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Radiosynthesis of the diastereomerically pure (E)-[11 C]ABP688.

Bdair H, Tsai IH, Smart K, Benkelfat C, Leyton M, Kostikov A.

J Labelled Comp Radiopharm. 2019 Oct;62(12):860-864. doi: 10.1002/jlcr.3802. Epub 2019 Sep 18.


Why Is Aging a Risk Factor for Cognitive Impairment in Parkinson's Disease?-A Resting State fMRI Study.

Nagano-Saito A, Bellec P, Hanganu A, Jobert S, Mejia-Constain B, Degroot C, Lafontaine AL, Lissemore JI, Smart K, Benkelfat C, Monchi O.

Front Neurol. 2019 Mar 22;10:267. doi: 10.3389/fneur.2019.00267. eCollection 2019.


Neural function in DCC mutation carriers with and without mirror movements.

Vosberg DE, Beaulé V, Torres-Berrío A, Cooke D, Chalupa A, Jaworska N, Cox SML, Larcher K, Zhang Y, Allard D, Durand F, Dagher A, Benkelfat C, Srour M, Tampieri D, La Piana R, Joober R, Lepore F, Rouleau G, Pascual-Leone A, Fox MD, Flores C, Leyton M, Théoret H.

Ann Neurol. 2019 Mar;85(3):433-442. doi: 10.1002/ana.25418. Epub 2019 Feb 4.


Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.

Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M.

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1179-1183. doi: 10.1007/s00259-018-4252-4. Epub 2019 Jan 9.


Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans.

Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M.

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1175-1178. doi: 10.1007/s00259-018-4237-3. Epub 2019 Jan 3.


Test-retest variability of [11 C]ABP688 estimates of metabotropic glutamate receptor subtype 5 availability in humans.

Smart K, Cox SML, Nagano-Saito A, Rosa-Neto P, Leyton M, Benkelfat C.

Synapse. 2018 Sep;72(9):e22041. doi: 10.1002/syn.22041. Epub 2018 Jul 20.


Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers.

Vosberg DE, Zhang Y, Menegaux A, Chalupa A, Manitt C, Zehntner S, Eng C, DeDuck K, Allard D, Durand F, Dagher A, Benkelfat C, Srour M, Joober R, Lepore F, Rouleau G, Théoret H, Bedell BJ, Flores C, Leyton M.

J Neurosci. 2018 May 16;38(20):4655-4665. doi: 10.1523/JNEUROSCI.3251-17.2018. Epub 2018 Apr 30.


Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline.

Lissemore JI, Sookman D, Gravel P, Berney A, Barsoum A, Diksic M, Nordahl TE, Pinard G, Sibon I, Cottraux J, Leyton M, Benkelfat C.

Transl Psychiatry. 2018 Apr 18;8(1):82. doi: 10.1038/s41398-018-0128-4.


Differential Associations between Cortical Thickness and Striatal Dopamine in Treatment-Naïve Adults with ADHD vs. Healthy Controls.

Cherkasova MV, Faridi N, Casey KF, Larcher K, O'Driscoll GA, Hechtman L, Joober R, Baker GB, Palmer J, Evans AC, Dagher A, Benkelfat C, Leyton M.

Front Hum Neurosci. 2017 Aug 22;11:421. doi: 10.3389/fnhum.2017.00421. eCollection 2017.


Posterior dopamine D2/3 receptors and brain network functional connectivity.

Nagano-Saito A, Lissemore JI, Gravel P, Leyton M, Carbonell F, Benkelfat C.

Synapse. 2017 Nov;71(11). doi: 10.1002/syn.21993. Epub 2017 Aug 7.


Dopamine and light: effects on facial emotion recognition.

Cawley E, Tippler M, Coupland NJ, Benkelfat C, Boivin DB, Aan Het Rot M, Leyton M.

J Psychopharmacol. 2017 Sep;31(9):1225-1233. doi: 10.1177/0269881117711707. Epub 2017 Jun 21.


Cocaine Cue-Induced Dopamine Release in Recreational Cocaine Users.

Cox SML, Yau Y, Larcher K, Durand F, Kolivakis T, Delaney JS, Dagher A, Benkelfat C, Leyton M.

Sci Rep. 2017 Apr 26;7:46665. doi: 10.1038/srep46665.


Is there a relation between novelty seeking, striatal dopamine release and frontal cortical thickness?

Jaworska N, Cox SM, Casey KF, Boileau I, Cherkasova M, Larcher K, Dagher A, Benkelfat C, Leyton M.

PLoS One. 2017 Mar 27;12(3):e0174219. doi: 10.1371/journal.pone.0174219. eCollection 2017.


Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.

Booij L, Welfeld K, Leyton M, Dagher A, Boileau I, Sibon I, Baker GB, Diksic M, Soucy JP, Pruessner JC, Cawley-Fiset E, Casey KF, Benkelfat C.

Transl Psychiatry. 2016 Feb 23;6:e740. doi: 10.1038/tp.2016.6.


Cocaine cue-induced dopamine release in the human prefrontal cortex.

Milella MS, Fotros A, Gravel P, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Reader AJ, Dagher A, Benkelfat C, Leyton M.

J Psychiatry Neurosci. 2016 Aug;41(5):322-30. doi: 10.1503/jpn.150207.


Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha-[(11) C]methyl-l-tryptophan study.

Booij L, Soucy JP, Young SN, Regoli M, Gravel P, Diksic M, Leyton M, Pihl RO, Benkelfat C.

J Neurochem. 2014 Dec;131(5):634-44. doi: 10.1111/jnc.12826. Epub 2014 Aug 21.


Limbic system mGluR5 availability in cocaine dependent subjects: a high-resolution PET [(11)C]ABP688 study.

Milella MS, Marengo L, Larcher K, Fotros A, Dagher A, Rosa-Neto P, Benkelfat C, Leyton M.

Neuroimage. 2014 Sep;98:195-202. doi: 10.1016/j.neuroimage.2014.04.061. Epub 2014 May 2.


Dopamine precursor depletion impairs structure and efficiency of resting state brain functional networks.

Carbonell F, Nagano-Saito A, Leyton M, Cisek P, Benkelfat C, He Y, Dagher A.

Neuropharmacology. 2014 Sep;84:90-100. doi: 10.1016/j.neuropharm.2013.12.021. Epub 2014 Jan 9.


Amphetamine-induced dopamine release and neurocognitive function in treatment-naive adults with ADHD.

Cherkasova MV, Faridi N, Casey KF, O'Driscoll GA, Hechtman L, Joober R, Baker GB, Palmer J, Dagher A, Leyton M, Benkelfat C.

Neuropsychopharmacology. 2014 May;39(6):1498-507. doi: 10.1038/npp.2013.349. Epub 2013 Dec 30.


The effect of acute tryptophan depletion on mood and impulsivity in polydrug ecstasy users.

Young SN, Regoli M, Leyton M, Pihl RO, Benkelfat C.

Psychopharmacology (Berl). 2014 Feb;231(4):707-16. doi: 10.1007/s00213-013-3287-2. Epub 2013 Oct 19.


Reduced dopamine response to amphetamine in subjects at ultra-high risk for addiction.

Casey KF, Benkelfat C, Cherkasova MV, Baker GB, Dagher A, Leyton M.

Biol Psychiatry. 2014 Jul 1;76(1):23-30. doi: 10.1016/j.biopsych.2013.08.033. Epub 2013 Oct 17.


Individual differences in frontal cortical thickness correlate with the d-amphetamine-induced striatal dopamine response in humans.

Casey KF, Cherkasova MV, Larcher K, Evans AC, Baker GB, Dagher A, Benkelfat C, Leyton M.

J Neurosci. 2013 Sep 18;33(38):15285-94. doi: 10.1523/JNEUROSCI.5029-12.2013.


Stress-induced dopamine release in human medial prefrontal cortex--18F-fallypride/PET study in healthy volunteers.

Nagano-Saito A, Dagher A, Booij L, Gravel P, Welfeld K, Casey KF, Leyton M, Benkelfat C.

Synapse. 2013 Dec;67(12):821-30. doi: 10.1002/syn.21700. Epub 2013 Sep 12.


Differential striatal dopamine responses following oral alcohol in individuals at varying risk for dependence.

Setiawan E, Pihl RO, Dagher A, Schlagintweit H, Casey KF, Benkelfat C, Leyton M.

Alcohol Clin Exp Res. 2014 Jan;38(1):126-34. doi: 10.1111/acer.12218. Epub 2013 Aug 6.


Dopamine and light: dissecting effects on mood and motivational states in women with subsyndromal seasonal affective disorder.

Cawley EI, Park S, aan het Rot M, Sancton K, Benkelfat C, Young SN, Boivin DB, Leyton M.

J Psychiatry Neurosci. 2013 Nov;38(6):388-97. doi: 10.1503/jpn.120181.


Cocaine cue-induced dopamine release in amygdala and hippocampus: a high-resolution PET [¹⁸F]fallypride study in cocaine dependent participants.

Fotros A, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Gravel P, Reader AJ, Dagher A, Benkelfat C, Leyton M.

Neuropsychopharmacology. 2013 Aug;38(9):1780-8. doi: 10.1038/npp.2013.77. Epub 2013 Apr 1.


The neurobiology of depression--revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies.

Albert PR, Benkelfat C.

Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20120535. doi: 10.1098/rstb.2012.0535. Print 2013.


Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.

Setiawan E, Pihl RO, Benkelfat C, Leyton M.

Pharmacogenomics. 2012 Jul;13(10):1161-72. doi: 10.2217/pgs.12.99. Review.


The effects of age and estrogen on stress responsivity in older women.

Dumas JA, Albert KM, Naylor MR, Sites CK, Benkelfat C, Newhouse PA.

Am J Geriatr Psychiatry. 2012 Sep;20(9):734-43. doi: 10.1097/JGP.0b013e31825c0a14.


The neurobiology of depression--revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms.

Albert PR, Benkelfat C, Descarries L.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 5;367(1601):2378-81. doi: 10.1098/rstb.2012.0190.


Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression.

Wang D, Szyf M, Benkelfat C, Provençal N, Turecki G, Caramaschi D, Côté SM, Vitaro F, Tremblay RE, Booij L.

PLoS One. 2012;7(6):e39501. doi: 10.1371/journal.pone.0039501. Epub 2012 Jun 20.


From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion study.

Nagano-Saito A, Cisek P, Perna AS, Shirdel FZ, Benkelfat C, Leyton M, Dagher A.

J Neurophysiol. 2012 Jul;108(2):501-12. doi: 10.1152/jn.00592.2011. Epub 2012 May 2.


Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: a 27-year longitudinal study.

Booij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque ML, Arseneault L, Diksic M, Tremblay RE.

Eur Neuropsychopharmacol. 2012 Jun;22(6):419-23. doi: 10.1016/j.euroneuro.2011.11.002. Epub 2012 Jan 17.


The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.

Liggins J, Pihl RO, Benkelfat C, Leyton M.

PLoS One. 2012;7(1):e28370. doi: 10.1371/journal.pone.0028370. Epub 2012 Jan 4.


Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addiction.

Venugopalan VV, Casey KF, O'Hara C, O'Loughlin J, Benkelfat C, Fellows LK, Leyton M.

Neuropsychopharmacology. 2011 Nov;36(12):2469-76. doi: 10.1038/npp.2011.135. Epub 2011 Jul 20.


Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans.

Booij L, Turecki G, Leyton M, Gravel P, Lopez De Lara C, Diksic M, Benkelfat C.

Mol Psychiatry. 2012 Jul;17(8):809-17. doi: 10.1038/mp.2011.79. Epub 2011 Jul 12.


Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [¹¹C]raclopride study in humans.

Cox SM, Benkelfat C, Dagher A, Delaney JS, Durand F, Kolivakis T, Casey KF, Leyton M.

Br J Psychiatry. 2011 Nov;199(5):391-7. doi: 10.1192/bjp.bp.110.084178. Epub 2011 May 4. Erratum in: Br J Psychiatry. 2012 Jul;201:77.


The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype.

Setiawan E, Pihl RO, Cox SM, Gianoulakis C, Palmour RM, Benkelfat C, Leyton M.

Alcohol Clin Exp Res. 2011 Jun;35(6):1134-41. doi: 10.1111/j.1530-0277.2011.01446.x. Epub 2011 Mar 15.


Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder.

Berney A, Leyton M, Gravel P, Sibon I, Sookman D, Rosa Neto P, Diksic M, Nakai A, Pinard G, Todorov C, Okazawa H, Blier P, Nordahl TE, Benkelfat C.

Arch Gen Psychiatry. 2011 Jul;68(7):732-41. doi: 10.1001/archgenpsychiatry.2011.16. Epub 2011 Mar 7.


Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal women.

Newhouse PA, Dumas J, Wilkins H, Coderre E, Sites CK, Naylor M, Benkelfat C, Young SN.

Menopause. 2010 Jul;17(4):860-73. doi: 10.1097/gme.0b013e3181e15df4.


Effect of D-amphetamine on inhibition and motor planning as a function of baseline performance.

Allman AA, Benkelfat C, Durand F, Sibon I, Dagher A, Leyton M, Baker GB, O'Driscoll GA.

Psychopharmacology (Berl). 2010 Sep;211(4):423-33. doi: 10.1007/s00213-010-1912-x. Epub 2010 Jul 4.


Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study.

Booij L, Tremblay RE, Leyton M, Séguin JR, Vitaro F, Gravel P, Perreau-Linck E, Lévesque ML, Durand F, Diksic M, Turecki G, Benkelfat C.

PLoS One. 2010 Jun 22;5(6):e11255. doi: 10.1371/journal.pone.0011255.


Recognizing emotions in faces: effects of acute tryptophan depletion and bright light.

aan het Rot M, Coupland N, Boivin DB, Benkelfat C, Young SN.

J Psychopharmacol. 2010 Oct;24(10):1447-54. doi: 10.1177/0269881109348169. Epub 2009 Nov 25.


Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.

Sequeira A, Mamdani F, Ernst C, Vawter MP, Bunney WE, Lebel V, Rehal S, Klempan T, Gratton A, Benkelfat C, Rouleau GA, Mechawar N, Turecki G.

PLoS One. 2009 Aug 11;4(8):e6585. doi: 10.1371/journal.pone.0006585.


Striatal dopamine responses to intranasal cocaine self-administration in humans.

Cox SM, Benkelfat C, Dagher A, Delaney JS, Durand F, McKenzie SA, Kolivakis T, Casey KF, Leyton M.

Biol Psychiatry. 2009 May 15;65(10):846-50. doi: 10.1016/j.biopsych.2009.01.021. Epub 2009 Feb 27.


MicroPET imaging of 5-HT 1A receptors in rat brain: a test-retest [18F]MPPF study.

Aznavour N, Benkelfat C, Gravel P, Aliaga A, Rosa-Neto P, Bedell B, Zimmer L, Descarries L.

Eur J Nucl Med Mol Imaging. 2009 Jan;36(1):53-62. doi: 10.1007/s00259-008-0891-1. Epub 2008 Aug 15.


The role of dopamine in alcohol self-administration in humans: individual differences.

Barrett SP, Pihl RO, Benkelfat C, Brunelle C, Young SN, Leyton M.

Eur Neuropsychopharmacol. 2008 Jun;18(6):439-47. doi: 10.1016/j.euroneuro.2008.01.008. Epub 2008 Mar 25.


CTN-194 (PICCO): design of a trial of citalopram for the prevention of depression and its consequences in HIV-hepatitis C co-infected individuals initiating pegylated interferon/ribavirin therapy.

Klein MB, Cooper C, Brouillette MJ, Sheehan NL, Benkelfat C, Annable L, Weston F, Kraus D, Singer J; CTN194 Investigators.

Contemp Clin Trials. 2008 Jul;29(4):617-30. doi: 10.1016/j.cct.2008.01.001. Epub 2008 Jan 12.


Decreased [18F]MPPF binding potential in the dorsal raphe nucleus after a single oral dose of fluoxetine: a positron-emission tomography study in healthy volunteers.

Sibon I, Benkelfat C, Gravel P, Aznavour N, Costes N, Mzengeza S, Booij L, Baker G, Soucy JP, Zimmer L, Descarries L.

Biol Psychiatry. 2008 Jun 15;63(12):1135-40. doi: 10.1016/j.biopsych.2007.11.016. Epub 2008 Jan 14.


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