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Items: 1 to 50 of 204

1.

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection.

Rodríguez-Mora S, De Wit F, García-Perez J, Bermejo M, López-Huertas MR, Mateos E, Martí P, Rocha S, Vigón L, Christ F, Debyser Z, Vílchez JJ, Coiras M, Alcamí J.

PLoS Pathog. 2019 Aug 29;15(8):e1007958. doi: 10.1371/journal.ppat.1007958. eCollection 2019 Aug.

2.

"Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy.

Hens B, Corsetti M, Bermejo M, Löbenberg R, González PM, Mitra A, Desai D, Chilukuri DM, Aceituno A.

AAPS J. 2019 Jun 6;21(4):75. doi: 10.1208/s12248-019-0346-6.

PMID:
31172358
3.

Association of a single nucleotide polymorphism in the ubxn6 gene with long-term non-progression phenotype in HIV-positive individuals.

Díez-Fuertes F, De La Torre-Tarazona HE, Calonge E, Pernas M, Bermejo M, García-Pérez J, Álvarez A, Capa L, García-García F, Saumoy M, Riera M, Boland-Auge A, López-Galíndez C, Lathrop M, Dopazo J, Sakuntabhai A, Alcamí J.

Clin Microbiol Infect. 2019 May 31. pii: S1198-743X(19)30274-5. doi: 10.1016/j.cmi.2019.05.015. [Epub ahead of print]

PMID:
31158522
4.

From groups to communities in western lowland gorillas.

Forcina G, Vallet D, Le Gouar PJ, Bernardo-Madrid R, Illera G, Molina-Vacas G, Dréano S, Revilla E, Rodríguez-Teijeiro JD, Ménard N, Bermejo M, Vilà C.

Proc Biol Sci. 2019 Feb 13;286(1896):20182019. doi: 10.1098/rspb.2018.2019.

PMID:
30963928
5.

Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers.

Pérez-Sánchez A, Cuyàs E, Ruiz-Torres V, Agulló-Chazarra L, Verdura S, González-Álvarez I, Bermejo M, Joven J, Micol V, Bosch-Barrera J, Menendez JA.

Int J Mol Sci. 2019 Mar 31;20(7). pii: E1606. doi: 10.3390/ijms20071606.

6.

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses.

Bermejo M, Kuminek G, Al-Gousous J, Ruiz-Picazo A, Tsume Y, Garcia-Arieta A, González-Alvarez I, Hens B, Amidon GE, Rodriguez-Hornedo N, Amidon GL, Mudie D.

Pharmaceutics. 2019 Mar 15;11(3). pii: E122. doi: 10.3390/pharmaceutics11030122.

7.

Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications.

Al-Gousous J, Ruan H, Blechar JA, Sun KX, Salehi N, Langguth P, Job NM, Lipka E, Loebenberg R, Bermejo M, Amidon GE, Amidon GL.

Eur J Pharm Biopharm. 2019 Jun;139:47-58. doi: 10.1016/j.ejpb.2019.03.012. Epub 2019 Mar 11.

PMID:
30872012
8.

Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin.

Martínez-Martínez M, Rodríguez-Berna G, Bermejo M, Gonzalez-Alvarez I, Gonzalez-Alvarez M, Merino V.

Eur J Pharm Biopharm. 2019 Mar;136:174-183. doi: 10.1016/j.ejpb.2019.01.009. Epub 2019 Jan 14.

PMID:
30654016
9.

Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method.

delMoral-Sanchez JM, Ruiz-Picazo A, Gonzalez-Alvarez M, Navarro A, Gonzalez-Alvarez I, Bermejo M.

Int J Pharm. 2019 Feb 25;557:154-161. doi: 10.1016/j.ijpharm.2018.12.047. Epub 2018 Dec 27.

PMID:
30594686
10.

Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug.

Lozoya-Agullo I, Planelles M, Merino-Sanjuán M, Bermejo M, Sarmento B, González-Álvarez I, González-Álvarez M.

Int J Pharm. 2019 Feb 25;557:36-42. doi: 10.1016/j.ijpharm.2018.12.038. Epub 2018 Dec 20.

PMID:
30578978
11.

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.

Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Löbenberg R, Talattof A, Sun D, Amidon GL.

Mol Pharm. 2018 Dec 3;15(12):5468-5478. doi: 10.1021/acs.molpharmaceut.8b00736. Epub 2018 Nov 12.

PMID:
30417648
12.

Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs.

Di Meo C, Martínez-Martínez M, Coviello T, Bermejo M, Merino V, Gonzalez-Alvarez I, Gonzalez-Alvarez M, Matricardi P.

Pharmaceutics. 2018 Nov 3;10(4). pii: E213. doi: 10.3390/pharmaceutics10040213.

13.

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.

Bermejo M, Paixão P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Löbenberg R, Lee A, Frances A, Amidon GE, Yu A, Salehi N, Talattof A, Benninghoff G, Sun D, Kuminek G, Cavanagh KL, Rodríguez-Hornedo N, Amidon GL.

Mol Pharm. 2018 Dec 3;15(12):5454-5467. doi: 10.1021/acs.molpharmaceut.8b00515. Epub 2018 Nov 12.

PMID:
30372084
14.

Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance.

Al-Gousous J, Sun KX, McNamara DP, Hens B, Salehi N, Langguth P, Bermejo M, Amidon GE, Amidon GL.

Mol Pharm. 2018 Nov 5;15(11):5291-5301. doi: 10.1021/acs.molpharmaceut.8b00783. Epub 2018 Oct 26.

PMID:
30362350
15.

Giardiasis: Characteristics, Pathogenesis and New Insights About Treatment.

Vivancos V, González-Alvarez I, Bermejo M, Gonzalez-Alvarez M.

Curr Top Med Chem. 2018;18(15):1287-1303. doi: 10.2174/1568026618666181002095314. Review.

PMID:
30277155
16.

Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin.

Caldeira TG, Ruiz-Picazo A, Lozoya-Agullo I, Saúde-Guimarães DA, González-Álvarez M, de Souza J, González-Álvarez I, Bermejo M.

Int J Pharm. 2018 Nov 15;551(1-2):148-157. doi: 10.1016/j.ijpharm.2018.09.022. Epub 2018 Sep 13.

PMID:
30218825
17.

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance.

Tsume Y, Patel S, Fotaki N, Bergstrӧm C, Amidon GL, Brasseur JG, Mudie DM, Sun D, Bermejo M, Gao P, Zhu W, Sperry DC, Vertzoni M, Parrott N, Lionberger R, Kambayashi A, Hermans A, Lu X, Amidon GE.

AAPS J. 2018 Sep 6;20(6):100. doi: 10.1208/s12248-018-0260-3. No abstract available.

PMID:
30191341
18.

Evaluation of resistance to HIV-1 infection ex vivo of PBMCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors.

Bermejo M, Ambrosioni J, Bautista G, Climent N, Mateos E, Rovira C, Rodríguez-Mora S, López-Huertas MR, García-Gutiérrez V, Steegmann JL, Duarte R, Cervantes F, Plana M, Miró JM, Alcamí J, Coiras M.

Biochem Pharmacol. 2018 Oct;156:248-264. doi: 10.1016/j.bcp.2018.08.031. Epub 2018 Aug 22.

PMID:
30142322
19.

Preclinical models for colonic absorption, application to controlled release formulation development.

Lozoya-Agullo I, González-Álvarez I, Merino-Sanjuán M, Bermejo M, González-Álvarez M.

Eur J Pharm Biopharm. 2018 Sep;130:247-259. doi: 10.1016/j.ejpb.2018.07.008. Epub 2018 Jul 6. Review.

PMID:
30064699
20.

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project.

Hens B, Sinko PD, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixão P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, Lennernäs H, Hasler WL, Marciani L, Dickens J, Shedden K, Sun D, Amidon GE, Amidon GL.

Int J Pharm. 2018 Sep 5;548(1):120-127. doi: 10.1016/j.ijpharm.2018.06.050. Epub 2018 Jun 23. Review.

PMID:
29944899
21.

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach.

Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Löbenberg R, Talattof A, Sun D, Amidon GL.

Eur J Pharm Biopharm. 2018 Aug;129:162-174. doi: 10.1016/j.ejpb.2018.05.033. Epub 2018 May 29.

PMID:
29857136
22.

Biopharmaceutical optimization in neglected diseases for paediatric patients by applying the provisional paediatric biopharmaceutical classification system.

Del Moral Sanchez JM, Gonzalez-Alvarez I, Cerda-Revert A, Gonzalez-Alvarez M, Navarro-Ruiz A, Amidon GL, Bermejo M.

Br J Clin Pharmacol. 2018 Oct;84(10):2231-2241. doi: 10.1111/bcp.13650. Epub 2018 Jul 17.

PMID:
29846973
23.

In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC.

Ruiz Picazo A, Martinez-Martinez MT, Colón-Useche S, Iriarte R, Sánchez-Dengra B, González-Álvarez M, García-Arieta A, González-Álvarez I, Bermejo M.

Mol Pharm. 2018 Jun 4;15(6):2307-2315. doi: 10.1021/acs.molpharmaceut.8b00153. Epub 2018 May 17.

PMID:
29746133
24.

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

Reynaldo-Fernández G, Solozábal J, Amaro D, Fernández-Sánchez EM, Rodríguez-Vera L, Bermejo M, Mangas-Sanjuan V, Troconiz IF.

Eur J Pharm Sci. 2018 Jul 30;120:123-132. doi: 10.1016/j.ejps.2018.04.047. Epub 2018 May 2.

PMID:
29729414
25.

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.

González-García I, García-Arieta A, Merino-Sanjuan M, Mangas-Sanjuan V, Bermejo M.

Eur J Pharm Sci. 2018 Jul 1;119:200-207. doi: 10.1016/j.ejps.2018.04.025. Epub 2018 Apr 20.

PMID:
29680456
26.

Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model.

Hens B, Talattof A, Paixão P, Bermejo M, Tsume Y, Löbenberg R, Amidon GL.

AAPS J. 2018 Mar 29;20(3):57. doi: 10.1208/s12248-018-0217-6.

PMID:
29600330
27.

Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System.

Martínez-Martínez M, Rodríguez-Berna G, Gonzalez-Alvarez I, Hernández MJ, Corma A, Bermejo M, Merino V, Gonzalez-Alvarez M.

Biomacromolecules. 2018 Apr 9;19(4):1294-1304. doi: 10.1021/acs.biomac.8b00108. Epub 2018 Mar 22.

PMID:
29537830
28.

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter.

Mangas-Sanjuan V, Navarro-Fontestad C, García-Arieta A, Trocóniz IF, Bermejo M.

Eur J Pharm Sci. 2018 May 30;117:193-203. doi: 10.1016/j.ejps.2018.02.014. Epub 2018 Feb 13.

PMID:
29452210
29.

IVIVC approach based on carbamazepine bioequivalence studies combination.

González-García I, Mangas-Sanjuan V, Merino-Sanjuán M, Álvarez-Álvarez C, Díaz-Garzón Marco J, Rodríguez-Bonnín MA, Langguth T, Torrado-Durán JJ, Langguth P, García-Arieta A, Bermejo M.

Pharmazie. 2017 Aug 1;72(8):449-455. doi: 10.1691/ph.2017.7011.

PMID:
29441903
30.

Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.

Hens B, Bermejo M, Tsume Y, Gonzalez-Alvarez I, Ruan H, Matsui K, Amidon GE, Cavanagh KL, Kuminek G, Benninghoff G, Fan J, Rodríguez-Hornedo N, Amidon GL.

Eur J Pharm Sci. 2018 Mar 30;115:258-269. doi: 10.1016/j.ejps.2018.01.039.

PMID:
29378253
31.

Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.

Lozoya-Agullo I, Gonzalez-Alvarez I, Zur M, Fine-Shamir N, Cohen Y, Markovic M, Garrigues TM, Dahan A, Gonzalez-Alvarez M, Merino-Sanjuán M, Bermejo M, Avdeef A.

Pharm Res. 2017 Dec 29;35(1):2. doi: 10.1007/s11095-017-2331-z.

PMID:
29288412
32.

PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.

Lozoya-Agullo I, Araújo F, González-Álvarez I, Merino-Sanjuán M, González-Álvarez M, Bermejo M, Sarmento B.

Eur J Pharm Sci. 2018 Mar 30;115:119-125. doi: 10.1016/j.ejps.2017.12.009. Epub 2017 Dec 14.

PMID:
29248559
33.

Gated Mesoporous Silica Nanocarriers for a "Two-Step" Targeted System to Colonic Tissue.

González-Alvarez M, Coll C, Gonzalez-Alvarez I, Giménez C, Aznar E, Martínez-Bisbal MC, Lozoya-Agulló I, Bermejo M, Martínez-Máñez R, Sancenón F.

Mol Pharm. 2017 Dec 4;14(12):4442-4453. doi: 10.1021/acs.molpharmaceut.7b00565. Epub 2017 Nov 9.

PMID:
29064714
34.

Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells.

Sánchez-Del Cojo M, López-Huertas MR, Díez-Fuertes F, Rodríguez-Mora S, Bermejo M, López-Campos G, Mateos E, Jiménez-Tormo L, Gómez-Esquer F, Díaz-Gil G, Alcamí J, Coiras M.

PLoS One. 2017 Oct 2;12(10):e0185677. doi: 10.1371/journal.pone.0185677. eCollection 2017.

35.

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs.

Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Loebenberg R, Lee A, Frances A, Amidon G, Yu A, Benninghoff G, Salehi N, Talattof A, Sun D, Amidon GL.

Mol Pharm. 2017 Dec 4;14(12):4281-4294. doi: 10.1021/acs.molpharmaceut.7b00426. Epub 2017 Aug 4.

PMID:
28737409
36.

Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.

Ruiz-Picazo A, Lozoya-Agullo I, Ortiz-Azcarate M, Merino-Sanjuán M, González-Álvarez M, González-Álvarez I, Bermejo M.

Eur J Pharm Sci. 2017 Sep 30;107:191-196. doi: 10.1016/j.ejps.2017.06.033. Epub 2017 Jul 4.

PMID:
28687530
37.

Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.

Lozoya-Agullo I, Zur M, Fine-Shamir N, Markovic M, Cohen Y, Porat D, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M, Dahan A.

Int J Pharm. 2017 Jul 15;527(1-2):135-141. doi: 10.1016/j.ijpharm.2017.05.018. Epub 2017 May 10.

PMID:
28501438
38.

Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture.

Lozoya-Agullo I, Araújo F, González-Álvarez I, Merino-Sanjuán M, González-Álvarez M, Bermejo M, Sarmento B.

Mol Pharm. 2017 Apr 3;14(4):1264-1270. doi: 10.1021/acs.molpharmaceut.6b01165. Epub 2017 Mar 10.

PMID:
28263609
39.

Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers.

Pérez-Sánchez A, Borrás-Linares I, Barrajón-Catalán E, Arráez-Román D, González-Álvarez I, Ibáñez E, Segura-Carretero A, Bermejo M, Micol V.

PLoS One. 2017 Feb 24;12(2):e0172063. doi: 10.1371/journal.pone.0172063. eCollection 2017.

40.

Different Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State.

Calonge E, Bermejo M, Diez-Fuertes F, Mangeot I, González N, Coiras M, Jiménez Tormo L, García-Perez J, Dereuddre-Bosquet N, Le Grand R, Alcamí J.

J Virol. 2017 Mar 29;91(8). pii: e01379-16. doi: 10.1128/JVI.01379-16. Print 2017 Apr 15.

41.

Population pharmacokinetic model of lithium and drug compliance assessment.

Pérez-Castelló I, Mangas-Sanjuan V, González-García I, Gonzalez-Alvarez I, Bermejo M, Marco-Garbayo JL, Trocóniz IF.

Eur Neuropsychopharmacol. 2016 Dec;26(12):1868-1876. doi: 10.1016/j.euroneuro.2016.11.005. Epub 2016 Nov 16.

PMID:
27865605
42.

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion.

Lozoya-Agullo I, Zur M, Beig A, Fine N, Cohen Y, González-Álvarez M, Merino-Sanjuán M, González-Álvarez I, Bermejo M, Dahan A.

Int J Pharm. 2016 Dec 30;515(1-2):201-208. doi: 10.1016/j.ijpharm.2016.09.061. Epub 2016 Sep 22.

PMID:
27667756
43.

Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles.

Mangas-Sanjuan V, Colon-Useche S, Gonzalez-Alvarez I, Bermejo M, Garcia-Arieta A.

AAPS J. 2016 Nov;18(6):1550-1561. Epub 2016 Aug 29.

PMID:
27571779
44.

Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol.

Lozoya-Agullo I, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M.

Eur J Pharm Sci. 2016 Oct 10;93:334-40. doi: 10.1016/j.ejps.2016.08.035. Epub 2016 Aug 20.

PMID:
27552904
45.

Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

Bermejo M, Mangas-Sanjuan V, Gonzalez-Alvarez I, Gonzalez-Alvarez M.

Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):1-10. doi: 10.1007/s13318-016-0369-7. Review.

PMID:
27538882
46.

"The Golden Method": Electrochemical Synthesis Is an Efficient Route to Gold Complexes.

González-Barcia LM, Romero MJ, González Noya AM, Bermejo MR, Maneiro M, Zaragoza G, Pedrido R.

Inorg Chem. 2016 Aug 15;55(16):7823-5. doi: 10.1021/acs.inorgchem.6b01362. Epub 2016 Aug 2.

PMID:
27483164
47.

IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle.

Coiras M, Bermejo M, Descours B, Mateos E, García-Pérez J, López-Huertas MR, Lederman MM, Benkirane M, Alcamí J.

Cell Rep. 2016 Mar 8;14(9):2100-2107. doi: 10.1016/j.celrep.2016.02.022. Epub 2016 Feb 25.

48.

Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.

Bermejo M, López-Huertas MR, García-Pérez J, Climent N, Descours B, Ambrosioni J, Mateos E, Rodríguez-Mora S, Rus-Bercial L, Benkirane M, Miró JM, Plana M, Alcamí J, Coiras M.

Biochem Pharmacol. 2016 Apr 15;106:30-45. doi: 10.1016/j.bcp.2016.02.002. Epub 2016 Feb 4.

PMID:
26851491
49.

Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling.

Pham-The H, Casañola-Martin G, Garrigues T, Bermejo M, González-Álvarez I, Nguyen-Hai N, Cabrera-Pérez MÁ, Le-Thi-Thu H.

Mol Divers. 2016 Feb;20(1):93-109. doi: 10.1007/s11030-015-9649-4. Epub 2015 Dec 7.

PMID:
26643659
50.

Health education: an analysis of wine and carbonated beverage consumption in college students in Extremadura.

Cubero Juánez J, Franco-Reynolds L, Pozo A, Sánchez S, Benítez A, Bermejo M.

Nutr Hosp. 2015 Dec 1;32 Suppl 2:10287. doi: 10.3305/nh.2015.32.sup2.10287. No abstract available.

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