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Items: 1 to 50 of 101

1.

Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.

Pandruvada SN, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah NG, Vacher J.

Mol Cell Biol. 2015 Nov 23;36(3):507-21. doi: 10.1128/MCB.00656-15. Print 2016 Feb 1.

2.

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.

Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, Seidah NG.

J Biol Chem. 2015 Jul 24;290(30):18609-20. doi: 10.1074/jbc.M115.647180. Epub 2015 Jun 17.

3.

Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels.

Berthold HK, Seidah NG, Benjannet S, Gouni-Berthold I.

PLoS One. 2013;8(3):e60095. doi: 10.1371/journal.pone.0060095. Epub 2013 Mar 27.

4.

Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation.

Benjannet S, Hamelin J, Chrétien M, Seidah NG.

J Biol Chem. 2012 Sep 28;287(40):33745-55. Epub 2012 Aug 8.

5.

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

Abifadel M, Guerin M, Benjannet S, Rabès JP, Le Goff W, Julia Z, Hamelin J, Carreau V, Varret M, Bruckert E, Tosolini L, Meilhac O, Couvert P, Bonnefont-Rousselot D, Chapman J, Carrié A, Michel JB, Prat A, Seidah NG, Boileau C.

Atherosclerosis. 2012 Aug;223(2):394-400. doi: 10.1016/j.atherosclerosis.2012.04.006. Epub 2012 May 17.

PMID:
22683120
6.

Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial.

Awan Z, Seidah NG, MacFadyen JG, Benjannet S, Chasman DI, Ridker PM, Genest J.

Clin Chem. 2012 Jan;58(1):183-9. doi: 10.1373/clinchem.2011.172932. Epub 2011 Nov 7.

7.

Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome.

Richard C, Couture P, Desroches S, Benjannet S, Seidah NG, Lichtenstein AH, Lamarche B.

Br J Nutr. 2012 Mar;107(5):705-11. doi: 10.1017/S0007114511003436. Epub 2011 Jul 26.

PMID:
21787450
8.

Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Benjannet S, Chamberland A, Day R, Szumska D, Constam D, Bhattacharya S, Prat A, Seidah NG.

J Biol Chem. 2011 Jul 1;286(26):22785-94. doi: 10.1074/jbc.M111.233577. Epub 2011 May 5.

9.

N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1.

Zandberg WF, Benjannet S, Hamelin J, Pinto BM, Seidah NG.

Glycobiology. 2011 Oct;21(10):1290-300. doi: 10.1093/glycob/cwr060. Epub 2011 Apr 28.

PMID:
21527438
10.

Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.

Rousselet E, Benjannet S, Marcinkiewicz E, Asselin MC, Lazure C, Seidah NG.

J Biol Chem. 2011 Mar 18;286(11):9185-95. doi: 10.1074/jbc.M110.189936. Epub 2011 Jan 5.

11.

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men.

Tremblay AJ, Lamarche B, Lemelin V, Hoos L, Benjannet S, Seidah NG, Davis HR Jr, Couture P.

J Lipid Res. 2011 Mar;52(3):558-65. doi: 10.1194/jlr.M011080. Epub 2010 Dec 1.

12.

The proprotein convertase PC7: unique zymogen activation and trafficking pathways.

Rousselet E, Benjannet S, Hamelin J, Canuel M, Seidah NG.

J Biol Chem. 2011 Jan 28;286(4):2728-38. doi: 10.1074/jbc.M110.192344. Epub 2010 Nov 12.

13.

Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events.

Benjannet S, Saavedra YG, Hamelin J, Asselin MC, Essalmani R, Pasquato A, Lemaire P, Duke G, Miao B, Duclos F, Parker R, Mayer G, Seidah NG.

J Biol Chem. 2010 Dec 24;285(52):40965-78. doi: 10.1074/jbc.M110.154815. Epub 2010 Oct 11.

14.

A new method for measurement of total plasma PCSK9: clinical applications.

Dubuc G, Tremblay M, Paré G, Jacques H, Hamelin J, Benjannet S, Boulet L, Genest J, Bernier L, Seidah NG, Davignon J.

J Lipid Res. 2010 Jan;51(1):140-9. doi: 10.1194/jlr.M900273-JLR200.

15.

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein.

Ozden S, Lucas-Hourani M, Ceccaldi PE, Basak A, Valentine M, Benjannet S, Hamelin J, Jacob Y, Mamchaoui K, Mouly V, Desprès P, Gessain A, Butler-Browne G, Chrétien M, Tangy F, Vidalain PO, Seidah NG.

J Biol Chem. 2008 Aug 8;283(32):21899-908. doi: 10.1074/jbc.M802444200. Epub 2008 Jun 17.

16.

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.

Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG.

J Biol Chem. 2008 Jan 25;283(4):2363-72. Epub 2007 Nov 26.

17.

The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization.

Pullikotil P, Benjannet S, Mayne J, Seidah NG.

J Biol Chem. 2007 Sep 14;282(37):27402-13. Epub 2007 Jul 10.

18.

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.

Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG.

Traffic. 2007 Jun;8(6):718-32. Epub 2007 Apr 25. Erratum in: Traffic. 2007 Jul;8(7):950.

19.

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG.

J Biol Chem. 2006 Oct 13;281(41):30561-72. Epub 2006 Aug 15.

20.

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

Salvas A, Benjannet S, Reudelhuber TL, Chrétien M, Seidah NG.

FEBS Lett. 2005 Oct 24;579(25):5621-5. Epub 2005 Sep 28.

21.

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.

Vincent MJ, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, Seidah NG, Nichol ST.

Virol J. 2005 Aug 22;2:69.

22.

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase.

Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ.

J Biol Chem. 2005 Nov 4;280(44):36551-9. Epub 2005 Aug 18. Erratum in: J Biol Chem. 2005 Dec 9;280(49):41124.

23.

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.

Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM.

Oncogene. 2005 Oct 20;24(46):6925-35.

PMID:
16007151
24.

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.

Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG.

J Neurochem. 2005 Jan;92(1):93-102.

25.

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

Benjannet S, Cromlish JA, Diallo K, Chrétien M, Seidah NG.

Biochem Biophys Res Commun. 2004 Dec 3;325(1):235-42.

PMID:
15522224
26.

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG.

J Biol Chem. 2004 Nov 19;279(47):48865-75. Epub 2004 Sep 9.

27.

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM.

J Clin Invest. 2003 Jun;111(11):1723-32.

28.

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.

Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, Derré A, Villéger L, Farnier M, Beucler I, Bruckert E, Chambaz J, Chanu B, Lecerf JM, Luc G, Moulin P, Weissenbach J, Prat A, Krempf M, Junien C, Seidah NG, Boileau C.

Nat Genet. 2003 Jun;34(2):154-6.

PMID:
12730697
30.

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.

Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):928-33. Epub 2003 Jan 27.

31.

Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity.

Elagoz A, Benjannet S, Mammarbassi A, Wickham L, Seidah NG.

J Biol Chem. 2002 Mar 29;277(13):11265-75. Epub 2001 Dec 26.

32.

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chrétien M, Seidah NG.

J Biol Chem. 2001 Apr 6;276(14):10879-87. Epub 2001 Jan 10.

33.

Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system.

Winsky-Sommerer R, Benjannet S, Rovère C, Barbero P, Seidah NG, Epelbaum J, Dournaud P.

J Comp Neurol. 2000 Aug 28;424(3):439-60.

PMID:
10906712
34.

The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1.

Seidah NG, Benjannet S, Hamelin J, Mamarbachi AM, Basak A, Marcinkiewicz J, Mbikay M, Chrétien M, Marcinkiewicz M.

Ann N Y Acad Sci. 1999 Oct 20;885:57-74. Review.

PMID:
10816641
35.
36.

Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.

Touré BB, Munzer JS, Basak A, Benjannet S, Rochemont J, Lazure C, Chrétien M, Seidah NG.

J Biol Chem. 2000 Jan 28;275(4):2349-58.

37.

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.

Zhong M, Munzer JS, Basak A, Benjannet S, Mowla SJ, Decroly E, Chrétien M, Seidah NG.

J Biol Chem. 1999 Nov 26;274(48):33913-20.

38.

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.

Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Touré BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chrétien M, Marcinkiewicz M.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1321-6.

39.
40.

Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity.

Benjannet S, Mamarbachi AM, Hamelin J, Savaria D, Munzer JS, Chrétien M, Seidah NG.

FEBS Lett. 1998 May 22;428(1-2):37-42.

41.

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway.

Benjannet S, Savaria D, Laslop A, Munzer JS, Chrétien M, Marcinkiewicz M, Seidah NG.

J Biol Chem. 1997 Oct 17;272(42):26210-8.

42.
43.

In vitro characterization of the novel proprotein convertase PC7.

Munzer JS, Basak A, Zhong M, Mamarbachi A, Hamelin J, Savaria D, Lazure C, Hendy GN, Benjannet S, Chrétien M, Seidah NG.

J Biol Chem. 1997 Aug 8;272(32):19672-81. Erratum in: J Biol Chem 1997 Nov 28;272(48):30589.

44.

Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160.

Decroly E, Benjannet S, Savaria D, Seidah NG.

FEBS Lett. 1997 Mar 17;405(1):68-72.

45.

Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform.

Zhong M, Benjannet S, Lazure C, Munzer S, Seidah NG.

FEBS Lett. 1996 Oct 28;396(1):31-6.

46.

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.

Seidah NG, Benjannet S, Pareek S, Savaria D, Hamelin J, Goulet B, Laliberte J, Lazure C, Chrétien M, Murphy RA.

Biochem J. 1996 Mar 15;314 ( Pt 3):951-60.

47.

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.

Vollenweider F, Benjannet S, Decroly E, Savaria D, Lazure C, Thomas G, Chrétien M, Seidah NG.

Biochem J. 1996 Mar 1;314 ( Pt 2):521-32.

48.

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases.

Seidah NG, Benjannet S, Pareek S, Chrétien M, Murphy RA.

FEBS Lett. 1996 Feb 5;379(3):247-50.

49.

7B2 is a specific intracellular binding protein of the prohormone convertase PC2.

Benjannet S, Savaria D, Chrétien M, Seidah NG.

J Neurochem. 1995 May;64(5):2303-11.

PMID:
7722516
50.

Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex.

Benjannet S, Lusson J, Hamelin J, Savaria D, Chrétien M, Seidah NG.

FEBS Lett. 1995 Apr 3;362(2):151-5.

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