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Extracellular and Intracellular Cyclophilin A, Native and Post-Translationally Modified, Show Diverse and Specific Pathological Roles in Diseases.

Xue C, Sowden MP, Berk BC.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):986-993. doi: 10.1161/ATVBAHA.117.310661. Epub 2018 Mar 29. Review.


Extracellular Cyclophilin A, Especially Acetylated, Causes Pulmonary Hypertension by Stimulating Endothelial Apoptosis, Redox Stress, and Inflammation.

Xue C, Sowden M, Berk BC.

Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1138-1146. doi: 10.1161/ATVBAHA.117.309212. Epub 2017 Apr 27. Erratum in: Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):e68.


G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.

Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, Xue C, Wang X, Coia H, Cui Z, Smolock EM, Libby RT, Berk BC, Pang J.

Cell Rep. 2016 Dec 6;17(10):2532-2541. doi: 10.1016/j.celrep.2016.11.017.


Cyclophilin A modulates bone marrow-derived CD117(+) cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis.

Perrucci GL, Straino S, Corlianò M, Scopece A, Napolitano M, Berk BC, Lombardi F, Pompilio G, Capogrossi MC, Nigro P.

Int J Cardiol. 2016 Jun 1;212:324-35. doi: 10.1016/j.ijcard.2016.03.082. Epub 2016 Mar 24.


Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events.

Heo KS, Berk BC, Abe J.

Antioxid Redox Signal. 2016 Sep 1;25(7):435-50. doi: 10.1089/ars.2015.6556. Epub 2016 Apr 5. Review.


The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.

Shi X, O'Neill MM, MacDonnell S, Brookes PS, Yan C, Berk BC.

J Cardiovasc Pharmacol Ther. 2016 Mar;21(2):177-86. doi: 10.1177/1074248415591700. Epub 2015 Jun 30.


State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.

Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S; American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular Surgery and Anesthesia.

Circ Res. 2015 May 22;116(11):e99-132. doi: 10.1161/RES.0000000000000054. Epub 2015 Apr 30. No abstract available.


The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease.

Burke RM, Berk BC.

Antioxid Redox Signal. 2015 May 10;22(14):1243-56. doi: 10.1089/ars.2014.6182. Epub 2015 Mar 23. Review.


Novel mechanisms of endothelial mechanotransduction.

Abe J, Berk BC.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2378-86. doi: 10.1161/ATVBAHA.114.303428. Epub 2014 Oct 9. Review.


Decreased BMP2 signal in GIT1 knockout mice slows bone healing.

Sheu TJ, Zhou W, Fan J, Zhou H, Zuscik MJ, Xie C, Yin G, Berk BC.

Mol Cell Biochem. 2014 Dec;397(1-2):67-74. doi: 10.1007/s11010-014-2173-5. Epub 2014 Aug 20.


Intima modifier locus 2 controls endothelial cell activation and vascular permeability.

Smolock EM, Burke RM, Wang C, Thomas T, Batchu SN, Qiu X, Zettel M, Fujiwara K, Berk BC, Korshunov VA.

Physiol Genomics. 2014 Sep 1;46(17):624-33. doi: 10.1152/physiolgenomics.00048.2014. Epub 2014 Jul 1.


Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC.

PLoS One. 2014 Feb 19;9(2):e89127. doi: 10.1371/journal.pone.0089127. eCollection 2014.


Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.

Spindel ON, Burke RM, Yan C, Berk BC.

Circ Res. 2014 Mar 28;114(7):1125-32. doi: 10.1161/CIRCRESAHA.114.301315. Epub 2014 Feb 10.


Cyclophilin A is an important mediator of platelet function by regulating integrin αIIbβ3 bidirectional signalling.

Wang L, Soe NN, Sowden M, Xu Y, Modjeski K, Baskaran P, Kim Y, Smolock EM, Morrell CN, Berk BC.

Thromb Haemost. 2014 May 5;111(5):873-82. doi: 10.1160/TH13-09-0738. Epub 2014 Jan 16.


Acetylation of cyclophilin A is required for its secretion and vascular cell activation.

Soe NN, Sowden M, Baskaran P, Kim Y, Nigro P, Smolock EM, Berk BC.

Cardiovasc Res. 2014 Mar 1;101(3):444-53. doi: 10.1093/cvr/cvt268. Epub 2013 Nov 29.


G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.

Majumder S, Sowden MP, Gerber SA, Thomas T, Christie CK, Mohan A, Yin G, Lord EM, Berk BC, Pang J.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):419-26. doi: 10.1161/ATVBAHA.113.302689. Epub 2013 Nov 21.


Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells.

Soe NN, Sowden M, Baskaran P, Smolock EM, Kim Y, Nigro P, Berk BC.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2147-53. doi: 10.1161/ATVBAHA.113.301894. Epub 2013 Jul 11.


Atheroprone flow activation of the sterol regulatory element binding protein 2 and nod-like receptor protein 3 inflammasome mediates focal atherosclerosis.

Abe J, Berk BC.

Circulation. 2013 Aug 6;128(6):579-82. doi: 10.1161/CIRCULATIONAHA.113.004390. Epub 2013 Jul 9. No abstract available.


Cezanne paints inflammation by regulating ubiquitination.

Abe J, Berk BC.

Circ Res. 2013 Jun 7;112(12):1526-8. doi: 10.1161/CIRCRESAHA.113.301518. No abstract available.


Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery.

Smolock EM, Machleder DE, Korshunov VA, Berk BC.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):1014-9. doi: 10.1161/ATVBAHA.112.301129. Epub 2013 Feb 28.


G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration.

Pang J, Xu X, Wang X, Majumder S, Wang J, Korshunov VA, Berk BC.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):999-1005. doi: 10.1161/ATVBAHA.112.300966. Epub 2013 Feb 21.


Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.

Park SY, Shi X, Pang J, Yan C, Berk BC.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):737-43. doi: 10.1161/ATVBAHA.112.300386. Epub 2013 Feb 7.


Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.

Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk BC.

Circulation. 2012 Nov 13;126(20):2418-27. doi: 10.1161/CIRCULATIONAHA.112.125971. Epub 2012 Oct 12.


p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells.

Kim GY, Nigro P, Fujiwara K, Abe J, Berk BC.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2974-80. doi: 10.1161/ATVBAHA.112.300054. Epub 2012 Sep 27.


Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV.

Nature. 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087.


Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.

Spindel ON, Yan C, Berk BC.

Arterioscler Thromb Vasc Biol. 2012 May;32(5):1264-70. doi: 10.1161/ATVBAHA.111.244681. Epub 2012 Feb 16.


Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.

Wang XQ, Nigro P, World C, Fujiwara K, Yan C, Berk BC.

Circ Res. 2012 Feb 17;110(4):560-8. doi: 10.1161/CIRCRESAHA.111.256362. Epub 2012 Jan 19.


Redox redux: protecting the ischemic myocardium.

Spindel ON, Berk BC.

J Clin Invest. 2012 Jan;122(1):30-2. doi: 10.1172/JCI61467. Epub 2011 Dec 27.


Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms.

Spindel ON, World C, Berk BC.

Antioxid Redox Signal. 2012 Mar 15;16(6):587-96. doi: 10.1089/ars.2011.4137. Epub 2011 Dec 20. Review.


G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart.

Pang J, Xu X, Getman MR, Shi X, Belmonte SL, Michaloski H, Mohan A, Blaxall BC, Berk BC.

J Mol Cell Cardiol. 2011 Nov;51(5):769-76. doi: 10.1016/j.yjmcc.2011.06.020. Epub 2011 Jul 2.


PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.

Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J.

J Cell Biol. 2011 May 30;193(5):867-84. doi: 10.1083/jcb.201010051.


p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.

Shi X, Yan C, Nadtochiy SM, Abe J, Brookes PS, Berk BC.

J Mol Cell Cardiol. 2011 Aug;51(2):272-5. doi: 10.1016/j.yjmcc.2011.05.005. Epub 2011 May 14. Erratum in: J Mol Cell Cardiol. 2012 Jan;52(1):292.


Vascular-derived reactive oxygen species for homeostasis and diseases.

Satoh K, Berk BC, Shimokawa H.

Nitric Oxide. 2011 Aug 1;25(2):211-5. doi: 10.1016/j.niox.2011.04.005. Epub 2011 May 3. Review.


Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.

Satoh K, Nigro P, Zeidan A, Soe NN, Jaffré F, Oikawa M, O'Dell MR, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall BC, Berk BC.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1116-23. doi: 10.1161/ATVBAHA.110.214601. Epub 2011 Feb 17.


Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice.

Nigro P, Satoh K, O'Dell MR, Soe NN, Cui Z, Mohan A, Abe J, Alexis JD, Sparks JD, Berk BC.

J Exp Med. 2011 Jan 17;208(1):53-66. doi: 10.1084/jem.20101174. Epub 2010 Dec 20.


Flow shear stress and atherosclerosis: a matter of site specificity.

Nigro P, Abe J, Berk BC.

Antioxid Redox Signal. 2011 Sep 1;15(5):1405-14. doi: 10.1089/ars.2010.3679. Epub 2011 Apr 8. Review.


Cyclophilin A: promising new target in cardiovascular therapy.

Satoh K, Shimokawa H, Berk BC.

Circ J. 2010 Nov;74(11):2249-56. Epub 2010 Oct 15. Review.


Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.

Wang J, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1976-82. doi: 10.1161/ATVBAHA.110.212415. Epub 2010 Aug 5.


GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.

Menon P, Yin G, Smolock EM, Zuscik MJ, Yan C, Berk BC.

J Cell Physiol. 2010 Nov;225(3):777-85. doi: 10.1002/jcp.22282.


PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.

Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC.

Blood. 2010 Sep 16;116(11):1971-9. doi: 10.1182/blood-2010-02-269134. Epub 2010 Jun 10.


Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB.

Cavet ME, Smolock EM, Menon P, Konishi A, Korshunov VA, Berk BC.

Hypertension. 2010 Jul;56(1):105-11. doi: 10.1161/HYPERTENSIONAHA.109.144642. Epub 2010 May 17.


Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.

Jeon KI, Xu X, Aizawa T, Lim JH, Jono H, Kwon DS, Abe J, Berk BC, Li JD, Yan C.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800. doi: 10.1073/pnas.0914414107. Epub 2010 May 6.


Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.

Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC.

Brain Res. 2010 Mar 4;1317:218-26. doi: 10.1016/j.brainres.2009.11.084. Epub 2010 Jan 4.


GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions.

Zhang N, Cai W, Yin G, Nagel DJ, Berk BC.

Cell Biol Int. 2009 Dec 16;34(1):41-7. doi: 10.1042/CBI20090016.


Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice.

Massett MP, Fan R, Berk BC.

Physiol Genomics. 2009 Dec 30;40(1):15-22. doi: 10.1152/physiolgenomics.00116.2009. Epub 2009 Sep 29.


Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A.

Satoh K, Nigro P, Berk BC.

Antioxid Redox Signal. 2010 Mar 1;12(5):675-82. doi: 10.1089/ars.2009.2875. Review.


Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.

Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, Shi X, Mohan A, Yan C, Abe J, Illig KA, Berk BC.

Nat Med. 2009 Jun;15(6):649-56. doi: 10.1038/nm.1958.


Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.

Pan S, World CJ, Kovacs CJ, Berk BC.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):895-901. doi: 10.1161/ATVBAHA.109.184812. Epub 2009 Apr 9.


G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.

Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC.

Circulation. 2009 Mar 24;119(11):1524-32. doi: 10.1161/CIRCULATIONAHA.108.823997. Epub 2009 Mar 9.

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