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Items: 1 to 50 of 57

1.

AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.

Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC.

J Biol Chem. 2001 Aug 3;276(31):28969-75. Epub 2001 May 31.

2.

Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.

Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI.

J Biol Chem. 2001 Jun 8;276(23):20125-9. Epub 2001 Mar 27.

3.

Cloning, expression, and pharmacological characterization of a novel human histamine receptor.

Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ, Boyce R, Alston J, Tierney LA, Li X, Herrity NC, Vawter L, Sarau HM, Ames RS, Davenport CM, Hieble JP, Wilson S, Bergsma DJ, Fitzgerald LR.

Mol Pharmacol. 2001 Mar;59(3):434-41.

PMID:
11179436
4.

A G protein-coupled receptor for UDP-glucose.

Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, Zhu Y, McLaughlin MM, Murdock P, McMillan L, Trill J, Swift A, Aiyar N, Taylor P, Vawter L, Naheed S, Szekeres P, Hervieu G, Scott C, Watson JM, Murphy AJ, Duzic E, Klein C, Bergsma DJ, Wilson S, Livi GP.

J Biol Chem. 2000 Apr 14;275(15):10767-71.

5.

Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid.

Fitzgerald LR, Dytko GM, Sarau HM, Mannan IJ, Ellis C, Lane PA, Tan KB, Murdock PR, Wilson S, Bergsma DJ, Ames RS, Foley JJ, Campbell DA, McMillan L, Evans N, Elshourbagy NA, Minehart H, Tsui P.

Biochem Biophys Res Commun. 2000 Jul 14;273(3):805-10.

PMID:
10891327
6.

Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.

Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM.

J Biol Chem. 2000 Aug 25;275(34):25965-71.

7.

Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.

Szekeres PG, Muir AI, Spinage LD, Miller JE, Butler SI, Smith A, Rennie GI, Murdock PR, Fitzgerald LR, Wu Hl, McMillan LJ, Guerrera S, Vawter L, Elshourbagy NA, Mooney JL, Bergsma DJ, Wilson S, Chambers JK.

J Biol Chem. 2000 Jul 7;275(27):20247-50.

8.

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA.

Nature. 1999 Sep 16;401(6750):282-6. Erratum in: Nature 1999 Dec 23-30;402(6764):898.

PMID:
10499587
9.

Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.

Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW.

Mol Pharmacol. 1999 Sep;56(3):657-63.

PMID:
10462554
10.

Orphan G-protein-coupled receptors: the next generation of drug targets?

Wilson S, Bergsma DJ, Chambers JK, Muir AI, Fantom KG, Ellis C, Murdock PR, Herrity NC, Stadel JM.

Br J Pharmacol. 1998 Dec;125(7):1387-92. Review.

11.

Molecular cloning and characterization of the porcine calcitonin gene-related peptide receptor.

Elshourbagy NA, Adamou JE, Swift AM, Disa J, Mao J, Ganguly S, Bergsma DJ, Aiyar N.

Endocrinology. 1998 Apr;139(4):1678-83.

PMID:
9528949
12.

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Mar 6;92(5):1 page following 696. No abstract available.

13.

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.

Cell. 1998 Feb 20;92(4):573-85.

14.

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery.

Stadel JM, Wilson S, Bergsma DJ.

Trends Pharmacol Sci. 1997 Nov;18(11):430-7. Review.

PMID:
9426471
15.

Ser165 of transmembrane helix IV is not involved in the interaction of catecholamines with the alpha-2a-adrenoceptor.

Hehr A, Hieble JP, Li YO, Bergsma DJ, Swift AM, Ganguly S, Ruffolo RR Jr.

Pharmacology. 1997 Jul;55(1):18-24.

PMID:
9309797
16.

Fine structure of the human galactokinase GALK1 gene.

Bergsma DJ, Ai Y, Skach WR, Nesburn K, Anoia E, Van Horn S, Stambolian D.

Genome Res. 1996 Oct;6(10):980-5.

17.

Molecular cloning and characterization of the human anaphylatoxin C3a receptor.

Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C.

J Biol Chem. 1996 Aug 23;271(34):20231-4.

18.

A cDNA encoding the calcitonin gene-related peptide type 1 receptor.

Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y.

J Biol Chem. 1996 May 10;271(19):11325-9.

19.

Mouse galactokinase: isolation, characterization, and location on chromosome 11.

Ai Y, Jenkins NA, Copeland NG, Gilbert DH, Bergsma DJ, Stambolian D.

Genome Res. 1995 Aug;5(1):53-9.

20.

Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2.

Ai Y, Basu M, Bergsma DJ, Stambolian D.

Biochem Biophys Res Commun. 1995 Jul 17;212(2):687-91.

PMID:
7542884
21.

Cloning of the galactokinase cDNA and identification of mutations in two families with cataracts.

Stambolian D, Ai Y, Sidjanin D, Nesburn K, Sathe G, Rosenberg M, Bergsma DJ.

Nat Genet. 1995 Jul;10(3):307-12.

PMID:
7670469
22.

Cloning, expression and functional characterization of type 1 and type 2 steroid 5 alpha-reductases from Cynomolgus monkey: comparisons with human and rat isoenzymes.

Levy MA, Brandt M, Sheedy KM, Holt DA, Heaslip JI, Trill JJ, Ryan PJ, Morris RA, Garrison LM, Bergsma DJ.

J Steroid Biochem Mol Biol. 1995 Apr;52(4):307-19.

PMID:
7734398
23.

Benzophenone- and indolecarboxylic acids: potent type-2 specific inhibitors of human steroid 5 alpha-reductase.

Holt DA, Yamashita DS, Konialian-Beck AL, Luengo JI, Abell AD, Bergsma DJ, Brandt M, Levy MA.

J Med Chem. 1995 Jan 6;38(1):13-5. No abstract available.

PMID:
7837223
24.

Mutations in transmembrane segment VII of the AT1 receptor differentiate between closely related insurmountable and competitive angiotensin antagonists.

Schambye HT, von Wijk B, Hjorth SA, Wienen W, Entzeroth M, Bergsma DJ, Schwartz TW.

Br J Pharmacol. 1994 Oct;113(2):331-3.

25.

Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors.

Schambye HT, Hjorth SA, Bergsma DJ, Sathe G, Schwartz TW.

Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7046-50.

26.

Characterization of a functional angiotensin II receptor in Xenopus laevis heart.

Aiyar N, Baker E, Pullen M, Nuthulaganti P, Bergsma DJ, Kumar C, Nambi P.

Pharmacology. 1994 Apr;48(4):242-9.

PMID:
8177910
27.

Human AT1 receptor is a single copy gene: characterization in a stable cell line.

Aiyar N, Baker E, Wu HL, Nambi P, Edwards RM, Trill JJ, Ellis C, Bergsma DJ.

Mol Cell Biochem. 1994 Feb 9;131(1):75-86.

PMID:
8047068
28.

Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2.

Levy MA, Brandt M, Sheedy KM, Dinh JT, Holt DA, Garrison LM, Bergsma DJ, Metcalf BW.

J Steroid Biochem Mol Biol. 1994 Feb;48(2-3):197-206.

PMID:
8142295
29.

Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu.

Bossard MJ, Bergsma DJ, Brandt M, Livi GP, Eng WK, Johnson RK, Levy MA.

Biochem J. 1994 Jan 15;297 ( Pt 2):365-72.

30.

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM, Faucette L, Eng WK, Johnson RK, Livi GP.

Mol Cell Biol. 1993 Oct;13(10):6012-23.

31.

Isolation and expression of a novel angiotensin II receptor from Xenopus laevis heart.

Bergsma DJ, Ellis C, Nuthulaganti PR, Nambi P, Scaife K, Kumar C, Aiyar N.

Mol Pharmacol. 1993 Aug;44(2):277-84.

PMID:
8355665
32.

The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.

Koser PL, Eng WK, Bossard MJ, McLaughlin MM, Cafferkey R, Sathe GM, Faucette L, Levy MA, Johnson RK, Bergsma DJ, Livi GP.

Gene. 1993 Jul 30;129(2):159-65.

PMID:
8325502
33.

Molecular characterization and regulation of the human endothelin receptors.

Elshourbagy NA, Korman DR, Wu HL, Sylvester DR, Lee JA, Nuthalaganti P, Bergsma DJ, Kumar CS, Nambi P.

J Biol Chem. 1993 Feb 25;268(6):3873-9.

34.

Characterization of [3H]SK&F 108566 as a radioligand for angiotensin type-1 receptor.

Aiyar N, Griffin E, Shu A, Heys R, Bergsma DJ, Weinstock J, Edwards R.

J Recept Res. 1993;13(5):849-61.

PMID:
8463997
35.

Cloning and characterization of a human angiotensin II type 1 receptor.

Bergsma DJ, Ellis C, Kumar C, Nuthulaganti P, Kersten H, Elshourbagy N, Griffin E, Stadel JM, Aiyar N.

Biochem Biophys Res Commun. 1992 Mar 31;183(3):989-95.

PMID:
1567413
36.

The yeast cyclophilin multigene family: purification, cloning and characterization of a new isoform.

McLaughlin MM, Bossard MJ, Koser PL, Cafferkey R, Morris RA, Miles LM, Strickler J, Bergsma DJ, Levy MA, Livi GP.

Gene. 1992 Feb 1;111(1):85-92.

PMID:
1547957
37.

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

Bergsma DJ, Eder C, Gross M, Kersten H, Sylvester D, Appelbaum E, Cusimano D, Livi GP, McLaughlin MM, Kasyan K, et al.

J Biol Chem. 1991 Dec 5;266(34):23204-14.

38.

The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence.

Koser PL, Bergsma DJ, Cafferkey R, Eng WK, McLaughlin MM, Ferrara A, Silverman C, Kasyan K, Bossard MJ, Johnson RK, Porterd TG, Levy MA, Livi GP.

Gene. 1991 Dec 1;108(1):73-80.

PMID:
1761234
39.

Variants of the human high-affinity receptor (Fc gamma RI) for immunoglobulin G.

Chaikin MA, Sweet RW, Sylvester DR, Bergsma DJ.

Gene. 1991 Aug 15;104(2):285-6.

PMID:
1717350
40.

A single Trp121 to Ala121 mutation in human cyclophilin alters cyclosporin A affinity and peptidyl-prolyl isomerase activity.

Bossard MJ, Koser PL, Brandt M, Bergsma DJ, Levy MA.

Biochem Biophys Res Commun. 1991 May 15;176(3):1142-8.

PMID:
2039499
41.

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.

Koltin Y, Faucette L, Bergsma DJ, Levy MA, Cafferkey R, Koser PL, Johnson RK, Livi GP.

Mol Cell Biol. 1991 Mar;11(3):1718-23.

42.

Purification and characterization of human T-cell cyclophilin expressed in Escherichia coli.

Levy MA, Brandt M, Livi GP, Bergsma DJ.

Transplant Proc. 1991 Feb;23(1 Pt 1):319-22. No abstract available.

PMID:
1990542
43.

A Candida albicans homolog of a human cyclophilin gene encodes a peptidyl-prolyl cis-trans isomerase.

Koser PL, Livi GP, Levy MA, Rosenberg M, Bergsma DJ.

Gene. 1990 Dec 15;96(2):189-95.

PMID:
2269432
44.
45.

A second cyclophilin-related gene in Saccharomyces cerevisiae.

Koser PL, Sylvester D, Livi GP, Bergsma DJ.

Nucleic Acids Res. 1990 Mar 25;18(6):1643. No abstract available.

46.

A Chinese hamster ovary cyclophilin cDNA sequence.

Bergsma DJ, Sylvester D.

Nucleic Acids Res. 1990 Jan 11;18(1):200. No abstract available.

47.

Transient production and secretion of human transforming growth factor TGF-beta 2.

Caltabiano MM, Tsang ML, Weatherbee JA, Lucas R, Sathe G, Sutton J, Johnson GD, Bergsma DJ.

Gene. 1989 Dec 28;85(2):479-88.

PMID:
2628179

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