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Items: 1 to 50 of 135

1.

Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish.

Lelieveld LT, Mirzaian M, Kuo CL, Artola M, Ferraz MJ, Peter REA, Akiyama H, Greimel P, van den Berg RJBHN, Overkleeft HS, Boot RG, Meijer AH, Aerts JMFG.

J Lipid Res. 2019 Nov;60(11):1851-1867. doi: 10.1194/jlr.RA119000154. Epub 2019 Sep 27.

PMID:
31562193
2.

A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals.

Rugen MD, Vernet MMJL, Hantouti L, Soenens A, Andriotis VME, Rejzek M, Brett P, van den Berg RJBHN, Aerts JMFG, Overkleeft HS, Field RA.

Sci Rep. 2018 Nov 6;8(1):16421. doi: 10.1038/s41598-018-34749-1.

3.

Two-step activity-based protein profiling of diacylglycerol lipase.

van Rooden EJ, Kreekel R, Hansen T, Janssen APA, van Esbroeck ACM, den Dulk H, van den Berg RJBHN, Codée JDC, van der Stelt M.

Org Biomol Chem. 2018 Jul 25;16(29):5250-5253. doi: 10.1039/c8ob01499j.

PMID:
30004552
4.

Development of a Cannabinoid-Based Photoaffinity Probe to Determine the Δ8/9-Tetrahydrocannabinol Protein Interaction Landscape in Neuroblastoma Cells.

Soethoudt M, Alachouzos G, van Rooden EJ, Moya-Garzón MD, van den Berg RJBHN, Heitman LH, van der Stelt M.

Cannabis Cannabinoid Res. 2018 Jul 1;3(1):136-151. doi: 10.1089/can.2018.0003. eCollection 2018.

5.

Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and α,β-Hydrolase Domain Containing Protein 6.

van Rooden EJ, Kohsiek M, Kreekel R, van Esbroeck ACM, van den Nieuwendijk AMCH, Janssen APA, van den Berg RJBHN, Overkleeft HS, van der Stelt M.

Chem Asian J. 2018 Nov 16;13(22):3491-3500. doi: 10.1002/asia.201800452. Epub 2018 Jun 14.

PMID:
29901868
6.

Endobronchial metastasis of mixed Mullerian tumour of the uterus.

Baskaran V, Pugh L, Berg RJ, Anderson J.

BMJ Case Rep. 2017 Dec 28;2017. pii: bcr-2017-222219. doi: 10.1136/bcr-2017-222219.

7.

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29.

8.

The Relationship between Age, Common Bile Duct Diameter and Diagnostic Probability in Suspected Choledocholithiasis.

Karamanos E, Inaba K, Berg RJ, Resnick S, Okoye O, Alexopoulos S, Chouliaras K, Demetriades D.

Dig Surg. 2017;34(5):421-428. doi: 10.1159/000455272. Epub 2017 Jul 1.

PMID:
28668951
9.

Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors.

Deng H, van der Wel T, van den Berg RJBHN, van den Nieuwendijk AMCH, Janssen FJ, Baggelaar MP, Overkleeft HS, van der Stelt M.

Medchemcomm. 2017 Mar 10;8(5):982-988. doi: 10.1039/c7md00029d. eCollection 2017 May 1.

10.

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.

Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, Baggelaar MP, Janssen FJ, van den Berg RJ, den Dulk H, Cravatt BF, Overkleeft HS, Rensen PC, van der Stelt M.

J Med Chem. 2017 Jan 12;60(1):428-440. doi: 10.1021/acs.jmedchem.6b01482. Epub 2016 Dec 19.

PMID:
27992221
11.

Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors.

van den Berg RJ, van Rijssel ER, Ferraz MJ, Houben J, Strijland A, Donker-Koopman WE, Wennekes T, Bonger KM, Ghisaidoobe AB, Hoogendoorn S, van der Marel GA, Codée JD, Overkleeft HS, Aerts JM.

ChemMedChem. 2015 Dec;10(12):2042-62. doi: 10.1002/cmdc.201500407. Epub 2015 Oct 23.

PMID:
26492941
12.

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy.

Wisse P, de Geus MA, Cross G, van den Nieuwendijk AM, van Rooden EJ, van den Berg RJ, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS.

J Org Chem. 2015 Jul 17;80(14):7258-65. doi: 10.1021/acs.joc.5b00823. Epub 2015 Jun 25.

PMID:
26061009
13.

The peril of thoracoabdominal firearm trauma: 984 civilian injuries reviewed.

Berg RJ, Inaba K, Okoye O, Karamanos E, Strumwasser A, Chouliaras K, Teixeira PG, Demetriades D.

J Trauma Acute Care Surg. 2014 Nov;77(5):684-691.

PMID:
25494418
14.

The impact of heat stress on operative performance and cognitive function during simulated laparoscopic operative tasks.

Berg RJ, Inaba K, Sullivan M, Okoye O, Siboni S, Minneti M, Teixeira PG, Demetriades D.

Surgery. 2015 Jan;157(1):87-95. doi: 10.1016/j.surg.2014.06.012.

PMID:
25482467
15.

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.

Ghisaidoobe AT, van den Berg RJ, Butt SS, Strijland A, Donker-Koopman WE, Scheij S, van den Nieuwendijk AM, Koomen GJ, van Loevezijn A, Leemhuis M, Wennekes T, van der Stelt M, van der Marel GA, van Boeckel CA, Aerts JM, Overkleeft HS.

J Med Chem. 2014 Nov 13;57(21):9096-104. doi: 10.1021/jm501181z. Epub 2014 Oct 17.

PMID:
25250725
16.

The contemporary management of penetrating splenic injury.

Berg RJ, Inaba K, Okoye O, Pasley J, Teixeira PG, Esparza M, Demetriades D.

Injury. 2014 Sep;45(9):1394-400. doi: 10.1016/j.injury.2014.04.025. Epub 2014 Apr 18. Review.

PMID:
24880885
17.

The persistent diagnostic challenge of thoracoabdominal stab wounds.

Berg RJ, Karamanos E, Inaba K, Okoye O, Teixeira PG, Demetriades D.

J Trauma Acute Care Surg. 2014 Feb;76(2):418-23. doi: 10.1097/TA.0000000000000120.

PMID:
24458047
18.

Multidetector Computed Tomographic Angiography (MDCTA) for Penetrating Neck Injuries.

Pasley J, Berg RJ, Inaba K.

Rambam Maimonides Med J. 2012 Jul 31;3(3):e0016. doi: 10.5041/RMMJ.10084. Print 2012 Jul.

19.

Effect of sugammadex on QT/QTc interval prolongation when combined with QTc-prolonging sevoflurane or propofol anaesthesia.

de Kam PJ, Grobara P, Dennie J, Cammu G, Ramael S, Jagt-Smook ML, van den Heuvel MW, Berg RJ, Peeters PA.

Clin Drug Investig. 2013 Aug;33(8):545-51. doi: 10.1007/s40261-013-0095-8.

PMID:
23824662
20.

Prospective evaluation of early follow-up chest radiography after penetrating thoracic injury.

Berg RJ, Inaba K, Recinos G, Barmparas G, Teixeira PG, Georgiou C, Shatz D, Rhee P, Demetriades D.

World J Surg. 2013 Jun;37(6):1286-90. doi: 10.1007/s00268-013-2002-0.

PMID:
23536101
21.

Extremity firearm trauma: the impact of injury pattern on clinical outcomes.

Berg RJ, Okoye O, Inaba K, Konstantinidis A, Branco B, Meisel E, Barmparas G, Demetriades D.

Am Surg. 2012 Dec;78(12):1383-7.

PMID:
23265128
22.

Diagnosis of Clostridium difficile infection using real-time PCR.

van den Berg RJ, Bakker D, Kuijper EJ.

Methods Mol Biol. 2013;943:247-56. doi: 10.1007/978-1-60327-353-4_16.

PMID:
23104294
23.

Half-life prolongation of therapeutic proteins by conjugation to ATIII-binding pentasaccharides: a first-in-human study of CarboCarrier® insulin.

Miltenburg AM, Prohn M, van Kuijk JH, Tiessen RG, de Kort M, Berg RJ.

Br J Clin Pharmacol. 2013 May;75(5):1221-30. doi: 10.1111/j.1365-2125.2012.04460.x.

24.

Limits of miniaturization: assessing ITP performance in sub-micron and nanochannels.

Janssen KG, Li J, Hoang HT, Vulto P, van den Berg RJ, Overkleeft HS, Eijkel JC, Tas NR, van der Linden HJ, Hankemeier T.

Lab Chip. 2012 Aug 21;12(16):2888-93. doi: 10.1039/c2lc21011h. Epub 2012 Jun 12.

PMID:
22691967
25.

Magnetococcus marinus gen. nov., sp. nov., a marine, magnetotactic bacterium that represents a novel lineage (Magnetococcaceae fam. nov., Magnetococcales ord. nov.) at the base of the Alphaproteobacteria.

Bazylinski DA, Williams TJ, Lefèvre CT, Berg RJ, Zhang CL, Bowser SS, Dean AJ, Beveridge TJ.

Int J Syst Evol Microbiol. 2013 Mar;63(Pt 3):801-8. doi: 10.1099/ijs.0.038927-0. Epub 2012 May 11.

PMID:
22581902
26.

The double jeopardy of blunt thoracoabdominal trauma.

Berg RJ, Okoye O, Teixeira PG, Inaba K, Demetriades D.

Arch Surg. 2012 Jun;147(6):498-504. doi: 10.1001/archsurg.2011.2289.

PMID:
22351879
27.

Ultrasonic wave propagation assessment of native cartilage explants and hydrogel scaffolds for tissue engineering.

Kohles SS, Mason SS, Adams AP, Berg RJ, Blank J, Gibson F, Righetti J, Washington IS, Saha AK.

Int J Biomed Eng Technol. 2012;10(3):296-307.

28.

Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor.

van Koppen CJ, de Gooyer ME, Karstens WJ, Plate R, Conti PG, van Achterberg TA, van Amstel MG, Brands JH, Wat J, Berg RJ, Lane JR, Miltenburg AM, Timmers CM.

Br J Pharmacol. 2012 Apr;165(7):2314-24. doi: 10.1111/j.1476-5381.2011.01709.x.

29.

Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.

van den Berg RJ, Wennekes T, Ghisaidoobe A, Donker-Koopman WE, Strijland A, Boot RG, van der Marel GA, Aerts JM, Overkleeft HS.

ACS Med Chem Lett. 2011 Apr 7;2(7):519-22. doi: 10.1021/ml200050s. eCollection 2011 Jul 14.

30.

Three distinct modes of exocytosis revealed by amperometry in neuroendocrine cells.

van Kempen GT, vanderLeest HT, van den Berg RJ, Eilers P, Westerink RH.

Biophys J. 2011 Feb 16;100(4):968-77. doi: 10.1016/j.bpj.2011.01.010.

31.

Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.

Ghisaidoobe A, Bikker P, de Bruijn AC, Godschalk FD, Rogaar E, Guijt MC, Hagens P, Halma JM, Van't Hart SM, Luitjens SB, van Rixel VH, Wijzenbroek M, Zweegers T, Donker-Koopman WE, Strijland A, Boot R, van der Marel G, Overkleeft HS, Aerts JM, van den Berg RJ.

ACS Med Chem Lett. 2010 Dec 2;2(2):119-23. doi: 10.1021/ml100192b. eCollection 2011 Feb 10.

32.

Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.

van den Nieuwendijk AM, Ruben M, Engelsma SE, Risseeuw MD, van den Berg RJ, Boot RG, Aerts JM, Brussee J, van der Marel GA, Overkleeft HS.

Org Lett. 2010 Sep 3;12(17):3957-9. doi: 10.1021/ol101556k.

PMID:
20690611
33.

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.

Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, Aerts JM.

J Med Chem. 2010 Jan 28;53(2):689-98. doi: 10.1021/jm901281m.

PMID:
20000679
34.

Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.

van Scherpenzeel M, van den Berg RJ, Donker-Koopman WE, Liskamp RM, Aerts JM, Overkleeft HS, Pieters RJ.

Bioorg Med Chem. 2010 Jan 1;18(1):267-73. doi: 10.1016/j.bmc.2009.10.060. Epub 2009 Oct 31.

PMID:
19931460
35.

Glycosphingolipids--nature, function, and pharmacological modulation.

Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM.

Angew Chem Int Ed Engl. 2009;48(47):8848-69. doi: 10.1002/anie.200902620. Review.

PMID:
19862781
36.

Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.

Risseeuw MD, van den Berg RJ, Donker-Koopman WE, van der Marel GA, Aerts JM, Overhand M, Overkleeft HS.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3. doi: 10.1016/j.bmcl.2009.10.022. Epub 2009 Oct 8.

PMID:
19853441
37.

Complementary chemoenzymatic routes to both enantiomers of febrifugine.

Wijdeven MA, van den Berg RJ, Wijtmans R, Botman PN, Blaauw RH, Schoemaker HE, van Delft FL, Rutjes FP.

Org Biomol Chem. 2009 Jul 21;7(14):2976-80. doi: 10.1039/b901670h. Epub 2009 Jun 4.

PMID:
19582308
38.

Comparison of molecular typing methods applied to Clostridium difficile.

Kuijper EJ, van den Berg RJ, Brazier JS.

Methods Mol Biol. 2009;551:159-71. doi: 10.1007/978-1-60327-999-4_13. Review.

PMID:
19521874
39.

Discovery of selective luteinizing hormone receptor agonists using the bivalent ligand method.

Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, van Koppen CJ, Timmers CM, Overkleeft HS, van der Marel GA.

ChemMedChem. 2009 Jul;4(7):1189-95. doi: 10.1002/cmdc.200900058.

PMID:
19475639
40.

Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina.

Goorhuis A, Legaria MC, van den Berg RJ, Harmanus C, Klaassen CH, Brazier JS, Lumelsky G, Kuijper EJ.

Clin Microbiol Infect. 2009 Dec;15(12):1080-6. doi: 10.1111/j.1469-0691.2009.02759.x. Epub 2009 May 11.

41.

Successful combat of an outbreak due to Clostridium difficile PCR ribotype 027 and recognition of specific risk factors.

Debast SB, Vaessen N, Choudry A, Wiegers-Ligtvoet EA, van den Berg RJ, Kuijper EJ.

Clin Microbiol Infect. 2009 May;15(5):427-34. doi: 10.1111/j.1469-0691.2009.02713.x. Epub 2009 Mar 23.

42.

Laboratory-acquired clostridium difficile polymerase chain reaction ribotype 027: a new risk for laboratory workers?

Bouza E, Martin A, Van den Berg RJ, Kuijper EJ.

Clin Infect Dis. 2008 Dec 1;47(11):1493-4. doi: 10.1086/593109. No abstract available.

PMID:
18986267
43.

N,N-acetals as N-acyliminium ion precursors: synthesis and absolute stereochemistry of epiquinamide.

Wijdeven MA, Wijtmans R, van den Berg RJ, Noorduin W, Schoemaker HE, Sonke T, van Delft FL, Blaauw RH, Fitch RW, Spande TF, Daly JW, Rutjes FP.

Org Lett. 2008 Sep 18;10(18):4001-3. doi: 10.1021/ol801490m. Epub 2008 Aug 15.

PMID:
18702495
44.

The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells.

Rampaart LJ, Beekwilder JP, van Kempen GT, van den Berg RJ, Ypey DL.

Anesth Analg. 2008 Jun;106(6):1778-83. doi: 10.1213/ane.0b013e318172c3a2.

PMID:
18499609
45.

Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile-associated disease.

Debast SB, van Kregten E, Oskam KM, van den Berg T, Van den Berg RJ, Kuijper EJ.

Clin Microbiol Infect. 2008 Jun;14(6):622-4. doi: 10.1111/j.1469-0691.2008.01999.x. Epub 2008 Apr 3.

46.

Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core.

Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, Ijzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA.

Bioorg Med Chem. 2008 Apr 1;16(7):3744-58. doi: 10.1016/j.bmc.2008.01.054. Epub 2008 Feb 2.

PMID:
18282756
47.

Use of highly discriminatory fingerprinting to analyze clusters of Clostridium difficile infection cases due to epidemic ribotype 027 strains.

Fawley WN, Freeman J, Smith C, Harmanus C, van den Berg RJ, Kuijper EJ, Wilcox MH.

J Clin Microbiol. 2008 Mar;46(3):954-60. doi: 10.1128/JCM.01764-07. Epub 2008 Jan 23.

48.

Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing.

Killgore G, Thompson A, Johnson S, Brazier J, Kuijper E, Pepin J, Frost EH, Savelkoul P, Nicholson B, van den Berg RJ, Kato H, Sambol SP, Zukowski W, Woods C, Limbago B, Gerding DN, McDonald LC.

J Clin Microbiol. 2008 Feb;46(2):431-7. Epub 2007 Nov 26.

49.

Characteristics and incidence of Clostridium difficile-associated disease in The Netherlands, 2005.

Paltansing S, van den Berg RJ, Guseinova RA, Visser CE, van der Vorm ER, Kuijper EJ.

Clin Microbiol Infect. 2007 Nov;13(11):1058-64.

50.

Enzymatic enantioselective C-C-bond formation in microreactors.

Koch K, van den Berg RJ, Nieuwland PJ, Wijtmans R, Schoemaker HE, van Hest JC, Rutjes FP.

Biotechnol Bioeng. 2008 Mar 1;99(4):1028-33.

PMID:
17879309

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