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Items: 46


Wilms' tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90.

Kuai Y, Gong X, Ding L, Li F, Lei L, Gong Y, Liu Q, Tan H, Zhang X, Liu D, Ren G, Pan H, Shi Y, Berberich-Siebelt F, Mao Z, Zhou R.

Cell Commun Signal. 2018 Aug 24;16(1):50. doi: 10.1186/s12964-018-0258-6.


Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.

Man K, Gabriel SS, Liao Y, Gloury R, Preston S, Henstridge DC, Pellegrini M, Zehn D, Berberich-Siebelt F, Febbraio MA, Shi W, Kallies A.

Immunity. 2017 Dec 19;47(6):1129-1141.e5. doi: 10.1016/j.immuni.2017.11.021. Epub 2017 Dec 12.


Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Vaeth M, Maus M, Klein-Hessling S, Freinkman E, Yang J, Eckstein M, Cameron S, Turvey SE, Serfling E, Berberich-Siebelt F, Possemato R, Feske S.

Immunity. 2017 Oct 17;47(4):664-679.e6. doi: 10.1016/j.immuni.2017.09.003. Epub 2017 Oct 11.


NFATc1 controls the cytotoxicity of CD8+ T cells.

Klein-Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, Qureischi M, Beilhack A, Vaeth M, Kummerow C, Backes C, Schoppmeyer R, Hahn U, Hoth M, Bopp T, Berberich-Siebelt F, Patra A, Avots A, Müller N, Schulze A, Serfling E.

Nat Commun. 2017 Sep 11;8(1):511. doi: 10.1038/s41467-017-00612-6.


Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.

Campos Carrascosa L, Klein M, Kitagawa Y, Lückel C, Marini F, König A, Guralnik A, Raifer H, Hagner-Benes S, Rädler D, Böck A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M.

Nat Commun. 2017 May 12;8:15366. doi: 10.1038/ncomms15366.


The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin's-lymphoma.

Shi Y, Kuai Y, Lei L, Weng Y, Berberich-Siebelt F, Zhang X, Wang J, Zhou Y, Jiang X, Ren G, Pan H, Mao Z, Zhou R.

Oncotarget. 2016 Nov 22;7(47):77444-77456. doi: 10.18632/oncotarget.12680.


Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.

Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. Epub 2016 Sep 6.


Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.

Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, Vaeth M, Kuen J, Holtappels R, Podlech J, Mottok A, Kraus S, Jordán-Garrote AL, Bäuerlein CA, Brede C, Ribechini E, Fick A, Seher A, Polz J, Ottmüller KJ, Baker J, Nishikii H, Ritz M, Mattenheimer K, Schwinn S, Winter T, Schäfer V, Krappmann S, Einsele H, Müller TD, Reddehase MJ, Lutz MB, Männel DN, Berberich-Siebelt F, Wajant H, Beilhack A.

J Exp Med. 2016 Aug 22;213(9):1881-900. doi: 10.1084/jem.20151563. Epub 2016 Aug 15.


Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity.

Vaeth M, Eckstein M, Shaw PJ, Kozhaya L, Yang J, Berberich-Siebelt F, Clancy R, Unutmaz D, Feske S.

Immunity. 2016 Jun 21;44(6):1350-64. doi: 10.1016/j.immuni.2016.04.013. Epub 2016 May 31.


The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6.

Stauss D, Brunner C, Berberich-Siebelt F, Höpken UE, Lipp M, Müller G.

EMBO J. 2016 Apr 15;35(8):881-98. doi: 10.15252/embj.201591459. Epub 2016 Mar 8.


Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling.

Haarmann A, Nowak E, Deiß A, van der Pol S, Monoranu CM, Kooij G, Müller N, van der Valk P, Stoll G, de Vries HE, Berberich-Siebelt F, Buttmann M.

Acta Neuropathol. 2015 May;129(5):639-52. doi: 10.1007/s00401-015-1417-0. Epub 2015 Mar 27.


TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production.

Vogel SZ, Schlickeiser S, Jürchott K, Akyuez L, Schumann J, Appelt C, Vogt K, Schröder M, Vaeth M, Berberich-Siebelt F, Lutz MB, Grütz G, Sawitzki B.

J Immunol. 2015 Apr 1;194(7):3136-46. doi: 10.4049/jimmunol.1400713. Epub 2015 Mar 6.


NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms.

Dietz L, Frommer F, Vogel AL, Vaeth M, Serfling E, Waisman A, Buttmann M, Berberich-Siebelt F.

Eur J Immunol. 2015 May;45(5):1377-89. doi: 10.1002/eji.201444638. Epub 2015 Feb 19.


Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity.

Vaeth M, Bäuerlein CA, Pusch T, Findeis J, Chopra M, Mottok A, Rosenwald A, Beilhack A, Berberich-Siebelt F.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1125-30. doi: 10.1073/pnas.1409290112. Epub 2015 Jan 12.


Immature dendritic cells convert anergic nonregulatory T cells into Foxp3- IL-10+ regulatory T cells by engaging CD28 and CTLA-4.

Pletinckx K, Vaeth M, Schneider T, Beyersdorf N, Hünig T, Berberich-Siebelt F, Lutz MB.

Eur J Immunol. 2015 Feb;45(2):480-91. doi: 10.1002/eji.201444991. Epub 2014 Dec 2.


The mitochondrial protein TCAIM regulates activation of T cells and thereby promotes tolerance induction of allogeneic transplants.

Schumann J, Stanko K, Woertge S, Appelt C, Schumann M, Kühl AA, Panov I, Schliesser U, Vogel S, Ahrlich S, Vaeth M, Berberich-Siebelt F, Waisman A, Sawitzki B.

Am J Transplant. 2014 Dec;14(12):2723-35. doi: 10.1111/ajt.12941. Epub 2014 Oct 31.


Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.

Vaeth M, Müller G, Stauss D, Dietz L, Klein-Hessling S, Serfling E, Lipp M, Berberich I, Berberich-Siebelt F.

J Exp Med. 2014 Mar 10;211(3):545-61. doi: 10.1084/jem.20130604. Epub 2014 Mar 3.


NFATc1 induction in peripheral T and B lymphocytes.

Hock M, Vaeth M, Rudolf R, Patra AK, Pham DA, Muhammad K, Pusch T, Bopp T, Schmitt E, Rost R, Berberich-Siebelt F, Tyrsin D, Chuvpilo S, Avots A, Serfling E, Klein-Hessling S.

J Immunol. 2013 Mar 1;190(5):2345-53. doi: 10.4049/jimmunol.1201591. Epub 2013 Jan 30.


Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB.

Mueller K, Quandt J, Marienfeld RB, Weihrich P, Fiedler K, Claussnitzer M, Laumen H, Vaeth M, Berberich-Siebelt F, Serfling E, Wirth T, Brunner C.

Nucleic Acids Res. 2013 Feb 1;41(4):2138-54. doi: 10.1093/nar/gks1349. Epub 2013 Jan 4.


Natalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis.

Benkert TF, Dietz L, Hartmann EM, Leich E, Rosenwald A, Serfling E, Buttmann M, Berberich-Siebelt F.

PLoS One. 2012;7(12):e52208. doi: 10.1371/journal.pone.0052208. Epub 2012 Dec 20.


Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.

Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, Jonuleit H, Waisman A, Müller MR, Serfling E, Sawitzki BS, Berberich-Siebelt F.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16258-63. doi: 10.1073/pnas.1203870109. Epub 2012 Sep 18.


NFATc1/αA: The other Face of NFAT Factors in Lymphocytes.

Serfling E, Avots A, Klein-Hessling S, Rudolf R, Vaeth M, Berberich-Siebelt F.

Cell Commun Signal. 2012 Jul 5;10(1):16. doi: 10.1186/1478-811X-10-16.


Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells.

Klein M, Vaeth M, Scheel T, Grabbe S, Baumgrass R, Berberich-Siebelt F, Bopp T, Schmitt E, Becker C.

J Immunol. 2012 Feb 1;188(3):1091-7. doi: 10.4049/jimmunol.1102045. Epub 2011 Dec 21.


Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells.

Azukizawa H, Döhler A, Kanazawa N, Nayak A, Lipp M, Malissen B, Autenrieth I, Katayama I, Riemann M, Weih F, Berberich-Siebelt F, Lutz MB.

Eur J Immunol. 2011 May;41(5):1420-34. doi: 10.1002/eji.201040930. Epub 2011 Apr 14.


NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.

Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, Jellusova J, Schweizer A, Nitschke L, Leich E, Rosenwald A, Brunner C, Engelmann S, Bommhardt U, Avots A, Müller MR, Kondo E, Serfling E.

J Exp Med. 2011 Apr 11;208(4):823-39. doi: 10.1084/jem.20100945. Epub 2011 Apr 4.


Transcriptional programming in the immune system: report on the International Workshop of the Transregio TR52, November 17-20, 2010 in Würzburg, Germany.

Berberich-Siebelt F, Avots A, Serfling E.

Eur J Immunol. 2011 Apr;41(4):885-8. doi: 10.1002/eji.201190016. No abstract available.


Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).

Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, Bodor J.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2480-5. doi: 10.1073/pnas.1009463108. Epub 2011 Jan 24.


Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase.

Nayak A, Glöckner-Pagel J, Vaeth M, Schumann JE, Buttmann M, Bopp T, Schmitt E, Serfling E, Berberich-Siebelt F.

J Biol Chem. 2009 Apr 17;284(16):10935-46. doi: 10.1074/jbc.M900465200. Epub 2009 Feb 14.


Blimp-1Deltaexon7: a naturally occurring Blimp-1 deletion mutant with auto-regulatory potential.

Schmidt D, Nayak A, Schumann JE, Schimpl A, Berberich I, Berberich-Siebelt F.

Exp Cell Res. 2008 Dec 10;314(20):3614-27. doi: 10.1016/j.yexcr.2008.09.008. Epub 2008 Sep 25.


NFAT in lymphocytes: a factor for all events?

Serfling E, Berberich-Siebelt F, Avots A.

Sci STKE. 2007 Aug 7;2007(398):pe42. Review.


Interferon-beta is a potent inducer of interferon regulatory factor-1/2-dependent IP-10/CXCL10 expression in primary human endothelial cells.

Buttmann M, Berberich-Siebelt F, Serfling E, Rieckmann P.

J Vasc Res. 2007;44(1):51-60. Epub 2006 Dec 13.


SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells.

Berberich-Siebelt F, Berberich I, Andrulis M, Santner-Nanan B, Jha MK, Klein-Hessling S, Schimpl A, Serfling E.

J Immunol. 2006 Apr 15;176(8):4843-51.


Subcutaneous interferon-beta injections in patients with multiple sclerosis initiate inflammatory skin reactions by local chemokine induction.

Buttmann M, Goebeler M, Toksoy A, Schmid S, Graf W, Berberich-Siebelt F, Rieckmann P.

J Neuroimmunol. 2005 Nov;168(1-2):175-82. Epub 2005 Aug 26.


NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation.

Wurzer WJ, Ehrhardt C, Pleschka S, Berberich-Siebelt F, Wolff T, Walczak H, Planz O, Ludwig S.

J Biol Chem. 2004 Jul 23;279(30):30931-7. Epub 2004 May 12.


NFAT and NF-kappaB factors-the distant relatives.

Serfling E, Berberich-Siebelt F, Avots A, Chuvpilo S, Klein-Hessling S, Jha MK, Kondo E, Pagel P, Schulze-Luehrmann J, Palmetshofer A.

Int J Biochem Cell Biol. 2004 Jul;36(7):1166-70. Review.


Borna disease virus nucleoprotein interacts with the CDC2-cyclin B1 complex.

Planz O, Pleschka S, Oesterle K, Berberich-Siebelt F, Ehrhardt C, Stitz L, Ludwig S.

J Virol. 2003 Oct;77(20):11186-92.


Protein kinase A regulates GATA-3-dependent activation of IL-5 gene expression in Th2 cells.

Klein-Hessling S, Jha MK, Santner-Nanan B, Berberich-Siebelt F, Baumruker T, Schimpl A, Serfling E.

J Immunol. 2003 Mar 15;170(6):2956-61.


Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis.

Chuvpilo S, Jankevics E, Tyrsin D, Akimzhanov A, Moroz D, Jha MK, Schulze-Luehrmann J, Santner-Nanan B, Feoktistova E, König T, Avots A, Schmitt E, Berberich-Siebelt F, Schimpl A, Serfling E.

Immunity. 2002 Jun;16(6):881-95.


Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-kappaB control.

Marienfeld R, Berberich-Siebelt F, Berberich I, Denk A, Serfling E, Neumann M.

Oncogene. 2001 Dec 6;20(56):8142-7.


Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals.

von Gise A, Lorenz P, Wellbrock C, Hemmings B, Berberich-Siebelt F, Rapp UR, Troppmair J.

Mol Cell Biol. 2001 Apr;21(7):2324-36.


The role of NF-AT transcription factors in T cell activation and differentiation.

Serfling E, Berberich-Siebelt F, Chuvpilo S, Jankevics E, Klein-Hessling S, Twardzik T, Avots A.

Biochim Biophys Acta. 2000 Oct 20;1498(1):1-18. Review.


C/EBPbeta enhances IL-4 but impairs IL-2 and IFN-gamma induction in T cells.

Berberich-Siebelt F, Klein-Hessling S, Hepping N, Santner-Nanan B, Lindemann D, Schimpl A, Berberich I, Serfling E.

Eur J Immunol. 2000 Sep;30(9):2576-85.


A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death.

Kuss AW, Knödel M, Berberich-Siebelt F, Lindemann D, Schimpl A, Berberich I.

Eur J Immunol. 1999 Oct;29(10):3077-88.


Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes.

Chuvpilo S, Avots A, Berberich-Siebelt F, Glöckner J, Fischer C, Kerstan A, Escher C, Inashkina I, Hlubek F, Jankevics E, Brabletz T, Serfling E.

J Immunol. 1999 Jun 15;162(12):7294-301.


Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells.

Chuvpilo S, Zimmer M, Kerstan A, Glöckner J, Avots A, Escher C, Fischer C, Inashkina I, Jankevics E, Berberich-Siebelt F, Schmitt E, Serfling E.

Immunity. 1999 Feb;10(2):261-9.


Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice.

Schuh K, Kneitz B, Heyer J, Bommhardt U, Jankevics E, Berberich-Siebelt F, Pfeffer K, Müller-Hermelink HK, Schimpl A, Serfling E.

Eur J Immunol. 1998 Aug;28(8):2456-66.

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