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Items: 24


A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions.

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ.

JCI Insight. 2017 Sep 7;2(17). pii: 95193. doi: 10.1172/jci.insight.95193. [Epub ahead of print]


Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.

Nguyen TB, Jayaraman P, Bergseng E, Madhusudhan MS, Kim CY, Sollid LM.

J Biol Chem. 2017 Jun 2;292(22):9218-9228. doi: 10.1074/jbc.M117.785139. Epub 2017 Mar 31.


Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes.

Dørum S, Steinsbø Ø, Bergseng E, Arntzen MØ, de Souza GA, Sollid LM.

Sci Rep. 2016 May 5;6:25565. doi: 10.1038/srep25565.


Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease.

Christophersen A, Risnes LF, Bergseng E, Lundin KE, Sollid LM, Qiao SW.

J Immunol. 2016 Mar 15;196(6):2819-26. doi: 10.4049/jimmunol.1501152. Epub 2016 Feb 19.


Small bowel, celiac disease and adaptive immunity.

Sollid LM, Iversen R, Steinsbø Ø, Qiao SW, Bergseng E, Dørum S, du Pré MF, Stamnaes J, Christophersen A, Cardoso I, Hnida K, Chen X, Snir O, Lundin KE.

Dig Dis. 2015;33(2):115-21. doi: 10.1159/000369512. Epub 2015 Apr 22. Review.


Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires.

Bergseng E, Dørum S, Arntzen MØ, Nielsen M, Nygård S, Buus S, de Souza GA, Sollid LM.

Immunogenetics. 2015 Feb;67(2):73-84. doi: 10.1007/s00251-014-0819-9. Epub 2014 Dec 12.


HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes.

Dørum S, Bodd M, Fallang LE, Bergseng E, Christophersen A, Johannesen MK, Qiao SW, Stamnaes J, de Souza GA, Sollid LM.

J Immunol. 2014 Nov 1;193(9):4497-506. doi: 10.4049/jimmunol.1301466. Epub 2014 Sep 26.


Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge.

Christophersen A, Ráki M, Bergseng E, Lundin KE, Jahnsen J, Sollid LM, Qiao SW.

United European Gastroenterol J. 2014 Aug;2(4):268-78. doi: 10.1177/2050640614540154. Erratum in: United European Gastroenterol J. 2014 Dec;2(6):550.


Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease.

Bodd M, Ráki M, Bergseng E, Jahnsen J, Lundin KE, Sollid LM.

Eur J Immunol. 2013 Oct;43(10):2605-12. doi: 10.1002/eji.201343382. Epub 2013 Jul 15.


Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells.

Bodd M, Tollefsen S, Bergseng E, Lundin KE, Sollid LM.

Hum Immunol. 2012 Apr;73(4):376-81. doi: 10.1016/j.humimm.2012.01.016. Epub 2012 Jan 31.


Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test.

Brottveit M, Ráki M, Bergseng E, Fallang LE, Simonsen B, Løvik A, Larsen S, Løberg EM, Jahnsen FL, Sollid LM, Lundin KE.

Am J Gastroenterol. 2011 Jul;106(7):1318-24. doi: 10.1038/ajg.2011.23. Epub 2011 Mar 1. Erratum in: Am J Gastroenterol. 2012 Apr;107(4):638.


HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22.

Bodd M, Ráki M, Tollefsen S, Fallang LE, Bergseng E, Lundin KE, Sollid LM.

Mucosal Immunol. 2010 Nov;3(6):594-601. doi: 10.1038/mi.2010.36. Epub 2010 Jun 23.


Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation.

Fallang LE, Bergseng E, Hotta K, Berg-Larsen A, Kim CY, Sollid LM.

Nat Immunol. 2009 Oct;10(10):1096-101. doi: 10.1038/ni.1780. Epub 2009 Aug 30.


Noninflammatory gluten peptide analogs as biomarkers for celiac sprue.

Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C.

Chem Biol. 2009 Aug 28;16(8):868-81. doi: 10.1016/j.chembiol.2009.07.009.


Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein.

Jüse U, Fleckenstein B, Bergseng E, Sollid LM.

Immunogenetics. 2009 Feb;61(2):81-9. doi: 10.1007/s00251-008-0338-7. Epub 2008 Nov 6.


Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM.

Fallang LE, Roh S, Holm A, Bergseng E, Yoon T, Fleckenstein B, Bandyopadhyay A, Mellins ED, Sollid LM.

J Immunol. 2008 Oct 15;181(8):5451-5461. Erratum in: J Immunol. 2009 Jan 1;182(1):726.


Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules.

Bergseng E, Sidney J, Sette A, Sollid LM.

Hum Immunol. 2008 Feb;69(2):94-100. doi: 10.1016/j.humimm.2008.01.002. Epub 2008 Feb 8.


Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.

Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM.

Bioorg Med Chem. 2007 Oct 15;15(20):6565-73. Epub 2007 Jul 25.


Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients.

Ráki M, Fallang LE, Brottveit M, Bergseng E, Quarsten H, Lundin KE, Sollid LM.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2831-6. Epub 2007 Feb 16.


Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin.

Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C.

J Am Chem Soc. 2006 Feb 15;128(6):1859-67.


Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.

Bergseng E, Xia J, Kim CY, Khosla C, Sollid LM.

J Biol Chem. 2005 Jun 10;280(23):21791-6. Epub 2005 Apr 12.


Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion.

Qiao SW, Bergseng E, Molberg Ø, Xia J, Fleckenstein B, Khosla C, Sollid LM.

J Immunol. 2004 Aug 1;173(3):1757-62.


Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.

Kim CY, Quarsten H, Bergseng E, Khosla C, Sollid LM.

Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4175-9. Epub 2004 Mar 12.

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