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Items: 1 to 50 of 58

1.

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis.

Pellicoro A, Aucott RL, Ramachandran P, Robson AJ, Fallowfield JA, Snowdon VK, Hartland SN, Vernon M, Duffield JS, Benyon RC, Forbes SJ, Iredale JP.

Hepatology. 2012 Jun;55(6):1965-75. doi: 10.1002/hep.25567. Epub 2012 Apr 18.

PMID:
22223197
2.

Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation.

Fowell AJ, Collins JE, Duncombe DR, Pickering JA, Rosenberg WM, Benyon RC.

Biochem Biophys Res Commun. 2011 Apr 8;407(2):277-82. doi: 10.1016/j.bbrc.2011.02.009. Epub 2011 Feb 15.

PMID:
21300026
3.

Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin.

Hartland SN, Murphy F, Aucott RL, Abergel A, Zhou X, Waung J, Patel N, Bradshaw C, Collins J, Mann D, Benyon RC, Iredale JP.

Liver Int. 2009 Aug;29(7):966-78. doi: 10.1111/j.1478-3231.2009.02070.x.

PMID:
19580633
4.

p75 Neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis.

Kendall TJ, Hennedige S, Aucott RL, Hartland SN, Vernon MA, Benyon RC, Iredale JP.

Hepatology. 2009 Mar;49(3):901-10. doi: 10.1002/hep.22701.

PMID:
19072833
5.

The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation.

Conti JA, Kendall TJ, Bateman A, Armstrong TA, Papa-Adams A, Xu Q, Packham G, Primrose JN, Benyon RC, Iredale JP.

Clin Cancer Res. 2008 Oct 15;14(20):6405-13. doi: 10.1158/1078-0432.CCR-08-0816.

6.

Can matrix metalloproteinases be targeted in hepatic ischemia/reperfusion injury?

Fowell AJ, Benyon RC.

Hepatology. 2008 Jan;47(1):14-6. No abstract available.

PMID:
18161726
7.

Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis.

Fallowfield JA, Mizuno M, Kendall TJ, Constandinou CM, Benyon RC, Duffield JS, Iredale JP.

J Immunol. 2007 Apr 15;178(8):5288-95.

8.

Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis.

Zhou X, Jamil A, Nash A, Chan J, Trim N, Iredale JP, Benyon RC.

J Biol Chem. 2006 Dec 29;281(52):39757-65. Epub 2006 Oct 23.

9.

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

Armstrong T, Packham G, Murphy LB, Bateman AC, Conti JA, Fine DR, Johnson CD, Benyon RC, Iredale JP.

Clin Cancer Res. 2004 Nov 1;10(21):7427-37.

10.

Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis.

Zhou X, Hovell CJ, Pawley S, Hutchings MI, Arthur MJ, Iredale JP, Benyon RC.

Liver Int. 2004 Oct;24(5):492-501.

PMID:
15482348
11.

Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking.

Issa R, Zhou X, Constandinou CM, Fallowfield J, Millward-Sadler H, Gaca MD, Sands E, Suliman I, Trim N, Knorr A, Arthur MJ, Benyon RC, Iredale JP.

Gastroenterology. 2004 Jun;126(7):1795-808.

PMID:
15188175
12.

How can transforming growth factor beta be targeted usefully to combat liver fibrosis?

Shek FW, Benyon RC.

Eur J Gastroenterol Hepatol. 2004 Feb;16(2):123-6.

PMID:
15075983
13.

Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells.

Zhou X, Murphy FR, Gehdu N, Zhang J, Iredale JP, Benyon RC.

J Biol Chem. 2004 Jun 4;279(23):23996-4006. Epub 2004 Mar 24.

14.

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1.

Murphy F, Waung J, Collins J, Arthur MJ, Nagase H, Mann D, Benyon RC, Iredale JP.

Comp Hepatol. 2004 Jan 14;3 Suppl 1:S8.

15.

Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis.

Oakley F, Trim N, Constandinou CM, Ye W, Gray AM, Frantz G, Hillan K, Kendall T, Benyon RC, Mann DA, Iredale JP.

Am J Pathol. 2003 Nov;163(5):1849-58.

16.
17.

What can be learned about the fibrosis of asthma from rodent models?

Lackie PM, Benyon RC.

Clin Exp Allergy. 2003 May;33(5):546-9. No abstract available.

PMID:
12752580
18.

The heterogeneity of mast cell tryptase from human lung and skin.

Peng Q, McEuen AR, Benyon RC, Walls AF.

Eur J Biochem. 2003 Jan;270(2):270-83.

19.

Matrix metalloproteinase-2 from bronchial epithelial cells induces the proliferation of subepithelial fibroblasts.

Xu J, Benyon RC, Leir SH, Zhang S, Holgate ST, Lackie PM.

Clin Exp Allergy. 2002 Jun;32(6):881-8.

PMID:
12047435
20.

Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis.

Shek FW, Benyon RC, Walker FM, McCrudden PR, Pender SL, Williams EJ, Johnson PA, Johnson CD, Bateman AC, Fine DR, Iredale JP.

Am J Pathol. 2002 May;160(5):1787-98.

21.
22.

Extracellular matrix degradation and the role of hepatic stellate cells.

Benyon RC, Arthur MJ.

Semin Liver Dis. 2001 Aug;21(3):373-84. Review.

PMID:
11586466
23.

Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo.

Williams EJ, Benyon RC, Trim N, Hadwin R, Grove BH, Arthur MJ, Unemori EN, Iredale JP.

Gut. 2001 Oct;49(4):577-83.

24.

Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors.

Issa R, Williams E, Trim N, Kendall T, Arthur MJ, Reichen J, Benyon RC, Iredale JP.

Gut. 2001 Apr;48(4):548-57.

25.

Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells.

Williams EJ, Gaça MD, Brigstock DR, Arthur MJ, Benyon RC.

J Hepatol. 2000 May;32(5):754-61.

PMID:
10845662
26.

Is liver fibrosis reversible?

Benyon RC, Iredale JP.

Gut. 2000 Apr;46(4):443-6. Review. No abstract available.

27.

Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation.

Benyon RC, Hovell CJ, Da Gaça M, Jones EH, Iredale JP, Arthur MJ.

Hepatology. 1999 Oct;30(4):977-86.

PMID:
10498650
28.
29.

Mast cells in the liver.

Benyon RC.

Clin Exp Allergy. 1999 Feb;29(2):155-8. Review. No abstract available.

PMID:
10051717
30.

Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins.

Bahr MJ, Vincent KJ, Arthur MJ, Fowler AV, Smart DE, Wright MC, Clark IM, Benyon RC, Iredale JP, Mann DA.

Hepatology. 1999 Mar;29(3):839-48.

PMID:
10051488
31.

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJ.

J Clin Invest. 1998 Aug 1;102(3):538-49.

32.

Mechanisms of hepatic fibrosis.

Benyon RC, Arthur MJ.

J Pediatr Gastroenterol Nutr. 1998 Jul;27(1):75-85. Review. No abstract available.

PMID:
9669730
33.

The plasminogen-activating system in hepatic stellate cells.

Leyland H, Gentry J, Arthur MJ, Benyon RC.

Hepatology. 1996 Nov;24(5):1172-8.

PMID:
8903394
34.

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis.

Iredale JP, Benyon RC, Arthur MJ, Ferris WF, Alcolado R, Winwood PJ, Clark N, Murphy G.

Hepatology. 1996 Jul;24(1):176-84.

PMID:
8707259
35.

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver.

Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJ.

Gastroenterology. 1996 Mar;110(3):821-31.

PMID:
8608892
36.
37.

In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin.

Okayama Y, Benyon RC, Lowman MA, Church MK.

Allergy. 1994 Apr;49(4):246-53.

PMID:
7518654
38.
39.

Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestine.

Okayama Y, Benyon RC, Rees PH, Lowman MA, Hillier K, Church MK.

Clin Exp Allergy. 1992 Mar;22(3):401-9.

PMID:
1375128
40.

Tumor necrosis factor-alpha dependent cytotoxicity of human skin mast cells is enhanced by anti-IgE antibodies.

Benyon RC, Bissonnette EY, Befus AD.

J Immunol. 1991 Oct 1;147(7):2253-8.

PMID:
1918961
41.

Mast cell heterogeneity: protein composition, biosynthesis and mRNA characterization.

Benyon RC, Imai T, Abe T, Befus D.

Int Arch Allergy Appl Immunol. 1991;94(1-4):218-9.

PMID:
1937877
42.

The human skin mast cell.

Benyon RC.

Clin Exp Allergy. 1989 Jul;19(4):375-87. Review.

PMID:
2667702
44.

Mast cells, neuropeptides and inflammation.

Church MK, Lowman MA, Rees PH, Benyon RC.

Agents Actions. 1989 Apr;27(1-2):8-16. Review. No abstract available.

PMID:
2473641
45.

Activation of human mast cells after immunoglobulin E-dependent and neuropeptide stimulation.

Holgate ST, Benyon RC, Lowman MA, Church MK.

Prog Clin Biol Res. 1989;297:103-12; discussion 112-3. Review. No abstract available.

PMID:
2685815
46.

Allergy or inflammation? From neuropeptide stimulation of human skin mast cells to studies on the mechanism of the late asthmatic response.

Church MK, Benyon RC, Lowman MA, Hutson PA, Holgate ST.

Agents Actions. 1989 Jan;26(1-2):22-30. Review.

PMID:
2653005
47.

Interaction of neuropeptides with human mast cells.

Church MK, Lowman MA, Robinson C, Holgate ST, Benyon RC.

Int Arch Allergy Appl Immunol. 1989;88(1-2):70-8. Review.

PMID:
2468622
48.
49.

IgE-dependent activation of human lung mast cells is not associated with increased phospholipid methylation.

Benyon RC, Church MK, Holgate ST.

J Immunol. 1988 Aug 1;141(3):954-60.

PMID:
2456337
50.

The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells.

Robinson C, Benyon RC, Agius RM, Jones DB, Wright DH, Holgate ST.

J Invest Dermatol. 1988 Mar;90(3):359-65.

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