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Items: 1 to 50 of 285


G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel.

Lagman J, Sayegh P, Lee CS, Sulon SM, Jacinto AZ, Sok V, Peng N, Alp D, Benovic JL, So CH.

Mol Cell Biochem. 2019 Nov;461(1-2):103-118. doi: 10.1007/s11010-019-03594-9. Epub 2019 Jul 30.


Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma.

Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso J, Benovic JL.

Mol Cancer Res. 2019 Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19.


Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling.

Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG.

Theranostics. 2018 Sep 9;8(17):4664-4678. doi: 10.7150/thno.26619. eCollection 2018.


Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.

Chaturvedi M, Schilling J, Beautrait A, Bouvier M, Benovic JL, Shukla AK.

Trends Biochem Sci. 2018 Jul;43(7):533-546. doi: 10.1016/j.tibs.2018.04.003. Epub 2018 May 4. Review.


Pepducins as a potential treatment strategy for asthma and COPD.

Panettieri RA, Pera T, Liggett SB, Benovic JL, Penn RB.

Curr Opin Pharmacol. 2018 Jun;40:120-125. doi: 10.1016/j.coph.2018.04.008. Epub 2018 May 2. Review.


Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.

Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr, Benovic JL, An SS, Dulin NO, Penn RB.

FASEB J. 2018 Feb;32(2):862-874. doi: 10.1096/fj.201700555R. Epub 2018 Jan 4.


G protein-coupled receptor kinases: Past, present and future.

Komolov KE, Benovic JL.

Cell Signal. 2018 Jan;41:17-24. doi: 10.1016/j.cellsig.2017.07.004. Epub 2017 Jul 12.


Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL.

Cell. 2017 Apr 20;169(3):407-421.e16. doi: 10.1016/j.cell.2017.03.047.


G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin.

Luo J, Busillo JM, Stumm R, Benovic JL.

Mol Pharmacol. 2017 Jun;91(6):554-566. doi: 10.1124/mol.116.106468. Epub 2017 Mar 22.


Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.

Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE.

Mol Cancer Res. 2017 May;15(5):501-506. doi: 10.1158/1541-7786.MCR-17-0007. Epub 2017 Feb 21. Review.


G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.

Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL.

J Biol Chem. 2017 Apr 7;292(14):5943-5956. doi: 10.1074/jbc.M116.760850. Epub 2017 Feb 17.


β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction.

Carr R 3rd, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4107-16. doi: 10.1073/pnas.1606267113. Epub 2016 Jun 27.


c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.

DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR.

J Cell Biochem. 2017 Jan;118(1):66-73. doi: 10.1002/jcb.25611. Epub 2016 Jul 12.


The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.

Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL.

J Biol Chem. 2016 Jul 8;291(28):14510-25. doi: 10.1074/jbc.M116.716589. Epub 2016 May 11.


From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins.

Carr R 3rd, Benovic JL.

Biochem Soc Trans. 2016 Apr 15;44(2):555-61. doi: 10.1042/BST20150230. Review.


Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms.

Carr R 3rd, Koziol-White C, Zhang J, Lam H, An SS, Tall GG, Panettieri RA Jr, Benovic JL.

Mol Pharmacol. 2016 Jan;89(1):94-104. doi: 10.1124/mol.115.100339. Epub 2015 Oct 13.


Structural biology: Arresting developments in receptor signalling.

Benovic JL.

Nature. 2015 Jul 30;523(7562):538-9. doi: 10.1038/nature14637. Epub 2015 Jul 22. No abstract available.


Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases.

Komolov KE, Bhardwaj A, Benovic JL.

J Biol Chem. 2015 Aug 21;290(34):20629-47. doi: 10.1074/jbc.M115.647297. Epub 2015 Jun 1.


Consequence of the tumor-associated conversion to cyclin D1b.

Augello MA, Berman-Booty LD, Carr R 3rd, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE.

EMBO Mol Med. 2015 May;7(5):628-47. doi: 10.15252/emmm.201404242.


Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization.

Martinez-Martin N, Viejo-Borbolla A, Martín R, Blanco S, Benovic JL, Thelen M, Alcamí A.

Nat Commun. 2015 Jan 27;6:6163. doi: 10.1038/ncomms7163.


New frontiers in kinases.

Benovic JL, Armstrong RN.

Biochemistry. 2015 Jan 13;54(1):1. doi: 10.1021/bi501533e. Epub 2014 Dec 29. No abstract available.


Development and characterization of pepducins as Gs-biased allosteric agonists.

Carr R 3rd, Du Y, Quoyer J, Panettieri RA Jr, Janz JM, Bouvier M, Kobilka BK, Benovic JL.

J Biol Chem. 2014 Dec 26;289(52):35668-84. doi: 10.1074/jbc.M114.618819. Epub 2014 Nov 13.


Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking.

Kang DS, Tian X, Benovic JL.

Curr Opin Cell Biol. 2014 Apr;27:63-71. doi: 10.1016/ Epub 2013 Dec 14. Review.


Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors.

Benovic JL, von Zastrow M.

Curr Opin Cell Biol. 2014 Apr;27:v-vi. doi: 10.1016/ Epub 2014 Feb 12. No abstract available.


Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.

Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW 3rd, Bouvier M.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97. doi: 10.1073/pnas.1312515110. Epub 2013 Dec 5.


β-arrestins and G protein-coupled receptor trafficking.

Tian X, Kang DS, Benovic JL.

Handb Exp Pharmacol. 2014;219:173-86. doi: 10.1007/978-3-642-41199-1_9. Review.


Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death.

Kook S, Zhan X, Cleghorn WM, Benovic JL, Gurevich VV, Gurevich EV.

Cell Death Differ. 2014 Jan;21(1):172-84. doi: 10.1038/cdd.2013.143. Epub 2013 Oct 18.


G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation.

So CH, Michal A, Komolov KE, Luo J, Benovic JL.

Mol Biol Cell. 2013 Sep;24(18):2795-806. doi: 10.1091/mbc.E13-01-0013. Epub 2013 Jul 31.


β-Arrestins and G protein-coupled receptor trafficking.

Kang DS, Tian X, Benovic JL.

Methods Enzymol. 2013;521:91-108. doi: 10.1016/B978-0-12-391862-8.00005-3. Review.


G-protein-coupled receptors signal victory.

Benovic JL.

Cell. 2012 Dec 7;151(6):1148-50. doi: 10.1016/j.cell.2012.11.015. Epub 2012 Nov 29.


Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor.

Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E.

J Neurochem. 2013 Jan;124(2):189-99. doi: 10.1111/jnc.12071. Epub 2012 Nov 30.


G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition.

So CH, Michal AM, Mashayekhi R, Benovic JL.

J Biol Chem. 2012 May 18;287(21):17088-99. doi: 10.1074/jbc.M112.353854. Epub 2012 Mar 30.


Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.

Wood JF, Wang J, Benovic JL, Ferkey DM.

J Biol Chem. 2012 Apr 13;287(16):12634-44. doi: 10.1074/jbc.M111.336818. Epub 2012 Feb 28.


G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression.

Michal AM, So CH, Beeharry N, Shankar H, Mashayekhi R, Yen TJ, Benovic JL.

J Biol Chem. 2012 Feb 24;287(9):6928-40. doi: 10.1074/jbc.M111.298034. Epub 2012 Jan 5.


Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.

Woerner BM, Luo J, Brown KR, Jackson E, Dahiya SM, Mischel P, Benovic JL, Piwnica-Worms D, Rubin JB.

Mol Cancer Res. 2012 Jan;10(1):156-66. doi: 10.1158/1541-7786.MCR-11-0411. Epub 2011 Nov 15.


Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV.

Neurobiol Dis. 2011 Nov;44(2):248-58. doi: 10.1016/j.nbd.2011.07.009. Epub 2011 Jul 20.


G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4.

Barker BL, Benovic JL.

Biochemistry. 2011 Aug 16;50(32):6933-41. doi: 10.1021/bi2005202. Epub 2011 Jul 12.


Differential expression of arrestins is a predictor of breast cancer progression and survival.

Michal AM, Peck AR, Tran TH, Liu C, Rimm DL, Rui H, Benovic JL.

Breast Cancer Res Treat. 2011 Dec;130(3):791-807. doi: 10.1007/s10549-011-1374-9. Epub 2011 Feb 12.


Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG.

Mol Cell. 2010 Dec 22;40(6):877-92. doi: 10.1016/j.molcel.2010.11.029.


Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but β-arrestin-independent pathways.

Huang H, He X, Deng X, Li G, Ying G, Sun Y, Shi L, Benovic JL, Zhou N.

Biochemistry. 2010 Dec 28;49(51):10862-72. doi: 10.1021/bi1014425. Epub 2010 Dec 2.


Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i).

Chen XP, Yang W, Fan Y, Luo JS, Hong K, Wang Z, Yan JF, Chen X, Lu JX, Benovic JL, Zhou NM.

Br J Pharmacol. 2010 Dec;161(8):1817-34. doi: 10.1111/j.1476-5381.2010.01006.x.


Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.

Li G, Shi Y, Huang H, Zhang Y, Wu K, Luo J, Sun Y, Lu J, Benovic JL, Zhou N.

J Biol Chem. 2010 Jul 16;285(29):22605-18. doi: 10.1074/jbc.M109.087213. Epub 2010 May 11.


Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.

Palmitessa A, Benovic JL.

J Biol Chem. 2010 May 14;285(20):15187-200. doi: 10.1074/jbc.M110.104612. Epub 2010 Mar 5.


Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling.

Mundell SJ, Matharu AL, Nisar S, Palmer TM, Benovic JL, Kelly E.

Br J Pharmacol. 2010 Feb 1;159(3):518-33. doi: 10.1111/j.1476-5381.2009.00598.x. Epub 2010 Jan 28.


Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function.

Shankar H, Michal A, Kern RC, Kang DS, Gurevich VV, Benovic JL.

J Biol Chem. 2010 Mar 12;285(11):8316-29. doi: 10.1074/jbc.M109.062521. Epub 2010 Jan 7.


Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.

Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL.

J Biol Chem. 2010 Mar 5;285(10):7805-17. doi: 10.1074/jbc.M109.091173. Epub 2010 Jan 4.


G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N.

Biochem J. 2009 Dec 14;425(1):169-78. doi: 10.1042/BJ20090908.


Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation.

Pao CS, Barker BL, Benovic JL.

Biochemistry. 2009 Aug 4;48(30):7325-33. doi: 10.1021/bi900408g.


Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking.

Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL.

J Biol Chem. 2009 Oct 23;284(43):29860-72. doi: 10.1074/jbc.M109.023366. Epub 2009 Aug 25.

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