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Items: 36

1.

Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial.

Zubizarreta I, Flórez-Grau G, Vila G, Cabezón R, España C, Andorra M, Saiz A, Llufriu S, Sepulveda M, Sola-Valls N, Martinez-Lapiscina EH, Pulido-Valdeolivas I, Casanova B, Martinez Gines M, Tellez N, Oreja-Guevara C, Español M, Trias E, Cid J, Juan M, Lozano M, Blanco Y, Steinman L, Benitez-Ribas D, Villoslada P.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8463-8470. doi: 10.1073/pnas.1820039116. Epub 2019 Apr 8.

2.

Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions.

Castella M, Boronat A, Martín-Ibáñez R, Rodríguez V, Suñé G, Caballero M, Marzal B, Pérez-Amill L, Martín-Antonio B, Castaño J, Bueno C, Balagué O, González-Navarro EA, Serra-Pages C, Engel P, Vilella R, Benitez-Ribas D, Ortiz-Maldonado V, Cid J, Tabera J, Canals JM, Lozano M, Baumann T, Vilarrodona A, Trias E, Campo E, Menendez P, Urbano-Ispizua Á, Yagüe J, Pérez-Galán P, Rives S, Delgado J, Juan M.

Mol Ther Methods Clin Dev. 2018 Dec 6;12:134-144. doi: 10.1016/j.omtm.2018.11.010. eCollection 2019 Mar 15.

3.

Differences in Peripheral and Tissue Immune Cell Populations Following Haematopoietic Stem Cell Transplantation in Crohn's Disease Patients.

Corraliza AM, Ricart E, López-García A, Carme Masamunt M, Veny M, Esteller M, Mayorgas A, Le Bourhis L, Allez M, Planell N, Visvanathan S, Baum P, España C, Cabezón-Cabello R, Benítez-Ribas D, Rovira M, Panés J, Salas A.

J Crohns Colitis. 2019 Apr 26;13(5):634-647. doi: 10.1093/ecco-jcc/jjy203.

4.

Tolerogenic Dendritic Cells as a Promising Antigen-Specific Therapy in the Treatment of Multiple Sclerosis and Neuromyelitis Optica From Preclinical to Clinical Trials.

Flórez-Grau G, Zubizarreta I, Cabezón R, Villoslada P, Benitez-Ribas D.

Front Immunol. 2018 May 31;9:1169. doi: 10.3389/fimmu.2018.01169. eCollection 2018. Review.

5.

Corrigendum: Immune Response Generated With the Administration of Autologous Dendritic Cells Pulsed With an Allogenic Tumoral Cell-Lines Lysate in Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma.

Benitez-Ribas D, Cabezón R, Flórez-Grau G, Molero MC, Puerta P, Guillen A, González-Navarro EA, Paco S, Carcaboso AM, Santa-Maria Lopez V, Cruz O, de Torres C, Salvador N, Juan M, Mora J, Morales La Madrid A.

Front Oncol. 2018 Jun 5;8:201. doi: 10.3389/fonc.2018.00201. eCollection 2018.

6.

Immune Response Generated With the Administration of Autologous Dendritic Cells Pulsed With an Allogenic Tumoral Cell-Lines Lysate in Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma.

Benitez-Ribas D, Cabezón R, Flórez-Grau G, Molero MC, Puerta P, Guillen A, Paco S, Carcaboso AM, Santa-Maria Lopez V, Cruz O, de Torres C, Salvador N, Juan M, Mora J, La Madrid AM.

Front Oncol. 2018 Apr 26;8:127. doi: 10.3389/fonc.2018.00127. eCollection 2018. Erratum in: Front Oncol. 2018 Jun 05;8:201.

7.

Up-regulation of EP2 and EP3 receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE2.

Flórez-Grau G, Cabezón R, Borgman KJE, España C, Lozano JJ, Garcia-Parajo MF, Benítez-Ribas D.

J Leukoc Biol. 2017 Sep;102(3):881-895. doi: 10.1189/jlb.2A1216-526R. Epub 2017 Jun 19.

PMID:
28630103
8.

Restoring immune tolerance in neuromyelitis optica: Part II.

Bar-Or A, Steinman L, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Smith TJ, Yeaman MR.

Neurol Neuroimmunol Neuroinflamm. 2016 Sep 7;3(5):e277. doi: 10.1212/NXI.0000000000000277. eCollection 2016 Oct. Review.

9.

Restoring immune tolerance in neuromyelitis optica: Part I.

Steinman L, Bar-Or A, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Yeaman MR, Smith TJ.

Neurol Neuroimmunol Neuroinflamm. 2016 Sep 7;3(5):e276. doi: 10.1212/NXI.0000000000000276. eCollection 2016 Oct. Review.

10.

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies.

Lord P, Spiering R, Aguillon JC, Anderson AE, Appel S, Benitez-Ribas D, Ten Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van Kooten C, Lopez Diaz de Cerio A, Nikolic T, Oral HB, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres EM, Hilkens CMU.

PeerJ. 2016 Aug 30;4:e2300. doi: 10.7717/peerj.2300. eCollection 2016.

11.

Nanoencapsulated budesonide in self-stratified polyurethane-polyurea nanoparticles is highly effective in inducing human tolerogenic dendritic cells.

Flórez-Grau G, Rocas P, Cabezón R, España C, Panés J, Rocas J, Albericio F, Benítez-Ribas D.

Int J Pharm. 2016 Sep 25;511(2):785-93. doi: 10.1016/j.ijpharm.2016.07.056. Epub 2016 Jul 28.

PMID:
27477102
12.

Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients.

Caballero-Baños M, Benitez-Ribas D, Tabera J, Varea S, Vilana R, Bianchi L, Ayuso JR, Pagés M, Carrera G, Cuatrecasas M, Martin-Richard M, Cid J, Lozano M, Castells A, García-Albéniz X, Maurel J, Vilella R.

Eur J Cancer. 2016 Sep;64:167-74. doi: 10.1016/j.ejca.2016.06.008. Epub 2016 Jul 16.

PMID:
27428073
13.

Dendritic Cells as Vaccines: Key Regulators of Tolerance and Immunity.

Tel J, Benitez-Ribas D, Janssen EM, Smits EL, Jacobs JF.

Mediators Inflamm. 2016;2016:5789725. doi: 10.1155/2016/5789725. Epub 2016 May 31. No abstract available.

14.

Commensal-Specific CD4(+) Cells From Patients With Crohn's Disease Have a T-Helper 17 Inflammatory Profile.

Calderón-Gómez E, Bassolas-Molina H, Mora-Buch R, Dotti I, Planell N, Esteller M, Gallego M, Martí M, Garcia-Martín C, Martínez-Torró C, Ordás I, Singh S, Panés J, Benítez-Ribas D, Salas A.

Gastroenterology. 2016 Sep;151(3):489-500.e3. doi: 10.1053/j.gastro.2016.05.050. Epub 2016 Jun 4.

15.

New insights into the phenotype of human dendritic cell populations.

Clark GJ, Kupresanin F, Fromm PD, Ju X, Muusers L, Silveira PA, Elgundi Z, Gasiorowski RE, Papadimitrious MS, Bryant C, Lee KM, Clarke CJ, Young JW, Chan A, Harman A, Botting R, Cabezón R, Benitez-Ribas D, Brooks AE, Dunbar PR, Hart DN.

Clin Transl Immunology. 2016 Jan 29;5(1):e61. doi: 10.1038/cti.2015.40. eCollection 2016 Jan.

16.

Placental Microparticles and MicroRNAs in Pregnant Women with Plasmodium falciparum or HIV Infection.

Moro L, Bardají A, Macete E, Barrios D, Morales-Prieto DM, España C, Mandomando I, Sigaúque B, Dobaño C, Markert UR, Benitez-Ribas D, Alonso PL, Menéndez C, Mayor A.

PLoS One. 2016 Jan 12;11(1):e0146361. doi: 10.1371/journal.pone.0146361. eCollection 2016.

17.

Intraperitoneal Administration of Autologous Tolerogenic Dendritic Cells for Refractory Crohn's Disease: A Phase I Study.

Jauregui-Amezaga A, Cabezón R, Ramírez-Morros A, España C, Rimola J, Bru C, Pinó-Donnay S, Gallego M, Masamunt MC, Ordás I, Lozano M, Cid J, Panés J, Benítez-Ribas D, Ricart E.

J Crohns Colitis. 2015 Dec;9(12):1071-8. doi: 10.1093/ecco-jcc/jjv144. Epub 2015 Aug 24.

PMID:
26303633
18.

MERTK as negative regulator of human T cell activation.

Cabezón R, Carrera-Silva EA, Flórez-Grau G, Errasti AE, Calderón-Gómez E, Lozano JJ, España C, Ricart E, Panés J, Rothlin CV, Benítez-Ribas D.

J Leukoc Biol. 2015 Apr;97(4):751-60. doi: 10.1189/jlb.3A0714-334R. Epub 2015 Jan 26.

19.

In vivo tracking and immunological properties of pulsed porcine monocyte-derived dendritic cells.

Crisci E, Fraile L, Novellas R, Espada Y, Cabezón R, Martínez J, Cordoba L, Bárcena J, Benitez-Ribas D, Montoya M.

Mol Immunol. 2015 Feb;63(2):343-54. doi: 10.1016/j.molimm.2014.08.006. Epub 2014 Oct 1.

PMID:
25282042
20.

Priming by chemokines restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nano-aggregates on human mature dendritic cells.

Borgman KJ, van Zanten TS, Manzo C, Cabezón R, Cambi A, Benítez-Ribas D, Garcia-Parajo MF.

PLoS One. 2014 Jun 19;9(6):e99589. doi: 10.1371/journal.pone.0099589. eCollection 2014.

21.

Therapeutic potential of tolerogenic dendritic cells in IBD: from animal models to clinical application.

Cabezón R, Benítez-Ribas D.

Clin Dev Immunol. 2013;2013:789814. doi: 10.1155/2013/789814. Epub 2013 Nov 12. Review.

22.

Dendritic cells phenotype fitting under hypoxia or lipopolysaccharide; adenosine 5'-triphosphate-binding cassette transporters far beyond an efflux pump.

Lloberas N, Rama I, Llaudó I, Torras J, Cerezo G, Cassis L, Franquesa M, Merino A, Benitez-Ribas D, Cruzado JM, Herrero-Fresneda I, Bestard O, Grinyó JM.

Clin Exp Immunol. 2013 Jun;172(3):444-54. doi: 10.1111/cei.12067.

23.

Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients.

Tel J, Aarntzen EH, Baba T, Schreibelt G, Schulte BM, Benitez-Ribas D, Boerman OC, Croockewit S, Oyen WJ, van Rossum M, Winkels G, Coulie PG, Punt CJ, Figdor CG, de Vries IJ.

Cancer Res. 2013 Feb 1;73(3):1063-75. doi: 10.1158/0008-5472.CAN-12-2583. Epub 2013 Jan 23.

24.

Gram-negative enterobacteria induce tolerogenic maturation in dexamethasone conditioned dendritic cells.

Cabezón R, Ricart E, España C, Panés J, Benitez-Ribas D.

PLoS One. 2012;7(12):e52456. doi: 10.1371/journal.pone.0052456. Epub 2012 Dec 27.

25.

Mesenchymal stem cell therapy of Crohn's disease: are the far-away hills getting closer?

Panés J, Benitez-Ribas D, Salas A.

Gut. 2011 Jun;60(6):742-4. doi: 10.1136/gut.2010.235507. Epub 2011 Mar 22. No abstract available.

PMID:
21427198
26.

DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells.

Tel J, Benitez-Ribas D, Hoosemans S, Cambi A, Adema GJ, Figdor CG, Tacken PJ, de Vries IJ.

Eur J Immunol. 2011 Apr;41(4):1014-23. doi: 10.1002/eji.201040790. Epub 2011 Mar 17.

27.

[Dendritic cells: a new horizon in cell therapy for inflammatory bowel disease?].

Ricart E, Panés J, Benítez-Ribas D.

Gastroenterol Hepatol. 2011 Feb;34(2):100-6. doi: 10.1016/j.gastrohep.2010.10.011. Epub 2011 Feb 17. Spanish.

PMID:
21333391
28.

Prophylactic vaccines mimic synthetic CpG oligonucleotides in their ability to modulate immune responses.

de Vries IJ, Tel J, Benitez-Ribas D, Torensma R, Figdor CG.

Mol Immunol. 2011 Mar;48(6-7):810-7. doi: 10.1016/j.molimm.2010.12.022. Epub 2011 Jan 22.

PMID:
21257206
29.

Analysis of HLDA9 mAbs on plasmacytoid dendritic cells.

Cabezón R, Sintes J, Llinàs L, Benitez-Ribas D.

Immunol Lett. 2011 Jan 30;134(2):167-73. doi: 10.1016/j.imlet.2010.09.020. Epub 2010 Oct 7.

PMID:
20933012
30.

Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells.

Schreibelt G, Benitez-Ribas D, Schuurhuis D, Lambeck AJ, van Hout-Kuijer M, Schaft N, Punt CJ, Figdor CG, Adema GJ, de Vries IJ.

Blood. 2010 Jul 29;116(4):564-74. doi: 10.1182/blood-2009-11-251884. Epub 2010 Apr 27.

31.

Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy.

Schreibelt G, Tel J, Sliepen KH, Benitez-Ribas D, Figdor CG, Adema GJ, de Vries IJ.

Cancer Immunol Immunother. 2010 Oct;59(10):1573-82. doi: 10.1007/s00262-010-0833-1. Epub 2010 Mar 5. Review.

PMID:
20204387
32.

Polyinosinic polycytidylic acid prevents efficient antigen expression after mRNA electroporation of clinical grade dendritic cells.

Schuurhuis DH, Lesterhuis WJ, Kramer M, Looman MG, van Hout-Kuijer M, Schreibelt G, Boullart AC, Aarntzen EH, Benitez-Ribas D, Figdor CG, Punt CJ, de Vries IJ, Adema GJ.

Cancer Immunol Immunother. 2009 Jul;58(7):1109-15. doi: 10.1007/s00262-008-0626-y. Epub 2008 Nov 19.

PMID:
19018531
33.
34.

Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration.

Boullart AC, Aarntzen EH, Verdijk P, Jacobs JF, Schuurhuis DH, Benitez-Ribas D, Schreibelt G, van de Rakt MW, Scharenborg NM, de Boer A, Kramer M, Figdor CG, Punt CJ, Adema GJ, de Vries IJ.

Cancer Immunol Immunother. 2008 Nov;57(11):1589-97. doi: 10.1007/s00262-008-0489-2. Epub 2008 Mar 6.

35.

Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.

Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, de Vries IJ, Adema GJ.

Blood. 2008 Apr 15;111(8):4245-53. doi: 10.1182/blood-2007-03-081398. Epub 2008 Feb 7.

36.

Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake.

Benitez-Ribas D, Adema GJ, Winkels G, Klasen IS, Punt CJ, Figdor CG, de Vries IJ.

J Exp Med. 2006 Jul 10;203(7):1629-35. Epub 2006 Jun 19.

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