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Items: 1 to 50 of 55

1.

Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling.

Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ.

Cell Rep. 2018 Dec 4;25(10):2919-2934.e8. doi: 10.1016/j.celrep.2018.11.041.

2.

Macrophages release plasma membrane-derived particles rich in accessible cholesterol.

He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8499-E8508. doi: 10.1073/pnas.1810724115. Epub 2018 Aug 20.

3.

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.

Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L.

Cell Metab. 2018 Sep 4;28(3):504-515.e7. doi: 10.1016/j.cmet.2018.06.002. Epub 2018 Jun 28.

4.

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.

Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN.

Cell Metab. 2018 Sep 4;28(3):490-503.e7. doi: 10.1016/j.cmet.2018.06.001. Epub 2018 Jun 28.

5.

Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice.

Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2016-2027. doi: 10.1161/ATVBAHA.118.311266.

6.

Maintenance of CD4 T cell fitness through regulation of Foxo1.

Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA.

Nat Immunol. 2018 Aug;19(8):838-848. doi: 10.1038/s41590-018-0157-4. Epub 2018 Jul 9.

7.

Mechanobiological Mimicry of Helper T Lymphocytes to Evaluate Cell-Biomaterials Crosstalk.

Hasani-Sadrabadi MM, Majedi FS, Bensinger SJ, Wu BM, Bouchard LS, Weiss PS, Moshaverinia A.

Adv Mater. 2018 Jun;30(23):e1706780. doi: 10.1002/adma.201706780. Epub 2018 Apr 23.

PMID:
29682803
8.

Cytokine Secreting Microparticles Engineer the Fate and the Effector Functions of T-Cells.

Majedi FS, Hasani-Sadrabadi MM, Kidani Y, Thauland TJ, Moshaverinia A, Butte MJ, Bensinger SJ, Bouchard LS.

Adv Mater. 2018 Feb;30(7). doi: 10.1002/adma.201703178. Epub 2018 Jan 8.

9.

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA.

Nat Med. 2017 Nov;23(11):1342-1351. doi: 10.1038/nm.4418. Epub 2017 Oct 9.

10.

Reviewing the impact of lipid synthetic flux on Th17 function.

Kidani Y, Bensinger SJ.

Curr Opin Immunol. 2017 Jun;46:121-126. doi: 10.1016/j.coi.2017.03.012. Epub 2017 Jun 29. Review.

PMID:
28668661
11.

Reelin Deficiency Delays Mammary Tumor Growth and Metastatic Progression.

Khialeeva E, Chou JW, Allen DE, Chiu AM, Bensinger SJ, Carpenter EM.

J Mammary Gland Biol Neoplasia. 2017 Mar;22(1):59-69. doi: 10.1007/s10911-017-9373-z. Epub 2017 Jan 26.

12.

Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease.

Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P.

Immunity. 2016 Dec 20;45(6):1311-1326. doi: 10.1016/j.immuni.2016.11.008.

13.

An optimized method for measuring fatty acids and cholesterol in stable isotope-labeled cells.

Argus JP, Yu AK, Wang ES, Williams KJ, Bensinger SJ.

J Lipid Res. 2017 Feb;58(2):460-468. doi: 10.1194/jlr.D069336. Epub 2016 Dec 14.

14.

The Therapeutic Potential of T Cell Metabolism.

Zarrinpar A, Bensinger SJ.

Am J Transplant. 2017 Jul;17(7):1705-1712. doi: 10.1111/ajt.14149. Epub 2017 Jan 19. Review.

15.

Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model.

Palumbo T, Nakamura K, Lassman C, Kidani Y, Bensinger SJ, Busuttil R, Kupiec-Weglinski J, Zarrinpar A.

Transplantation. 2017 Feb;101(2):322-331. doi: 10.1097/TP.0000000000001552.

16.

Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division.

Gholkar AA, Cheung K, Williams KJ, Lo YC, Hamideh SA, Nnebe C, Khuu C, Bensinger SJ, Torres JZ.

J Biol Chem. 2016 Aug 12;291(33):17001-8. doi: 10.1074/jbc.C116.737346. Epub 2016 Jul 4.

17.

Modulating Cholesterol Homeostasis to Build a Better T Cell.

Kidani Y, Bensinger SJ.

Cell Metab. 2016 Jun 14;23(6):963-964. doi: 10.1016/j.cmet.2016.05.015.

18.

Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux.

Meriwether D, Sulaiman D, Wagner A, Grijalva V, Kaji I, Williams KJ, Yu L, Fogelman S, Volpe C, Bensinger SJ, Anantharamaiah GM, Shechter I, Fogelman AM, Reddy ST.

J Lipid Res. 2016 Jul;57(7):1175-93. doi: 10.1194/jlr.M067025. Epub 2016 May 19.

19.

Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence.

Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG.

PLoS Pathog. 2016 Jan 25;12(1):e1005356. doi: 10.1371/journal.ppat.1005356. eCollection 2016 Jan.

20.

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.

York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ.

Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.

21.

Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.

Mercer JL, Argus JP, Crabtree DM, Keenan MM, Wilks MQ, Chi JT, Bensinger SJ, Lavau CP, Wechsler DS.

PLoS One. 2015 Jun 15;10(6):e0129776. doi: 10.1371/journal.pone.0129776. eCollection 2015.

22.

Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis.

Xie LX, Williams KJ, He CH, Weng E, Khong S, Rose TE, Kwon O, Bensinger SJ, Marbois BN, Clarke CF.

J Lipid Res. 2015 Apr;56(4):909-19. doi: 10.1194/jlr.M057919. Epub 2015 Feb 14.

23.

Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus.

Kidani Y, Bensinger SJ.

J Clin Invest. 2014 Feb;124(2):482-5. doi: 10.1172/JCI74141. Epub 2014 Jan 27.

24.

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.

Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST.

Nat Immunol. 2013 Oct;14(10):1073-83. doi: 10.1038/ni.2707. Epub 2013 Sep 8.

25.

Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth.

York AG, Bensinger SJ.

J Exp Med. 2013 Aug 26;210(9):1653-6. doi: 10.1084/jem.20131335. Review.

26.

Immunology. Fueling function over expansion in T cells.

Argus JP, Bensinger SJ.

Science. 2013 Jul 5;341(6141):37-8. doi: 10.1126/science.1242100. No abstract available.

PMID:
23828930
27.

Doxycycline alters metabolism and proliferation of human cell lines.

Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR.

PLoS One. 2013 May 31;8(5):e64561. doi: 10.1371/journal.pone.0064561. Print 2013.

28.

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.

Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ.

Nat Immunol. 2013 May;14(5):489-99. doi: 10.1038/ni.2570. Epub 2013 Apr 7.

29.

De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.

Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, Sasayama T, James CD, Kornblum HI, Cloughesy TF, Cavenee WK, Bensinger SJ, Mischel PS.

Cancer Discov. 2013 May;3(5):534-47. doi: 10.1158/2159-8290.CD-12-0502. Epub 2013 Mar 26.

30.

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.

Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ.

Cancer Res. 2013 May 1;73(9):2850-62. doi: 10.1158/0008-5472.CAN-13-0382-T. Epub 2013 Feb 25.

31.

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity.

Kidani Y, Bensinger SJ.

Immunol Rev. 2012 Sep;249(1):72-83. doi: 10.1111/j.1600-065X.2012.01153.x. Review.

32.

New aspects of the Warburg effect in cancer cell biology.

Bensinger SJ, Christofk HR.

Semin Cell Dev Biol. 2012 Jun;23(4):352-61. doi: 10.1016/j.semcdb.2012.02.003. Epub 2012 Mar 8. Review.

PMID:
22406683
33.

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.

Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ.

J Clin Invest. 2012 Jan;122(1):337-47. doi: 10.1172/JCI58393. Epub 2011 Dec 12.

34.

Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development.

Ribas V, Drew BG, Le JA, Soleymani T, Daraei P, Sitz D, Mohammad L, Henstridge DC, Febbraio MA, Hewitt SC, Korach KS, Bensinger SJ, Hevener AL.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16457-62. doi: 10.1073/pnas.1104533108. Epub 2011 Sep 7. Erratum in: Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):645.

35.

Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death.

Wolkers MC, Bensinger SJ, Green DR, Schoenberger SP, Janssen EM.

Immunol Lett. 2011 Sep 30;139(1-2):25-32. doi: 10.1016/j.imlet.2011.04.011. Epub 2011 May 20.

36.

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.

Guo D, Prins RM, Dang J, Kuga D, Iwanami A, Soto H, Lin KY, Huang TT, Akhavan D, Hock MB, Zhu S, Kofman AA, Bensinger SJ, Yong WH, Vinters HV, Horvath S, Watson AD, Kuhn JG, Robins HI, Mehta MP, Wen PY, DeAngelis LM, Prados MD, Mellinghoff IK, Cloughesy TF, Mischel PS.

Sci Signal. 2009 Dec 15;2(101):ra82. doi: 10.1126/scisignal.2000446.

37.

Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A.

Immunity. 2009 Aug 21;31(2):245-58. doi: 10.1016/j.immuni.2009.06.018. Epub 2009 Jul 30.

38.

A Nurr1 pathway for neuroprotection.

Bensinger SJ, Tontonoz P.

Cell. 2009 Apr 3;137(1):26-8. doi: 10.1016/j.cell.2009.03.024.

39.

Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas.

Frank MJ, Dawson DW, Bensinger SJ, Hong JS, Knosp WM, Xu L, Balatoni CE, Allen EL, Shen RR, Bar-Sagi D, Martin GR, Teitell MA.

Blood. 2009 Mar 12;113(11):2478-87. doi: 10.1182/blood-2008-05-156943. Epub 2009 Jan 15.

40.

Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.

Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P.

Mol Endocrinol. 2008 Dec;22(12):2596-608. doi: 10.1210/me.2008-0161. Epub 2008 Oct 22.

41.

HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation.

Hummasti S, Hong C, Bensinger SJ, Tontonoz P.

J Lipid Res. 2008 Dec;49(12):2535-44. doi: 10.1194/jlr.M800269-JLR200. Epub 2008 Jul 29.

42.

Integration of metabolism and inflammation by lipid-activated nuclear receptors.

Bensinger SJ, Tontonoz P.

Nature. 2008 Jul 24;454(7203):470-7. doi: 10.1038/nature07202. Review.

PMID:
18650918
43.

LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P.

Cell. 2008 Jul 11;134(1):97-111. doi: 10.1016/j.cell.2008.04.052.

44.

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.

Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA.

J Clin Invest. 2006 Sep;116(9):2521-31. Epub 2006 Aug 17.

45.

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.

Saleh M, Mathison JC, Wolinski MK, Bensinger SJ, Fitzgerald P, Droin N, Ulevitch RJ, Green DR, Nicholson DW.

Nature. 2006 Apr 20;440(7087):1064-8. Erratum in: Nature. 2014 Apr 10;508(7495):274.

PMID:
16625199
46.

Developmental alterations in thymocyte sensitivity are actively regulated by MHC class II expression in the thymic medulla.

Eck SC, Zhu P, Pepper M, Bensinger SJ, Freedman BD, Laufer TM.

J Immunol. 2006 Feb 15;176(4):2229-37.

47.

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, Griffith TS, Green DR, Schoenberger SP.

Nature. 2005 Mar 3;434(7029):88-93.

PMID:
15744305
48.

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.

Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH.

Mol Cell Biol. 2004 Oct;24(20):9038-47.

49.

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.

Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA.

J Immunol. 2004 May 1;172(9):5287-96.

50.

Homeostatic proliferation is a barrier to transplantation tolerance.

Wu Z, Bensinger SJ, Zhang J, Chen C, Yuan X, Huang X, Markmann JF, Kassaee A, Rosengard BR, Hancock WW, Sayegh MH, Turka LA.

Nat Med. 2004 Jan;10(1):87-92. Epub 2003 Nov 30.

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