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Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.

Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ 3rd, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, Horan JT; Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.

Cancer. 2019 Oct 29. doi: 10.1002/cncr.32552. [Epub ahead of print]


Frizzled 4 regulates ventral blood vessel remodeling in the zebrafish retina.

Caceres L, Prykhozhij SV, Cairns E, Gjerde H, Duff NM, Collett K, Ngo M, Nasrallah GK, McMaster CR, Litvak M, Robitaille JM, Berman JN.

Dev Dyn. 2019 Dec;248(12):1243-1256. doi: 10.1002/dvdy.117. Epub 2019 Oct 21.


Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431.

Mast KJ, Taub JW, Alonzo TA, Gamis AS, Mosse CA, Mathew P, Berman JN, Wang YC, Jones HM, Campana D, Coustan-Smith E, Raimondi SC, Hirsch B, Hitzler JK, Head DR.

Arch Pathol Lab Med. 2019 Aug 20. doi: 10.5858/arpa.2018-0526-OA. [Epub ahead of print]


High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.

Wang S, Hwang EE, Guha R, O'Neill AF, Melong N, Veinotte CJ, Conway Saur A, Wuerthele K, Shen M, McKnight C, Alexe G, Lemieux ME, Wang A, Hughes E, Xu X, Boxer MB, Hall MD, Kung A, Berman JN, Davis MI, Stegmaier K, Crompton BD.

Clin Cancer Res. 2019 Jul 15;25(14):4552-4566. doi: 10.1158/1078-0432.CCR-17-0375. Epub 2019 Apr 12.


Fats enhance stem cell emergence.

Rajan V, Berman JN.

Science. 2019 Mar 8;363(6431):1041-1042. doi: 10.1126/science.aaw7059. No abstract available.


Zebrafish knock-ins swim into the mainstream.

Prykhozhij SV, Berman JN.

Dis Model Mech. 2018 Oct 24;11(10). pii: dmm037515. doi: 10.1242/dmm.037515.


Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9.

Prykhozhij SV, Fuller C, Steele SL, Veinotte CJ, Razaghi B, Robitaille JM, McMaster CR, Shlien A, Malkin D, Berman JN.

Nucleic Acids Res. 2018 Sep 28;46(17):9252. doi: 10.1093/nar/gky674. No abstract available.


Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9.

Prykhozhij SV, Fuller C, Steele SL, Veinotte CJ, Razaghi B, Robitaille JM, McMaster CR, Shlien A, Malkin D, Berman JN.

Nucleic Acids Res. 2018 Sep 28;46(17):e102. doi: 10.1093/nar/gky512. Erratum in: Nucleic Acids Res. 2018 Sep 28;46(17):9252.


Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome.

Cloney K, Steele SL, Stoyek MR, Croll RP, Smith FM, Prykhozhij SV, Brown MM, Midgen C, Blake K, Berman JN.

FEBS J. 2018 Jun;285(11):2125-2140. doi: 10.1111/febs.14473. Epub 2018 Apr 27.


How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases.

Strynatka KA, Gurrola-Gal MC, Berman JN, McMaster CR.

Genetics. 2018 Mar;208(3):833-851. doi: 10.1534/genetics.117.300124. Review.


Phloridzin docosahexaenoate, a novel flavonoid derivative, suppresses growth and induces apoptosis in T-cell acute lymphoblastic leukemia cells.

Arumuggam N, Melong N, Too CK, Berman JN, Rupasinghe HV.

Am J Cancer Res. 2017 Dec 1;7(12):2452-2464. eCollection 2017.


New Developments in CRISPR/Cas-based Functional Genomics and their Implications for Research Using Zebrafish.

Prykhozhij SV, Caceres L, Berman JN.

Curr Gene Ther. 2017;17(4):286-300. doi: 10.2174/1566523217666171121164132. Review.


Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia.

Melong N, Steele S, MacDonald M, Holly A, Collins CC, Zoubeidi A, Berman JN, Dellaire G.

Sci Rep. 2017 Oct 31;7(1):14698. doi: 10.1038/s41598-017-14413-w.


hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms.

Razaghi B, Steele SL, Prykhozhij SV, Stoyek MR, Hill JA, Cooper MD, McDonald L, Lin W, Daugaard M, Crapoulet N, Chacko S, Lewis SM, Scott IC, Sorensen PHB, Berman JN.

Dev Dyn. 2018 Feb;247(2):289-303. doi: 10.1002/dvdy.24600. Epub 2017 Oct 27.


Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking.

Corkery DP, Clarke LE, Gebremeskel S, Salsman J, Pinder J, Le Page C, Meunier L, Xu Z, Mes-Masson AM, Berman JN, Johnston B, Dellaire G.

Oncogene. 2018 Jan 11;37(2):174-184. doi: 10.1038/onc.2017.318. Epub 2017 Sep 11.


In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.

Leung AWY, Veinotte CJ, Melong N, Oh MH, Chen K, Enfield KSS, Backstrom I, Warburton C, Yapp D, Berman JN, Bally MB, Lockwood WW.

Clin Cancer Res. 2017 Nov 1;23(21):6555-6566. doi: 10.1158/1078-0432.CCR-17-0700. Epub 2017 Aug 8.


Improved outcomes for myeloid leukemia of Down syndrome: a report from the Children's Oncology Group AAML0431 trial.

Taub JW, Berman JN, Hitzler JK, Sorrell AD, Lacayo NJ, Mast K, Head D, Raimondi S, Hirsch B, Ge Y, Gerbing RB, Wang YC, Alonzo TA, Campana D, Coustan-Smith E, Mathew P, Gamis AS.

Blood. 2017 Jun 22;129(25):3304-3313. doi: 10.1182/blood-2017-01-764324. Epub 2017 Apr 7.


A rapid and effective method for screening, sequencing and reporter verification of engineered frameshift mutations in zebrafish.

Prykhozhij SV, Steele SL, Razaghi B, Berman JN.

Dis Model Mech. 2017 Jun 1;10(6):811-822. doi: 10.1242/dmm.026765. Epub 2017 Mar 9.


FISH identifies a KAT6A/CREBBP fusion caused by a cryptic insertional t(8;16) in a case of spontaneously remitting congenital acute myeloid leukemia with a normal karyotype.

Barrett R, Morash B, Roback D, Pambrun C, Marfleet L, Ketterling RP, Harrison K, Berman JN.

Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26450. Epub 2017 Jan 18.


Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.

Couturier AM, Fleury H, Patenaude AM, Bentley VL, Rodrigue A, Coulombe Y, Niraj J, Pauty J, Berman JN, Dellaire G, Di Noia JM, Mes-Masson AM, Masson JY.

Nucleic Acids Res. 2016 Dec 15;44(22):10879-10897. Epub 2016 Oct 24.


Using zebrafish models of leukemia to streamline drug screening and discovery.

Deveau AP, Bentley VL, Berman JN.

Exp Hematol. 2017 Jan;45:1-9. doi: 10.1016/j.exphem.2016.09.012. Epub 2016 Oct 6. Review.


T Cell Immune Deficiency in zap70 Mutant Zebrafish.

Moore JC, Mulligan TS, Yordán NT, Castranova D, Pham VN, Tang Q, Lobbardi R, Anselmo A, Liwski RS, Berman JN, Sadreyev RI, Weinstein BM, Langenau DM.

Mol Cell Biol. 2016 Nov 14;36(23):2868-2876. doi: 10.1128/MCB.00281-16. Print 2016 Dec 1.


Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models.

Rajan V, Dellaire G, Berman JN.

Methods Mol Biol. 2016;1451:171-89. doi: 10.1007/978-1-4939-3771-4_12.


Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9.

Ceasar SA, Rajan V, Prykhozhij SV, Berman JN, Ignacimuthu S.

Biochim Biophys Acta. 2016 Sep;1863(9):2333-44. doi: 10.1016/j.bbamcr.2016.06.009. Epub 2016 Jun 24. Review.


The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool.

Wertman J, Veinotte CJ, Dellaire G, Berman JN.

Adv Exp Med Biol. 2016;916:289-314. doi: 10.1007/978-3-319-30654-4_13. Review.


Study of Glycine and Folic Acid Supplementation to Ameliorate Transfusion Dependence in Congenital SLC25A38 Mutated Sideroblastic Anemia.

LeBlanc MA, Bettle A, Berman JN, Price VE, Pambrun C, Yu Z, Tiller M, McMaster CR, Fernandez CV.

Pediatr Blood Cancer. 2016 Jul;63(7):1307-9. doi: 10.1002/pbc.25981. Epub 2016 Apr 1.


Characterization of the Zebrafish Homolog of β-Glucosidase 2: A Target of the Drug Miglustat.

Sultana S, Truong NY, Vieira DB, Wigger JG, Forrester AM, Veinotte CJ, Berman JN, van der Spoel AC.

Zebrafish. 2016 Jun;13(3):177-87. doi: 10.1089/zeb.2015.1152. Epub 2016 Feb 24.


Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia.

Fernández-Murray JP, Prykhozhij SV, Dufay JN, Steele SL, Gaston D, Nasrallah GK, Coombs AJ, Liwski RS, Fernandez CV, Berman JN, McMaster CR.

PLoS Genet. 2016 Jan 28;12(1):e1005783. doi: 10.1371/journal.pgen.1005783. eCollection 2016 Jan.


A Guide to Computational Tools and Design Strategies for Genome Editing Experiments in Zebrafish Using CRISPR/Cas9.

Prykhozhij SV, Rajan V, Berman JN.

Zebrafish. 2016 Feb;13(1):70-3. doi: 10.1089/zeb.2015.1158. Epub 2015 Dec 18.


Correction: CRISPR MultiTargeter: A Web Tool to Find Common and Unique CRISPR Single Guide RNA Targets in a Set of Similar Sequences.

Prykhozhij SV, Rajan V, Gaston D, Berman JN.

PLoS One. 2015 Sep 14;10(9):e0138634. doi: 10.1371/journal.pone.0138634. eCollection 2015. No abstract available.


Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN).

Dhanraj S, Gunja SM, Deveau AP, Nissbeck M, Boonyawat B, Coombs AJ, Renieri A, Mucciolo M, Marozza A, Buoni S, Turner L, Li H, Jarrar A, Sabanayagam M, Kirby M, Shago M, Pinto D, Berman JN, Scherer SW, Virtanen A, Dror Y.

J Med Genet. 2015 Nov;52(11):738-48. doi: 10.1136/jmedgenet-2015-103292. Epub 2015 Sep 4.


Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98-HOXA9-induced myeloid disease.

Deveau AP, Forrester AM, Coombs AJ, Wagner GS, Grabher C, Chute IC, Léger D, Mingay M, Alexe G, Rajan V, Liwski R, Hirst M, Steigmaier K, Lewis SM, Look AT, Berman JN.

Leukemia. 2015 Oct;29(10):2086-97. doi: 10.1038/leu.2015.126. Epub 2015 May 28.


Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.

El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH.

Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003.


CRISPR multitargeter: a web tool to find common and unique CRISPR single guide RNA targets in a set of similar sequences.

Prykhozhij SV, Rajan V, Gaston D, Berman JN.

PLoS One. 2015 Mar 5;10(3):e0119372. doi: 10.1371/journal.pone.0119372. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138634.


Hematopoietic neck lesions.

Lubek JE, Shihabi A, Murphy LA, Berman JN.

Atlas Oral Maxillofac Surg Clin North Am. 2015 Mar;23(1):31-7. doi: 10.1016/j.cxom.2014.10.004. Epub 2014 Dec 8. Review. No abstract available.


Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.

Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W, Peterson RT.

Sci Transl Med. 2014 Dec 10;6(266):266ra170. doi: 10.1126/scitranslmed.3010189.


Mast cell development and function in the zebrafish.

Da'as SI, Balci TB, Berman JN.

Methods Mol Biol. 2015;1220:29-57. doi: 10.1007/978-1-4939-1568-2_3.


Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia.

Bentley VL, Veinotte CJ, Corkery DP, Pinder JB, LeBlanc MA, Bedard K, Weng AP, Berman JN, Dellaire G.

Haematologica. 2015 Jan;100(1):70-6. doi: 10.3324/haematol.2014.110742. Epub 2014 Oct 3.


Optimized cell transplantation using adult rag2 mutant zebrafish.

Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN, Liwski RS, Houvras Y, Langenau DM.

Nat Methods. 2014 Aug;11(8):821-4. doi: 10.1038/nmeth.3031. Epub 2014 Jul 20.


A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis.

Balci TB, Prykhozhij SV, Teh EM, Da'as SI, McBride E, Liwski R, Chute IC, Leger D, Lewis SM, Berman JN.

Br J Haematol. 2014 Oct;167(1):48-61. doi: 10.1111/bjh.12999. Epub 2014 Jul 2.


Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era.

Veinotte CJ, Dellaire G, Berman JN.

Dis Model Mech. 2014 Jul;7(7):745-54. doi: 10.1242/dmm.015784. Review.


The progress and promise of zebrafish as a model to study mast cells.

Prykhozhij SV, Berman JN.

Dev Comp Immunol. 2014 Sep;46(1):74-83. doi: 10.1016/j.dci.2014.01.023. Epub 2014 Feb 6. Review.


Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation.

Wu Z, Li Y, MacNeil AJ, Junkins RD, Berman JN, Lin TJ.

J Immunol. 2013 Dec 15;191(12):5885-94. doi: 10.4049/jimmunol.1301271. Epub 2013 Nov 11.


Zebrafish as a model system for mitochondrial biology and diseases.

Steele SL, Prykhozhij SV, Berman JN.

Transl Res. 2014 Feb;163(2):79-98. doi: 10.1016/j.trsl.2013.08.008. Epub 2013 Sep 20. Review.


Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.

Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH.

Nat Commun. 2013;4:2180. doi: 10.1038/ncomms3180.


Mast cell FcεRI-induced early growth response 2 regulates CC chemokine ligand 1-dependent CD4+ T cell migration.

Wu Z, Macneil AJ, Junkins R, Li B, Berman JN, Lin TJ.

J Immunol. 2013 May 1;190(9):4500-7. doi: 10.4049/jimmunol.1203158. Epub 2013 Mar 27.


Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation.

Wu Z, MacNeil AJ, Berman JN, Lin TJ.

PLoS One. 2013;8(3):e58560. doi: 10.1371/journal.pone.0058560. Epub 2013 Mar 6.


Investigations regarding the utility of prodigiosenes to treat leukemia.

Smithen DA, Forrester AM, Corkery DP, Dellaire G, Colpitts J, McFarland SA, Berman JN, Thompson A.

Org Biomol Chem. 2013 Jan 7;11(1):62-8. doi: 10.1039/c2ob26535d.


Zebrafish xenografts as a tool for in vivo studies on human cancer.

Konantz M, Balci TB, Hartwig UF, Dellaire G, André MC, Berman JN, Lengerke C.

Ann N Y Acad Sci. 2012 Aug;1266:124-37. doi: 10.1111/j.1749-6632.2012.06575.x. Review.


Myelopoiesis and myeloid leukaemogenesis in the zebrafish.

Forrester AM, Berman JN, Payne EM.

Adv Hematol. 2012;2012:358518. doi: 10.1155/2012/358518. Epub 2012 Jul 19.

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