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Items: 31


Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis.

Flynn AF, Joyce MG, Taylor RT, Bennuru S, Lindrose AR, Sterling SL, Morris CP, Nutman TB, Mitre E.

PLoS Negl Trop Dis. 2019 Sep 12;13(9):e0007687. doi: 10.1371/journal.pntd.0007687. eCollection 2019 Sep.


Integrating multiple biomarkers to increase sensitivity for the detection of Onchocerca volvulus infection.

Bennuru S, Oduro-Boateng G, Osigwe C, Del-Valle P, Golden A, Ogawa GM, Cama V, Lustigman S, Nutman TB.

J Infect Dis. 2019 Jun 14. pii: jiz307. doi: 10.1093/infdis/jiz307. [Epub ahead of print]


Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.

Patton JB, Bennuru S, Eberhard ML, Hess JA, Torigian A, Lustigman S, Nutman TB, Abraham D.

PLoS Negl Trop Dis. 2018 Dec 12;12(12):e0006977. doi: 10.1371/journal.pntd.0006977. eCollection 2018 Dec.


Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.

Zhan B, Arumugam S, Kennedy MW, Tricoche N, Lian LY, Asojo OA, Bennuru S, Bottazzi ME, Hotez PJ, Lustigman S, Klei TR.

PLoS Negl Trop Dis. 2018 Oct 8;12(10):e0006772. doi: 10.1371/journal.pntd.0006772. eCollection 2018 Oct.


Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion.

Narasimhan PB, Akabas L, Tariq S, Huda N, Bennuru S, Sabzevari H, Hofmeister R, Nutman TB, Tolouei Semnani R.

PLoS Negl Trop Dis. 2018 Apr 18;12(4):e0006404. doi: 10.1371/journal.pntd.0006404. eCollection 2018 Apr.


Tackling Hypotheticals in Helminth Genomes.

International Molecular Helminthology Annotation Network (IMHAN); IMHAN consortium authors include, Palevich N, Britton C, Kamenetzky L, Mitreva M, de Moraes MourĂ£o M, Bennuru S, Quack T, Scholte LLS, Tyagi R, Slatko BE.

Trends Parasitol. 2018 Mar;34(3):179-183. doi: 10.1016/ Epub 2017 Dec 14.


Mining Filarial Genomes for Diagnostic and Therapeutic Targets.

Bennuru S, O'Connell EM, Drame PM, Nutman TB.

Trends Parasitol. 2018 Jan;34(1):80-90. doi: 10.1016/ Epub 2017 Oct 12. Review.


Insights Into Onchocerca volvulus Population Biology Through Multilocus Immunophenotyping.

Norice-Tra CT, Ribeiro J, Bennuru S, Fay MP, Tyagi R, Mitreva M, Nutman TB.

J Infect Dis. 2017 Sep 15;216(6):736-743. doi: 10.1093/infdis/jix394.


Discovery of Specific Antigens That Can Predict Microfilarial Intensity in Loa loa Infection.

Drame PM, Bennuru S, Nutman TB.

J Clin Microbiol. 2017 Sep;55(9):2671-2678. doi: 10.1128/JCM.00513-17. Epub 2017 Jun 21.


Metabolite profiling of infection-associated metabolic markers of onchocerciasis.

Bennuru S, Lustigman S, Abraham D, Nutman TB.

Mol Biochem Parasitol. 2017 Jul;215:58-69. doi: 10.1016/j.molbiopara.2017.01.008. Epub 2017 Feb 8.


Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its Wolbachia Endosymbiont.

Bennuru S, Cotton JA, Ribeiro JM, Grote A, Harsha B, Holroyd N, Mhashilkar A, Molina DM, Randall AZ, Shandling AD, Unnasch TR, Ghedin E, Berriman M, Lustigman S, Nutman TB.

MBio. 2016 Nov 23;7(6). pii: e02028-16. doi: 10.1128/mBio.02028-16.


The genome of Onchocerca volvulus, agent of river blindness.

Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A, Beech R, Doyle SR, Dunn M, Hotopp JC, Holroyd N, Kikuchi T, Lambert O, Mhashilkar A, Mutowo P, Nursimulu N, Ribeiro JM, Rogers MB, Stanley E, Swapna LS, Tsai IJ, Unnasch TR, Voronin D, Parkinson J, Nutman TB, Ghedin E, Berriman M, Lustigman S.

Nat Microbiol. 2016 Nov 21;2:16216. doi: 10.1038/nmicrobiol.2016.216.


Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells.

Narasimhan PB, Bennuru S, Meng Z, Cotton RN, Elliott KR, Ganesan S, McDonald-Fleming R, Veenstra TD, Nutman TB, Tolouei Semnani R.

Infect Immun. 2016 Aug 19;84(9):2463-72. doi: 10.1128/IAI.00174-16. Print 2016 Sep.


Identification and Validation of Loa loa Microfilaria-Specific Biomarkers: a Rational Design Approach Using Proteomics and Novel Immunoassays.

Drame PM, Meng Z, Bennuru S, Herrick JA, Veenstra TD, Nutman TB.

MBio. 2016 Feb 16;7(1):e02132-15. doi: 10.1128/mBio.02132-15.


Understanding Hidden Antigens and Targeting Parasitic Nematodes.

Bennuru S.

EBioMedicine. 2015 Sep 14;2(9):1010-1. doi: 10.1016/j.ebiom.2015.09.021. eCollection 2015 Sep. No abstract available.


A Proteomic Analysis of the Body Wall, Digestive Tract, and Reproductive Tract of Brugia malayi.

Morris CP, Bennuru S, Kropp LE, Zweben JA, Meng Z, Taylor RT, Chan K, Veenstra TD, Nutman TB, Mitre E.

PLoS Negl Trop Dis. 2015 Sep 14;9(9):e0004054. doi: 10.1371/journal.pntd.0004054. eCollection 2015.


Point-of-care quantification of blood-borne filarial parasites with a mobile phone microscope.

D'Ambrosio MV, Bakalar M, Bennuru S, Reber C, Skandarajah A, Nilsson L, Switz N, Kamgno J, Pion S, Boussinesq M, Nutman TB, Fletcher DA.

Sci Transl Med. 2015 May 6;7(286):286re4. doi: 10.1126/scitranslmed.aaa3480.


Targeting Filarial Abl-like Kinases: Orally Available, Food and Drug Administration-Approved Tyrosine Kinase Inhibitors Are Microfilaricidal and Macrofilaricidal.

O'Connell EM, Bennuru S, Steel C, Dolan MA, Nutman TB.

J Infect Dis. 2015 Sep 1;212(5):684-93. doi: 10.1093/infdis/jiv065. Epub 2015 Feb 5.


Helminth infection alters IgE responses to allergens structurally related to parasite proteins.

Santiago Hda C, Ribeiro-Gomes FL, Bennuru S, Nutman TB.

J Immunol. 2015 Jan 1;194(1):93-100. doi: 10.4049/jimmunol.1401638. Epub 2014 Nov 17.


Repurposed automated handheld counter as a point-of-care tool to identify individuals 'at risk' of serious post-ivermectin encephalopathy.

Bennuru S, Pion SD, Kamgno J, Wanji S, Nutman TB.

PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3180. doi: 10.1371/journal.pntd.0003180. eCollection 2014 Sep.


Single molecule sequencing and genome assembly of a clinical specimen of Loa loa, the causative agent of loiasis.

Tallon LJ, Liu X, Bennuru S, Chibucos MC, Godinez A, Ott S, Zhao X, Sadzewicz L, Fraser CM, Nutman TB, Dunning Hotopp JC.

BMC Genomics. 2014 Sep 12;15:788. doi: 10.1186/1471-2164-15-788.


Human monocyte subsets at homeostasis and their perturbation in numbers and function in filarial infection.

Tolouei Semnani R, Moore V, Bennuru S, McDonald-Fleming R, Ganesan S, Cotton R, Anuradha R, Babu S, Nutman TB.

Infect Immun. 2014 Nov;82(11):4438-46. doi: 10.1128/IAI.01973-14. Epub 2014 Aug 11.


Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion.

Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman TB, Semnani RT.

Infect Immun. 2013 May;81(5):1420-9. doi: 10.1128/IAI.01301-12. Epub 2013 Feb 19.


Structural differences between human proteins and aero- and microbial allergens define allergenicity.

Santiago Hda C, Bennuru S, Ribeiro JM, Nutman TB.

PLoS One. 2012;7(7):e40552. doi: 10.1371/journal.pone.0040552. Epub 2012 Jul 18.


Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization.

Santiago HC, LeeVan E, Bennuru S, Ribeiro-Gomes F, Mueller E, Wilson M, Wynn T, Garboczi D, Urban J, Mitre E, Nutman TB.

J Allergy Clin Immunol. 2012 Jul;130(1):248-56.e9. doi: 10.1016/j.jaci.2012.02.045. Epub 2012 Apr 25.


Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia.

Bennuru S, Meng Z, Ribeiro JM, Semnani RT, Ghedin E, Chan K, Lucas DA, Veenstra TD, Nutman TB.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9649-54. doi: 10.1073/pnas.1011481108. Epub 2011 May 23.


Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis.

Santiago HC, Bennuru S, Boyd A, Eberhard M, Nutman TB.

J Allergy Clin Immunol. 2011 Feb;127(2):479-86. doi: 10.1016/j.jaci.2010.11.007. Epub 2010 Dec 24.


Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections.

Bennuru S, Maldarelli G, Kumaraswami V, Klion AD, Nutman TB.

Am J Trop Med Hyg. 2010 Oct;83(4):884-90. doi: 10.4269/ajtmh.2010.10-0039.


Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling.

Bennuru S, Nutman TB.

Lymphat Res Biol. 2009 Dec;7(4):215-9. doi: 10.1089/lrb.2009.0022. Review.


Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: implications for pathogenesis.

Bennuru S, Nutman TB.

PLoS Pathog. 2009 Dec;5(12):e1000688. doi: 10.1371/journal.ppat.1000688. Epub 2009 Dec 11.


Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling.

Bennuru S, Semnani R, Meng Z, Ribeiro JM, Veenstra TD, Nutman TB.

PLoS Negl Trop Dis. 2009;3(4):e410. doi: 10.1371/journal.pntd.0000410. Epub 2009 Apr 7.

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