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Items: 38

1.

Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of Fosmidomycin.

Sooriyaarachchi S, Chofor R, Risseeuw MD, Bergfors T, Pouyez J, Dowd CS, Maes L, Wouters J, Jones TA, Van Calenbergh S, Mowbray SL.

ChemMedChem. 2016 Sep 20;11(18):2024-36. doi: 10.1002/cmdc.201600249. Epub 2016 Aug 3.

PMID:
27487410
2.

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Chofor R, Sooriyaarachchi S, Risseeuw MD, Bergfors T, Pouyez J, Johny C, Haymond A, Everaert A, Dowd CS, Maes L, Coenye T, Alex A, Couch RD, Jones TA, Wouters J, Mowbray SL, Van Calenbergh S.

J Med Chem. 2015 Apr 9;58(7):2988-3001. doi: 10.1021/jm5014264. Epub 2015 Mar 31.

PMID:
25781377
3.

Microseed matrix screening for optimization in protein crystallization: what have we learned?

D'Arcy A, Bergfors T, Cowan-Jacob SW, Marsh M.

Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1117-26. doi: 10.1107/S2053230X14015507. Epub 2014 Aug 29.

4.

DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.

Jansson AM, Więckowska A, Björkelid C, Yahiaoui S, Sooriyaarachchi S, Lindh M, Bergfors T, Dharavath S, Desroses M, Suresh S, Andaloussi M, Nikhil R, Sreevalli S, Srinivasa BR, Larhed M, Jones TA, Karlén A, Mowbray SL.

J Med Chem. 2013 Aug 8;56(15):6190-9. doi: 10.1021/jm4006498. Epub 2013 Jul 17.

PMID:
23819803
5.

Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase.

Björkelid C, Bergfors T, Raichurkar AK, Mukherjee K, Malolanarasimhan K, Bandodkar B, Jones TA.

J Biol Chem. 2013 Jun 21;288(25):18260-70. doi: 10.1074/jbc.M113.476473. Epub 2013 May 9.

6.

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.

Fullam E, Pojer F, Bergfors T, Jones TA, Cole ST.

Open Biol. 2012 Jan;2(1):110026. doi: 10.1098/rsob.110026.

7.

Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098.

Björkelid C, Bergfors T, Unge T, Mowbray SL, Jones TA.

Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):134-43. doi: 10.1107/S0907444911052231. Epub 2012 Jan 6.

PMID:
22281742
8.

From screen to structure with a harvestable microfluidic device.

Stojanoff V, Jakoncic J, Oren DA, Nagarajan V, Poulsen JC, Adams-Cioaba MA, Bergfors T, Sommer MO.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):971-5. doi: 10.1107/S1744309111024456. Epub 2011 Jul 26.

9.

Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Andaloussi M, Henriksson LM, Więckowska A, Lindh M, Björkelid C, Larsson AM, Suresh S, Iyer H, Srinivasa BR, Bergfors T, Unge T, Mowbray SL, Larhed M, Jones TA, Karlén A.

J Med Chem. 2011 Jul 28;54(14):4964-76. doi: 10.1021/jm2000085. Epub 2011 Jul 1.

PMID:
21678907
10.

Structural and functional studies of mycobacterial IspD enzymes.

Björkelid C, Bergfors T, Henriksson LM, Stern AL, Unge T, Mowbray SL, Jones TA.

Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):403-14. doi: 10.1107/S0907444911006160. Epub 2011 Apr 8.

PMID:
21543842
11.

Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis.

Covarrubias AS, Högbom M, Bergfors T, Carroll P, Mannerstedt K, Oscarson S, Parish T, Jones TA, Mowbray SL.

J Mol Biol. 2008 Sep 5;381(3):622-33. doi: 10.1016/j.jmb.2008.05.086. Epub 2008 Jun 10.

PMID:
18621388
12.

X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation.

Ericsson DJ, Kasrayan A, Johansson P, Bergfors T, Sandström AG, Bäckvall JE, Mowbray SL.

J Mol Biol. 2008 Feb 8;376(1):109-19. Epub 2007 Nov 6.

PMID:
18155238
13.

Crystal structures of a family 19 chitinase from Brassica juncea show flexibility of binding cleft loops.

Ubhayasekera W, Tang CM, Ho SWT, Berglund G, Bergfors T, Chye ML, Mowbray SL.

FEBS J. 2007 Jul;274(14):3695-3703. doi: 10.1111/j.1742-4658.2007.05906.x. Epub 2007 Jul 2.

14.
15.

Structural mechanics of the pH-dependent activity of beta-carbonic anhydrase from Mycobacterium tuberculosis.

Covarrubias AS, Bergfors T, Jones TA, Högbom M.

J Biol Chem. 2006 Feb 24;281(8):4993-9. Epub 2005 Dec 1.

16.

Crystal structure of Thermobifida fusca endoglucanase Cel6A in complex with substrate and inhibitor: the role of tyrosine Y73 in substrate ring distortion.

Larsson AM, Bergfors T, Dultz E, Irwin DC, Roos A, Driguez H, Wilson DB, Jones TA.

Biochemistry. 2005 Oct 4;44(39):12915-22.

PMID:
16185060
17.

Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function.

Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL.

J Mol Biol. 2005 Sep 2;351(5):1048-56.

PMID:
16051262
18.

Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.

Suarez Covarrubias A, Larsson AM, Högbom M, Lindberg J, Bergfors T, Björkelid C, Mowbray SL, Unge T, Jones TA.

J Biol Chem. 2005 May 13;280(19):18782-9. Epub 2005 Mar 6.

19.

Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.

Roos AK, Andersson CE, Bergfors T, Jacobsson M, Karlén A, Unge T, Jones TA, Mowbray SL.

J Mol Biol. 2004 Jan 16;335(3):799-809.

PMID:
14687575
20.

The crystal structure of Echinococcus granulosus fatty-acid-binding protein 1.

Jakobsson E, Alvite G, Bergfors T, Esteves A, Kleywegt GJ.

Biochim Biophys Acta. 2003 Jun 26;1649(1):40-50.

PMID:
12818189
21.

Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site.

Arand M, Hallberg BM, Zou J, Bergfors T, Oesch F, van der Werf MJ, de Bont JA, Jones TA, Mowbray SL.

EMBO J. 2003 Jun 2;22(11):2583-92.

22.

Seeds to crystals.

Bergfors T.

J Struct Biol. 2003 Apr;142(1):66-76. Review.

PMID:
12718920
23.

Crystallization and preliminary X-ray analysis of a xyloglucan endotransglycosylase from Populus tremula x tremuloides.

Johansson P, Denman S, Brumer H, Kallas AM, Henriksson H, Bergfors T, Teeri TT, Jones TA.

Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):535-7. Epub 2003 Feb 21.

PMID:
12595718
24.

Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein.

van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA.

J Mol Biol. 2001 May 25;309(1):181-92.

PMID:
11491287
25.
26.

A new scaffold for binding haem in the cytochrome domain of the extracellular flavocytochrome cellobiose dehydrogenase.

Hallberg BM, Bergfors T, Bäckbro K, Pettersson G, Henriksson G, Divne C.

Structure. 2000 Jan 15;8(1):79-88.

27.

Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids.

Chaudhuri BN, Kleywegt GJ, Broutin-L'Hermite I, Bergfors T, Senn H, Le Motte P, Partouche O, Jones TA.

Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1850-7.

PMID:
10531482
28.

Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.

Kleywegt GJ, Bergfors T, Senn H, Le Motte P, Gsell B, Shudo K, Jones TA.

Structure. 1994 Dec 15;2(12):1241-58.

PMID:
7704533
29.

Crystallization and preliminary X-ray analysis of recombinant bovine cellular retinoic acid-binding protein.

Bergfors T, Kleywegt GJ, Jones TA.

Acta Crystallogr D Biol Crystallogr. 1994 Jul 1;50(Pt 4):370-4.

PMID:
15299387
30.

Crystallization and preliminary X-ray studies of lipase B from Candida antarctica.

Uppenberg J, Patkar S, Bergfors T, Jones TA.

J Mol Biol. 1994 Jan 14;235(2):790-2.

PMID:
8289302
31.

Structural basis of pilus subunit recognition by the PapD chaperone.

Kuehn MJ, Ogg DJ, Kihlberg J, Slonim LN, Flemmer K, Bergfors T, Hultgren SJ.

Science. 1993 Nov 19;262(5137):1234-41.

PMID:
7901913
32.

Three-dimensional structure of cellobiohydrolase II from Trichoderma reesei.

Rouvinen J, Bergfors T, Teeri T, Knowles JK, Jones TA.

Science. 1990 Jul 27;249(4967):380-6. Erratum in: Science 1990 Sep 21;249(4975):1359.

PMID:
2377893
33.

Crystallization of the core protein of cellobiohydrolase II from Trichoderma reesei.

Bergfors T, Rouvinen J, Lehtovaara P, Caldentey X, Tomme P, Claeyssens M, Pettersson G, Teeri T, Knowles J, Jones TA.

J Mol Biol. 1989 Sep 5;209(1):167-9.

PMID:
2810367
34.

Crystallization of GST2, a human class alpha glutathione transferase.

Cowan SW, Bergfors T, Jones TA, Tibbelin G, Olin B, Board PG, Mannervik B.

J Mol Biol. 1989 Jul 20;208(2):369-70.

PMID:
2769766
35.

The three-dimensional structure of P2 myelin protein.

Jones TA, Bergfors T, Sedzik J, Unge T.

EMBO J. 1988 Jun;7(6):1597-604.

36.

Bovine P2 myelin basic protein crystallizes in three different forms.

Sedzik J, Bergfors T, Jones TA, Weise M.

J Neurochem. 1988 Jun;50(6):1908-13.

PMID:
2453613
37.

Crystallization of P2 myelin protein.

Bergfors T, Sedzik J, Unge T, Fridborg K, Jones TA, Weise M.

J Mol Biol. 1987 Nov 20;198(2):357-8.

PMID:
2448481
38.

On the mechanical properties of the vitelline membrane of the frog egg.

Mild KH, Lovtrup S, Bergfors T.

J Exp Biol. 1974 Jun;60(3):807-20. No abstract available.

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