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Items: 1 to 50 of 103


Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.

Romanos J, Benke D, Saab AS, Zeilhofer HU, Santello M.

Commun Biol. 2019 Apr 5;2:127. doi: 10.1038/s42003-019-0367-9. eCollection 2019.


Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.

Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU.

Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0.


Impact on GABA systems in monogenetic developmental CNS disorders: Clues to symptomatic treatment.

Benke D, Möhler H.

Neuropharmacology. 2018 Jul 1;136(Pt A):46-55. doi: 10.1016/j.neuropharm.2017.07.030. Epub 2017 Jul 29. Review.


GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [18F]flumazenil PET.

Müller Herde A, Benke D, Ralvenius WT, Mu L, Schibli R, Zeilhofer HU, Krämer SD.

Neuroimage. 2017 Apr 15;150:279-291. doi: 10.1016/j.neuroimage.2017.02.022. Epub 2017 Feb 10.


Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia.

Notter T, Coughlin JM, Gschwind T, Weber-Stadlbauer U, Wang Y, Kassiou M, Vernon AC, Benke D, Pomper MG, Sawa A, Meyer U.

Mol Psychiatry. 2018 Feb;23(2):323-334. doi: 10.1038/mp.2016.248. Epub 2017 Jan 17.


Mastering hysteresis in magnetocaloric materials.

Gutfleisch O, Gottschall T, Fries M, Benke D, Radulov I, Skokov KP, Wende H, Gruner M, Acet M, Entel P, Farle M.

Philos Trans A Math Phys Eng Sci. 2016 Aug 13;374(2074). pii: 20150308. doi: 10.1098/rsta.2015.0308.


The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.

Ralvenius WT, Acuña MA, Benke D, Matthey A, Daali Y, Rudolph U, Desmeules J, Zeilhofer HU, Besson M.

Neuropharmacology. 2016 Oct;109:366-375. doi: 10.1016/j.neuropharm.2016.07.004. Epub 2016 Jul 5.


Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.

Acuña MA, Yévenes GE, Ralvenius WT, Benke D, Di Lio A, Lara CO, Muñoz B, Burgos CF, Moraga-Cid G, Corringer PJ, Zeilhofer HU.

J Clin Invest. 2016 Jul 1;126(7):2547-60. doi: 10.1172/JCI83817. Epub 2016 Jun 6.


The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice.

Zemoura K, Ralvenius WT, Malherbe P, Benke D.

Neuropharmacology. 2016 Sep;108:172-8. doi: 10.1016/j.neuropharm.2016.04.028. Epub 2016 Apr 22.


A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice.

Behlke LM, Foster RA, Liu J, Benke D, Benham RS, Nathanson AJ, Yee BK, Zeilhofer HU, Engin E, Rudolph U.

Neuropsychopharmacology. 2016 Sep;41(10):2492-501. doi: 10.1038/npp.2016.49. Epub 2016 Apr 12.


Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference.

Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U.

J Neurosci. 2015 Oct 7;35(40):13698-712. doi: 10.1523/JNEUROSCI.1370-15.2015.


Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.

Ralvenius WT, Benke D, Acuña MA, Rudolph U, Zeilhofer HU.

Nat Commun. 2015 Apr 13;6:6803. doi: 10.1038/ncomms7803.


Synthesis and Characterization of Gelatin-Based Magnetic Hydrogels.

Helminger M, Wu B, Kollmann T, Benke D, Schwahn D, Pipich V, Faivre D, Zahn D, Cölfen H.

Adv Funct Mater. 2014 Jun;24(21):3187-3196. Epub 2014 Feb 12.


Regulation of cell surface GABA(B) receptors: contribution to synaptic plasticity in neurological diseases.

Benke D, Balakrishnan K, Zemoura K.

Adv Pharmacol. 2015;73:41-70. doi: 10.1016/bs.apha.2014.11.002. Epub 2015 Jan 14.


Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.

Zemoura K, Schenkel M, Acuña MA, Yévenes GE, Zeilhofer HU, Benke D.

J Biol Chem. 2013 Nov 29;288(48):34897-905. doi: 10.1074/jbc.M113.514745. Epub 2013 Oct 10.


GABAB receptor trafficking and interacting proteins: targets for the development of highly specific therapeutic strategies to treat neurological disorders?

Benke D.

Biochem Pharmacol. 2013 Dec 1;86(11):1525-30. doi: 10.1016/j.bcp.2013.09.016. Epub 2013 Sep 29. Review.


Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites.

Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU.

Neuropsychopharmacology. 2014 Jan;39(2):477-87. doi: 10.1038/npp.2013.221. Epub 2013 Aug 28.


Divorce of obligatory partners in pain: disruption of GABA(B) receptor heterodimers in neuralgia.

Benke D, Zeilhofer HU.

EMBO J. 2012 Aug 1;31(15):3234-6. doi: 10.1038/emboj.2012.174. Epub 2012 Jun 26. No abstract available.


Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation.

Benke D, Zemoura K, Maier PJ.

World J Biol Chem. 2012 Apr 26;3(4):61-72. doi: 10.4331/wjbc.v3.i4.61.


Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control.

Zeilhofer HU, Benke D, Yevenes GE.

Annu Rev Pharmacol Toxicol. 2012;52:111-33. doi: 10.1146/annurev-pharmtox-010611-134636. Epub 2011 Aug 15. Review.


Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.

Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM.

J Physiol. 2011 Oct 15;589(Pt 20):4959-80. doi: 10.1113/jphysiol.2011.216028. Epub 2011 Aug 8.


HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain.

Di Lio A, Benke D, Besson M, Desmeules J, Daali Y, Wang ZJ, Edwankar R, Cook JM, Zeilhofer HU.

Neuropharmacology. 2011 Mar;60(4):626-32. doi: 10.1016/j.neuropharm.2010.11.026. Epub 2010 Dec 8.


Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.

Maier PJ, Marin I, Grampp T, Sommer A, Benke D.

J Biol Chem. 2010 Nov 12;285(46):35606-14. doi: 10.1074/jbc.M110.142406. Epub 2010 Sep 7.


Comparative evaluation of the usability of 2 different methods to perform mild hypothermia in patients with out-of-hospital cardiac arrest.

Rana M, W Schröder J, Saygili E, Hameed U, Benke D, Hoffmann R, Schauerte P, Marx N, Rana OR.

Int J Cardiol. 2011 Nov 3;152(3):321-6. doi: 10.1016/j.ijcard.2010.07.026. Epub 2010 Aug 1.


Mechanisms of GABAB receptor exocytosis, endocytosis, and degradation.

Benke D.

Adv Pharmacol. 2010;58:93-111. doi: 10.1016/S1054-3589(10)58004-9. Review.


The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits.

Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D.

J Neurochem. 2009 Jul;110(1):244-54. doi: 10.1111/j.1471-4159.2009.06119.x. Epub 2009 Apr 27.


Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1.

Singer P, Yee BK, Feldon J, Iwasato T, Itohara S, Grampp T, Prenosil G, Benke D, Möhler H, Boison D.

Neuroscience. 2009 Jun 30;161(2):635-54. doi: 10.1016/j.neuroscience.2009.03.056. Epub 2009 Mar 28.


Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABA(B) receptors in cortical neurons.

Grampp T, Notz V, Broll I, Fischer N, Benke D.

Mol Cell Neurosci. 2008 Dec;39(4):628-37. doi: 10.1016/j.mcn.2008.09.004. Epub 2008 Oct 2.


GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts.

Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H.

Neuropharmacology. 2009 Jan;56(1):174-81. doi: 10.1016/j.neuropharm.2008.06.013. Epub 2008 Jun 17.


Survival and quality of life in patients with cardiac resynchronization therapy for severe heart failure and in heart transplant recipients within a contemporary heart failure management program.

Becker M, Erdmann N, Stegemann E, Benke D, Schauerte PN, Schaefer WM, Autschbach R, Kelm M, Koch KC.

J Heart Lung Transplant. 2008 Jul;27(7):746-52. doi: 10.1016/j.healun.2008.03.024. Epub 2008 May 19.


Benzodiazepine binding to GABA(A) receptors.

Benke D, Möhler H.

Curr Protoc Pharmacol. 2006 Dec;Chapter 1:Unit1.16. doi: 10.1002/0471141755.ph0116s35.


Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor alpha3 subunit-null mice.

Studer R, von Boehmer L, Haenggi T, Schweizer C, Benke D, Rudolph U, Fritschy JM.

Eur J Neurosci. 2006 Sep;24(5):1307-15.


Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.

Yee BK, Balic E, Singer P, Schwerdel C, Grampp T, Gabernet L, Knuesel I, Benke D, Feldon J, Mohler H, Boison D.

J Neurosci. 2006 Mar 22;26(12):3169-81.


Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigens.

Benke D, Krüger T, Lang A, Hamilton-Williams EE, Kurts C.

J Immunol Methods. 2006 Mar 20;310(1-2):12-9. Epub 2006 Jan 19.


A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction.

Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, Dong Y, Malenka RC, Fritschy JM, Bluethmann H, Feldon J, Möhler H, Rudolph U.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17154-9. Epub 2005 Nov 11.


Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.

Sauter K, Grampp T, Fritschy JM, Kaupmann K, Bettler B, Mohler H, Benke D.

J Biol Chem. 2005 Sep 30;280(39):33566-72. Epub 2005 Aug 4.


Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens.

Hamilton-Williams EE, Lang A, Benke D, Davey GM, Wiesmüller KH, Kurts C.

J Immunol. 2005 Feb 1;174(3):1159-63.


Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.

Lang A, Benke D, Eitner F, Engel D, Ehrlich S, Breloer M, Hamilton-Williams E, Specht S, Hoerauf A, Floege J, von Bonin A, Kurts C.

J Am Soc Nephrol. 2005 Feb;16(2):383-91. Epub 2004 Dec 15.


Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain.

Fritschy JM, Sidler C, Parpan F, Gassmann M, Kaupmann K, Bettler B, Benke D.

J Comp Neurol. 2004 Sep 20;477(3):235-52.


Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits.

Benke D, Fakitsas P, Roggenmoser C, Michel C, Rudolph U, Mohler H.

J Biol Chem. 2004 Oct 15;279(42):43654-60. Epub 2004 Aug 10.


Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis.

Krüger T, Benke D, Eitner F, Lang A, Wirtz M, Hamilton-Williams EE, Engel D, Giese B, Müller-Newen G, Floege J, Kurts C.

J Am Soc Nephrol. 2004 Mar;15(3):613-21.


Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient.

Christen U, Benke D, Wolfe T, Rodrigo E, Rhode A, Hughes AC, Oldstone MB, von Herrath MG.

J Clin Invest. 2004 Jan;113(1):74-84.


Structure of GABAB receptors in rat retina.

Benke D, Michel C, Mohler H.

J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):253-66.


Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors.

Crestani F, Keist R, Fritschy JM, Benke D, Vogt K, Prut L, Blüthmann H, Möhler H, Rudolph U.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8980-5.


Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium.

Gao B, Wenzel A, Grimm C, Vavricka SR, Benke D, Meier PJ, Remè CE.

Invest Ophthalmol Vis Sci. 2002 Feb;43(2):510-4.


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