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Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis.

Yang W, Gibson SA, Yan Z, Wei H, Tao J, Sha B, Qin H, Benveniste EN.

Mucosal Immunol. 2020 Jan 27. doi: 10.1038/s41385-020-0258-x. [Epub ahead of print]


Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.

Kalinin S, Meares GP, Lin SX, Pietruczyk EA, Saher G, Spieth L, Nave KA, Boullerne AI, Lutz SE, Benveniste EN, Feinstein DL.

Glia. 2020 Mar;68(3):600-616. doi: 10.1002/glia.23742. Epub 2019 Oct 30.


Reactive astrocytes foster brain metastases via STAT3 signaling.

McFarland BC, Benveniste EN.

Ann Transl Med. 2019 Jul;7(Suppl 3):S83. doi: 10.21037/atm.2019.04.17. No abstract available.


Tissue-Resident Macrophages Promote Renal Cystic Disease.

Zimmerman KA, Song CJ, Li Z, Lever JM, Crossman DK, Rains A, Aloria EJ, Gonzalez NM, Bassler JR, Zhou J, Crowley MR, Revell DZ, Yan Z, Shan D, Benveniste EN, George JF, Mrug M, Yoder BK.

J Am Soc Nephrol. 2019 Oct;30(10):1841-1856. doi: 10.1681/ASN.2018080810. Epub 2019 Jul 23.


Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production.

Yan Z, Yang W, Parkitny L, Gibson SA, Lee KS, Collins F, Deshane JS, Cheng W, Weinmann AS, Wei H, Qin H, Benveniste EN.

JCI Insight. 2019 Apr 2;5. pii: 126520. doi: 10.1172/jci.insight.126520.


CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1.

Gibson SA, Yang W, Yan Z, Qin H, Benveniste EN.

J Immunol. 2018 Jul 15;201(2):383-392. doi: 10.4049/jimmunol.1701592. Epub 2018 Jun 11.


MicroRNA-31 is required for astrocyte specification.

Meares GP, Rajbhandari R, Gerigk M, Tien CL, Chang C, Fehling SC, Rowse A, Mulhern KC, Nair S, Gray GK, Berbari NF, Bredel M, Benveniste EN, Nozell SE.

Glia. 2018 May;66(5):987-998. doi: 10.1002/glia.23296. Epub 2018 Jan 30.


Protein Kinase CK2: An Emerging Regulator of Immunity.

Gibson SA, Benveniste EN.

Trends Immunol. 2018 Feb;39(2):82-85. doi: 10.1016/ Epub 2018 Jan 4.


Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease.

Harms AS, Thome AD, Yan Z, Schonhoff AM, Williams GP, Li X, Liu Y, Qin H, Benveniste EN, Standaert DG.

Exp Neurol. 2018 Feb;300:179-187. doi: 10.1016/j.expneurol.2017.11.010. Epub 2017 Nov 16.


Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.

Gibson SA, Yang W, Yan Z, Liu Y, Rowse AL, Weinmann AS, Qin H, Benveniste EN.

J Immunol. 2017 Jun 1;198(11):4244-4254. doi: 10.4049/jimmunol.1601912. Epub 2017 May 3.


Speaking out about gender imbalance in invited speakers improves diversity.

Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH.

Nat Immunol. 2017 Apr 18;18(5):475-478. doi: 10.1038/ni.3707. No abstract available.


Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells.

Rowse AL, Gibson SA, Meares GP, Rajbhandari R, Nozell SE, Dees KJ, Hjelmeland AB, McFarland BC, Benveniste EN.

J Neurooncol. 2017 Apr;132(2):219-229. doi: 10.1007/s11060-017-2378-z. Epub 2017 Feb 8.


Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo.

Lai YJ, Tsai JC, Tseng YT, Wu MS, Liu WS, Lam HI, Yu JH, Nozell SE, Benveniste EN.

Oncotarget. 2017 Mar 14;8(11):18031-18049. doi: 10.18632/oncotarget.14949.


Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury.

Zhao J, Yu H, Liu Y, Gibson SA, Yan Z, Xu X, Gaggar A, Li PK, Li C, Wei S, Benveniste EN, Qin H.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L868-L880. doi: 10.1152/ajplung.00281.2016. Epub 2016 Sep 16.


Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases.

Yan Z, Gibson SA, Buckley JA, Qin H, Benveniste EN.

Clin Immunol. 2018 Apr;189:4-13. doi: 10.1016/j.clim.2016.09.014. Epub 2016 Oct 3. Review.


Mitochondrial STAT3 is negatively regulated by SOCS3 and upregulated after spinal cord injury.

Park KW, Lin CY, Benveniste EN, Lee YS.

Exp Neurol. 2016 Oct;284(Pt A):98-105. doi: 10.1016/j.expneurol.2016.08.002. Epub 2016 Aug 5.


Correction: SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation.

Qin H, Holdbrooks AT, Liu Y, Reynolds SL, Yanagisawa LL, Benveniste EN.

J Immunol. 2016 Jul 1;197(1):387-9. doi: 10.4049/jimmunol.1600710. No abstract available.


Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses.

Guthrie LN, Abiraman K, Plyler ES, Sprenkle NT, Gibson SA, McFarland BC, Rajbhandari R, Rowse AL, Benveniste EN, Meares GP.

J Biol Chem. 2016 Jul 22;291(30):15830-40. doi: 10.1074/jbc.M116.738021. Epub 2016 May 23.


Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration.

Qin H, Buckley JA, Li X, Liu Y, Fox TH 3rd, Meares GP, Yu H, Yan Z, Harms AS, Li Y, Standaert DG, Benveniste EN.

J Neurosci. 2016 May 4;36(18):5144-59. doi: 10.1523/JNEUROSCI.4658-15.2016.


Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma.

McFarland BC, Marks MP, Rowse AL, Fehling SC, Gerigk M, Qin H, Benveniste EN.

Oncotarget. 2016 Apr 12;7(15):20621-35. doi: 10.18632/oncotarget.7992.


Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma.

Rajbhandari R, McFarland BC, Patel A, Gerigk M, Gray GK, Fehling SC, Bredel M, Berbari NF, Kim H, Marks MP, Meares GP, Sinha T, Chuang J, Benveniste EN, Nozell SE.

Oncotarget. 2015 Jul 10;6(19):17805-16.


Preferential Recruitment of Neutrophils into the Cerebellum and Brainstem Contributes to the Atypical Experimental Autoimmune Encephalomyelitis Phenotype.

Liu Y, Holdbrooks AT, Meares GP, Buckley JA, Benveniste EN, Qin H.

J Immunol. 2015 Aug 1;195(3):841-52. doi: 10.4049/jimmunol.1403063. Epub 2015 Jun 17.


SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells.

Yu H, Liu Y, McFarland BC, Deshane JS, Hurst DR, Ponnazhagan S, Benveniste EN, Qin H.

Cancer Immunol Res. 2015 Jul;3(7):727-40. doi: 10.1158/2326-6066.CIR-15-0004. Epub 2015 Feb 3.


IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.

Basu R, Whitley SK, Bhaumik S, Zindl CL, Schoeb TR, Benveniste EN, Pear WS, Hatton RD, Weaver CT.

Nat Immunol. 2015 Mar;16(3):286-95. doi: 10.1038/ni.3099. Epub 2015 Feb 2.


Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases.

Liu Y, Gibson SA, Benveniste EN, Qin H.

Crit Rev Immunol. 2015;35(6):505-27. doi: 10.1615/CritRevImmunol.2016015517. Review.


NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age.

Gray GK, McFarland BC, Nozell SE, Benveniste EN.

Expert Rev Neurother. 2014 Nov;14(11):1293-306. doi: 10.1586/14737175.2014.964211. Epub 2014 Sep 29. Review.


Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells.

Gray GK, McFarland BC, Rowse AL, Gibson SA, Benveniste EN.

Oncotarget. 2014 Aug 15;5(15):6484-96.


PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.

Meares GP, Liu Y, Rajbhandari R, Qin H, Nozell SE, Mobley JA, Corbett JA, Benveniste EN.

Mol Cell Biol. 2014 Oct;34(20):3911-25. doi: 10.1128/MCB.00980-14. Epub 2014 Aug 11.


Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.

Liu Y, Holdbrooks AT, De Sarno P, Rowse AL, Yanagisawa LL, McFarland BC, Harrington LE, Raman C, Sabbaj S, Benveniste EN, Qin H.

J Immunol. 2014 Jan 1;192(1):59-72. doi: 10.4049/jimmunol.1301513. Epub 2013 Dec 9.


NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.

McFarland BC, Hong SW, Rajbhandari R, Twitty GB Jr, Gray GK, Yu H, Benveniste EN, Nozell SE.

PLoS One. 2013 Nov 11;8(11):e78728. doi: 10.1371/journal.pone.0078728. eCollection 2013.


Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.

Zheng Y, McFarland BC, Drygin D, Yu H, Bellis SL, Kim H, Bredel M, Benveniste EN.

Clin Cancer Res. 2013 Dec 1;19(23):6484-94. doi: 10.1158/1078-0432.CCR-13-0265. Epub 2013 Sep 13.


Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells.

McFarland BC, Gray GK, Nozell SE, Hong SW, Benveniste EN.

Mol Cancer Res. 2013 May;11(5):494-505. doi: 10.1158/1541-7786.MCR-12-0528. Epub 2013 Feb 5.


Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3.

Park KW, Nozell SE, Benveniste EN.

PLoS One. 2012;7(11):e50874. doi: 10.1371/journal.pone.0050874. Epub 2012 Nov 30.


AMP-activated protein kinase restricts IFN-γ signaling.

Meares GP, Qin H, Liu Y, Holdbrooks AT, Benveniste EN.

J Immunol. 2013 Jan 1;190(1):372-80. doi: 10.4049/jimmunol.1202390. Epub 2012 Nov 23.


SOCS3 deficiency promotes M1 macrophage polarization and inflammation.

Qin H, Holdbrooks AT, Liu Y, Reynolds SL, Yanagisawa LL, Benveniste EN.

J Immunol. 2012 Oct 1;189(7):3439-48. Epub 2012 Aug 27. Erratum in: J Immunol. 2016 Jul 1;197(1):387-9.


Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation.

Qin H, Yeh WI, De Sarno P, Holdbrooks AT, Liu Y, Muldowney MT, Reynolds SL, Yanagisawa LL, Fox TH 3rd, Park K, Harrington LE, Raman C, Benveniste EN.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5004-9. doi: 10.1073/pnas.1117218109. Epub 2012 Mar 12.


Regulation of CCL20 expression in astrocytes by IL-6 and IL-17.

Meares GP, Ma X, Qin H, Benveniste EN.

Glia. 2012 May;60(5):771-81. doi: 10.1002/glia.22307. Epub 2012 Feb 8.


ELISA methodology to quantify astrocyte production of cytokines/chemokines in vitro.

Qin H, Benveniste EN.

Methods Mol Biol. 2012;814:235-49. doi: 10.1007/978-1-61779-452-0_16.


Therapeutic potential of AZD1480 for the treatment of human glioblastoma.

McFarland BC, Ma JY, Langford CP, Gillespie GY, Yu H, Zheng Y, Nozell SE, Huszar D, Benveniste EN.

Mol Cancer Ther. 2011 Dec;10(12):2384-93. doi: 10.1158/1535-7163.MCT-11-0480. Epub 2011 Oct 25.


Loss of the promyelocytic leukemia protein in gastric cancer: implications for IP-10 expression and tumor-infiltrating lymphocytes.

Kim HJ, Song DE, Lim SY, Lee SH, Kang JL, Lee SJ, Benveniste EN, Choi YH.

PLoS One. 2011;6(10):e26264. doi: 10.1371/journal.pone.0026264. Epub 2011 Oct 12.


IRE1-dependent activation of AMPK in response to nitric oxide.

Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA.

Mol Cell Biol. 2011 Nov;31(21):4286-97. doi: 10.1128/MCB.05668-11. Epub 2011 Sep 6.


Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production.

Feng T, Qin H, Wang L, Benveniste EN, Elson CO, Cong Y.

J Immunol. 2011 Jun 1;186(11):6313-8. doi: 10.4049/jimmunol.1001454. Epub 2011 Apr 29.


A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway.

Zheng Y, Qin H, Frank SJ, Deng L, Litchfield DW, Tefferi A, Pardanani A, Lin FT, Li J, Sha B, Benveniste EN.

Blood. 2011 Jul 7;118(1):156-66. doi: 10.1182/blood-2010-01-266320. Epub 2011 Apr 28.


An NF-κB p65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas.

Zhao X, Laver T, Hong SW, Twitty GB Jr, Devos A, Devos M, Benveniste EN, Nozell SE.

J Neurooncol. 2011 May;102(3):367-81. doi: 10.1007/s11060-010-0346-y. Epub 2011 Jan 30.


Viral exploitation of host SOCS protein functions.

Akhtar LN, Benveniste EN.

J Virol. 2011 Mar;85(5):1912-21. doi: 10.1128/JVI.01857-10. Epub 2010 Nov 17. Review.


Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid.

Feng T, Cong Y, Qin H, Benveniste EN, Elson CO.

J Immunol. 2010 Nov 15;185(10):5915-25. doi: 10.4049/jimmunol.1001233. Epub 2010 Oct 13.


The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.

Lai YJ, Lin VT, Zheng Y, Benveniste EN, Lin FT.

Mol Cell Biol. 2010 Dec;30(23):5582-96. doi: 10.1128/MCB.00134-10. Epub 2010 Sep 27.


Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages.

Akhtar LN, Qin H, Muldowney MT, Yanagisawa LL, Kutsch O, Clements JE, Benveniste EN.

J Immunol. 2010 Aug 15;185(4):2393-404. doi: 10.4049/jimmunol.0903563. Epub 2010 Jul 14.


IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia.

Baker BJ, Park KW, Qin H, Ma X, Benveniste EN.

Glia. 2010 Jul;58(9):1082-93. doi: 10.1002/glia.20989.

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