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Items: 1 to 50 of 258

1.

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion.

Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, Werner MT, Huang AC, Alexander KA, Wu JE, Attanasio J, Yan P, George SM, Bengsch B, Staupe RP, Donahue G, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Kaye J, Berger SL, Wherry EJ.

Nature. 2019 Jul;571(7764):211-218. doi: 10.1038/s41586-019-1325-x. Epub 2019 Jun 17.

PMID:
31207603
2.

p63 establishes epithelial enhancers at critical craniofacial development genes.

Lin-Shiao E, Lan Y, Welzenbach J, Alexander KA, Zhang Z, Knapp M, Mangold E, Sammons M, Ludwig KU, Berger SL.

Sci Adv. 2019 May 1;5(5):eaaw0946. doi: 10.1126/sciadv.aaw0946. eCollection 2019 May.

3.

Comparison of genotoxic versus nongenotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks.

Catizone AN, Good CR, Alexander KA, Berger SL, Sammons MA.

Cell Cycle. 2019 Apr;18(8):809-823. doi: 10.1080/15384101.2019.1593643. Epub 2019 Apr 9.

4.

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.

Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL.

Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14.

PMID:
30773298
5.

Histone modification signatures in human sperm distinguish clinical abnormalities.

Schon SB, Luense LJ, Wang X, Bartolomei MS, Coutifaris C, Garcia BA, Berger SL.

J Assist Reprod Genet. 2019 Feb;36(2):267-275. doi: 10.1007/s10815-018-1354-7. Epub 2018 Nov 5.

PMID:
30397898
6.

Antennal Olfactory Physiology and Behavior of Males of the Ponerine Ant Harpegnathos saltator.

Ghaninia M, Berger SL, Reinberg D, Zwiebel LJ, Ray A, Liebig J.

J Chem Ecol. 2018 Nov;44(11):999-1007. doi: 10.1007/s10886-018-1013-6. Epub 2018 Sep 7.

PMID:
30191433
7.

Regulation of chromatin and gene expression by metabolic enzymes and metabolites.

Li X, Egervari G, Wang Y, Berger SL, Lu Z.

Nat Rev Mol Cell Biol. 2018 Sep;19(9):563-578. doi: 10.1038/s41580-018-0029-7. Review.

PMID:
29930302
8.

Epigenetic Regulation in Neurodegenerative Diseases.

Berson A, Nativio R, Berger SL, Bonini NM.

Trends Neurosci. 2018 Sep;41(9):587-598. doi: 10.1016/j.tins.2018.05.005. Epub 2018 Jun 7. Review.

PMID:
29885742
9.

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.

Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH, Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL, Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, Bushman FD, June CH, Melenhorst JJ.

Nature. 2018 Jun;558(7709):307-312. doi: 10.1038/s41586-018-0178-z. Epub 2018 May 30.

10.

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling.

Lee JV, Berry CT, Kim K, Sen P, Kim T, Carrer A, Trefely S, Zhao S, Fernandez S, Barney LE, Schwartz AD, Peyton SR, Snyder NW, Berger SL, Freedman BD, Wellen KE.

Genes Dev. 2018 Apr 1;32(7-8):497-511. doi: 10.1101/gad.311027.117. Epub 2018 Apr 19.

11.

Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse.

Dou Z, Berger SL.

Cell Metab. 2018 Apr 3;27(4):710-711. doi: 10.1016/j.cmet.2018.03.009.

12.

Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL.

Nat Neurosci. 2018 Jul;21(7):1018. doi: 10.1038/s41593-018-0124-2.

PMID:
29556027
13.

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL.

Nat Neurosci. 2018 Apr;21(4):497-505. doi: 10.1038/s41593-018-0101-9. Epub 2018 Mar 5. Erratum in: Nat Neurosci. 2018 Mar 19;:.

14.

KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis.

Lin-Shiao E, Lan Y, Coradin M, Anderson A, Donahue G, Simpson CL, Sen P, Saffie R, Busino L, Garcia BA, Berger SL, Capell BC.

Genes Dev. 2018 Jan 15;32(2):181-193. doi: 10.1101/gad.306241.117. Epub 2018 Feb 12.

15.

Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment.

Berger SL, Leo-Macias A, Yuen S, Khatri L, Pfennig S, Zhang Y, Agullo-Pascual E, Caillol G, Zhu MS, Rothenberg E, Melendez-Vasquez CV, Delmar M, Leterrier C, Salzer JL.

Neuron. 2018 Feb 7;97(3):555-570.e6. doi: 10.1016/j.neuron.2017.12.039. Epub 2018 Jan 25.

16.

TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.

Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM.

Curr Biol. 2017 Dec 4;27(23):3579-3590.e6. doi: 10.1016/j.cub.2017.10.024. Epub 2017 Nov 16.

17.

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH.

Hepatology. 2018 Aug;68(2):663-676. doi: 10.1002/hep.29626. Epub 2018 May 14.

PMID:
29091290
18.

Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M.

Genes Dev. 2017 Sep 15;31(18):1926. doi: 10.1101/gad.307207.117. No abstract available.

19.

Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.

Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.

20.

eRNA binding produces tailored CBP activity profiles to regulate gene expression.

Bose DA, Berger SL.

RNA Biol. 2017 Dec 2;14(12):1655-1659. doi: 10.1080/15476286.2017.1353862. Epub 2017 Sep 26. Review.

21.

Specialized odorant receptors in social insects that detect cuticular hydrocarbon cues and candidate pheromones.

Pask GM, Slone JD, Millar JG, Das P, Moreira JA, Zhou X, Bello J, Berger SL, Bonasio R, Desplan C, Reinberg D, Liebig J, Zwiebel LJ, Ray A.

Nat Commun. 2017 Aug 17;8(1):297. doi: 10.1038/s41467-017-00099-1.

22.

The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants.

Gospocic J, Shields EJ, Glastad KM, Lin Y, Penick CA, Yan H, Mikheyev AS, Linksvayer TA, Garcia BA, Berger SL, Liebig J, Reinberg D, Bonasio R.

Cell. 2017 Aug 10;170(4):748-759.e12. doi: 10.1016/j.cell.2017.07.014.

23.

An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants.

Yan H, Opachaloemphan C, Mancini G, Yang H, Gallitto M, Mlejnek J, Leibholz A, Haight K, Ghaninia M, Huo L, Perry M, Slone J, Zhou X, Traficante M, Penick CA, Dolezal K, Gokhale K, Stevens K, Fetter-Pruneda I, Bonasio R, Zwiebel LJ, Berger SL, Liebig J, Reinberg D, Desplan C.

Cell. 2017 Aug 10;170(4):736-747.e9. doi: 10.1016/j.cell.2017.06.051.

24.

The interplay between epigenetic changes and the p53 protein in stem cells.

Levine AJ, Berger SL.

Genes Dev. 2017 Jun 15;31(12):1195-1201. doi: 10.1101/gad.298984.117. Review.

25.

Functional characterization of odorant receptors in the ponerine ant, Harpegnathos saltator.

Slone JD, Pask GM, Ferguson ST, Millar JG, Berger SL, Reinberg D, Liebig J, Ray A, Zwiebel LJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8586-8591. doi: 10.1073/pnas.1704647114. Epub 2017 Jul 10.

26.

Chemosensory sensitivity reflects reproductive status in the ant Harpegnathos saltator.

Ghaninia M, Haight K, Berger SL, Reinberg D, Zwiebel LJ, Ray A, Liebig J.

Sci Rep. 2017 Jun 16;7(1):3732. doi: 10.1038/s41598-017-03964-7.

27.

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory.

Mews P, Donahue G, Drake AM, Luczak V, Abel T, Berger SL.

Nature. 2017 Jun 15;546(7658):381-386. doi: 10.1038/nature22405. Epub 2017 May 31.

28.

RNA Binding to CBP Stimulates Histone Acetylation and Transcription.

Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL.

Cell. 2017 Jan 12;168(1-2):135-149.e22. doi: 10.1016/j.cell.2016.12.020. Epub 2017 Jan 12.

29.

The Sustained Impact of Model Organisms-in Genetics and Epigenetics.

Bonini NM, Berger SL.

Genetics. 2017 Jan;205(1):1-4. doi: 10.1534/genetics.116.187864. No abstract available.

30.

Metabolic Signaling to Chromatin.

Berger SL, Sassone-Corsi P.

Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11). pii: a019463. doi: 10.1101/cshperspect.a019463. Review.

31.

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.

Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen DR, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ.

Science. 2016 Dec 2;354(6316):1160-1165. Epub 2016 Oct 27.

32.

Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence.

Crowe EP, Tuzer F, Gregory BD, Donahue G, Gosai SJ, Cohen J, Leung YY, Yetkin E, Nativio R, Wang LS, Sell C, Bonini NM, Berger SL, Johnson FB, Torres C.

Front Aging Neurosci. 2016 Aug 31;8:208. doi: 10.3389/fnagi.2016.00208. eCollection 2016.

33.

Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.

Hur SK, Freschi A, Ideraabdullah F, Thorvaldsen JL, Luense LJ, Weller AH, Berger SL, Cerrato F, Riccio A, Bartolomei MS.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10938-43. doi: 10.1073/pnas.1603066113. Epub 2016 Sep 12.

34.

Lysine methylation represses p53 activity in teratocarcinoma cancer cells.

Zhu J, Dou Z, Sammons MA, Levine AJ, Berger SL.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9822-7. doi: 10.1073/pnas.1610387113. Epub 2016 Aug 17.

35.

Epigenetic Mechanisms of Longevity and Aging.

Sen P, Shah PP, Nativio R, Berger SL.

Cell. 2016 Aug 11;166(4):822-839. doi: 10.1016/j.cell.2016.07.050. Review.

36.

Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.

Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD.

Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x.

37.

Exploring the Dynamic Relationship Between Cellular Metabolism and Chromatin Structure Using SILAC-Mass Spec and ChIP-Sequencing.

Mews P, Berger SL.

Methods Enzymol. 2016;574:311-329. doi: 10.1016/bs.mie.2016.04.002. Epub 2016 May 31.

PMID:
27423866
38.

A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction.

Monteith JA, Mellert H, Sammons MA, Kuswanto LA, Sykes SM, Resnick-Silverman L, Manfredi JJ, Berger SL, McMahon SB.

Mol Oncol. 2016 Oct;10(8):1207-20. doi: 10.1016/j.molonc.2016.05.007. Epub 2016 Jun 7.

39.

A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription.

Sammons MA, Zhu J, Berger SL.

G3 (Bethesda). 2016 Aug 9;6(8):2671-8. doi: 10.1534/g3.116.031534.

40.

Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells.

Luense LJ, Wang X, Schon SB, Weller AH, Lin Shiao E, Bryant JM, Bartolomei MS, Coutifaris C, Garcia BA, Berger SL.

Epigenetics Chromatin. 2016 Jun 21;9:24. doi: 10.1186/s13072-016-0072-6. eCollection 2016.

41.

MLL1 is essential for the senescence-associated secretory phenotype.

Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL.

Genes Dev. 2016 Feb 1;30(3):321-36. doi: 10.1101/gad.271882.115.

42.

Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus.

Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, Berger SL.

Science. 2016 Jan 1;351(6268):aac6633. doi: 10.1126/science.aac6633.

43.

Mammalian autophagy degrades nuclear constituents in response to tumorigenic stress.

Dou Z, Ivanov A, Adams PD, Berger SL.

Autophagy. 2016 Aug 2;12(8):1416-7. doi: 10.1080/15548627.2015.1127465. Epub 2015 Dec 10.

44.

H4K44 Acetylation Facilitates Chromatin Accessibility during Meiosis.

Hu J, Donahue G, Dorsey J, Govin J, Yuan Z, Garcia BA, Shah PP, Berger SL.

Cell Rep. 2015 Dec 1;13(9):1772-80. doi: 10.1016/j.celrep.2015.10.070. Epub 2015 Nov 25.

45.

Autophagy mediates degradation of nuclear lamina.

Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL.

Nature. 2015 Nov 5;527(7576):105-9. doi: 10.1038/nature15548. Epub 2015 Oct 28.

46.

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.

Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL.

Nature. 2015 Sep 10;525(7568):206-11. doi: 10.1038/nature15251. Epub 2015 Sep 2.

47.

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest.

Dikovskaya D, Cole JJ, Mason SM, Nixon C, Karim SA, McGarry L, Clark W, Hewitt RN, Sammons MA, Zhu J, Athineos D, Leach JD, Marchesi F, van Tuyn J, Tait SW, Brock C, Morton JP, Wu H, Berger SL, Blyth K, Adams PD.

Cell Rep. 2015 Sep 1;12(9):1483-96. doi: 10.1016/j.celrep.2015.07.055. Epub 2015 Aug 20.

48.

Cuticular Hydrocarbon Pheromones for Social Behavior and Their Coding in the Ant Antenna.

Sharma KR, Enzmann BL, Schmidt Y, Moore D, Jones GR, Parker J, Berger SL, Reinberg D, Zwiebel LJ, Breit B, Liebig J, Ray A.

Cell Rep. 2015 Aug 25;12(8):1261-71. doi: 10.1016/j.celrep.2015.07.031. Epub 2015 Aug 13.

49.

Chemoreceptor Evolution in Hymenoptera and Its Implications for the Evolution of Eusociality.

Zhou X, Rokas A, Berger SL, Liebig J, Ray A, Zwiebel LJ.

Genome Biol Evol. 2015 Aug 12;7(8):2407-16. doi: 10.1093/gbe/evv149.

50.

CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.

McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, Ridky TW.

Cancer Discov. 2015 Oct;5(10):1072-85. doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16.

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