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Items: 1 to 50 of 186

1.

Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.

Regula JT, Imhof-Jung S, Mølhøj M, Benz J, Ehler A, Bujotzek A, Schaefer W, Klein C.

Protein Eng Des Sel. 2018 Aug 28. doi: 10.1093/protein/gzy021. [Epub ahead of print]

PMID:
30169707
2.

Isolation, identification and characterization of lignocellulolytic aerobic and anaerobic fungi in one- and two-phase biogas plants.

Young D, Dollhofer V, Callaghan TM, Reitberger S, Lebuhn M, Benz JP.

Bioresour Technol. 2018 Nov;268:470-479. doi: 10.1016/j.biortech.2018.07.103. Epub 2018 Jul 21.

PMID:
30114666
3.

Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters.

Kumar A, Sørensen JL, Hansen FT, Arvas M, Syed MF, Hassan L, Benz JP, Record E, Henrissat B, Pöggeler S, Kempken F.

Sci Rep. 2018 Jul 5;8(1):10187. doi: 10.1038/s41598-018-28473-z.

4.

Symbiont selection via alcohol benefits fungus farming by ambrosia beetles.

Ranger CM, Biedermann PHW, Phuntumart V, Beligala GU, Ghosh S, Palmquist DE, Mueller R, Barnett J, Schultz PB, Reding ME, Benz JP.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4447-4452. doi: 10.1073/pnas.1716852115. Epub 2018 Apr 9.

5.

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W.

J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13.

PMID:
29590750
6.

Adenosine A1 Receptor-Mediated Attenuation of Reciprocal Dendro-Dendritic Inhibition in the Mouse Olfactory Bulb.

Schulz K, Rotermund N, Grzelka K, Benz J, Lohr C, Hirnet D.

Front Cell Neurosci. 2018 Jan 15;11:435. doi: 10.3389/fncel.2017.00435. eCollection 2017.

7.

Interprofessional Education and Team-Based Learning in a Research Methods Course.

Schug V, Finch-Guthrie P, Benz J.

Nurs Educ Perspect. 2018 Nov/Dec;39(6):380-382. doi: 10.1097/01.NEP.0000000000000264.

PMID:
29256995
8.

Correction to: Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes.

Benz JP, Protzko RJ, Andrich JMS, Bauer S, Dueber JE, Somerville CR.

Biotechnol Biofuels. 2017 Dec 4;10:287. doi: 10.1186/s13068-017-0955-1. eCollection 2017.

9.

Comparing the physiochemical parameters of three celluloses reveals new insights into substrate suitability for fungal enzyme production.

Hassan L, Reppke MJ, Thieme N, Schweizer SA, Mueller CW, Benz JP.

Fungal Biol Biotechnol. 2017 Nov 3;4:10. doi: 10.1186/s40694-017-0039-9. eCollection 2017.

10.

HPAEC-PAD for oligosaccharide analysis-novel insights into analyte sensitivity and response stability.

Mechelke M, Herlet J, Benz JP, Schwarz WH, Zverlov VV, Liebl W, Kornberger P.

Anal Bioanal Chem. 2017 Dec;409(30):7169-7181. doi: 10.1007/s00216-017-0678-y. Epub 2017 Oct 12.

PMID:
29026979
11.

Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products.

Kuglstatter A, Stihle M, Neumann C, Müller C, Schaefer W, Klein C, Benz J; Roche Pharmaceutical Research and Early Development.

Protein Eng Des Sel. 2017 Sep 1;30(9):649-656. doi: 10.1093/protein/gzx041.

PMID:
28985438
12.

Network reconstruction and systems analysis of plant cell wall deconstruction by Neurospora crassa.

Samal A, Craig JP, Coradetti ST, Benz JP, Eddy JA, Price ND, Glass NL.

Biotechnol Biofuels. 2017 Sep 21;10:225. doi: 10.1186/s13068-017-0901-2. eCollection 2017.

13.

Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target.

Lyamichev VI, Goodrich LE, Sullivan EH, Bannen RM, Benz J, Albert TJ, Patel JJ.

Sci Rep. 2017 Sep 21;7(1):12116. doi: 10.1038/s41598-017-12440-1.

14.

Obesity in America.

Rosenthal RJ, Morton J, Brethauer S, Mattar S, De Maria E, Benz JK, Titus J, Sterrett D.

Surg Obes Relat Dis. 2017 Oct;13(10):1643-1650. doi: 10.1016/j.soard.2017.08.002. Epub 2017 Aug 12.

PMID:
28935198
15.

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.

Ruderisch N, Schlatter D, Kuglstatter A, Guba W, Huber S, Cusulin C, Benz J, Rufer AC, Hoernschemeyer J, Schweitzer C, Bülau T, Gärtner A, Hoffmann E, Niewoehner J, Patsch C, Baumann K, Loetscher H, Kitas E, Freskgård PO.

EBioMedicine. 2017 Oct;24:76-92. doi: 10.1016/j.ebiom.2017.09.004. Epub 2017 Sep 7.

16.

Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins.

Steffen W, Ko FC, Patel J, Lyamichev V, Albert TJ, Benz J, Rudolph MG, Bergmann F, Streidl T, Kratzsch P, Boenitz-Dulat M, Oelschlaegel T, Schraeml M.

J Biol Chem. 2017 Sep 22;292(38):15622-15635. doi: 10.1074/jbc.M117.797811. Epub 2017 Jul 27.

17.

The transcription factor PDR-1 is a multi-functional regulator and key component of pectin deconstruction and catabolism in Neurospora crassa.

Thieme N, Wu VW, Dietschmann A, Salamov AA, Wang M, Johnson J, Singan VR, Grigoriev IV, Glass NL, Somerville CR, Benz JP.

Biotechnol Biofuels. 2017 Jun 12;10:149. doi: 10.1186/s13068-017-0807-z. eCollection 2017.

18.

Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.

Klein C, Waldhauer I, Nicolini VG, Freimoser-Grundschober A, Nayak T, Vugts DJ, Dunn C, Bolijn M, Benz J, Stihle M, Lang S, Roemmele M, Hofer T, van Puijenbroek E, Wittig D, Moser S, Ast O, Brünker P, Gorr IH, Neumann S, de Vera Mudry MC, Hinton H, Crameri F, Saro J, Evers S, Gerdes C, Bacac M, van Dongen G, Moessner E, Umaña P.

Oncoimmunology. 2017 Jan 11;6(3):e1277306. doi: 10.1080/2162402X.2016.1277306. eCollection 2017.

19.

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.

Kuhn B, Tichý M, Wang L, Robinson S, Martin RE, Kuglstatter A, Benz J, Giroud M, Schirmeister T, Abel R, Diederich F, Hert J.

J Med Chem. 2017 Mar 23;60(6):2485-2497. doi: 10.1021/acs.jmedchem.6b01881. Epub 2017 Mar 13.

PMID:
28287264
20.

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody.

Favuzza P, Guffart E, Tamborrini M, Scherer B, Dreyer AM, Rufer AC, Erny J, Hoernschemeyer J, Thoma R, Schmid G, Gsell B, Lamelas A, Benz J, Joseph C, Matile H, Pluschke G, Rudolph MG.

Elife. 2017 Feb 14;6. pii: e20383. doi: 10.7554/eLife.20383.

21.

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide⋅⋅⋅Heteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.

Giroud M, Ivkovic J, Martignoni M, Fleuti M, Trapp N, Haap W, Kuglstatter A, Benz J, Kuhn B, Schirmeister T, Diederich F.

ChemMedChem. 2017 Feb 3;12(3):257-270. doi: 10.1002/cmdc.201600563. Epub 2017 Jan 12.

PMID:
27992115
22.

Social Resources and Community Resilience in the Wake of Superstorm Sandy.

Cagney KA, Sterrett D, Benz J, Tompson T.

PLoS One. 2016 Aug 31;11(8):e0160824. doi: 10.1371/journal.pone.0160824. eCollection 2016.

23.

Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.

Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, Debulpaep M, Fry D, Huber W, Kremer T, Laeremans T, Matile H, Ross A, Rufer AC, Schoch G, Steinmetz MO, Steyaert J, Rudolph MG, Thoma R, Ruf A.

J Biol Chem. 2016 Jul 29;291(31):16292-306. doi: 10.1074/jbc.M116.726547. Epub 2016 May 10.

24.

VH-VL orientation prediction for antibody humanization candidate selection: A case study.

Bujotzek A, Lipsmeier F, Harris SF, Benz J, Kuglstatter A, Georges G.

MAbs. 2016;8(2):288-305. doi: 10.1080/19420862.2015.1117720.

25.

De Novo Assembly and Genome Analyses of the Marine-Derived Scopulariopsis brevicaulis Strain LF580 Unravels Life-Style Traits and Anticancerous Scopularide Biosynthetic Gene Cluster.

Kumar A, Henrissat B, Arvas M, Syed MF, Thieme N, Benz JP, Sørensen JL, Record E, Pöggeler S, Kempken F.

PLoS One. 2015 Oct 27;10(10):e0140398. doi: 10.1371/journal.pone.0140398. eCollection 2015.

26.

MoFvAb: Modeling the Fv region of antibodies.

Bujotzek A, Fuchs A, Qu C, Benz J, Klostermann S, Antes I, Georges G.

MAbs. 2015;7(5):838-52. doi: 10.1080/19420862.2015.1068492.

27.

Genome-wide analysis of the endoplasmic reticulum stress response during lignocellulase production in Neurospora crassa.

Fan F, Ma G, Li J, Liu Q, Benz JP, Tian C, Ma Y.

Biotechnol Biofuels. 2015 Apr 14;8:66. doi: 10.1186/s13068-015-0248-5. eCollection 2015.

28.

Functional Analysis of Two l-Arabinose Transporters from Filamentous Fungi Reveals Promising Characteristics for Improved Pentose Utilization in Saccharomyces cerevisiae.

Li J, Xu J, Cai P, Wang B, Ma Y, Benz JP, Tian C.

Appl Environ Microbiol. 2015 Jun 15;81(12):4062-70. doi: 10.1128/AEM.00165-15. Epub 2015 Apr 3.

29.

Deletion of the Sm1 encoding motif in the lsm gene results in distinct changes in the transcriptome and enhanced swarming activity of Haloferax cells.

Maier LK, Benz J, Fischer S, Alstetter M, Jaschinski K, Hilker R, Becker A, Allers T, Soppa J, Marchfelder A.

Biochimie. 2015 Oct;117:129-37. doi: 10.1016/j.biochi.2015.02.023. Epub 2015 Mar 6.

30.

Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.

Dengl S, Hoffmann E, Grote M, Wagner C, Mundigl O, Georges G, Thorey I, Stubenrauch KG, Bujotzek A, Josel HP, Dziadek S, Benz J, Brinkmann U.

FASEB J. 2015 May;29(5):1763-79. doi: 10.1096/fj.14-263665. Epub 2015 Feb 10.

31.

Avera McKennan finds innovative strategies to address orthopedic pain management.

Benz J.

OR Manager. 2014 Dec;30(12):22-4. No abstract available.

PMID:
25585452
32.

Mapping the conformational space accessible to catechol-O-methyltransferase.

Ehler A, Benz J, Schlatter D, Rudolph MG.

Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2163-74. doi: 10.1107/S1399004714012917. Epub 2014 Jul 25.

33.

Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.

Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey-Giraud F, Pradel LP, Feuerhake F, Klaman I, Jones T, Jucknischke U, Scheiblich S, Kaluza K, Gorr IH, Walz A, Abiraj K, Cassier PA, Sica A, Gomez-Roca C, de Visser KE, Italiano A, Le Tourneau C, Delord JP, Levitsky H, Blay JY, Rüttinger D.

Cancer Cell. 2014 Jun 16;25(6):846-59. doi: 10.1016/j.ccr.2014.05.016. Epub 2014 Jun 2.

34.

Generation and phenotyping of a collection of sRNA gene deletion mutants of the haloarchaeon Haloferax volcanii.

Jaschinski K, Babski J, Lehr M, Burmester A, Benz J, Heyer R, Dörr M, Marchfelder A, Soppa J.

PLoS One. 2014 Mar 17;9(3):e90763. doi: 10.1371/journal.pone.0090763. eCollection 2014.

35.

Antibacterial effector/immunity systems: it's just the tip of the iceberg.

Benz J, Meinhart A.

Curr Opin Microbiol. 2014 Feb;17:1-10. doi: 10.1016/j.mib.2013.11.002. Epub 2013 Dec 8. Review.

36.

Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes.

Benz JP, Protzko RJ, Andrich JM, Bauer S, Dueber JE, Somerville CR.

Biotechnol Biofuels. 2014 Feb 6;7(1):20. doi: 10.1186/1754-6834-7-20. Erratum in: Biotechnol Biofuels. 2017 Dec 4;10 :287.

37.

Preventing Maltreatment with a Community-Based Implementation of Parent-Child Interaction Therapy.

Lanier P, Kohl PL, Benz J, Swinger D, Drake B.

J Child Fam Stud. 2014 Feb 1;23(2):449-460.

38.

A comparative systems analysis of polysaccharide-elicited responses in Neurospora crassa reveals carbon source-specific cellular adaptations.

Benz JP, Chau BH, Zheng D, Bauer S, Glass NL, Somerville CR.

Mol Microbiol. 2014 Jan;91(2):275-99. doi: 10.1111/mmi.12459. Epub 2013 Dec 4.

39.

Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.

Hilpert H, Mauser H, Humm R, Anselm L, Kuehne H, Hartmann G, Gruener S, Banner DW, Benz J, Gsell B, Kuglstatter A, Stihle M, Thoma R, Sanchez RA, Iding H, Wirz B, Haap W.

J Med Chem. 2013 Dec 12;56(23):9789-801. doi: 10.1021/jm401528k. Epub 2013 Nov 22.

PMID:
24224654
40.

Determination of protein-ligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry.

Cubrilovic D, Haap W, Barylyuk K, Ruf A, Badertscher M, Gubler M, Tetaz T, Joseph C, Benz J, Zenobi R.

ACS Chem Biol. 2014 Jan 17;9(1):218-26. doi: 10.1021/cb4007002. Epub 2013 Nov 6.

PMID:
24128068
41.

The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans.

Kuhn B, Benz J, Greif M, Engel AM, Sobek H, Rudolph MG.

Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1826-38. doi: 10.1107/S0907444913015412. Epub 2013 Aug 17.

PMID:
23999306
42.

Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium.

Benz J, Reinstein J, Meinhart A.

PLoS One. 2013 Jun 27;8(6):e67362. doi: 10.1371/journal.pone.0067362. Print 2013.

43.

BACE1 inhibitors: a head group scan on a series of amides.

Woltering TJ, Wostl W, Hilpert H, Rogers-Evans M, Pinard E, Mayweg A, Göbel M, Banner DW, Benz J, Travagli M, Pollastrini M, Marconi G, Gabellieri E, Guba W, Mauser H, Andreini M, Jacobsen H, Power E, Narquizian R.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4239-43. doi: 10.1016/j.bmcl.2013.05.003. Epub 2013 May 18.

PMID:
23735744
44.

Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.

Banner DW, Gsell B, Benz J, Bertschinger J, Burger D, Brack S, Cuppuleri S, Debulpaep M, Gast A, Grabulovski D, Hennig M, Hilpert H, Huber W, Kuglstatter A, Kusznir E, Laeremans T, Matile H, Miscenic C, Rufer AC, Schlatter D, Steyaert J, Stihle M, Thoma R, Weber M, Ruf A.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1124-37. doi: 10.1107/S0907444913006574. Epub 2013 May 15.

PMID:
23695257
45.

The healthy people initiative: understanding the user's perspective.

Benz J, Blakey C, Oppenheimer CC, Scherer H, Robinson WT.

J Public Health Manag Pract. 2013 Mar-Apr;19(2):103-9. doi: 10.1097/PHH.0b013e318254cc31.

PMID:
23358287
46.

Structure of gentlyase, the neutral metalloprotease of Paenibacillus polymyxa.

Ruf A, Stihle M, Benz J, Schmidt M, Sobek H.

Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):24-31. doi: 10.1107/S0907444912041169. Epub 2012 Dec 20.

47.

Structural insights into the effector-immunity system Tse1/Tsi1 from Pseudomonas aeruginosa.

Benz J, Sendlmeier C, Barends TR, Meinhart A.

PLoS One. 2012;7(7):e40453. doi: 10.1371/journal.pone.0040453. Epub 2012 Jul 6.

48.

Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.

Dawson RJ, Benz J, Stohler P, Tetaz T, Joseph C, Huber S, Schmid G, Hügin D, Pflimlin P, Trube G, Rudolph MG, Hennig M, Ruf A.

Nat Commun. 2012 Jul 3;3:936. doi: 10.1038/ncomms1917.

PMID:
22760635
49.

Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain.

Schlatter D, Brack S, Banner DW, Batey S, Benz J, Bertschinger J, Huber W, Joseph C, Rufer A, van der Klooster A, Weber M, Grabulovski D, Hennig M.

MAbs. 2012 Jul-Aug;4(4):497-508. doi: 10.4161/mabs.20452. Epub 2012 Jul 1.

50.

Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors.

Dietz M, Mohr P, Kuhn B, Maerki HP, Hartman P, Ruf A, Benz J, Grether U, Wright MB.

ChemMedChem. 2012 Jun;7(6):1101-11. doi: 10.1002/cmdc.201100598. Epub 2012 Apr 4.

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