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Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames.

Zanker DJ, Oveissi S, Tscharke DC, Duan M, Wan S, Zhang X, Xiao K, Mifsud NA, Gibbs J, Izzard L, Dlugolenski D, Faou P, Laurie KL, Vigneron N, Barr IG, Stambas J, Van den Eynde BJ, Bennink JR, Yewdell JW, Chen W.

J Immunol. 2019 Jun 15;202(12):3370-3380. doi: 10.4049/jimmunol.1900070. Epub 2019 May 15.


Bacterial Superantigens Expand and Activate, Rather than Delete or Incapacitate, Preexisting Antigen-Specific Memory CD8+ T Cells.

Meilleur CE, Wardell CM, Mele TS, Dikeakos JD, Bennink JR, Mu HH, McCormick JK, Haeryfar SMM.

J Infect Dis. 2019 Apr 8;219(8):1307-1317. doi: 10.1093/infdis/jiy647.


PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8+ T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination.

Memarnejadian A, Meilleur CE, Shaler CR, Khazaie K, Bennink JR, Schell TD, Haeryfar SMM.

J Immunol. 2017 Nov 1;199(9):3348-3359. doi: 10.4049/jimmunol.1700643. Epub 2017 Sep 22.


Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation Events Generate a Common Peptide from Influenza A Virus M2 and M1 mRNAs.

Yang N, Gibbs JS, Hickman HD, Reynoso GV, Ghosh AK, Bennink JR, Yewdell JW.

J Immunol. 2016 May 1;196(9):3608-17. doi: 10.4049/jimmunol.1502303. Epub 2016 Mar 25.


Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread.

Cush SS, Reynoso GV, Kamenyeva O, Bennink JR, Yewdell JW, Hickman HD.

PLoS Pathog. 2016 Mar 18;12(3):e1005493. doi: 10.1371/journal.ppat.1005493. eCollection 2016 Mar.


Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity.

Altman MO, Bennink JR, Yewdell JW, Herrin BR.

Elife. 2015 Aug 7;4. doi: 10.7554/eLife.07467.


A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus.

Frank GM, Angeletti D, Ince WL, Gibbs JS, Khurana S, Wheatley AK, Max EE, McDermott AB, Golding H, Stevens J, Bennink JR, Yewdell JW.

MBio. 2015 Aug 4;6(4):e01156. doi: 10.1128/mBio.01156-15.


Ubiquitous Autofragmentation of Fluorescent Proteins Creates Abundant Defective Ribosomal Products (DRiPs) for Immunosurveillance.

Wei J, Gibbs JS, Hickman HD, Cush SS, Bennink JR, Yewdell JW.

J Biol Chem. 2015 Jun 26;290(26):16431-9. doi: 10.1074/jbc.M115.658062. Epub 2015 May 13.


CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.

Hickman HD, Reynoso GV, Ngudiankama BF, Cush SS, Gibbs J, Bennink JR, Yewdell JW.

Immunity. 2015 Mar 17;42(3):524-37. doi: 10.1016/j.immuni.2015.02.009. Epub 2015 Mar 10.


Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility.

Brooke CB, Ince WL, Wei J, Bennink JR, Yewdell JW.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16854-9. doi: 10.1073/pnas.1415396111. Epub 2014 Nov 10.


Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes.

Magadán JG, Altman MO, Ince WL, Hickman HD, Stevens J, Chevalier A, Baker D, Wilson PC, Ahmed R, Bennink JR, Yewdell JW.

PLoS Pathog. 2014 Jun 12;10(6):e1004204. doi: 10.1371/journal.ppat.1004204. eCollection 2014 Jun.


Career lasting influences.

Bennink JR.

Monoclon Antib Immunodiagn Immunother. 2014 Jun;33(3):199. doi: 10.1089/mab.2014.0004. Epub 2014 Jun 3. No abstract available.


Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity.

Magadán JG, Khurana S, Das SR, Frank GM, Stevens J, Golding H, Bennink JR, Yewdell JW.

J Virol. 2013 Sep;87(17):9742-53. doi: 10.1128/JVI.00471-13. Epub 2013 Jul 3.


Discovering naturally processed antigenic determinants that confer protective T cell immunity.

Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe JE Jr, Williams JV, Buus S, Sette A, Schumacher TN, Link AJ, Joyce S.

J Clin Invest. 2013 May;123(5):1976-87. doi: 10.1172/JCI67388. Epub 2013 Apr 1.


Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.

Das SR, Hensley SE, Ince WL, Brooke CB, Subba A, Delboy MG, Russ G, Gibbs JS, Bennink JR, Yewdell JW.

Cell Host Microbe. 2013 Mar 13;13(3):314-23. doi: 10.1016/j.chom.2013.02.008.


Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.

Hickman HD, Reynoso GV, Ngudiankama BF, Rubin EJ, Magadán JG, Cush SS, Gibbs J, Molon B, Bronte V, Bennink JR, Yewdell JW.

Cell Host Microbe. 2013 Feb 13;13(2):155-68. doi: 10.1016/j.chom.2013.01.004.


Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host.

Ince WL, Gueye-Mbaye A, Bennink JR, Yewdell JW.

J Virol. 2013 Apr;87(8):4330-8. doi: 10.1128/JVI.02749-12. Epub 2013 Jan 30.


Most influenza a virions fail to express at least one essential viral protein.

Brooke CB, Ince WL, Wrammert J, Ahmed R, Wilson PC, Bennink JR, Yewdell JW.

J Virol. 2013 Mar;87(6):3155-62. doi: 10.1128/JVI.02284-12. Epub 2013 Jan 2. Erratum in: J Virol. 2013 Jul;87(14):8267.


Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation.

Pavon-Eternod M, David A, Dittmar K, Berglund P, Pan T, Bennink JR, Yewdell JW.

Nucleic Acids Res. 2013 Feb 1;41(3):1914-21. doi: 10.1093/nar/gks986. Epub 2012 Dec 18.


Emetine optimally facilitates nascent chain puromycylation and potentiates the ribopuromycylation method (RPM) applied to inert cells.

David A, Bennink JR, Yewdell JW.

Histochem Cell Biol. 2013 Mar;139(3):501-4. doi: 10.1007/s00418-012-1063-8. Epub 2012 Dec 11.


Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.

Lu X, Gibbs JS, Hickman HD, David A, Dolan BP, Jin Y, Kranz DM, Bennink JR, Yewdell JW, Varma R.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15407-12. Epub 2012 Sep 4.


Monitoring cotranslational protein folding in mammalian cells at codon resolution.

Han Y, David A, Liu B, Magadán JG, Bennink JR, Yewdell JW, Qian SB.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12467-72. doi: 10.1073/pnas.1208138109. Epub 2012 Jul 16.


MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA.

Dolan BP, Sharma AA, Gibbs JS, Cunningham TJ, Bennink JR, Yewdell JW.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7025-30. doi: 10.1073/pnas.1112387109. Epub 2012 Apr 16.


Nuclear translation visualized by ribosome-bound nascent chain puromycylation.

David A, Dolan BP, Hickman HD, Knowlton JJ, Clavarino G, Pierre P, Bennink JR, Yewdell JW.

J Cell Biol. 2012 Apr 2;197(1):45-57. doi: 10.1083/jcb.201112145.


Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis.

David A, Das SR, Gibbs JS, Bennink JR, Yewdell JW.

PLoS One. 2012;7(3):e33072. doi: 10.1371/journal.pone.0033072. Epub 2012 Mar 9.


Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells.

Hou W, Gibbs JS, Lu X, Brooke CB, Roy D, Modlin RL, Bennink JR, Yewdell JW.

Blood. 2012 Mar 29;119(13):3128-31. doi: 10.1182/blood-2011-09-379479. Epub 2012 Feb 6.


Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy.

Das SR, Hensley SE, David A, Schmidt L, Gibbs JS, Puigbò P, Ince WL, Bennink JR, Yewdell JW.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1417-22. doi: 10.1073/pnas.1108754108. Epub 2011 Nov 21.


Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.

Hickman HD, Li L, Reynoso GV, Rubin EJ, Skon CN, Mays JW, Gibbs J, Schwartz O, Bennink JR, Yewdell JW.

J Exp Med. 2011 Nov 21;208(12):2511-24. doi: 10.1084/jem.20102545. Epub 2011 Oct 31.


RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes.

David A, Netzer N, Strader MB, Das SR, Chen CY, Gibbs J, Pierre P, Bennink JR, Yewdell JW.

J Biol Chem. 2011 Jun 10;286(23):20688-700. doi: 10.1074/jbc.M110.209452. Epub 2011 Apr 1.


Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.

Dolan BP, Bennink JR, Yewdell JW.

Cell Mol Life Sci. 2011 May;68(9):1481-9. doi: 10.1007/s00018-011-0656-z. Epub 2011 Mar 17. Review.


Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance.

Hensley SE, Das SR, Gibbs JS, Bailey AL, Schmidt LM, Bennink JR, Yewdell JW.

PLoS One. 2011 Feb 22;6(2):e15190. doi: 10.1371/journal.pone.0015190.


Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance.

Dolan BP, Li L, Veltri CA, Ireland CM, Bennink JR, Yewdell JW.

J Immunol. 2011 Feb 15;186(4):2065-72. doi: 10.4049/jimmunol.1003096. Epub 2011 Jan 12.


From optical bench to cageside: intravital microscopy on the long road to rational vaccine design.

Hickman HD, Bennink JR, Yewdell JW.

Immunol Rev. 2011 Jan;239(1):209-20. doi: 10.1111/j.1600-065X.2010.00973.x. Review.


Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain.

Das SR, Puigbò P, Hensley SE, Hurt DE, Bennink JR, Yewdell JW.

PLoS Pathog. 2010 Nov 24;6(11):e1001211. doi: 10.1371/journal.ppat.1001211.


RNA polymerase II inhibitors dissociate antigenic peptide generation from normal viral protein synthesis: a role for nuclear translation in defective ribosomal product synthesis?

Dolan BP, Knowlton JJ, David A, Bennink JR, Yewdell JW.

J Immunol. 2010 Dec 1;185(11):6728-33. doi: 10.4049/jimmunol.1002543. Epub 2010 Nov 3.


mTORC1 links protein quality and quantity control by sensing chaperone availability.

Qian SB, Zhang X, Sun J, Bennink JR, Yewdell JW, Patterson C.

J Biol Chem. 2010 Aug 27;285(35):27385-95. doi: 10.1074/jbc.M110.120295. Epub 2010 Jul 6.


Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action.

Lev A, Princiotta MF, Zanker D, Takeda K, Gibbs JS, Kumagai C, Waffarn E, Dolan BP, Burgevin A, Van Endert P, Chen W, Bennink JR, Yewdell JW.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6964-9. doi: 10.1073/pnas.0910997107. Epub 2010 Mar 29.


Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses.

Hensley SE, Zanker D, Dolan BP, David A, Hickman HD, Embry AC, Skon CN, Grebe KM, Griffin TA, Chen W, Bennink JR, Yewdell JW.

J Immunol. 2010 Apr 15;184(8):4115-22. doi: 10.4049/jimmunol.0903003. Epub 2010 Mar 12.


Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase.

Dolan BP, Li L, Takeda K, Bennink JR, Yewdell JW.

J Immunol. 2010 Feb 1;184(3):1419-24. doi: 10.4049/jimmunol.0901907. Epub 2009 Dec 28.


Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis.

Grebe KM, Takeda K, Hickman HD, Bailey AL, Embry AC, Bennink JR, Yewdell JW.

J Immunol. 2010 Jan 15;184(2):540-4. doi: 10.4049/jimmunol.0903395. Epub 2009 Dec 16. Erratum in: J Immunol. 2010 Mar 1;184(5):2736. Bailey, Adam M [corrected to Bailey, Adam L].


Innate immune and chemically triggered oxidative stress modifies translational fidelity.

Netzer N, Goodenbour JM, David A, Dittmar KA, Jones RB, Schneider JR, Boone D, Eves EM, Rosner MR, Gibbs JS, Embry A, Dolan B, Das S, Hickman HD, Berglund P, Bennink JR, Yewdell JW, Pan T.

Nature. 2009 Nov 26;462(7272):522-6. doi: 10.1038/nature08576.


Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift.

Hensley SE, Das SR, Bailey AL, Schmidt LM, Hickman HD, Jayaraman A, Viswanathan K, Raman R, Sasisekharan R, Bennink JR, Yewdell JW.

Science. 2009 Oct 30;326(5953):734-6. doi: 10.1126/science.1178258.


Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent.

Lev A, Dimberu P, Das SR, Maynard JC, Nicchitta CV, Bennink JR, Yewdell JW.

J Immunol. 2009 Oct 1;183(7):4205-10. doi: 10.4049/jimmunol.0901828. Epub 2009 Sep 14. Erratum in: J Immunol. 2010 Jul 1;185(1):770.


Quantitating T cell cross-reactivity for unrelated peptide antigens.

Ishizuka J, Grebe K, Shenderov E, Peters B, Chen Q, Peng Y, Wang L, Dong T, Pasquetto V, Oseroff C, Sidney J, Hickman H, Cerundolo V, Sette A, Bennink JR, McMichael A, Yewdell JW.

J Immunol. 2009 Oct 1;183(7):4337-45. doi: 10.4049/jimmunol.0901607. Epub 2009 Sep 4.


Murine norovirus infection has no significant effect on adaptive immunity to vaccinia virus or influenza A virus.

Hensley SE, Pinto AK, Hickman HD, Kastenmayer RJ, Bennink JR, Virgin HW, Yewdell JW.

J Virol. 2009 Jul;83(14):7357-60. doi: 10.1128/JVI.00623-09. Epub 2009 Apr 29.


Sympathetic nervous system control of anti-influenza CD8+ T cell responses.

Grebe KM, Hickman HD, Irvine KR, Takeda K, Bennink JR, Yewdell JW.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5300-5. doi: 10.1073/pnas.0808851106. Epub 2009 Mar 13.


Caught in the act: intravital multiphoton microscopy of host-pathogen interactions.

Hickman HD, Bennink JR, Yewdell JW.

Cell Host Microbe. 2009 Jan 22;5(1):13-21. doi: 10.1016/j.chom.2008.12.007.


Heterosubtypic immunity to influenza A virus: where do we stand?

Grebe KM, Yewdell JW, Bennink JR.

Microbes Infect. 2008 Jul;10(9):1024-9. doi: 10.1016/j.micinf.2008.07.002. Epub 2008 Jul 9. Review.


Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies.

Haeryfar SM, Hickman HD, Irvine KR, Tscharke DC, Bennink JR, Yewdell JW.

J Immunol. 2008 Jul 1;181(1):649-59.


The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.

Lev A, Takeda K, Zanker D, Maynard JC, Dimberu P, Waffarn E, Gibbs J, Netzer N, Princiotta MF, Neckers L, Picard D, Nicchitta CV, Chen W, Reiter Y, Bennink JR, Yewdell JW.

Immunity. 2008 Jun;28(6):787-98. doi: 10.1016/j.immuni.2008.04.015.

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