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Items: 43

1.

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation.

Hansen TH, Yan Y, Ahlberg G, Vad OB, Refsgaard L, Dos Santos JL, Mutsaers N, Svendsen JH, Olesen MS, Bentzen BH, Schmitt N.

Sci Rep. 2020 Jan 29;10(1):1453. doi: 10.1038/s41598-020-58475-9.

2.

The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts.

Kirchhoff JE, Skarsfeldt MA, Muthukumarasamy KM, Simó-Vicens R, Bomholtz SH, Abildgaard L, Jespersen T, Sørensen US, Grunnet M, Bentzen BH, Diness JG.

Front Pharmacol. 2019 Jun 19;10:668. doi: 10.3389/fphar.2019.00668. eCollection 2019.

3.

2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels.

Simó-Vicens R, Bomholtz SH, Sørensen US, Bentzen BH.

Front Pharmacol. 2018 Dec 3;9:1409. doi: 10.3389/fphar.2018.01409. eCollection 2018.

4.

Magnetocardiography on an isolated animal heart with a room-temperature optically pumped magnetometer.

Jensen K, Skarsfeldt MA, Stærkind H, Arnbak J, Balabas MV, Olesen SP, Bentzen BH, Polzik ES.

Sci Rep. 2018 Nov 1;8(1):16218. doi: 10.1038/s41598-018-34535-z.

5.

Homozygosity for SCN4A Arg1142Gln causes congenital myopathy with variable disease expression.

Sloth CK, Denti F, Schmitt N, Bentzen BH, Fagerberg C, Vissing J, Gaist D.

Neurol Genet. 2018 Sep 19;4(5):e267. doi: 10.1212/NXG.0000000000000267. eCollection 2018 Oct. No abstract available.

6.

Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation.

Denti F, Paludan-Müller C, Olesen SP, Haunsø S, Svendsen JH, Olesen MS, Bentzen BH, Schmitt N.

Per Med. 2018 Mar;15(2):93-102. doi: 10.2217/pme-2017-0076. Epub 2018 Jan 31.

PMID:
29714131
7.

Multiple genetic variations in sodium channel subunits in a case of sudden infant death syndrome.

Denti F, Bentzen BH, Wojciak J, Thomsen NM, Scheinman M, Schmitt N.

Pacing Clin Electrophysiol. 2018 Jun;41(6):620-626. doi: 10.1111/pace.13328. Epub 2018 Apr 25.

PMID:
29572929
8.

Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.

Skarsfeldt MA, Bomholtz SH, Lundegaard PR, Lopez-Izquierdo A, Tristani-Firouzi M, Bentzen BH.

Acta Physiol (Oxf). 2018 Jul;223(3):e13049. doi: 10.1111/apha.13049. Epub 2018 Feb 27.

PMID:
29412518
9.

4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries.

Khammy MM, Kim S, Bentzen BH, Lee S, Choi I, Aalkjaer C, Jepps TA.

Br J Pharmacol. 2018 Feb;175(3):501-516. doi: 10.1111/bph.14097. Epub 2018 Jan 5.

10.

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs.

Diness JG, Skibsbye L, Simó-Vicens R, Santos JL, Lundegaard P, Citerni C, Sauter DRP, Bomholtz SH, Svendsen JH, Olesen SP, Sørensen US, Jespersen T, Grunnet M, Bentzen BH.

Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005125. doi: 10.1161/CIRCEP.117.005125.

11.

A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels.

Simó-Vicens R, Kirchhoff JE, Dolce B, Abildgaard L, Speerschneider T, Sørensen US, Grunnet M, Diness JG, Bentzen BH.

Br J Pharmacol. 2017 Dec;174(23):4396-4408. doi: 10.1111/bph.14043. Epub 2017 Oct 22.

12.

Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants.

Gregers E, Ahlberg G, Christensen T, Jabbari J, Larsen KO, Herfelt CB, Henningsen KM, Andreasen L, Thiis JJ, Lund J, Holme S, Haunsø S, Bentzen BH, Schmitt N, Svendsen JH, Olesen MS.

Heart Rhythm. 2017 Oct;14(10):1531-1538. doi: 10.1016/j.hrthm.2017.05.027. Epub 2017 May 24.

PMID:
28549997
13.

Effect of antiarrhythmic drugs on small conductance calcium - activated potassium channels.

Simó-Vicens R, Sauter DRP, Grunnet M, Diness JG, Bentzen BH.

Eur J Pharmacol. 2017 May 15;803:118-123. doi: 10.1016/j.ejphar.2017.03.039. Epub 2017 Mar 18.

PMID:
28322838
14.

Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.

Liin SI, Larsson JE, Barro-Soria R, Bentzen BH, Larsson HP.

Elife. 2016 Sep 30;5. pii: e20272. doi: 10.7554/eLife.20272.

15.

Pharmacological inhibition of IK1 by PA-6 in isolated rat hearts affects ventricular repolarization and refractoriness.

Skarsfeldt MA, Carstensen H, Skibsbye L, Tang C, Buhl R, Bentzen BH, Jespersen T.

Physiol Rep. 2016 Apr;4(8). pii: e12734. doi: 10.14814/phy2.12734.

16.

Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes.

Liin SI, Karlsson U, Bentzen BH, Schmitt N, Elinder F.

Acta Physiol (Oxf). 2016 Sep;218(1):28-37. doi: 10.1111/apha.12663. Epub 2016 Mar 23.

17.

pH-dependent inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts.

Skarsfeldt MA, Jepps TA, Bomholtz SH, Abildgaard L, Sørensen US, Gregers E, Svendsen JH, Diness JG, Grunnet M, Schmitt N, Olesen SP, Bentzen BH.

Pflugers Arch. 2016 Apr;468(4):643-54. doi: 10.1007/s00424-015-1779-0. Epub 2016 Jan 5.

PMID:
26729267
18.
19.

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.

Liin SI, Silverå Ejneby M, Barro-Soria R, Skarsfeldt MA, Larsson JE, Starck Härlin F, Parkkari T, Bentzen BH, Schmitt N, Larsson HP, Elinder F.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5714-9. doi: 10.1073/pnas.1503488112. Epub 2015 Apr 21.

20.

Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium.

Skibsbye L, Wang X, Axelsen LN, Bomholtz SH, Nielsen MS, Grunnet M, Bentzen BH, Jespersen T.

J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76. doi: 10.1097/FJC.0000000000000259.

PMID:
25856531
21.

Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.

Diness JG, Bentzen BH, Sørensen US, Grunnet M.

J Cardiovasc Pharmacol. 2015 Nov;66(5):441-8. doi: 10.1097/FJC.0000000000000249. Review.

22.

BK channel activators and their therapeutic perspectives.

Bentzen BH, Olesen SP, Rønn LC, Grunnet M.

Front Physiol. 2014 Oct 9;5:389. doi: 10.3389/fphys.2014.00389. eCollection 2014. Review.

23.

KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury.

Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R.

PLoS One. 2014 Jul 29;9(7):e103402. doi: 10.1371/journal.pone.0103402. eCollection 2014.

24.

Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370.

Jepps TA, Bentzen BH, Stott JB, Povstyan OV, Sivaloganathan K, Dalby-Brown W, Greenwood IA.

Br J Pharmacol. 2014 Oct;171(19):4413-24. doi: 10.1111/bph.12805. Epub 2014 Aug 14.

25.

Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria.

Skibsbye L, Poulet C, Diness JG, Bentzen BH, Yuan L, Kappert U, Matschke K, Wettwer E, Ravens U, Grunnet M, Christ T, Jespersen T.

Cardiovasc Res. 2014 Jul 1;103(1):156-67. doi: 10.1093/cvr/cvu121. Epub 2014 May 9.

PMID:
24817686
26.

Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation.

Nielsen JB, Bentzen BH, Olesen MS, David JP, Olesen SP, Haunsø S, Svendsen JH, Schmitt N.

Biomark Med. 2014;8(4):557-70. doi: 10.2217/bmm.13.137.

PMID:
24796621
27.

Contribution of Kv7 channels to basal coronary flow and active response to ischemia.

Khanamiri S, Soltysinska E, Jepps TA, Bentzen BH, Chadha PS, Schmitt N, Greenwood IA, Olesen SP.

Hypertension. 2013 Dec;62(6):1090-7. doi: 10.1161/HYPERTENSIONAHA.113.01244. Epub 2013 Sep 30.

PMID:
24082059
28.

Anti-hypertensive treatment preserves appetite suppression while preventing cardiovascular adverse effects of tesofensine in rats.

Bentzen BH, Grunnet M, Hyveled-Nielsen L, Sundgreen C, Lassen JB, Hansen HH.

Obesity (Silver Spring). 2013 May;21(5):985-92. doi: 10.1002/oby.20122.

29.

Functionally selective AT(1) receptor activation reduces ischemia reperfusion injury.

Hostrup A, Christensen GL, Bentzen BH, Liang B, Aplin M, Grunnet M, Hansen JL, Jespersen T.

Cell Physiol Biochem. 2012;30(3):642-52. doi: 10.1159/000341445. Epub 2012 Jul 30.

30.

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation.

Olesen MS, Bentzen BH, Nielsen JB, Steffensen AB, David JP, Jabbari J, Jensen HK, Haunsø S, Svendsen JH, Schmitt N.

BMC Med Genet. 2012 Apr 3;13:24. doi: 10.1186/1471-2350-13-24.

31.

Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal.

Bentzen BH, Grunnet M.

Adv Pharmacol Sci. 2011;2011:578273. doi: 10.1155/2011/578273. Epub 2011 Nov 17.

32.

Attenuated ventricular β-adrenergic response and reduced repolarization reserve in a rabbit model of chronic heart failure.

Nissen JD, Thomsen MB, Bentzen BH, Diness JG, Diness TG, Jespersen T, Grunnet M.

J Cardiovasc Pharmacol. 2012 Feb;59(2):142-50. doi: 10.1097/FJC.0b013e318238727a.

PMID:
21992969
33.

Cardiac ion channels and mechanisms for protection against atrial fibrillation.

Grunnet M, Bentzen BH, Sørensen US, Diness JG.

Rev Physiol Biochem Pharmacol. 2012;162:1-58. doi: 10.1007/112_2011_3. Review.

PMID:
21987061
34.

The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na(+)/H(+) exchanger NHE1.

Andersen AD, Bentzen BH, Salling H, Klingberg H, Kanneworff M, Grunnet M, Pedersen SF.

Cell Physiol Biochem. 2011;28(1):13-24. doi: 10.1159/000331709. Epub 2011 Aug 16.

35.

Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits.

Bentzen BH, Bahrke S, Wu K, Larsen AP, Odening KE, Franke G, Storm vańs Gravesande K, Biermann J, Peng X, Koren G, Zehender M, Bode C, Grunnet M, Brunner M.

J Cardiovasc Pharmacol. 2011 Feb;57(2):223-30. doi: 10.1097/FJC.0b013e318203a44d.

PMID:
21135701
36.

Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels.

Larsen AP, Bentzen BH, Grunnet M.

Br J Pharmacol. 2010 Oct;161(3):614-28. doi: 10.1111/j.1476-5381.2010.00897.x.

37.

Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo.

Bentzen BH, Andersen RW, Olesen SP, Grunnet M, Nardi A.

Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar;381(3):271-83. doi: 10.1007/s00210-009-0456-2. Epub 2009 Oct 2.

PMID:
19798481
38.

Chamber-specific effects of hypokalaemia on ventricular arrhythmogenicity in isolated, perfused guinea-pig heart.

Osadchii OE, Bentzen BH, Olesen SP.

Exp Physiol. 2009 Apr;94(4):434-46. doi: 10.1113/expphysiol.2008.045567. Epub 2009 Jan 16.

39.

Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury.

Bentzen BH, Osadchii O, Jespersen T, Hansen RS, Olesen SP, Grunnet M.

Pflugers Arch. 2009 Mar;457(5):979-88. doi: 10.1007/s00424-008-0583-5. Epub 2008 Sep 2.

PMID:
18762970
40.

The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

Bentzen BH, Nardi A, Calloe K, Madsen LS, Olesen SP, Grunnet M.

Mol Pharmacol. 2007 Oct;72(4):1033-44. Epub 2007 Jul 16.

PMID:
17636045
41.

Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.

Nielsen NH, Winkel BG, Kanters JK, Schmitt N, Hofman-Bang J, Jensen HS, Bentzen BH, Sigurd B, Larsen LA, Andersen PS, Haunsø S, Kjeldsen K, Grunnet M, Christiansen M, Olesen SP.

Biochem Biophys Res Commun. 2007 Mar 16;354(3):776-82. Epub 2007 Jan 18.

PMID:
17266934
42.

The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.

Bentzen BH, Schmitt N, Calloe K, Dalby Brown W, Grunnet M, Olesen SP.

Neuropharmacology. 2006 Nov;51(6):1068-77. Epub 2006 Aug 10.

PMID:
16904708
43.

The effect of spironolactone on experimental periodontitis in rats.

Grauballe MC, Bentzen BH, Björnsson M, Moe D, Jonassen TE, Bendtzen K, Stoltze K, Holmstrup P.

J Periodontal Res. 2005 Jun;40(3):212-7.

PMID:
15853966

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