Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 223


Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity.

Mohammed HHH, Abdelhafez EMN, Abbas SH, Moustafa GAI, Hauk G, Berger JM, Mitarai S, Arai M, Abd El-Baky RM, Abuo-Rahma GEA.

Bioorg Chem. 2019 Apr 25;88:102952. doi: 10.1016/j.bioorg.2019.102952. [Epub ahead of print]


Caught in the Open: A Domain Insertion of M. tuberculosis Gyrase Suppresses ATPase Dimerization.

Hobson MJ, Berger JM.

Structure. 2019 Apr 2;27(4):561-563. doi: 10.1016/j.str.2019.03.010.


Physical Basis for the Loading of a Bacterial Replicative Helicase onto DNA.

Arias-Palomo E, Puri N, O'Shea Murray VL, Yan Q, Berger JM.

Mol Cell. 2019 Apr 4;74(1):173-184.e4. doi: 10.1016/j.molcel.2019.01.023. Epub 2019 Feb 20.


Tuning the sequence specificity of a transcription terminator.

Lawson MR, Berger JM.

Curr Genet. 2019 Jun;65(3):729-733. doi: 10.1007/s00294-019-00939-1. Epub 2019 Feb 9. Review.


Bone Mineral Density Adult Age Estimation in Forensic Anthropology: A Test of the DXAGE Application.

Bethard JD, Berger JM, Maiers J, Ross AH.

J Forensic Sci. 2018 Dec 14. doi: 10.1111/1556-4029.13987. [Epub ahead of print]


Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein.

Lawson MR, Ma W, Bellecourt MJ, Artsimovitch I, Martin A, Landick R, Schulten K, Berger JM.

Mol Cell. 2018 Sep 20;71(6):911-922.e4. doi: 10.1016/j.molcel.2018.07.014. Epub 2018 Aug 16.


Conformational control and DNA-binding mechanism of the metazoan origin recognition complex.

Bleichert F, Leitner A, Aebersold R, Botchan MR, Berger JM.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5906-E5915. doi: 10.1073/pnas.1806315115. Epub 2018 Jun 13.


Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons.

Gibson EG, Blower TR, Cacho M, Bax B, Berger JM, Osheroff N.

ACS Infect Dis. 2018 Aug 10;4(8):1211-1222. doi: 10.1021/acsinfecdis.8b00035. Epub 2018 May 17.


Dynamic coupling between conformations and nucleotide states in DNA gyrase.

Basu A, Hobson M, Lebel P, Fernandes LE, Tretter EM, Berger JM, Bryant Z.

Nat Chem Biol. 2018 Jun;14(6):565-574. doi: 10.1038/s41589-018-0037-0. Epub 2018 Apr 16.


The utility of abnormal initial arterial blood gas values in determining clinical futility of trauma cases with severe hemorrhage.

Katirai A, Landau MJ, Berger JM.

Am J Emerg Med. 2018 Jul;36(7):1253-1256. doi: 10.1016/j.ajem.2018.03.063. Epub 2018 Mar 23.


Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage.

Wendorff TJ, Berger JM.

Elife. 2018 Mar 29;7. pii: e31724. doi: 10.7554/eLife.31724.


Analysis of Class Characteristics of Reciprocating Saws.

Berger JM, Pokines JT, Moore TL.

J Forensic Sci. 2018 Nov;63(6):1661-1672. doi: 10.1111/1556-4029.13759. Epub 2018 Feb 21.


Corrigendum to "Osteocalcin is necessary and sufficient to maintain muscle mass in older mice" [Mol Metabol 5 (2017) 1042-1047].

Mera P, Laue K, Wei J, Berger JM, Karsenty G.

Mol Metab. 2017 Aug;6(8):941. doi: 10.1016/j.molmet.2017.06.006. Epub 2017 Jun 22. No abstract available.


Resveratrol: A novel type of topoisomerase II inhibitor.

Lee JH, Wendorff TJ, Berger JM.

J Biol Chem. 2017 Dec 22;292(51):21011-21022. doi: 10.1074/jbc.M117.810580. Epub 2017 Oct 26.


Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.

Ashley RE, Blower TR, Berger JM, Osheroff N.

Biochemistry. 2017 Oct 10;56(40):5440-5448. doi: 10.1021/acs.biochem.7b00681. Epub 2017 Sep 25.


Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice.

Berger JM, Loza Valdes A, Gromada J, Anderson N, Horton JD.

J Lipid Res. 2017 Aug;58(8):1661-1669. doi: 10.1194/jlr.M076844. Epub 2017 Jun 9.


Mechanisms for initiating cellular DNA replication.

Bleichert F, Botchan MR, Berger JM.

Science. 2017 Feb 24;355(6327). pii: eaah6317. doi: 10.1126/science.aah6317. Epub 2017 Feb 16. Review.


Interdomain Communication of the Chd1 Chromatin Remodeler across the DNA Gyres of the Nucleosome.

Nodelman IM, Bleichert F, Patel A, Ren R, Horvath KC, Berger JM, Bowman GD.

Mol Cell. 2017 Feb 2;65(3):447-459.e6. doi: 10.1016/j.molcel.2016.12.011. Epub 2017 Jan 19.


Mechanisms and regulation of DNA replication initiation in eukaryotes.

Parker MW, Botchan MR, Berger JM.

Crit Rev Biochem Mol Biol. 2017 Apr;52(2):107-144. doi: 10.1080/10409238.2016.1274717. Epub 2017 Jan 17. Review.


Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor.

Thomsen ND, Lawson MR, Witkowsky LB, Qu S, Berger JM.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7691-E7700. Epub 2016 Nov 16.


Ligand-induced and small-molecule control of substrate loading in a hexameric helicase.

Lawson MR, Dyer K, Berger JM.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13714-13719. Epub 2016 Nov 7.


Osteocalcin is necessary and sufficient to maintain muscle mass in older mice.

Mera P, Laue K, Wei J, Berger JM, Karsenty G.

Mol Metab. 2016 Jul 16;5(10):1042-1047. doi: 10.1016/j.molmet.2016.07.002. eCollection 2016 Oct. Erratum in: Mol Metab. 2017 Aug;6(8):941.


Challenges of pain control and the role of the ambulatory pain specialist in the outpatient surgery setting.

Vadivelu N, Kai AM, Kodumudi V, Berger JM.

J Pain Res. 2016 Jun 17;9:425-35. doi: 10.2147/JPR.S86579. eCollection 2016. Review.


The Clinical Applications of Extended-Release Abuse-Deterrent Opioids.

Vadivelu N, Schermer E, Kodumudi G, Berger JM.

CNS Drugs. 2016 Jul;30(7):637-46. doi: 10.1007/s40263-016-0357-0. Review.


IOTA: integration optimization, triage and analysis tool for the processing of XFEL diffraction images.

Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Murray TD, Sauter NK, Berger JM, Weis WI, Brunger AT.

J Appl Crystallogr. 2016 May 11;49(Pt 3):1057-1064. eCollection 2016 Jun 1.


Mechanisms and Functional Diversity of Macromolecular Remodeling by ATP-Dependent Motors.

Martin A, Berger JM, Sellers JR, Ostankovitch M.

J Mol Biol. 2016 May 8;428(9 Pt B):1819-21. doi: 10.1016/j.jmb.2016.04.008. No abstract available.


Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells.

Leventhal DS, Gilmore DC, Berger JM, Nishi S, Lee V, Malchow S, Kline DE, Kline J, Vander Griend DJ, Huang H, Socci ND, Savage PA.

Immunity. 2016 Apr 19;44(4):847-59. doi: 10.1016/j.immuni.2016.01.025. Epub 2016 Mar 29.


The role of ATP-dependent machines in regulating genome topology.

Hauk G, Berger JM.

Curr Opin Struct Biol. 2016 Feb;36:85-96. doi: 10.1016/ Epub 2016 Jan 29. Review.


Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.

Blower TR, Williamson BH, Kerns RJ, Berger JM.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1706-13. doi: 10.1073/pnas.1525047113. Epub 2016 Jan 20.


Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.

Aldred KJ, Blower TR, Kerns RJ, Berger JM, Osheroff N.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E839-46. doi: 10.1073/pnas.1525055113. Epub 2016 Jan 20.


A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions.

Murray TD, Lyubimov AY, Ogata CM, Vo H, Uervirojnangkoorn M, Brunger AT, Berger JM.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):1987-97. doi: 10.1107/S1399004715015011. Epub 2015 Sep 26.


Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.

Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE.

Mol Cell. 2015 Sep 17;59(6):891-903. doi: 10.1016/j.molcel.2015.07.022. Epub 2015 Aug 20.


An Atypical AAA+ ATPase Assembly Controls Efficient Transposition through DNA Remodeling and Transposase Recruitment.

Arias-Palomo E, Berger JM.

Cell. 2015 Aug 13;162(4):860-71. doi: 10.1016/j.cell.2015.07.037.


Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array.

Lyubimov AY, Murray TD, Koehl A, Araci IE, Uervirojnangkoorn M, Zeldin OB, Cohen AE, Soltis SM, Baxter EL, Brewster AS, Sauter NK, Brunger AT, Berger JM.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):928-40. doi: 10.1107/S1399004715002308. Epub 2015 Mar 27.


Crystal structure of the eukaryotic origin recognition complex.

Bleichert F, Botchan MR, Berger JM.

Nature. 2015 Mar 19;519(7543):321-6. doi: 10.1038/nature14239. Epub 2015 Mar 11.


PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension.

Berger JM, Vaillant N, Le May C, Calderon C, Brégeon J, Prieur X, Hadchouel J, Loirand G, Cariou B.

Atherosclerosis. 2015 Mar;239(1):252-9. doi: 10.1016/j.atherosclerosis.2015.01.012. Epub 2015 Jan 19.


Tapentadol extended release in the management of peripheral diabetic neuropathic pain.

Vadivelu N, Kai A, Maslin B, Kodumudi G, Legler A, Berger JM.

Ther Clin Risk Manag. 2015 Jan 14;11:95-105. doi: 10.2147/TCRM.S32193. eCollection 2015. Review.


Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.

Petojevic T, Pesavento JJ, Costa A, Liang J, Wang Z, Berger JM, Botchan MR.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):E249-58. doi: 10.1073/pnas.1422003112. Epub 2015 Jan 5.


Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.

Drlica K, Mustaev A, Towle TR, Luan G, Kerns RJ, Berger JM.

ACS Chem Biol. 2014 Dec 19;9(12):2895-904. doi: 10.1021/cb500629k. Epub 2014 Nov 4.


Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.

Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.

Cell. 2014 Aug 28;158(5):1011-1021. doi: 10.1016/j.cell.2014.07.028. Epub 2014 Aug 14.


DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

Costa A, Renault L, Swuec P, Petojevic T, Pesavento JJ, Ilves I, MacLellan-Gibson K, Fleck RA, Botchan MR, Berger JM.

Elife. 2014 Aug 12;3:e03273. doi: 10.7554/eLife.03273.


Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics.

Malik M, Li L, Zhao X, Kerns RJ, Berger JM, Drlica K.

J Antimicrob Chemother. 2014 Dec;69(12):3227-35. doi: 10.1093/jac/dku285. Epub 2014 Jul 31.


Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein.

Vos SM, Lyubimov AY, Hershey DM, Schoeffler AJ, Sengupta S, Nagaraja V, Berger JM.

Genes Dev. 2014 Jul 1;28(13):1485-97. doi: 10.1101/gad.241984.114.


Loading strategies of ring-shaped nucleic acid translocases and helicases.

O'Shea VL, Berger JM.

Curr Opin Struct Biol. 2014 Apr;25:16-24. doi: 10.1016/ Epub 2013 Dec 18. Review.


Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K.

J Biol Chem. 2014 May 2;289(18):12300-12. doi: 10.1074/jbc.M113.529164. Epub 2014 Feb 4.


The use of δ13C isotope ratio mass spectrometry for methamphetamine profiling: comparison of ephedrine and pseudoephedrine-based samples to P2P-based samples.

Toske SG, Morello DR, Berger JM, Vazquez ER.

Forensic Sci Int. 2014 Jan;234:1-6. doi: 10.1016/j.forsciint.2013.10.022. Epub 2013 Oct 31.


Nucleotide and partner-protein control of bacterial replicative helicase structure and function.

Strycharska MS, Arias-Palomo E, Lyubimov AY, Erzberger JP, O'Shea VL, Bustamante CJ, Berger JM.

Mol Cell. 2013 Dec 26;52(6):844-54. doi: 10.1016/j.molcel.2013.11.016.


Autism as the Early Closure of a Neuroplastic Critical Period Normally Seen in Adolescence.

Berger JM, Rohn TT, Oxford JT.

Biol Syst Open Access. 2013 Aug 20;1. doi: 10.4172/2329-6577.1000118.


A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.

Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM.

Elife. 2013 Oct 8;2:e00882. doi: 10.7554/eLife.00882.

Supplemental Content

Loading ...
Support Center