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Items: 1 to 50 of 78

1.

Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition.

Fischl AS, Wang X, Falcon BL, Almonte-Baldonado R, Bodenmiller D, Evans G, Stewart J, Wilson T, Hipskind P, Manro J, Uhlik MT, Chintharlapalli S, Gerald D, Alsop DC, Benjamin LE, Bhatt RS.

Mol Cancer Ther. 2019 Apr;18(4):856-867. doi: 10.1158/1535-7163.MCT-18-0548. Epub 2019 Feb 20.

PMID:
30787172
2.

RhoB antibody alters retinal vascularization in models of murine retinopathy.

Almonte-Baldonado R, Bravo-Nuevo A, Gerald D, Benjamin LE, Prendergast GC, Laury-Kleintop LD.

J Cell Biochem. 2019 Jun;120(6):9381-9391. doi: 10.1002/jcb.28213. Epub 2018 Dec 9.

PMID:
30536763
3.

Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels.

Sitohy B, Chang S, Sciuto TE, Masse E, Shen M, Kang PM, Jaminet SC, Benjamin LE, Bhatt RS, Dvorak AM, Nagy JA, Dvorak HF.

Am J Pathol. 2017 Oct;187(10):2337-2347. doi: 10.1016/j.ajpath.2017.06.010. Epub 2017 Jul 21.

4.

Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium.

Shafique E, Torina A, Reichert K, Colantuono B, Nur N, Zeeshan K, Ravichandran V, Liu Y, Feng J, Zeeshan K, Benjamin LE, Irani K, Harrington EO, Sellke FW, Abid MR.

Cardiovasc Res. 2017 Feb;113(2):234-246. doi: 10.1093/cvr/cvw249. Epub 2017 Jan 14.

5.

Commentary on "KRAS Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer".

Benjamin LE.

Cancer Res. 2016 Aug 1;76(15):4309-10. doi: 10.1158/0008-5472.CAN-16-1871. No abstract available.

6.

Profiling of Vascular Endothelial Growth Factor Receptor Heterogeneity Identifies Protein Expression-defined Subclasses of Human Non-small Cell Lung Carcinoma.

Holzer TR, Fulford AD, Reising LO, Nedderman DM, Zhang X, Benjamin LE, Schade AE, Nasir A.

Anticancer Res. 2016 Jul;36(7):3277-88.

PMID:
27354584
7.

Heterogeneity of Vascular Endothelial Growth Factor Receptors 1, 2, 3 in Primary Human Colorectal Carcinoma.

Nasir A, Reising LO, Nedderman DM, Fulford AD, Uhlik MT, Benjamin LE, Schade AE, Holzer TR.

Anticancer Res. 2016 Jun;36(6):2683-96.

PMID:
27272777
8.

Stromal-Based Signatures for the Classification of Gastric Cancer.

Uhlik MT, Liu J, Falcon BL, Iyer S, Stewart J, Celikkaya H, O'Mahony M, Sevinsky C, Lowes C, Douglass L, Jeffries C, Bodenmiller D, Chintharlapalli S, Fischl A, Gerald D, Xue Q, Lee JY, Santamaria-Pang A, Al-Kofahi Y, Sui Y, Desai K, Doman T, Aggarwal A, Carter JH, Pytowski B, Jaminet SC, Ginty F, Nasir A, Nagy JA, Dvorak HF, Benjamin LE.

Cancer Res. 2016 May 1;76(9):2573-86. doi: 10.1158/0008-5472.CAN-16-0022.

9.

VEGF-A/VEGFR Inhibition Restores Hematopoietic Homeostasis in the Bone Marrow and Attenuates Tumor Growth.

O'Donnell RK, Falcon B, Hanson J, Goldstein WE, Perruzzi C, Rafii S, Aird WC, Benjamin LE.

Cancer Res. 2016 Feb 1;76(3):517-24. doi: 10.1158/0008-5472.CAN-14-3023. Epub 2015 Dec 30.

10.

Genetic and Pharmacological Modulation of Akt1 for Improving Ovarian Graft Revascularization in a Mouse Model.

Cohen Y, Dafni H, Avni R, Fellus L, Bochner F, Rotkopf R, Raz T, Benjamin LE, Walsh K, Neeman M.

Biol Reprod. 2016 Jan;94(1):14. doi: 10.1095/biolreprod.115.131987. Epub 2015 Oct 21.

PMID:
26490838
11.

Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.

Phung TL, Du W, Xue Q, Ayyaswamy S, Gerald D, Antonello Z, Nhek S, Perruzzi CA, Acevedo I, Ramanna-Valmiki R, Rodriguez-Waitkus P, Enayati L, Hochman ML, Lev D, Geeganage S, Benjamin LE.

Cancer Res. 2015 Jan 1;75(1):40-50. doi: 10.1158/0008-5472.CAN-13-2961. Epub 2014 Nov 11.

12.

Can you tell that I'm in a relationship? Attachment and relationship visibility on Facebook.

Emery LF, Muise A, Dix EL, Le B.

Pers Soc Psychol Bull. 2014 Nov;40(11):1466-79. doi: 10.1177/0146167214549944. Epub 2014 Sep 17.

PMID:
25231798
13.

A linear relationship between crystal size and fragment binding time observed crystallographically: implications for fragment library screening using acoustic droplet ejection.

Cole K, Roessler CG, Mulé EA, Benson-Xu EJ, Mullen JD, Le BA, Tieman AM, Birone C, Brown M, Hernandez J, Neff S, Williams D, Allaire M, Orville AM, Sweet RM, Soares AS.

PLoS One. 2014 Jul 2;9(7):e101036. doi: 10.1371/journal.pone.0101036. eCollection 2014.

14.

Endothelial PGC-1α mediates vascular dysfunction in diabetes.

Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z.

Cell Metab. 2014 Feb 4;19(2):246-58. doi: 10.1016/j.cmet.2013.12.014.

15.

RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription.

Gerald D, Adini I, Shechter S, Perruzzi C, Varnau J, Hopkins B, Kazerounian S, Kurschat P, Blachon S, Khedkar S, Bagchi M, Sherris D, Prendergast GC, Klagsbrun M, Stuhlmann H, Rigby AC, Nagy JA, Benjamin LE.

Nat Commun. 2013;4:2824. doi: 10.1038/ncomms3824.

16.

Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung.

Holzer TR, Fulford AD, Nedderman DM, Umberger TS, Hozak RR, Joshi A, Melemed SA, Benjamin LE, Plowman GD, Schade AE, Ackermann BL, Konrad RJ, Nasir A.

PLoS One. 2013 Nov 14;8(11):e80292. doi: 10.1371/journal.pone.0080292. eCollection 2013.

17.

Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK.

Shafique E, Choy WC, Liu Y, Feng J, Cordeiro B, Lyra A, Arafah M, Yassin-Kassab A, Zanetti AV, Clements RT, Bianchi C, Benjamin LE, Sellke FW, Abid MR.

Aging (Albany NY). 2013 Jul;5(7):515-30.

18.

TUNABLE COMPLEMENT ACTIVATION BY PARTICLES WITH VARIABLE SIZE AND Fc DENSITY.

Pacheco PM, LE B, White D, Sulchek T.

Nano Life. 2013 Jun;3(2):1341001.

19.

Correction: Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice.

O'Donnell RK, Goldstein WE, Perruzzi C, Benjamin LE, Aird WC.

PLoS One. 2013 Jun 18;8(6). doi: 10.1371/annotation/207f3e91-451e-4508-afab-77f01dae3fe9. Print 2013.

20.

Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy.

Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE.

Cancer Res. 2013 Mar 15;73(6):1649-57. doi: 10.1158/0008-5472.CAN-12-4697. Epub 2013 Mar 6. Review.

21.

Overexpression of MyrAkt1 in endothelial cells leads to erythropoietin- and BMP4-independent splenic erythropoiesis in mice.

O'Donnell RK, Goldstein WE, Perruzzi C, Benjamin LE, Aird WC.

PLoS One. 2013;8(1):e55095. doi: 10.1371/journal.pone.0055095. Epub 2013 Jan 28. Erratum in: PLoS One. 2013 Jun 18;8(6):null. Aird, William [corrected to Aird, William C].

22.

RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.

Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher ON, Brown LF, Toker A, Prendergast GC, Benjamin LE.

Cancer Res. 2013 Jan 1;73(1):50-61. doi: 10.1158/0008-5472.CAN-11-3055. Epub 2012 Nov 7.

23.

Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.

Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K.

J Natl Cancer Inst. 2012 Mar 21;104(6):461-75. doi: 10.1093/jnci/djs009. Epub 2012 Feb 17.

24.

Predicting women's and men's reactions to geographic separation: relational interdependence matters.

Crockett EE, Loving TJ, Le B, Korn MS.

J Soc Psychol. 2011 Nov-Dec;151(6):710-26.

PMID:
22208109
25.

RhoB deficiency in thymic medullary epithelium leads to early thymic atrophy.

Bravo-Nuevo A, O'Donnell R, Rosendahl A, Chung JH, Benjamin LE, Odaka C.

Int Immunol. 2011 Oct;23(10):593-600. doi: 10.1093/intimm/dxr064. Epub 2011 Aug 23.

26.

RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice.

Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE.

Am J Pathol. 2011 Jan;178(1):245-52. doi: 10.1016/j.ajpath.2010.11.040. Epub 2010 Dec 23.

27.

B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.

Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10649-54. doi: 10.1073/pnas.1004934107. Epub 2010 May 24.

28.

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.

Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH.

Nature. 2010 May 27;465(7297):483-6. doi: 10.1038/nature09002.

PMID:
20445537
29.

Akt promotes endocardial-mesenchyme transition.

Meadows KN, Iyer S, Stevens MV, Wang D, Shechter S, Perruzzi C, Camenisch TD, Benjamin LE.

J Angiogenes Res. 2009 Sep 21;1:2. doi: 10.1186/2040-2384-1-2.

30.

Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase.

Xue Q, Nagy JA, Manseau EJ, Phung TL, Dvorak HF, Benjamin LE.

Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1172-8. doi: 10.1161/ATVBAHA.109.185918. Epub 2009 May 14.

31.

Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.

Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1344-51. doi: 10.1152/ajpheart.01246.2008. Epub 2009 Mar 20.

32.

Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.

Wang CY, Kim HH, Hiroi Y, Sawada N, Salomone S, Benjamin LE, Walsh K, Moskowitz MA, Liao JK.

Sci Signal. 2009 Mar 17;2(62):ra11. doi: 10.1126/scisignal.2000143.

33.

Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability.

Xue Q, Hopkins B, Perruzzi C, Udayakumar D, Sherris D, Benjamin LE.

Cancer Res. 2008 Nov 15;68(22):9551-7. doi: 10.1158/0008-5472.CAN-08-2058.

35.

Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch.

Rao S, Lobov IB, Vallance JE, Tsujikawa K, Shiojima I, Akunuru S, Walsh K, Benjamin LE, Lang RA.

Development. 2007 Dec;134(24):4449-58.

36.

Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression.

Phung TL, Eyiah-Mensah G, O'Donnell RK, Bieniek R, Shechter S, Walsh K, Kuperwasser C, Benjamin LE.

Cancer Res. 2007 Jun 1;67(11):5070-5. Erratum in: Cancer Res. 2007 Jul 1;67(13):6528.

37.

MRI detection of transcriptional regulation of gene expression in transgenic mice.

Cohen B, Ziv K, Plaks V, Israely T, Kalchenko V, Harmelin A, Benjamin LE, Neeman M.

Nat Med. 2007 Apr;13(4):498-503. Epub 2007 Mar 11.

PMID:
17351627
38.

Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.

Takeda Y, Kazarov AR, Butterfield CE, Hopkins BD, Benjamin LE, Kaipainen A, Hemler ME.

Blood. 2007 Feb 15;109(4):1524-32. Epub 2006 Oct 5.

39.

Pocket-sized psychology studies: exploring daily diary software for palm pilots.

Le B, Choi HN, Beal DJ.

Behav Res Methods. 2006 May;38(2):325-32.

PMID:
16956109
40.

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, Sessa WC, Dvorak HF, Benjamin LE.

Cancer Cell. 2006 Aug;10(2):159-70.

41.

Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.

Mukai Y, Rikitake Y, Shiojima I, Wolfrum S, Satoh M, Takeshita K, Hiroi Y, Salomone S, Kim HH, Benjamin LE, Walsh K, Liao JK.

J Clin Invest. 2006 Feb;116(2):334-43.

42.

Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors.

Sund M, Hamano Y, Sugimoto H, Sudhakar A, Soubasakos M, Yerramalla U, Benjamin LE, Lawler J, Kieran M, Shah A, Kalluri R.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2934-9. Epub 2005 Feb 14.

43.

Microvascular patterning is controlled by fine-tuning the Akt signal.

Sun JF, Phung T, Shiojima I, Felske T, Upalakalin JN, Feng D, Kornaga T, Dor T, Dvorak AM, Walsh K, Benjamin LE.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):128-33. Epub 2004 Dec 20.

44.

Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program.

Hajjeh RA, Sofair AN, Harrison LH, Lyon GM, Arthington-Skaggs BA, Mirza SA, Phelan M, Morgan J, Lee-Yang W, Ciblak MA, Benjamin LE, Sanza LT, Huie S, Yeo SF, Brandt ME, Warnock DW.

J Clin Microbiol. 2004 Apr;42(4):1519-27.

45.

Resolution of discrepant results for Candida species identification by using DNA probes.

Coignard C, Hurst SF, Benjamin LE, Brandt ME, Warnock DW, Morrison CJ.

J Clin Microbiol. 2004 Feb;42(2):858-61.

46.
47.

RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development.

Adini I, Rabinovitz I, Sun JF, Prendergast GC, Benjamin LE.

Genes Dev. 2003 Nov 1;17(21):2721-32.

48.

Blood markers for vasculogenesis increase with tumor progression in patients with breast carcinoma.

Sussman LK, Upalakalin JN, Roberts MJ, Kocher O, Benjamin LE.

Cancer Biol Ther. 2003 May-Jun;2(3):255-6.

PMID:
12878859
49.

Survival mechanisms of VEGF and PlGF during microvascular remodeling.

Upalakalin JN, Hemo I, Dehio C, Keshet E, Benjamin LE.

Cold Spring Harb Symp Quant Biol. 2002;67:181-7. Review. No abstract available.

PMID:
12858539
50.

Tumorigenesis and the angiogenic switch.

Bergers G, Benjamin LE.

Nat Rev Cancer. 2003 Jun;3(6):401-10. Review.

PMID:
12778130

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