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Items: 1 to 50 of 107

1.

Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema.

Koike K, Berdyshev EV, Mikosz AM, Bronova IA, Bronoff AS, Jung JP, Beatman EL, Ni K, Cao D, Scruggs AK, Serban KA, Petrache I.

Am J Respir Crit Care Med. 2019 Jul 2. doi: 10.1164/rccm.201812-2311OC. [Epub ahead of print]

PMID:
31265321
2.

The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype.

Leung DYM, Calatroni A, Zaramela LS, LeBeau PK, Dyjack N, Brar K, David G, Johnson K, Leung S, Ramirez-Gama M, Liang B, Rios C, Montgomery MT, Richers BN, Hall CF, Norquest KA, Jung J, Bronova I, Kreimer S, Talbot CC Jr, Crumrine D, Cole RN, Elias P, Zengler K, Seibold MA, Berdyshev E, Goleva E.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaav2685. doi: 10.1126/scitranslmed.aav2685.

PMID:
30787169
3.

Epithelial barrier repair and prevention of allergy.

Goleva E, Berdyshev E, Leung DY.

J Clin Invest. 2019 Apr 1;129(4):1463-1474. doi: 10.1172/JCI124608. Epub 2019 Feb 18. Review.

4.

Bioactive Sphingolipids in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Koike K, Berdyshev EV, Bowler RP, Scruggs AK, Cao D, Schweitzer KS, Serban KA, Petrache I.

Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S249-S252. doi: 10.1513/AnnalsATS.201809-592MG.

PMID:
30759004
5.

Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.

Ebenezer DL, Berdyshev EV, Bronova IA, Liu Y, Tiruppathi C, Komarova Y, Benevolenskaya EV, Suryadevara V, Ha AW, Harijith A, Tuder RM, Natarajan V, Fu P.

Thorax. 2019 Jun;74(6):579-591. doi: 10.1136/thoraxjnl-2018-212378. Epub 2019 Feb 5.

PMID:
30723184
6.

Elevated truncated oxidized phospholipids as a factor exacerbating ALI in the aging lungs.

Ke Y, Karki P, Kim J, Son S, Berdyshev E, Bochkov VN, Birukova AA, Birukov KG.

FASEB J. 2019 Mar;33(3):3887-3900. doi: 10.1096/fj.201800981R. Epub 2018 Dec 6.

PMID:
30521374
7.

Lipid abnormalities in atopic skin are driven by type 2 cytokines.

Berdyshev E, Goleva E, Bronova I, Dyjack N, Rios C, Jung J, Taylor P, Jeong M, Hall CF, Richers BN, Norquest KA, Zheng T, Seibold MA, Leung DY.

JCI Insight. 2018 Feb 22;3(4). pii: 98006. doi: 10.1172/jci.insight.98006. eCollection 2018 Feb 22.

8.

Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy.

Justice MJ, Bronova I, Schweitzer KS, Poirier C, Blum JS, Berdyshev EV, Petrache I.

J Lipid Res. 2018 Apr;59(4):596-606. doi: 10.1194/jlr.M080242. Epub 2018 Jan 29.

9.

Incorporation of iloprost in phospholipase-resistant phospholipid scaffold enhances its barrier protective effects on pulmonary endothelium.

Oskolkova O, Sarich N, Tian Y, Gawlak G, Meng F, Bochkov VN, Berdyshev E, Birukova AA, Birukov KG.

Sci Rep. 2018 Jan 17;8(1):879. doi: 10.1038/s41598-018-19197-1.

10.

Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase.

Suryadevara V, Fu P, Ebenezer DL, Berdyshev E, Bronova IA, Huang LS, Harijith A, Natarajan V.

Int J Mol Sci. 2018 Jan 1;19(1). pii: E114. doi: 10.3390/ijms19010114.

11.

Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.

Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I.

FASEB J. 2018 Apr;32(4):1880-1890. doi: 10.1096/fj.201700571R. Epub 2018 Jan 5.

12.

Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.

Le Master E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington DT, Lee J, Cho M, Fang Y, Minshall RD, Levitan I.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):64-75. doi: 10.1161/ATVBAHA.117.309907. Epub 2017 Oct 12.

13.

Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4.

Ke Y, Zebda N, Oskolkova O, Afonyushkin T, Berdyshev E, Tian Y, Meng F, Sarich N, Bochkov VN, Wang JM, Birukova AA, Birukov KG.

Circ Res. 2017 Jul 21;121(3):244-257. doi: 10.1161/CIRCRESAHA.116.310308. Epub 2017 May 18.

14.

Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells.

Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC.

Sci Rep. 2017 Mar 21;7:44867. doi: 10.1038/srep44867.

15.

Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids.

Ayee MAA, LeMaster E, Shentu TP, Singh DK, Barbera N, Soni D, Tiruppathi C, Subbaiah PV, Berdyshev E, Bronova I, Cho M, Akpa BS, Levitan I.

Biophys J. 2017 Jan 24;112(2):325-338. doi: 10.1016/j.bpj.2016.12.002.

16.

Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium.

Fu P, Ebenezer DL, Berdyshev EV, Bronova IA, Shaaya M, Harijith A, Natarajan V.

J Biol Chem. 2016 Dec 30;291(53):27187-27203. doi: 10.1074/jbc.M116.758946. Epub 2016 Nov 18.

17.

Structural and functional characterization of endothelial microparticles released by cigarette smoke.

Serban KA, Rezania S, Petrusca DN, Poirier C, Cao D, Justice MJ, Patel M, Tsvetkova I, Kamocki K, Mikosz A, Schweitzer KS, Jacobson S, Cardoso A, Carlesso N, Hubbard WC, Kechris K, Dragnea B, Berdyshev EV, McClintock J, Petrache I.

Sci Rep. 2016 Aug 17;6:31596. doi: 10.1038/srep31596.

18.

Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium.

Harijith A, Pendyala S, Ebenezer DL, Ha AW, Fu P, Wang YT, Ma K, Toth PT, Berdyshev EV, Kanteti P, Natarajan V.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L337-51. doi: 10.1152/ajplung.00447.2015. Epub 2016 Jun 24.

19.

Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.

Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM.

FASEB J. 2016 Jun;30(6):2435-50. doi: 10.1096/fj.201500197R. Epub 2016 Mar 22.

20.

Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation.

Oh MJ, Zhang C, LeMaster E, Adamos C, Berdyshev E, Bogachkov Y, Kohler EE, Baruah J, Fang Y, Schraufnagel DE, Wary KK, Levitan I.

J Lipid Res. 2016 May;57(5):791-808. doi: 10.1194/jlr.M062539. Epub 2016 Mar 17.

21.

Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.

Ackerman SJ, Park GY, Christman JW, Nyenhuis S, Berdyshev E, Natarajan V.

Biomark Med. 2016;10(2):123-35. doi: 10.2217/bmm.15.93. Epub 2016 Jan 14. Review.

22.

Ceramide Signaling and Metabolism in Pathophysiological States of the Lung.

Petrache I, Berdyshev EV.

Annu Rev Physiol. 2016;78:463-80. doi: 10.1146/annurev-physiol-021115-105221. Epub 2015 Nov 30. Review.

PMID:
26667073
23.

Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1.

Bronova I, Smith B, Aydogan B, Weichselbaum RR, Vemuri K, Erdelyi K, Makriyannis A, Pacher P, Berdyshev EV.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):555-62. doi: 10.1165/rcmb.2014-0331OC.

24.

Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy.

Huang LS, Berdyshev EV, Tran JT, Xie L, Chen J, Ebenezer DL, Mathew B, Gorshkova I, Zhang W, Reddy SP, Harijith A, Wang G, Feghali-Bostwick C, Noth I, Ma SF, Zhou T, Ma W, Garcia JG, Natarajan V.

Thorax. 2015 Dec;70(12):1138-48. doi: 10.1136/thoraxjnl-2014-206684. Epub 2015 Aug 18.

25.

Changes in the metabolism of sphingolipids after subarachnoid hemorrhage.

Testai FD, Xu HL, Kilkus J, Suryadevara V, Gorshkova I, Berdyshev E, Pelligrino DA, Dawson G.

J Neurosci Res. 2015 May;93(5):796-805. doi: 10.1002/jnr.23542. Epub 2015 Jan 19.

26.

Space radiation-associated lung injury in a murine model.

Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Schweitzer KS, Berdyshev EV, McCarthy M, Corbitt A, Alwood JS, Yu Y, Globus RK, Solomides CC, Ullrich RL, Petrache I.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L416-28. doi: 10.1152/ajplung.00260.2014. Epub 2014 Dec 19.

27.

Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma.

Lee YG, Jeong JJ, Nyenhuis S, Berdyshev E, Chung S, Ranjan R, Karpurapu M, Deng J, Qian F, Kelly EA, Jarjour NN, Ackerman SJ, Natarajan V, Christman JW, Park GY.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):772-84. doi: 10.1165/rcmb.2014-0255OC.

28.

The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.

Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF.

Am J Respir Crit Care Med. 2014 Nov 1;190(9):1032-43. doi: 10.1164/rccm.201401-0121OC.

29.

Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia.

Testai FD, Kilkus JP, Berdyshev E, Gorshkova I, Natarajan V, Dawson G.

J Neurochem. 2014 Nov;131(4):530-40. doi: 10.1111/jnc.12836. Epub 2014 Aug 14.

30.

The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.

Huang LS, Mathew B, Li H, Zhao Y, Ma SF, Noth I, Reddy SP, Harijith A, Usatyuk PV, Berdyshev EV, Kaminski N, Zhou T, Zhang W, Zhang Y, Rehman J, Kotha SR, Gurney TO, Parinandi NL, Lussier YA, Garcia JG, Natarajan V.

Am J Respir Crit Care Med. 2014 Jun 1;189(11):1402-15. doi: 10.1164/rccm.201310-1917OC.

31.

Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.

Chang Q, Berdyshev E, Cao D, Bogaard JD, White JJ, Chen S, Shah R, Mu W, Grantner R, Bettis S, Grassi MA.

J Biol Chem. 2014 Mar 21;289(12):8337-52. doi: 10.1074/jbc.M113.507152. Epub 2014 Feb 11.

32.

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis.

Montesi SB, Mathai SK, Brenner LN, Gorshkova IA, Berdyshev EV, Tager AM, Shea BS.

BMC Pulm Med. 2014 Jan 27;14:5. doi: 10.1186/1471-2466-14-5.

33.

Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.

Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y, Chung S, Karpurapu M, Deng J, Ranjan R, Xiao L, Jaffe HA, Corbridge SJ, Kelly EA, Jarjour NN, Chun J, Prestwich GD, Kaffe E, Ninou I, Aidinis V, Morris AJ, Smyth SS, Ackerman SJ, Natarajan V, Christman JW.

Am J Respir Crit Care Med. 2013 Oct 15;188(8):928-40. doi: 10.1164/rccm.201306-1014OC.

34.

Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins.

Harijith A, Pendyala S, Reddy NM, Bai T, Usatyuk PV, Berdyshev E, Gorshkova I, Huang LS, Mohan V, Garzon S, Kanteti P, Reddy SP, Raj JU, Natarajan V.

Am J Pathol. 2013 Oct;183(4):1169-1182. doi: 10.1016/j.ajpath.2013.06.018. Epub 2013 Aug 8.

35.

Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest.

Gorshkova IA, Wang H, Orbelyan GA, Goya J, Natarajan V, Beiser DG, Vanden Hoek TL, Berdyshev EV.

Life Sci. 2013 Sep 17;93(9-11):359-66. doi: 10.1016/j.lfs.2013.07.017. Epub 2013 Jul 24.

PMID:
23892195
36.

Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.

Natarajan V, Dudek SM, Jacobson JR, Moreno-Vinasco L, Huang LS, Abassi T, Mathew B, Zhao Y, Wang L, Bittman R, Weichselbaum R, Berdyshev E, Garcia JG.

Am J Respir Cell Mol Biol. 2013 Jul;49(1):6-17. doi: 10.1165/rcmb.2012-0411TR. Review.

37.

Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis.

Huang LS, Berdyshev E, Mathew B, Fu P, Gorshkova IA, He D, Ma W, Noth I, Ma SF, Pendyala S, Reddy SP, Zhou T, Zhang W, Garzon SA, Garcia JG, Natarajan V.

FASEB J. 2013 Apr;27(4):1749-60. doi: 10.1096/fj.12-219634. Epub 2013 Jan 11.

38.

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.

Watson DG, Tonelli F, Alossaimi M, Williamson L, Chan E, Gorshkova I, Berdyshev E, Bittman R, Pyne NJ, Pyne S.

Cell Signal. 2013 Apr;25(4):1011-7. doi: 10.1016/j.cellsig.2013.01.002. Epub 2013 Jan 11.

39.

The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.

Tonelli F, Alossaimi M, Natarajan V, Gorshkova I, Berdyshev E, Bittman R, Watson DG, Pyne S, Pyne NJ.

Biomolecules. 2013 Jun 10;3(2):316-33. doi: 10.3390/biom3020316.

40.

Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival.

Véret J, Coant N, Gorshkova IA, Giussani P, Fradet M, Riccitelli E, Skobeleva A, Goya J, Kassis N, Natarajan V, Portha B, Berdyshev EV, Le Stunff H.

Biochim Biophys Acta. 2013 Feb;1831(2):251-62. doi: 10.1016/j.bbalip.2012.10.003. Epub 2012 Oct 17.

PMID:
23085009
41.

Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.

Kalari S, Moolky N, Pendyala S, Berdyshev EV, Rolle C, Kanteti R, Kanteti A, Ma W, He D, Husain AN, Kindler HL, Kanteti P, Salgia R, Natarajan V.

PLoS One. 2012;7(9):e45330. doi: 10.1371/journal.pone.0045330. Epub 2012 Sep 17.

42.

RTP801 is required for ceramide-induced cell-specific death in the murine lung.

Kamocki K, Van Demark M, Fisher A, Rush NI, Presson RG Jr, Hubbard W, Berdyshev EV, Adamsky S, Feinstein E, Gandjeva A, Tuder RM, Petrache I.

Am J Respir Cell Mol Biol. 2013 Jan;48(1):87-93. doi: 10.1165/rcmb.2012-0254OC. Epub 2012 Sep 28.

43.

Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.

Poirier C, Berdyshev EV, Dimitropoulou C, Bogatcheva NV, Biddinger PW, Verin AD.

Mamm Genome. 2012 Dec;23(11-12):758-63. doi: 10.1007/s00335-012-9419-x. Epub 2012 Sep 4.

44.

Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage.

Testai FD, Hillmann M, Amin-Hanjani S, Gorshkova I, Berdyshev E, Gorelick PB, Dawson G.

Stroke. 2012 Aug;43(8):2066-70. doi: 10.1161/STROKEAHA.112.650390. Epub 2012 Jun 19.

PMID:
22713492
45.

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.

Lim KG, Tonelli F, Berdyshev E, Gorshkova I, Leclercq T, Pitson SM, Bittman R, Pyne S, Pyne NJ.

Int J Biochem Cell Biol. 2012 Sep;44(9):1457-64. doi: 10.1016/j.biocel.2012.05.012. Epub 2012 May 23.

PMID:
22634604
46.

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.

Gorshkova I, Zhou T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG, Berdyshev EV.

J Lipid Res. 2012 Aug;53(8):1553-68. doi: 10.1194/jlr.M026039. Epub 2012 May 21.

47.

Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.

Qin J, Berdyshev E, Poirer C, Schwartz NB, Dawson G.

J Biol Chem. 2012 Apr 20;287(17):13620-32. doi: 10.1074/jbc.M111.304857. Epub 2012 Mar 1.

48.

Therapeutic hypothermia cardioprotection in murine hemorrhagic shock/resuscitation differentially affects p38α/p38γ, Akt, and HspB1.

Li J, Beiser DG, Wang H, Das A, Berdyshev E, Li J, Leff AR, Stern SA, Vanden Hoek TL.

J Trauma. 2011 Nov;71(5):1262-70. doi: 10.1097/TA.0b013e31821280c5.

PMID:
22071928
49.

Mass spectrometry of fatty aldehydes.

Berdyshev EV.

Biochim Biophys Acta. 2011 Nov;1811(11):680-93. doi: 10.1016/j.bbalip.2011.08.018. Epub 2011 Sep 9. Review.

50.

Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.

Zhao J, He D, Su Y, Berdyshev E, Chun J, Natarajan V, Zhao Y.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L547-56. doi: 10.1152/ajplung.00058.2011. Epub 2011 Aug 5.

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