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Items: 1 to 50 of 189

1.

Clinical courses and complications of young adults with Autosomal Recessive Polycystic Kidney Disease (ARPKD).

Burgmaier K, Kilian S, Bammens B, Benzing T, Billing H, Büscher A, Galiano M, Grundmann F, Klaus G, Mekahli D, Michel-Calemard L, Milosevski-Lomic G, Ranchin B, Sauerstein K, Schaefer S, Shroff R, Sterenborg R, Verbeeck S, Weber LT, Wicher D, Wühl E, Dötsch J, Schaefer F, Liebau MC.

Sci Rep. 2019 May 28;9(1):7919. doi: 10.1038/s41598-019-43488-w.

2.

Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies.

Phipps EA, Thadhani R, Benzing T, Karumanchi SA.

Nat Rev Nephrol. 2019 Jun;15(6):386. doi: 10.1038/s41581-019-0156-1.

PMID:
31068691
3.

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.

Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB.

Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012.

4.

A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany.

Völker LA, Ehren R, Grundmann F, Benzing T, Weber LT, Brinkkötter PT.

Nephrol Dial Transplant. 2019 Apr 21. pii: gfz046. doi: 10.1093/ndt/gfz046. [Epub ahead of print] No abstract available.

PMID:
31006002
5.

Enzyme Replacement Therapy Clears Gb3 Deposits from a Podocyte Cell Culture Model of Fabry Disease but Fails to Restore Altered Cellular Signaling.

Braun F, Blomberg L, Brodesser S, Liebau MC, Schermer B, Benzing T, Kurschat CE.

Cell Physiol Biochem. 2019;52(5):1139-1150. doi: 10.33594/000000077.

6.

The prognostic significance of geriatric syndromes and resources.

Meyer AM, Becker I, Siri G, Brinkkötter PT, Benzing T, Pilotto A, Polidori MC.

Aging Clin Exp Res. 2019 Mar 25. doi: 10.1007/s40520-019-01168-9. [Epub ahead of print]

PMID:
30911909
7.

Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura.

Braun F, Suarez V, Dinter J, Haneder S, Quaas A, Benzing T, Nierhoff D, Müller RU.

BMJ Open Gastroenterol. 2019 Feb 8;6(1):e000252. doi: 10.1136/bmjgast-2018-000252. eCollection 2019.

8.

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.

Ignarski M, Rill C, Kaiser RWJ, Kaldirim M, Neuhaus R, Esmaillie R, Li X, Klein C, Bohl K, Petersen M, Frese CK, Höhne M, Atanassov I, Rinschen MM, Höpker K, Schermer B, Benzing T, Dieterich C, Fabretti F, Müller RU.

J Am Soc Nephrol. 2019 Apr;30(4):564-576. doi: 10.1681/ASN.2018090914. Epub 2019 Mar 13.

PMID:
30867249
9.

Glomerular podocytes in kidney health and disease.

Assady S, Benzing T, Kretzler M, Skorecki KL.

Lancet. 2019 Mar 2;393(10174):856-858. doi: 10.1016/S0140-6736(18)33000-9. No abstract available.

PMID:
30837131
10.

Pre-eclampsia: pathogenesis, novel diagnostics and therapies.

Phipps EA, Thadhani R, Benzing T, Karumanchi SA.

Nat Rev Nephrol. 2019 May;15(5):275-289. doi: 10.1038/s41581-019-0119-6. Review. Erratum in: Nat Rev Nephrol. 2019 Jun;15(6):386.

PMID:
30792480
11.

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis.

Jain M, Kaiser RWJ, Bohl K, Hoehne M, Göbel H, Bartram MP, Habbig S, Müller RU, Fogo AB, Benzing T, Schermer B, Höpker K, Slaats GG.

Kidney Int. 2019 Apr;95(4):846-858. doi: 10.1016/j.kint.2018.10.034. Epub 2019 Feb 13.

PMID:
30770218
12.

[Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine?]

Schermer B, Benzing T.

Dtsch Med Wochenschr. 2019 Feb;144(4):276-281. doi: 10.1055/a-0759-7180. Epub 2019 Feb 13. German.

PMID:
30759475
13.

Management of autosomal-dominant polycystic kidney disease-state-of-the-art.

Müller RU, Benzing T.

Clin Kidney J. 2018 Dec;11(Suppl 1):i2-i13. doi: 10.1093/ckj/sfy103. Epub 2018 Dec 17. Review.

14.

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM.

Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3.

PMID:
30522767
15.

New associations of the Multidimensional Prognostic Index.

Meyer AM, Becker I, Siri G, Brinkkötter PT, Benzing T, Pilotto A, Polidori MC.

Z Gerontol Geriatr. 2018 Nov 7. doi: 10.1007/s00391-018-01471-6. [Epub ahead of print]

PMID:
30406302
16.

Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents.

Völker LA, Maar BA, Pulido Guevara BA, Bilkei-Gorzo A, Zimmer A, Brönneke H, Dafinger C, Bertsch S, Wagener JR, Schweizer H, Schermer B, Benzing T, Hoehne M.

Genes Brain Behav. 2018 Nov;17(8):e12516. doi: 10.1111/gbb.12516. Epub 2018 Sep 14.

PMID:
30133126
17.

Urine-derived cells: a promising diagnostic tool in Fabry disease patients.

Slaats GG, Braun F, Hoehne M, Frech LE, Blomberg L, Benzing T, Schermer B, Rinschen MM, Kurschat CE.

Sci Rep. 2018 Jul 23;8(1):11042. doi: 10.1038/s41598-018-29240-w.

18.

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC.

Exp Mol Med. 2018 Jun 28;50(6):75. doi: 10.1038/s12276-018-0108-z.

19.

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus.

Karaiskos N, Rahmatollahi M, Boltengagen A, Liu H, Hoehne M, Rinschen M, Schermer B, Benzing T, Rajewsky N, Kocks C, Kann M, Müller RU.

J Am Soc Nephrol. 2018 Aug;29(8):2060-2068. doi: 10.1681/ASN.2018030238. Epub 2018 May 24.

PMID:
29794128
20.

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB.

Cell Rep. 2018 May 22;23(8):2495-2508. doi: 10.1016/j.celrep.2018.04.059.

21.

Protein half-life determines expression of proteostatic networks in podocyte differentiation.

Schroeter CB, Koehler S, Kann M, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM.

FASEB J. 2018 Sep;32(9):4696-4713. doi: 10.1096/fj.201701307R. Epub 2018 Apr 25.

PMID:
29694247
22.

Cystic Kidney Diseases From the Adult Nephrologist's Point of View.

Müller RU, Benzing T.

Front Pediatr. 2018 Mar 22;6:65. doi: 10.3389/fped.2018.00065. eCollection 2018. Review.

23.

Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.

Grundmann F, Müller RU, Reppenhorst A, Hülswitt L, Späth MR, Kubacki T, Scherner M, Faust M, Becker I, Wahlers T, Schermer B, Benzing T, Burst V.

J Am Heart Assoc. 2018 Mar 13;7(6). pii: e008181. doi: 10.1161/JAHA.117.008181.

24.

Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM.

Kidney Int. 2018 Jun;93(6):1308-1319. doi: 10.1016/j.kint.2017.12.012. Epub 2018 Mar 9.

PMID:
29530281
25.

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.

Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K.

Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11.

PMID:
29321668
26.

Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T.

Siedek F, Persigehl T, Mueller RU, Burst V, Benzing T, Maintz D, Haneder S.

MAGMA. 2018 Jun;31(3):367-374. doi: 10.1007/s10334-017-0658-4. Epub 2017 Oct 23.

PMID:
29063424
27.

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT.

FASEB J. 2018 Jan;32(1):208-219. doi: 10.1096/fj.201700309R. Epub 2017 Sep 6.

28.

Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease.

Franke M, Baeßler B, Vechtel J, Dafinger C, Höhne M, Borgal L, Göbel H, Koerber F, Maintz D, Benzing T, Schermer B, Persigehl T.

Kidney Int. 2017 Dec;92(6):1544-1554. doi: 10.1016/j.kint.2017.05.024. Epub 2017 Jul 26.

PMID:
28754558
29.

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

Rinschen MM, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T.

J Am Soc Nephrol. 2017 Oct;28(10):2867-2878. doi: 10.1681/ASN.2016101119. Epub 2017 Jul 19.

30.

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.

Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B.

EMBO Rep. 2017 Sep;18(9):1521-1535. doi: 10.15252/embr.201643846. Epub 2017 Jul 14.

31.

Induction therapy with rabbit antithymocyte globulin versus basiliximab after kidney transplantation: a health economic analysis from a German perspective.

Cremaschi L, von Versen R, Benzing T, Wiesener M, Zink N, Milkovich G, Paivanas T, Gallagher M, Thaiss F.

Transpl Int. 2017 Oct;30(10):1011-1019. doi: 10.1111/tri.12991. Epub 2017 Jul 24.

32.

Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer.

Bartram MP, Mishra T, Reintjes N, Fabretti F, Gharbi H, Adam AC, Göbel H, Franke M, Schermer B, Haneder S, Benzing T, Beck BB, Müller RU.

BMC Med Genet. 2017 May 12;18(1):53. doi: 10.1186/s12881-017-0416-5.

33.

YAP-mediated mechanotransduction determines the podocyte's response to damage.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165.

PMID:
28400537
34.

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations.

Ebner K, Dafinger C, Ortiz-Bruechle N, Koerber F, Schermer B, Benzing T, Dötsch J, Zerres K, Weber LT, Beck BB, Liebau MC.

Pediatr Nephrol. 2017 Jul;32(7):1269-1273. doi: 10.1007/s00467-017-3648-x. Epub 2017 Mar 31.

PMID:
28364132
35.

A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population.

Voskarides K, Stefanou C, Pieri M, Demosthenous P, Felekkis K, Arsali M, Athanasiou Y, Xydakis D, Stylianou K, Daphnis E, Goulielmos G, Loizou P, Savige J, Höhne M, Völker LA, Benzing T, Maxwell PH, Gale DP, Gorski M, Böger C, Kollerits B, Kronenberg F, Paulweber B, Zavros M, Pierides A, Deltas C.

PLoS One. 2017 Mar 23;12(3):e0174274. doi: 10.1371/journal.pone.0174274. eCollection 2017.

36.

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.

Koehler S, Brähler S, Braun F, Hagmann H, Rinschen MM, Späth MR, Höhne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT.

Kidney Int. 2017 Jun;91(6):1510-1517. doi: 10.1016/j.kint.2016.12.011. Epub 2017 Feb 7.

PMID:
28187984
37.

Burden of multimorbidity and outcome in ambulatory geriatric hemodialysis patients : Report from the QiN registry in Germany.

Röhrig G, Polidori MC, Rascher K, Schaller M, Benzing T, von Gersdorff G.

Z Gerontol Geriatr. 2018 Jan;51(1):60-66. doi: 10.1007/s00391-016-1149-3. Epub 2016 Nov 10.

PMID:
27832329
38.

Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion.

Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl MJ, Hagmann H, Höhne M, Vogt MC, Wunderlich CM, Wunderlich FT, Schweda F, Schermer B, Benzing T, Brinkkoetter PT.

Sci Rep. 2016 Oct 19;6:35400. doi: 10.1038/srep35400.

39.

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage.

Johnsen M, Späth MR, Denzel MS, Göbel H, Kubacki T, Hoyer KJ, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller RU.

PLoS One. 2016 Aug 24;11(8):e0161315. doi: 10.1371/journal.pone.0161315. eCollection 2016.

40.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Kind J, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB.

JCI Insight. 2016 Jun 16;1(9). pii: 86177. doi: 10.1172/jci.insight.86177.

41.

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation.

Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT.

Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C404-17. doi: 10.1152/ajpcell.00121.2016. Epub 2016 Jun 29.

42.

Detection of multiple annexin autoantibodies in a patient with recurrent miscarriages, fulminant stroke and seronegative antiphospholipid syndrome.

Scholz P, Auler M, Brachvogel B, Benzing T, Mallman P, Streichert T, Klatt AR.

Biochem Med (Zagreb). 2016;26(2):272-8. doi: 10.11613/BM.2016.032.

43.

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells.

Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F.

J Am Soc Nephrol. 2017 Jan;28(1):230-241. doi: 10.1681/ASN.2015111224. Epub 2016 Jun 13.

44.

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27.

45.

Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations.

Laghmani K, Beck BB, Yang SS, Seaayfan E, Wenzel A, Reusch B, Vitzthum H, Priem D, Demaretz S, Bergmann K, Duin LK, Göbel H, Mache C, Thiele H, Bartram MP, Dombret C, Altmüller J, Nürnberg P, Benzing T, Levtchenko E, Seyberth HW, Klaus G, Yigit G, Lin SH, Timmer A, de Koning TJ, Scherjon SA, Schlingmann KP, Bertrand MJ, Rinschen MM, de Backer O, Konrad M, Kömhoff M.

N Engl J Med. 2016 May 12;374(19):1853-63. doi: 10.1056/NEJMoa1507629. Epub 2016 Apr 27.

46.

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT.

Am J Pathol. 2016 May;186(5):1128-39. doi: 10.1016/j.ajpath.2015.12.018.

PMID:
27105734
47.

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.

Bartram MP, Amendola E, Benzing T, Schermer B, de Vita G, Müller RU.

BMC Mol Biol. 2016 Apr 18;17:11. doi: 10.1186/s12867-016-0064-x.

48.

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

Gandhirajan RK, Jain M, Walla B, Johnsen M, Bartram MP, Huynh Anh M, Rinschen MM, Benzing T, Schermer B.

J Biol Chem. 2016 May 27;291(22):11596-607. doi: 10.1074/jbc.M115.712539. Epub 2016 Apr 5.

49.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC.

Cell. 2016 Mar 24;165(1):125-138. doi: 10.1016/j.cell.2016.02.044.

50.

Hypertension: Testing for pre-eclampsia: paving the way to early diagnosis.

Benzing T.

Nat Rev Nephrol. 2016 Apr;12(4):200-2. doi: 10.1038/nrneph.2016.21. Epub 2016 Feb 29.

PMID:
26923207

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