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Items: 1 to 50 of 60

1.

Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.

Graham DL, Beio ML, Nelson DL, Berkowitz DB.

Front Mol Biosci. 2019 Mar 13;6:8. doi: 10.3389/fmolb.2019.00008. eCollection 2019. Review.

2.

Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.

Tu Y, Kreinbring CA, Hill M, Liu C, Petsko GA, McCune CD, Berkowitz DB, Liu D, Ringe D.

Biochemistry. 2018 Jun 5;57(22):3134-3145. doi: 10.1021/acs.biochem.8b00092. Epub 2018 Apr 13.

3.

A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.

Malik G, Swyka RA, Tiwari VK, Fei X, Applegate GA, Berkowitz DB.

Chem Sci. 2017 Dec 1;8(12):8050-8060. doi: 10.1039/c7sc04083k. Epub 2017 Oct 3.

4.

The In Situ Enzymatic Screening (ISES) Approach to Reaction Discovery and Catalyst Identification.

Swyka RA, Berkowitz DB.

Curr Protoc Chem Biol. 2017 Dec 14;9(4):285-305. doi: 10.1002/cpch.30.

5.

Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.

McCune CD, Beio ML, Sturdivant JM, de la Salud-Bea R, Darnell BM, Berkowitz DB.

J Am Chem Soc. 2017 Oct 11;139(40):14077-14089. doi: 10.1021/jacs.7b04690. Epub 2017 Sep 28.

6.

General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor.

Fei X, Zavorka ME, Malik G, Connelly CM, MacDonald RG, Berkowitz DB.

Org Lett. 2017 Aug 18;19(16):4267-4270. doi: 10.1021/acs.orglett.7b01914. Epub 2017 Jul 28.

7.

Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.

Nelson DL, Applegate GA, Beio ML, Graham DL, Berkowitz DB.

J Biol Chem. 2017 Aug 25;292(34):13986-14002. doi: 10.1074/jbc.M117.777904. Epub 2017 Jul 10.

8.

"Zipped Synthesis" by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model.

McCune CD, Chan SJ, Beio ML, Shen W, Chung WJ, Szczesniak LM, Chai C, Koh SQ, Wong PT, Berkowitz DB.

ACS Cent Sci. 2016 Apr 27;2(4):242-52. doi: 10.1021/acscentsci.6b00019. Epub 2016 Mar 9.

9.

Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.

Applegate GA, Berkowitz DB.

Adv Synth Catal. 2015 May 26;357(8):1619-1632. Epub 2015 May 12.

10.

Mini-ISES identifies promising carbafructopyranose-based salens for asymmetric catalysis: Tuning ligand shape via the anomeric effect.

Karukurichi KR, Fei X, Swyka RA, Broussy S, Shen W, Dey S, Roy SK, Berkowitz DB.

Sci Adv. 2015 Jul;1(6). pii: e1500066. Epub 2015 Jul 10.

11.

A useful methoxyvinyl cation equivalent: α-t-butyldimethylsilyl-α-methoxyacetaldehyde.

McCune CD, Beio ML, Friest JA, Ginotra S, Berkowitz DB.

Tetrahedron Lett. 2015 Jun 3;56(23):3575-3579.

12.
13.

Phosphatase-inert glucosamine 6-phosphate mimics serve as actuators of the glmS riboswitch.

Fei X, Holmes T, Diddle J, Hintz L, Delaney D, Stock A, Renner D, McDevitt M, Berkowitz DB, Soukup JK.

ACS Chem Biol. 2014 Dec 19;9(12):2875-82. doi: 10.1021/cb500458f. Epub 2014 Oct 27.

14.

Unleashing a "true" pSer-mimic in the cell.

Panigrahi K, Nelson DL, Berkowitz DB.

Chem Biol. 2012 Jun 22;19(6):666-7. doi: 10.1016/j.chembiol.2012.06.005.

15.

Halocarbocyclization entry into the oxabicyclo[4.3.1]decyl exomethylene-δ-lactone cores of linearifolin and zaluzanin A: exploiting combinatorial catalysis.

Ginotra SK, Friest JA, Berkowitz DB.

Org Lett. 2012 Feb 17;14(4):968-71. doi: 10.1021/ol203088g. Epub 2012 Feb 8.

16.

Combinatorial catalysis employing a visible enzymatic beacon in real time: synthetically versatile (pseudo)halometalation/carbocyclizations.

Friest JA, Broussy S, Chung WJ, Berkowitz DB.

Angew Chem Int Ed Engl. 2011 Sep 12;50(38):8895-9. doi: 10.1002/anie.201103365. Epub 2011 Aug 16. No abstract available.

17.

A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotère side chain.

Applegate GA, Cheloha RW, Nelson DL, Berkowitz DB.

Chem Commun (Camb). 2011 Feb 28;47(8):2420-2. doi: 10.1039/c0cc04585c. Epub 2010 Dec 20.

18.

Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (S)-profens.

Friest JA, Maezato Y, Broussy S, Blum P, Berkowitz DB.

J Am Chem Soc. 2010 May 5;132(17):5930-1. doi: 10.1021/ja910778p.

19.

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes.

Baxter NJ, Bowler MW, Alizadeh T, Cliff MJ, Hounslow AM, Wu B, Berkowitz DB, Williams NH, Blackburn GM, Waltho JP.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4555-60. doi: 10.1073/pnas.0910333106. Epub 2010 Feb 17.

20.

The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.

Panigrahi K, Eggen M, Maeng JH, Shen Q, Berkowitz DB.

Chem Biol. 2009 Sep 25;16(9):928-36. doi: 10.1016/j.chembiol.2009.08.008. Review.

21.

Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical Advantages.

Berkowitz DB, Karukurichi KR, de la Salud-Bea R, Nelson DL, McCune CD.

J Fluor Chem. 2008 Sep;129(9):731-742.

22.

Enantioselective, ketoreductase-based entry into pharmaceutical building blocks: ethanol as tunable nicotinamide reductant.

Broussy S, Cheloha RW, Berkowitz DB.

Org Lett. 2009 Jan 15;11(2):305-8. doi: 10.1021/ol802464g.

23.

A set of phosphatase-inert "molecular rulers" to probe for bivalent mannose 6-phosphate ligand-receptor interactions.

Fei X, Connelly CM, MacDonald RG, Berkowitz DB.

Bioorg Med Chem Lett. 2008 May 15;18(10):3085-9. Epub 2007 Nov 28.

24.

"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides.

Dey S, Powell DR, Hu C, Berkowitz DB.

Angew Chem Int Ed Engl. 2007;46(37):7010-4. No abstract available.

25.

Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

Wilstermann AM, Bender RP, Godfrey M, Choi S, Anklin C, Berkowitz DB, Osheroff N, Graves DE.

Biochemistry. 2007 Jul 17;46(28):8217-25. Epub 2007 Jun 20.

26.

Examination of the new alpha-(2'Z-fluoro)vinyl trigger with lysine decarboxylase: the absolute stereochemistry dictates the reaction course.

Karukurichi KR, de la Salud-Bea R, Jahng WJ, Berkowitz DB.

J Am Chem Soc. 2007 Jan 17;129(2):258-9. No abstract available.

27.

Protein structure similarity clustering: dynamic treatment of PDB structures facilitates clustering.

Charette BD, Macdonald RG, Wetzel S, Berkowitz DB, Waldmann H.

Angew Chem Int Ed Engl. 2006 Nov 27;45(46):7766-70. No abstract available.

PMID:
17075950
28.

α-Vinylic Amino Acids: Occurrence, Asymmetric Synthesis and Biochemical Mechanisms.

Berkowitz DB, Charette BD, Karukurichi KR, McFadden JM.

Tetrahedron Asymmetry. 2006 Mar 20;17(6):869-882. doi: 10.1016/j.tetasy.2006.02.026. Epub 2006 Apr 4.

30.

A continuous spectrophotometric assay for human cystathionine beta-synthase.

Shen W, McGath MK, Evande R, Berkowitz DB.

Anal Biochem. 2005 Jul 1;342(1):103-10.

31.

Double-cuvette ISES: in situ estimation of enantioselectivity and relative rate for catalyst screening.

Dey S, Karukurichi KR, Shen W, Berkowitz DB.

J Am Chem Soc. 2005 Jun 22;127(24):8610-1.

PMID:
15954763
32.

Mono- and bivalent ligands bearing mannose 6-phosphate (M6P) surrogates: targeting the M6P/insulin-like growth factor II receptor.

Berkowitz DB, Maiti G, Charette BD, Dreis CD, MacDonald RG.

Org Lett. 2004 Dec 23;6(26):4921-4.

PMID:
15606100
33.

In situ enzymatic screening (ISES) of P,N-ligands for Ni(0)-mediated asymmetric intramolecular allylic amination.

Berkowitz DB, Shen W, Maiti G.

Tetrahedron Asymmetry. 2004 Sep 20;15(18):2845-2851. doi: 10.1016/j.tetasy.2004.06.052. Epub 2004 Sep 13.

34.
35.
36.

Structure-activity analysis of guanidine group in agmatine for brain agmatinase.

Huang MJ, Regunathan S, Botta M, Lee K, McClendon E, Yi GB, Pedersen ML, Berkowitz DB, Wang G, Travagli M, Piletz JE.

Ann N Y Acad Sci. 2003 Dec;1009:52-63.

PMID:
15028570
37.

In situ enzymatic screening (ISES): a tool for catalyst discovery and reaction development.

Berkowitz DB, Bose M, Choi S.

Angew Chem Int Ed Engl. 2002 May 3;41(9):1603-7. No abstract available.

38.

Stereocontrolled Synthesis of Quaternary β,γ-Unsaturated Amino Acids: Chain Extension of D- & L- α-(2-Tributylstannyl)Vinyl Amino Acids.

Berkowitz DB, Chisowa E, McFadden JM.

Tetrahedron. 2001 Jul 23;57(30):6329-6343. doi: 10.1016/S0040-4020(01)00499-9.

39.

A convergent triflate displacement approach to (alpha-monofluoroalkyl)phosphonates.

Berkowitz DB, Bose M, Asher NG.

Org Lett. 2001 Jun 28;3(13):2009-12.

PMID:
11418036
40.

Organoselenium-Based Entry into Versatile, α-(2-Tributylstannyl)vinyl Amino Acids in Scalemic Form: A New Route to Vinyl Stannanes.

Berkowitz DB, McFadden JM, Chisowa E, Semerad CL.

J Am Chem Soc. 2000 Nov 8;122(44):11031-11032. doi: 10.1021/ja0055110. Epub 2000 Oct 21. No abstract available.

41.

alpha-fluorinated phosphonates as substrate mimics for glucose 6-phosphate dehydrogenase: the CHF stereochemistry matters.

Berkowitz DB, Bose M, Pfannenstiel TJ, Doukov T.

J Org Chem. 2000 Jul 28;65(15):4498-508.

PMID:
10959850
43.

Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin.

Berkowitz DB, Choi S, Maeng JH.

J Org Chem. 2000 Feb 11;65(3):847-60.

PMID:
10814019
44.

Novel "reverse Kahne-type glycosylation": access to O-, N-, and C-linked epipodophyllotoxin conjugates.

Berkowitz DB, Choi S, Bhuniya D, Shoemaker RK.

Org Lett. 2000 Apr 20;2(8):1149-52.

PMID:
10804576
45.

Synthesis of α-Vinyl Amino Acids.

Berkowitz DB, McFadden JM, Smith MK, Pedersen ML.

Methods Mol Med. 1999;23:467-88. doi: 10.1385/0-89603-517-4:467.

PMID:
21380914
46.

Pharmacokinetics of gammahydroxybutyrate (GHB) in narcoleptic patients.

Scharf MB, Lai AA, Branigan B, Stover R, Berkowitz DB.

Sleep. 1998 Aug 1;21(5):507-14.

PMID:
9703591
47.

α-VINYLLYSINE AND α-VINYLARGININE ARE TIME-DEPENDENT INHIBITORS OF THEIR COGNATE DECARBOXYLASES.

Berkowitz DB, Jahng WJ, Pedersen ML.

Bioorg Med Chem Lett. 1996 Sep 17;6(18):2151-2156. doi: 10.1016/0960-894X(96)00366-6.

49.

Synthesis of Higher α-Chlorovinyl and α-Bromovinyl Amino Acids: The Amino Protecting Group Determines the Reaction Course.

Berkowitz DB, Pedersen ML, Jahng WJ.

Tetrahedron Lett. 1996 Jun 17;37(25):4309-4312. doi: 10.1016/0040-4039(96)00832-5.

50.

A Convenient Synthesis of L-α-Vinylglycine from L-Homoserine Lactone.

Berkowitz DB, Smith MK.

Synthesis (Stuttg). 1996 Jan;1996(1):39-41. doi: 10.1055/s-1996-4177.

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