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Items: 1 to 50 of 115

1.

Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury.

Karhausen J, Choi HW, Maddipati KR, Mathew JP, Ma Q, Boulaftali Y, Lee RH, Bergmeier W, Abraham SN.

Sci Adv. 2020 Mar 18;6(12):eaay6314. doi: 10.1126/sciadv.aay6314. eCollection 2020 Mar.

2.

Glanzmann thrombasthenia: genetic basis and clinical correlates.

Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, Luo M, Mohan S, Ross JE, Bergmeier W, Di Paola J; ClinGen Platelet Disorder Variant Curation Expert Panel.

Haematologica. 2020 Apr;105(4):888-894. doi: 10.3324/haematol.2018.214239. Epub 2020 Mar 5. Review.

3.

Therapeutic strategies for thrombosis: new targets and approaches.

Mackman N, Bergmeier W, Stouffer GA, Weitz JI.

Nat Rev Drug Discov. 2020 Mar 4. doi: 10.1038/s41573-020-0061-0. [Epub ahead of print] Review.

PMID:
32132678
4.

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance.

Wang Y, Chen W, Zhang W, Lee-Sundlov MM, Casari C, Berndt MC, Lanza F, Bergmeier W, Hoffmeister KM, Zhang XF, Li R.

Haematologica. 2020 Jan 23. pii: haematol.2019.240440. doi: 10.3324/haematol.2019.240440. [Epub ahead of print]

5.

Impaired hemostatic activity of healthy transfused platelets in inherited and acquired platelet disorders: Mechanisms and implications.

Lee RH, Piatt R, Dhenge A, Lozano ML, Palma-Barqueros V, Rivera J, Bergmeier W.

Sci Transl Med. 2019 Dec 11;11(522). pii: eaay0203. doi: 10.1126/scitranslmed.aay0203.

PMID:
31826978
6.

Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis.

Holly SP, Gera N, Wang P, Wilson A, Guan Z, Lin L, Cooley B, Alfar HR, Patil RG, Piatt R, Leisner TM, Bergmeier W, Majumder R, Parise LV.

Blood Adv. 2019 Nov 26;3(22):3818-3828. doi: 10.1182/bloodadvances.2018030767.

7.

Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides.

Sarker M, Goliaei A, Golesi F, Poggi M, Cook AA, Khan MAI, Temple BR, Stefanini L, Canault M, Bergmeier W, Campbell SL.

J Thromb Haemost. 2020 Mar;18(3):693-705. doi: 10.1111/jth.14687. Epub 2019 Dec 30.

PMID:
31758832
8.

New insights into cytoskeletal remodeling during platelet production.

Ghalloussi D, Dhenge A, Bergmeier W.

J Thromb Haemost. 2019 Sep;17(9):1430-1439. doi: 10.1111/jth.14544. Epub 2019 Jul 16. Review.

PMID:
31220402
9.

Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection.

Misumi I, Cook KD, Mitchell JE, Lund MM, Vick SC, Lee RH, Uchimura T, Bergmeier W, Mieczkowski P, Pardo-Manuel de Villena F, Ting JPY, Whitmire JK.

Cell Rep. 2019 Apr 30;27(5):1387-1396.e5. doi: 10.1016/j.celrep.2019.04.004.

10.

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease.

Faes C, Ilich A, Sotiaux A, Sparkenbaugh EM, Henderson MW, Buczek L, Beckman JD, Ellsworth P, Noubouossie DF, Bhoopat L, Piegore M, Renoux C, Bergmeier W, Park Y, Ataga KI, Cooley B, Wolberg AS, Key NS, Pawlinski R.

Blood. 2019 Jun 6;133(23):2529-2541. doi: 10.1182/blood.2019000424. Epub 2019 Apr 5.

PMID:
30952675
11.

Small GTPases in megakaryocyte and platelet biology.

Stefanini L, Bergmeier W.

Platelets. 2019;30(1):7-8. doi: 10.1080/09537104.2018.1560938. Epub 2019 Jan 20.

PMID:
30663476
12.

RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.

Wu B, Zhang S, Guo Z, Wang G, Zhang G, Xie L, Lou J, Chen X, Wu D, Bergmeier W, Zheng J, Wan YY.

Immunity. 2018 Nov 20;49(5):886-898.e5. doi: 10.1016/j.immuni.2018.09.004. Epub 2018 Nov 13.

13.

Two novel, putative mechanisms of action for citalopram-induced platelet inhibition.

Roweth HG, Cook AA, Moroi M, Bonna AM, Jung SM, Bergmeier W, Sage SO, Jarvis GE.

Sci Rep. 2018 Nov 12;8(1):16677. doi: 10.1038/s41598-018-34389-5.

14.

STIM1 R304W causes muscle degeneration and impaired platelet activation in mice.

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E.

Cell Calcium. 2018 Dec;76:87-100. doi: 10.1016/j.ceca.2018.10.001. Epub 2018 Oct 5.

15.

Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation.

Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH.

Blood Adv. 2018 Sep 25;2(18):2358-2368. doi: 10.1182/bloodadvances.2018020487.

16.

Functional redundancy between RAP1 isoforms in murine platelet production and function.

Stefanini L, Lee RH, Paul DS, O'Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W.

Blood. 2018 Nov 1;132(18):1951-1962. doi: 10.1182/blood-2018-03-838714. Epub 2018 Aug 21.

17.

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.

Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H.

Res Pract Thromb Haemost. 2018 Apr 12;2(3):407-428. doi: 10.1002/rth2.12095. eCollection 2018 Jul. Review.

18.

Phenotype analysis and clinical management in a large family with a novel truncating mutation in RASGRP2, the CalDAG-GEFI encoding gene.

Desai A, Bergmeier W, Canault M, Alessi MC, Paul DS, Nurden P, Pillois X, Jy W, Ahn YS, Nurden AT.

Res Pract Thromb Haemost. 2017 Jun 20;1(1):128-133. doi: 10.1002/rth2.12019. eCollection 2017 Jul.

19.

Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation.

Akbar H, Duan X, Piatt R, Saleem S, Davis AK, Tandon NN, Bergmeier W, Zheng Y.

J Thromb Haemost. 2018 Oct;16(10):2083-2096. doi: 10.1111/jth.14240. Epub 2018 Aug 13.

20.

Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets.

Casari C, Paul DS, Susen S, Lavenu-Bombled C, Harroche A, Piatt R, Poe KO, Lee RH, Bryckaert M, Christophe OD, Lenting PJ, Denis CV, Bergmeier W.

Blood Adv. 2018 Jun 26;2(12):1417-1428. doi: 10.1182/bloodadvances.2017014290.

21.

RAP GTPases and platelet integrin signaling.

Stefanini L, Bergmeier W.

Platelets. 2019;30(1):41-47. doi: 10.1080/09537104.2018.1476681. Epub 2018 Jun 4. Review.

22.

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI.

Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W.

J Biol Chem. 2018 Jun 1;293(22):8521-8529. doi: 10.1074/jbc.RA118.002712. Epub 2018 Apr 5.

23.

Platelet Signaling Pathways and New Inhibitors.

Grover SP, Bergmeier W, Mackman N.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):e28-e35. doi: 10.1161/ATVBAHA.118.310224. Review. No abstract available.

24.

Platelets at the Vascular Interface.

Bergmeier W, Stefanini L.

Res Pract Thromb Haemost. 2018 Jan;2(1):27-33. doi: 10.1002/rth2.12061. Epub 2017 Dec 22.

25.

Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.

Plautz WE, Sekhar Pilli VS, Cooley BC, Chattopadhyay R, Westmark PR, Getz T, Paul D, Bergmeier W, Sheehan JP, Majumder R.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):816-828. doi: 10.1161/ATVBAHA.117.310588. Epub 2018 Feb 1.

26.

Negative regulators of platelet activation and adhesion.

Stefanini L, Bergmeier W.

J Thromb Haemost. 2018 Feb;16(2):220-230. doi: 10.1111/jth.13910. Epub 2017 Dec 26. Review.

27.

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.

Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W.

Blood Adv. 2017 Aug 8;1(18):1398-1408. doi: 10.1182/bloodadvances.2017006973.

28.

Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.

Sevivas T, Bastida JM, Paul DS, Caparros E, Palma-Barqueros V, Coucelo M, Marques D, Ferrer-Marín F, González-Porras JR, Vicente V, Hernández-Rivas JM, Watson SP, Lozano ML, Bergmeier W, Rivera J.

Platelets. 2018 Mar;29(2):192-195. doi: 10.1080/09537104.2017.1336214. Epub 2017 Aug 1.

29.

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).

Bermejo E, Alberto MF, Paul DS, Cook AA, Nurden P, Sanchez Luceros A, Nurden AT, Bergmeier W.

Platelets. 2018 Jan;29(1):84-86. doi: 10.1080/09537104.2017.1332759. Epub 2017 Jul 20.

30.

Sugar makes neutrophils RAGE: linking diabetes-associated hyperglycemia to thrombocytosis and platelet reactivity.

Lee RH, Bergmeier W.

J Clin Invest. 2017 Jun 1;127(6):2040-2043. doi: 10.1172/JCI94494. Epub 2017 May 15.

31.

Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis.

Lee RH, Piatt R, Conley PB, Bergmeier W.

Haematologica. 2017 Mar;102(3):e89-e92. doi: 10.3324/haematol.2016.155978. Epub 2016 Dec 15. No abstract available.

32.

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.

Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I.

J Biol Chem. 2017 Feb 3;292(5):1691-1704. doi: 10.1074/jbc.M116.746867. Epub 2016 Nov 30.

33.

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.

Deng W, Xu Y, Chen W, Paul DS, Syed AK, Dragovich MA, Liang X, Zakas P, Berndt MC, Di Paola J, Ware J, Lanza F, Doering CB, Bergmeier W, Zhang XF, Li R.

Nat Commun. 2016 Sep 27;7:12863. doi: 10.1038/ncomms12863.

34.

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.

Piatt R, Paul DS, Lee RH, McKenzie SE, Parise LV, Cowley DO, Cooley BC, Bergmeier W.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1838-46. doi: 10.1161/ATVBAHA.116.307874. Epub 2016 Jul 14.

35.

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.

Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, Ramón González-Porras J, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, Watson SP, Bergmeier W, Rivera J.

Blood. 2016 Sep 1;128(9):1282-9. doi: 10.1182/blood-2015-11-683102. Epub 2016 May 27.

36.

Acquired platelet disorders.

Casari C, Bergmeier W.

Thromb Res. 2016 May;141 Suppl 2:S73-5. doi: 10.1016/S0049-3848(16)30371-1. Review.

PMID:
27207431
37.

OC-04 - Tissue factor positive microvesicles activate platelets in vitro and in vivo and enhance thrombosis in mice.

Hisada Y, Geddings JE, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N.

Thromb Res. 2016 Apr;140 Suppl 1:S169-70. doi: 10.1016/S0049-3848(16)30121-9. Epub 2016 Apr 8.

PMID:
27161676
38.

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation.

Ren J, Cook AA, Bergmeier W, Sondek J.

Biochem Biophys Res Commun. 2016 May 20;474(1):193-198. doi: 10.1016/j.bbrc.2016.04.100. Epub 2016 Apr 21.

39.

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.

Boulaftali Y, Owens AP 3rd, Beale A, Piatt R, Casari C, Lee RH, Conley PB, Paul DS, Mackman N, Bergmeier W.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):792-9. doi: 10.1161/ATVBAHA.115.306347. Epub 2016 Mar 17.

40.

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.

Freeman SA, Goyette J, Furuya W, Woods EC, Bertozzi CR, Bergmeier W, Hinz B, van der Merwe PA, Das R, Grinstein S.

Cell. 2016 Jan 14;164(1-2):128-140. doi: 10.1016/j.cell.2015.11.048.

41.

Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development.

Lee RH, Bergmeier W.

J Thromb Haemost. 2016 Apr;14(4):645-54. doi: 10.1111/jth.13250. Epub 2016 Feb 16. Review.

42.

Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr.

Blood. 2016 Mar 17;127(11):1468-80. doi: 10.1182/blood-2015-08-663146. Epub 2016 Jan 7.

43.

Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.

Geddings JE, Hisada Y, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N.

J Thromb Haemost. 2016 Jan;14(1):153-66. doi: 10.1111/jth.13181. Epub 2015 Dec 11. Erratum in: J Thromb Haemost. 2016 Dec;14 (12 ):2566.

44.

RAP1-GTPase signaling and platelet function.

Stefanini L, Bergmeier W.

J Mol Med (Berl). 2016 Jan;94(1):13-9. doi: 10.1007/s00109-015-1346-3. Epub 2015 Oct 1. Review.

45.

Platelet signaling--blood's great balancing act.

Bergmeier W, Stefanini L.

Oncotarget. 2015 Aug 21;6(24):19922-3. No abstract available.

46.

Rap1 and its effector RIAM are required for lymphocyte trafficking.

Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR.

Blood. 2015 Dec 17;126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31.

47.

Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.

Owens AP 3rd, Edwards TL, Antoniak S, Geddings JE, Jahangir E, Wei WQ, Denny JC, Boulaftali Y, Bergmeier W, Daugherty A, Sampson UKA, Mackman N.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):2032-2041. doi: 10.1161/ATVBAHA.115.305537. Epub 2015 Jul 2. Erratum in: Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):e18.

48.

RASA3 is a critical inhibitor of RAP1-dependent platelet activation.

Stefanini L, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, Peters LL, Bergmeier W.

J Clin Invest. 2015 Apr;125(4):1419-32. doi: 10.1172/JCI77993. Epub 2015 Feb 23.

49.

Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.

Getz TM, Piatt R, Petrich BG, Monroe D, Mackman N, Bergmeier W.

J Thromb Haemost. 2015 Mar;13(3):417-25. doi: 10.1111/jth.12802. Epub 2015 Jan 9.

50.

CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes.

Amirkhosravi A, Boulaftali Y, Robles-Carrillo L, Meyer T, McKenzie SE, Francis JL, Bergmeier W.

J Thromb Haemost. 2014 Dec;12(12):2113-9. doi: 10.1111/jth.12748. Epub 2014 Oct 30.

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