillas JF, Téllez N.

J Neuroimmunol. 2015 Mar 15;280:8-11. doi: 10.1016/j.jneuroim.2015.01.011. Epub 2015 Jan 28.

PMID:
25773148
35.

Sustained value of proadrenomedullin as mortality predictor in severe sepsis.

Andaluz-Ojeda D, Cicuéndez R, Calvo D, Largo E, Nogales L, Muñoz MF, Bueno P, Eiros JM, Gandía F, Bermejo-Martín JF.

J Infect. 2015 Jul;71(1):136-9. doi: 10.1016/j.jinf.2015.02.002. Epub 2015 Feb 19. No abstract available.

PMID:
25704281
36.

Transcriptomic correlates of organ failure extent in sepsis.

Almansa R, Heredia-Rodríguez M, Gomez-Sanchez E, Andaluz-Ojeda D, Iglesias V, Rico L, Ortega A, Gomez-Pesquera E, Liu P, Aragón M, Eiros JM, Jiménez-Sousa MÁ, Resino S, Gómez-Herreras I, Bermejo-Martín JF, Tamayo E.

J Infect. 2015 May;70(5):445-56. doi: 10.1016/j.jinf.2014.12.010. Epub 2014 Dec 31.

PMID:
25557485
37.

Hyperimmune serum from healthy vaccinated individuals for Ebola virus disease?

Almansa R, Eiros JM, Fedson D, Bermejo-Martin JF.

Lancet Glob Health. 2014 Dec;2(12):e686. doi: 10.1016/S2214-109X(14)70341-9. Epub 2014 Oct 30. No abstract available.

38.

Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant.

Jiménez-Sousa MA, Tamayo E, Guzmán-Fulgencio M, Fernández-Rodríguez A, Heredia-Rodriguez M, García-Álvarez M, Bermejo-Martin JF, Pineda-Tenor D, Ruiz-Granado P, Alvarez-Fuente E, Gómez-Sanchez E, Gómez-Herreras JI, Resino S.

Int J Med Sci. 2014 Aug 17;11(11):1129-32. doi: 10.7150/ijms.9487. eCollection 2014.

39.

Immunoinformatics and systems biology in personalized medicine.

Lopez-Campos G, Bermejo-Martin JF, Almansa R, Martin-Sanchez F.

Methods Mol Biol. 2014;1184:457-75. doi: 10.1007/978-1-4939-1115-8_25.

PMID:
25048140
40.

Quantification of IgM molecular response by droplet digital PCR as a potential tool for the early diagnosis of sepsis.

Tamayo E, Almansa R, Carrasco E, Ávila-Alonso A, Rodríguez-Fernández A, Wain J, Heredia M, Gomez-Sanchez E, Soria S, Rico L, Iglesias V, Martínez-Martínez A, Andaluz-Ojeda D, Herreras JI, Eiros JM, Bermejo-Martin JF.

Crit Care. 2014 Jun 6;18(3):433. doi: 10.1186/cc13910. No abstract available.

41.

Mitochondrial DNA haplogroups are associated with severe sepsis and mortality in patients who underwent major surgery.

Jiménez-Sousa MA, Tamayo E, Guzmán-Fulgencio M, Heredia M, Fernández-Rodríguez A, Gómez E, Almansa R, Gómez-Herreras JI, García-Álvarez M, Gutiérrez-Junco S, Bermejo-Martin JF, Resino S; Spanish Sepsis Group (SpSG).

J Infect. 2015 Jan;70(1):20-9. doi: 10.1016/j.jinf.2014.07.005. Epub 2014 Jul 17.

PMID:
25043396
42.

Immunoglobulins IgG1, IgM and IgA: a synergistic team influencing survival in sepsis.

Bermejo-Martín JF, Rodriguez-Fernandez A, Herrán-Monge R, Andaluz-Ojeda D, Muriel-Bombín A, Merino P, García-García MM, Citores R, Gandía F, Almansa R, Blanco J; GRECIA Group (Grupo de Estudios y Análisis en Cuidados Intensivos).

J Intern Med. 2014 Oct;276(4):404-12. doi: 10.1111/joim.12265. Epub 2014 May 29.

43.

Inflammation and infection in critical care medicine.

Bermejo-Martin JF, Martín-Loeches I, Bosinger S.

Mediators Inflamm. 2014;2014:456256. doi: 10.1155/2014/456256. Epub 2014 Feb 2. No abstract available.

44.

Circulating neutrophil counts and mortality in septic shock.

Bermejo-Martín JF, Tamayo E, Ruiz G, Andaluz-Ojeda D, Herrán-Monge R, Muriel-Bombín A, Fe Muñoz M, Heredia-Rodríguez M, Citores R, Gómez-Herreras J, Blanco J; EXPRESS (Expresión Génica en Sepsis) and GRECIA (Grupo de Estudios y Análisis en Cuidados Intensivos) groups.

Crit Care. 2014 Feb 14;18(1):407. doi: 10.1186/cc13728. No abstract available.

45.

Immune response to influenza A(H1N1)v in HIV-infected patients.

Sansonetti P, Sali M, Fabbiani M, Morandi M, Martucci R, Danesh A, Delogu G, Bermejo-Martin JF, Sanguinetti M, Kelvin D, Cauda R, Fadda G, Rubino S.

J Infect Dev Ctries. 2014 Jan 15;8(1):101-9. doi: 10.3855/jidc.3147.

46.

Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock.

Almansa R, Tamayo E, Heredia M, Gutierrez S, Ruiz P, Alvarez E, Gomez-Sanchez E, Andaluz-Ojeda D, Ceña R, Rico L, Iglesias V, Gomez-Herreras JI, Bermejo-Martin JF.

J Crit Care. 2014 Apr;29(2):307-9. doi: 10.1016/j.jcrc.2013.11.020. Epub 2013 Dec 2. No abstract available.

PMID:
24388659
47.

IgA level in plasma as a differential factor for influenza infection in severe viral pneumonia.

Almansa R, Justel M, Socias L, Ramírez P, Andaluz-Ojeda D, Estella A, Loza A, Blanco J, Berezo JÁ, Rosich S, Cillòniz C, Torres A, de Lejarazu RO, Martin-Loeches I, Bermejo-Martin JF.

J Clin Virol. 2014 Feb;59(2):135-6. doi: 10.1016/j.jcv.2013.12.003. Epub 2013 Dec 12. No abstract available.

PMID:
24380719
48.

Cytokine profiles linked to fatal outcome in infective prosthetic valve endocarditis.

Bustamante J, Arévalo A, Tamayo E, Sarria C, Aguilar-Blanco EM, Heredia M, Almansa R, Rico L, Iglesias V, Bermejo-Martin JF.

APMIS. 2014 Jun;122(6):526-9. doi: 10.1111/apm.12189. Epub 2013 Sep 30.

PMID:
24106887
49.

IgM levels in plasma predict outcome in severe pandemic influenza.

Justel M, Socias L, Almansa R, Ramírez P, Gallegos MC, Fernandez V, Gordon M, Andaluz-Ojeda D, Nogales L, Rojo S, Vallés J, Estella A, Loza A, León C, Lopez-Mestanza C, Blanco J, Berezo JÁ, Rosich S, Cillòniz C, Torres A, de Lejarazu RO, Martin-Loeches I, Bermejo-Martin JF.

J Clin Virol. 2013 Nov;58(3):564-7. doi: 10.1016/j.jcv.2013.09.006. Epub 2013 Sep 18.

PMID:
24076102
50.

Early levels in blood of immunoglobulin M and natural killer cells predict outcome in nonseptic critically ill patients.

Andaluz-Ojeda D, Iglesias V, Bobillo F, Nocito M, Loma AM, Nieto C, Ramos E, Gandía F, Rico L, Bermejo-Martin JF.

J Crit Care. 2013 Dec;28(6):1110.e7-1110.e10. doi: 10.1016/j.jcrc.2013.06.007. Epub 2013 Aug 15.

PMID:
23953491

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