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Items: 1 to 50 of 112

1.

High efficacy full allelic CRISPR/Cas9 gene editing in tetraploid potato.

Johansen IE, Liu Y, Jørgensen B, Bennett EP, Andreasson E, Nielsen KL, Blennow A, Petersen BL.

Sci Rep. 2019 Nov 27;9(1):17715. doi: 10.1038/s41598-019-54126-w.

2.

Effect of Lozenges Containing Lactobacillus reuteri on the Severity of Recurrent Aphthous Ulcers: a Pilot Study.

Pedersen AML, Bukkehave KH, Bennett EP, Twetman S.

Probiotics Antimicrob Proteins. 2019 Aug 13. doi: 10.1007/s12602-019-09586-x. [Epub ahead of print]

PMID:
31410765
3.

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.

Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H.

Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18.

PMID:
31227230
4.

Improved CRISPR/Cas9 gene editing by fluorescence activated cell sorting of green fluorescence protein tagged protoplasts.

Petersen BL, Möller SR, Mravec J, Jørgensen B, Christensen M, Liu Y, Wandall HH, Bennett EP, Yang Z.

BMC Biotechnol. 2019 Jun 17;19(1):36. doi: 10.1186/s12896-019-0530-x.

5.

A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation.

Steentoft C, Yang Z, Wang S, Ju T, Vester-Christensen MB, Festari MF, King SL, Moremen K, Larsen ISB, Goth CK, Schjoldager KT, Hansen L, Bennett EP, Mandel U, Narimatsu Y.

Glycobiology. 2019 Aug 20;29(9):645-656. doi: 10.1093/glycob/cwz041.

PMID:
31172184
6.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2019 May 24;294(21):8349. doi: 10.1074/jbc.AAC119.009121. No abstract available.

7.

The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells.

Tian W, Ye Z, Wang S, Schulz MA, Van Coillie J, Sun L, Chen YH, Narimatsu Y, Hansen L, Kristensen C, Mandel U, Bennett EP, Jabbarzadeh-Tabrizi S, Schiffmann R, Shen JS, Vakhrushev SY, Clausen H, Yang Z.

Nat Commun. 2019 Apr 30;10(1):1785. doi: 10.1038/s41467-019-09809-3.

8.

Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics.

Narimatsu Y, Joshi HJ, Schjoldager KT, Hintze J, Halim A, Steentoft C, Nason R, Mandel U, Bennett EP, Clausen H, Vakhrushev SY.

Mol Cell Proteomics. 2019 Jul;18(7):1396-1409. doi: 10.1074/mcp.RA118.001121. Epub 2019 Apr 30.

PMID:
31040225
9.

Fast and Quantitative Identification of Ex Vivo Precise Genome Targeting-Induced Indel Events by IDAA.

König S, Yang Z, Wandall HH, Mussolino C, Bennett EP.

Methods Mol Biol. 2019;1961:45-66. doi: 10.1007/978-1-4939-9170-9_4.

PMID:
30912039
10.

Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines.

Hintze J, Ye Z, Narimatsu Y, Madsen TD, Joshi HJ, Goth CK, Linstedt A, Bachert C, Mandel U, Bennett EP, Vakhrushev SY, Schjoldager KT.

J Biol Chem. 2018 Dec 7;293(49):19064-19077. doi: 10.1074/jbc.RA118.004516. Epub 2018 Oct 16.

11.

Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa.

Nygaard MB, Herlihy AS, Jeanneau C, Nielsen JE, Bennett EP, Jørgensen N, Clausen H, Mandel U, Rajpert-De Meyts E, Almstrup K.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2949. doi: 10.3390/ijms19102949.

12.

The GAGOme: a cell-based library of displayed glycosaminoglycans.

Chen YH, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén D, Ellervik U, Bennett EP, Mao Y, Clausen H, Yang Z.

Nat Methods. 2018 Nov;15(11):881-888. doi: 10.1038/s41592-018-0086-z. Epub 2018 Aug 13.

PMID:
30104636
13.

Intestinal regulation of suppression of tumorigenicity 14 (ST14) and serine peptidase inhibitor, Kunitz type -1 (SPINT1) by transcription factor CDX2.

Danielsen ET, Olsen AK, Coskun M, Nonboe AW, Larsen S, Dahlgaard K, Bennett EP, Mitchelmore C, Vogel LK, Troelsen JT.

Sci Rep. 2018 Aug 7;8(1):11813. doi: 10.1038/s41598-018-30216-z.

14.

The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2.

Davidsen J, Larsen S, Coskun M, Gögenur I, Dahlgaard K, Bennett EP, Troelsen JT.

PLoS One. 2018 Jul 5;13(7):e0200215. doi: 10.1371/journal.pone.0200215. eCollection 2018.

15.

Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.

de Las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Compañón I, Jiménez-Barbero J, Schjoldager KT, Bennett EP, Vakhrushev SY, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R.

Chemistry. 2018 Jun 12;24(33):8382-8392. doi: 10.1002/chem.201800701. Epub 2018 May 16.

PMID:
29601100
16.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2018 May 11;293(19):7408-7422. doi: 10.1074/jbc.M117.817981. Epub 2018 Mar 20. Erratum in: J Biol Chem. 2019 May 24;294(21):8349.

17.

A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome.

Narimatsu Y, Joshi HJ, Yang Z, Gomes C, Chen YH, Lorenzetti FC, Furukawa S, Schjoldager KT, Hansen L, Clausen H, Bennett EP, Wandall HH.

Glycobiology. 2018 May 1;28(5):295-305. doi: 10.1093/glycob/cwx101.

PMID:
29315387
18.

De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

Lavrsen K, Dabelsteen S, Vakhrushev SY, Levann AMR, Haue AD, Dylander A, Mandel U, Hansen L, Frödin M, Bennett EP, Wandall HH.

J Biol Chem. 2018 Jan 26;293(4):1298-1314. doi: 10.1074/jbc.M117.812826. Epub 2017 Nov 29.

19.

Dynamics of Indel Profiles Induced by Various CRISPR/Cas9 Delivery Methods.

Kosicki M, Rajan SS, Lorenzetti FC, Wandall HH, Narimatsu Y, Metzakopian E, Bennett EP.

Prog Mol Biol Transl Sci. 2017;152:49-67. doi: 10.1016/bs.pmbts.2017.09.003. Epub 2017 Nov 6.

PMID:
29150004
20.

Functional control of polypeptide GalNAc-transferase 3 through an acetylation site in the C-terminal lectin domain.

Lorenz V, Cejas RB, Bennett EP, Nores GA, Irazoqui FJ.

Biol Chem. 2017 Oct 26;398(11):1237-1246. doi: 10.1515/hsz-2017-0130.

PMID:
28672761
21.

Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression.

Pinto R, Hansen L, Hintze J, Almeida R, Larsen S, Coskun M, Davidsen J, Mitchelmore C, David L, Troelsen JT, Bennett EP.

Nucleic Acids Res. 2017 Jul 27;45(13):e123. doi: 10.1093/nar/gkx371.

22.

Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis.

Lonowski LA, Narimatsu Y, Riaz A, Delay CE, Yang Z, Niola F, Duda K, Ober EA, Clausen H, Wandall HH, Hansen SH, Bennett EP, Frödin M.

Nat Protoc. 2017 Mar;12(3):581-603. doi: 10.1038/nprot.2016.165. Epub 2017 Feb 16.

PMID:
28207001
23.

Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis.

Lorenz V, Ditamo Y, Cejas RB, Carrizo ME, Bennett EP, Clausen H, Nores GA, Irazoqui FJ.

J Biol Chem. 2016 Dec 2;291(49):25339-25350. Epub 2016 Oct 13.

24.

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.

25.

Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family.

Revoredo L, Wang S, Bennett EP, Clausen H, Moremen KW, Jarvis DL, Ten Hagen KG, Tabak LA, Gerken TA.

Glycobiology. 2016 Apr;26(4):360-76. doi: 10.1093/glycob/cwv108. Epub 2015 Nov 26.

26.

Deconstruction of O-glycosylation--GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.

Schjoldager KT, Joshi HJ, Kong Y, Goth CK, King SL, Wandall HH, Bennett EP, Vakhrushev SY, Clausen H.

EMBO Rep. 2015 Dec;16(12):1713-22. doi: 10.15252/embr.201540796. Epub 2015 Nov 13.

27.

A novel monoclonal antibody to a defined peptide epitope in MUC16.

Marcos-Silva L, Ricardo S, Chen K, Blixt O, Arigi E, Pereira D, Høgdall E, Mandel U, Bennett EP, Vakhrushev SY, David L, Clausen H.

Glycobiology. 2015 Nov;25(11):1172-82. doi: 10.1093/glycob/cwv056. Epub 2015 Jul 22.

PMID:
26201951
28.

Engineered CHO cells for production of diverse, homogeneous glycoproteins.

Yang Z, Wang S, Halim A, Schulz MA, Frodin M, Rahman SH, Vester-Christensen MB, Behrens C, Kristensen C, Vakhrushev SY, Bennett EP, Wandall HH, Clausen H.

Nat Biotechnol. 2015 Aug;33(8):842-4. doi: 10.1038/nbt.3280. Epub 2015 Jul 20.

PMID:
26192319
29.

CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia.

Pinto R, Barros R, Pereira-Castro I, Mesquita P, da Costa LT, Bennett EP, Almeida R, David L.

Lab Invest. 2015 Jul;95(7):718-27. doi: 10.1038/labinvest.2015.52. Epub 2015 Apr 13.

30.

Fast and sensitive detection of indels induced by precise gene targeting.

Yang Z, Steentoft C, Hauge C, Hansen L, Thomsen AL, Niola F, Vester-Christensen MB, Frödin M, Clausen H, Wandall HH, Bennett EP.

Nucleic Acids Res. 2015 May 19;43(9):e59. doi: 10.1093/nar/gkv126. Epub 2015 Mar 9.

31.

O-linked glycosylation of the mucin domain of the herpes simplex virus type 1-specific glycoprotein gC-1 is temporally regulated in a seed-and-spread manner.

Nordén R, Halim A, Nyström K, Bennett EP, Mandel U, Olofsson S, Nilsson J, Larson G.

J Biol Chem. 2015 Feb 20;290(8):5078-91. doi: 10.1074/jbc.M114.616409. Epub 2014 Dec 29.

32.

A glycogene mutation map for discovery of diseases of glycosylation.

Hansen L, Lind-Thomsen A, Joshi HJ, Pedersen NB, Have CT, Kong Y, Wang S, Sparso T, Grarup N, Vester-Christensen MB, Schjoldager K, Freeze HH, Hansen T, Pedersen O, Henrissat B, Mandel U, Clausen H, Wandall HH, Bennett EP.

Glycobiology. 2015 Feb;25(2):211-24. doi: 10.1093/glycob/cwu104. Epub 2014 Sep 28.

33.

Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis.

Kong Y, Joshi HJ, Schjoldager KT, Madsen TD, Gerken TA, Vester-Christensen MB, Wandall HH, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Glycobiology. 2015 Jan;25(1):55-65. doi: 10.1093/glycob/cwu089. Epub 2014 Aug 25.

34.

Immature truncated O-glycophenotype of cancer directly induces oncogenic features.

Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA, Wandall HH.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75. doi: 10.1073/pnas.1406619111. Epub 2014 Aug 12.

35.

Precision genome editing: a small revolution for glycobiology.

Steentoft C, Bennett EP, Schjoldager KT, Vakhrushev SY, Wandall HH, Clausen H.

Glycobiology. 2014 Aug;24(8):663-80. doi: 10.1093/glycob/cwu046. Epub 2014 May 26. Review.

PMID:
24861053
36.

Characterization of binding epitopes of CA125 monoclonal antibodies.

Marcos-Silva L, Narimatsu Y, Halim A, Campos D, Yang Z, Tarp MA, Pereira PJ, Mandel U, Bennett EP, Vakhrushev SY, Levery SB, David L, Clausen H.

J Proteome Res. 2014 Jul 3;13(7):3349-59. doi: 10.1021/pr500215g. Epub 2014 Jun 4.

PMID:
24850311
37.

Low density lipoprotein receptor class A repeats are O-glycosylated in linker regions.

Pedersen NB, Wang S, Narimatsu Y, Yang Z, Halim A, Schjoldager KT, Madsen TD, Seidah NG, Bennett EP, Levery SB, Clausen H.

J Biol Chem. 2014 Jun 20;289(25):17312-24. doi: 10.1074/jbc.M113.545053. Epub 2014 May 5.

38.

High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs.

Duda K, Lonowski LA, Kofoed-Nielsen M, Ibarra A, Delay CM, Kang Q, Yang Z, Pruett-Miller SM, Bennett EP, Wandall HH, Davis GD, Hansen SH, Frödin M.

Nucleic Acids Res. 2014 Jun;42(10):e84. doi: 10.1093/nar/gku251. Epub 2014 Apr 21.

39.

Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.

Vester-Christensen MB, Halim A, Joshi HJ, Steentoft C, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21018-23. doi: 10.1073/pnas.1313446110. Epub 2013 Oct 7.

40.

Generation of monoclonal antibodies to native active human glycosyltransferases.

Vester-Christensen MB, Bennett EP, Clausen H, Mandel U.

Methods Mol Biol. 2013;1022:403-20. doi: 10.1007/978-1-62703-465-4_30.

PMID:
23765678
42.

Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.

Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.

EMBO J. 2013 May 15;32(10):1478-88. doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12.

43.

Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability.

Hansen L, Tawamie H, Murakami Y, Mang Y, ur Rehman S, Buchert R, Schaffer S, Muhammad S, Bak M, Nöthen MM, Bennett EP, Maeda Y, Aigner M, Reis A, Kinoshita T, Tommerup N, Baig SM, Abou Jamra R.

Am J Hum Genet. 2013 Apr 4;92(4):575-83. doi: 10.1016/j.ajhg.2013.03.008.

44.

Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).

van der Post S, Subramani DB, Bäckström M, Johansson ME, Vester-Christensen MB, Mandel U, Bennett EP, Clausen H, Dahlén G, Sroka A, Potempa J, Hansson GC.

J Biol Chem. 2013 May 17;288(20):14636-46. doi: 10.1074/jbc.M113.459479. Epub 2013 Apr 1.

45.

Enhanced mass spectrometric mapping of the human GalNAc-type O-glycoproteome with SimpleCells.

Vakhrushev SY, Steentoft C, Vester-Christensen MB, Bennett EP, Clausen H, Levery SB.

Mol Cell Proteomics. 2013 Apr;12(4):932-44. doi: 10.1074/mcp.O112.021972. Epub 2013 Feb 11.

46.

An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2.

Zlocowski N, Lorenz V, Bennett EP, Clausen H, Nores GA, Irazoqui FJ.

Biol Chem. 2013 Jan;394(1):69-77. doi: 10.1515/hsz-2012-0191.

PMID:
23096348
47.

Toward stable genetic engineering of human O-glycosylation in plants.

Yang Z, Bennett EP, Jørgensen B, Drew DP, Arigi E, Mandel U, Ulvskov P, Levery SB, Clausen H, Petersen BL.

Plant Physiol. 2012 Sep;160(1):450-63. doi: 10.1104/pp.112.198200. Epub 2012 Jul 12.

48.

Thiogalactopyranosides are resistant to hydrolysis by α-galactosidases.

Adlercreutz D, Yoshimura Y, Mannerstedt K, Wakarchuk WW, Bennett EP, Dovichi NJ, Hindsgaul O, Palcic MM.

Chembiochem. 2012 Jul 23;13(11):1673-9. doi: 10.1002/cbic.201200155. Epub 2012 Jun 27.

49.

Oral candidosis in lichen planus: the diagnostic approach is of major therapeutic importance.

Kragelund C, Kieffer-Kristensen L, Reibel J, Bennett EP.

Clin Oral Investig. 2013 Apr;17(3):957-65. doi: 10.1007/s00784-012-0757-6. Epub 2012 Jun 15.

PMID:
22699660
50.

The origin and function of platelet glycosyltransferases.

Wandall HH, Rumjantseva V, Sørensen AL, Patel-Hett S, Josefsson EC, Bennett EP, Italiano JE Jr, Clausen H, Hartwig JH, Hoffmeister KM.

Blood. 2012 Jul 19;120(3):626-35. doi: 10.1182/blood-2012-02-409235. Epub 2012 May 21.

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