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Items: 17


DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.

Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaao6451. doi: 10.1126/scitranslmed.aao6451.



Farahi N, Loutsios C, Tregay N, Wright AKA, Berair R, Lok LSC, Gillett D, Cullum I, Simmonds RP, Summers C, Wong A, Solanki CK, Buscombe J, Pang PH, Thavakumar A, Peters AM, Brightling CE, Condliffe AM, Chilvers ER.

J Allergy Clin Immunol. 2019 Mar;143(3):1265-1266. doi: 10.1016/j.jaci.2018.11.026. Epub 2019 Jan 11. No abstract available.


In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients.

Farahi N, Loutsios C, Tregay N, Wright AKA, Berair R, Lok LSC, Gillett D, Cullum I, Simmonds RP, Summers C, Wong A, Solanki CK, Buscombe J, Pang PH, Thavakumar A, Peters AM, Brightling CE, Condliffe AM, Chilvers ER.

J Allergy Clin Immunol. 2018 Nov;142(5):1659-1662.e8. doi: 10.1016/j.jaci.2018.07.011. Epub 2018 Jul 30. No abstract available.


In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.

Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, Brightling CE.

Eur Respir J. 2018 May 24;51(5). pii: 1701680. doi: 10.1183/13993003.01680-2017. Print 2018 May.


Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling.

Berair R, Hartley R, Mistry V, Sheshadri A, Gupta S, Singapuri A, Gonem S, Marshall RP, Sousa AR, Shikotra A, Kay R, Wardlaw A, Bradding P, Siddiqui S, Castro M, Brightling CE.

Eur Respir J. 2017 May 1;49(5). pii: 1601507. doi: 10.1183/13993003.01507-2016. Print 2017 May.


Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease.

Wright AK, Newby C, Hartley RA, Mistry V, Gupta S, Berair R, Roach KM, Saunders R, Thornton T, Shelley M, Edwards K, Barker B, Brightling CE.

Allergy. 2017 Apr;72(4):645-655. doi: 10.1111/all.13061. Epub 2016 Nov 10.


Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial.

Gonem S, Berair R, Singapuri A, Hartley R, Laurencin MFM, Bacher G, Holzhauer B, Bourne M, Mistry V, Pavord ID, Mansur AH, Wardlaw AJ, Siddiqui SH, Kay RA, Brightling CE.

Lancet Respir Med. 2016 Sep;4(9):699-707. doi: 10.1016/S2213-2600(16)30179-5. Epub 2016 Aug 5.


Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD.

Hollins F, Sutcliffe A, Gomez E, Berair R, Russell R, Szyndralewiez C, Saunders R, Brightling C.

Respir Res. 2016 Jul 19;17(1):84. doi: 10.1186/s12931-016-0403-y.


Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma.

Singh SR, Sullo N, Matteis M, Spaziano G, McDonald J, Saunders R, Woodman L, Urbanek K, De Angelis A, De Palma R, Berair R, Pancholi M, Mistry V, Rossi F, Guerrini R, Calò G, D'Agostino B, Brightling CE, Lambert DG.

Br J Pharmacol. 2016 Apr;173(8):1286-301. doi: 10.1111/bph.13416. Epub 2016 Mar 6.


IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

Kaur D, Gomez E, Doe C, Berair R, Woodman L, Saunders R, Hollins F, Rose FR, Amrani Y, May R, Kearley J, Humbles A, Cohen ES, Brightling CE.

Allergy. 2015 May;70(5):556-67. doi: 10.1111/all.12593. Epub 2015 Mar 16.


Asthma therapy and its effect on airway remodelling.

Berair R, Brightling CE.

Drugs. 2014 Aug;74(12):1345-69. doi: 10.1007/s40265-014-0250-4. Review.


Severe asthma: novel advances in the pathogenesis and therapy.

Hartley R, Berair R, Brightling CE.

Pol Arch Med Wewn. 2014;124(5):247-54. Epub 2014 Apr 29. Review.


Rationale and clinical results of inhibiting interleukin-5 for the treatment of severe asthma.

Berair R, Pavord ID.

Curr Allergy Asthma Rep. 2013 Oct;13(5):469-76. doi: 10.1007/s11882-013-0379-3. Review.


Origins of increased airway smooth muscle mass in asthma.

Berair R, Saunders R, Brightling CE.

BMC Med. 2013 Jun 6;11:145. doi: 10.1186/1741-7015-11-145. Review.


Airway smooth muscle hypercontractility in asthma.

Berair R, Hollins F, Brightling C.

J Allergy (Cairo). 2013;2013:185971. doi: 10.1155/2013/185971. Epub 2013 Mar 18.


Morbidity and mortality amongst infants of diabetic mothers admitted into Soba university hospital, Khartoum, Sudan.

Kheir AE, Berair R, Gulfan IG, Karrar MZ, Mohammed ZA.

Sudan J Paediatr. 2012;12(1):49-55.


[Scorpion stings in children. Saudi Arabian experience].

el Aminn EO, Berair R.

Arch Pediatr. 1995 Aug;2(8):766-73. Review. French.


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