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Why some organ allografts are tolerated better than others: new insights for an old question.

Hull TD, Benichou G, Madsen JC.

Curr Opin Organ Transplant. 2019 Feb;24(1):49-57. doi: 10.1097/MOT.0000000000000594.


Maintaining T cell tolerance of alloantigens: Lessons from animal studies.

Robinson KA, Orent W, Madsen JC, Benichou G.

Am J Transplant. 2018 Aug;18(8):1843-1856. doi: 10.1111/ajt.14984. Review.


Graft-derived exosomes. When small vesicles play a big role in transplant rejection.

Benichou G, Prunevieille A.

Am J Transplant. 2018 Jul;18(7):1585-1586. doi: 10.1111/ajt.14720. Epub 2018 Apr 2. No abstract available.


Emerging role of exosomes in allorecognition and allograft rejection.

Gonzalez-Nolasco B, Wang M, Prunevieille A, Benichou G.

Curr Opin Organ Transplant. 2018 Feb;23(1):22-27. doi: 10.1097/MOT.0000000000000489. Review.


Editorial: Allorecognition by Leukocytes of the Adaptive Immune System.

Benichou G, Kim J.

Front Immunol. 2017 Nov 15;8:1555. doi: 10.3389/fimmu.2017.01555. eCollection 2017. No abstract available.


Role of Memory T Cells in Allograft Rejection and Tolerance.

Benichou G, Gonzalez B, Marino J, Ayasoufi K, Valujskikh A.

Front Immunol. 2017 Feb 28;8:170. doi: 10.3389/fimmu.2017.00170. eCollection 2017. Review.


A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse.

Firl DJ, Benichou G, Kim JI, Yeh H.

Front Immunol. 2017 Feb 2;8:80. doi: 10.3389/fimmu.2017.00080. eCollection 2017. Review.


Allorecognition by T Lymphocytes and Allograft Rejection.

Marino J, Paster J, Benichou G.

Front Immunol. 2016 Dec 14;7:582. doi: 10.3389/fimmu.2016.00582. eCollection 2016. Review.


Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation.

Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G.

Sci Immunol. 2016 Jul 14;1(1). pii: aaf8759.


Induced regulatory T cells in allograft tolerance via transient mixed chimerism.

Hotta K, Aoyama A, Oura T, Yamada Y, Tonsho M, Huh KH, Kawai K, Schoenfeld D, Allan JS, Madsen JC, Benichou G, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T.

JCI Insight. 2016 Jul 7;1(10). pii: e86419.


Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants.

Buhler L, Illigens BM, Nadazdin O, Tena A, Lee S, Sachs DH, Cooper DK, Benichou G.

Am J Transplant. 2016 Jun;16(6):1917-22. doi: 10.1111/ajt.13695. Epub 2016 Mar 14.


B Cell Depletion With an Anti-CD20 Antibody Enhances Alloreactive Memory T Cell Responses After Transplantation.

Marino J, Paster JT, Trowell A, Maxwell L, Briggs KH, Crosby Bertorini P, Benichou G.

Am J Transplant. 2016 Feb;16(2):672-8. doi: 10.1111/ajt.13483. Epub 2015 Nov 9.


Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys.

Yamada Y, Nadazdin O, Boskovic S, Lee S, Zorn E, Smith RN, Colvin RB, Madsen JC, Cosimi AB, Kawai T, Benichou G.

Am J Transplant. 2015 Dec;15(12):3055-66. doi: 10.1111/ajt.13382. Epub 2015 Jul 17.


Pilot Study Evaluating Regulatory T Cell-Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model.

Lei J, Kim JI, Shi S, Zhang X, Machaidze Z, Lee S, Schuetz C, Martins PN, Oura T, Farkash EA, Rosales IA, Smith RN, Stott R, Lee KM, Soohoo J, Boskovic S, Cappetta K, Nadazdin OM, Yamada Y, Yeh H, Kawai T, Sachs DH, Benichou G, Markmann JF.

Am J Transplant. 2015 Oct;15(10):2739-49. doi: 10.1111/ajt.13329. Epub 2015 May 26.


Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism.

Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T, Madsen JC, Benichou G, Allan JS.

Am J Transplant. 2015 Aug;15(8):2231-9. doi: 10.1111/ajt.13274. Epub 2015 Apr 22.


Long-term lung transplantation in nonhuman primates.

Aoyama A, Tonsho M, Ng CY, Lee S, Millington T, Nadazdin O, Wain JC, Cosimi AB, Sachs DH, Smith RN, Colvin RB, Kawai T, Madsen JC, Benichou G, Allan JS.

Am J Transplant. 2015 May;15(5):1415-20. doi: 10.1111/ajt.13130. Epub 2015 Mar 13.


Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance.

Granados JM, Benichou G, Kawai T.

Curr Opin Organ Transplant. 2015 Feb;20(1):49-56. doi: 10.1097/MOT.0000000000000159. Review.


Both rejection and tolerance of allografts can occur in the absence of secondary lymphoid tissues.

Kant CD, Akiyama Y, Tanaka K, Shea S, Yamada Y, Connolly SE, Marino J, Tocco G, Benichou G.

J Immunol. 2015 Feb 1;194(3):1364-71. doi: 10.4049/jimmunol.1401157. Epub 2014 Dec 22.


Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates.

Yamada Y, Ochiai T, Boskovic S, Nadazdin O, Oura T, Schoenfeld D, Cappetta K, Smith RN, Colvin RB, Madsen JC, Sachs DH, Benichou G, Cosimi AB, Kawai T.

Am J Transplant. 2014 Dec;14(12):2704-12. doi: 10.1111/ajt.12936. Epub 2014 Nov 13.


Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo.

Wei M, Marino J, Trowell A, Zhang H, Stromp Peraino J, Rajasekera PV, Madsen JC, Sachs DH, Huang CA, Benichou G, Wang Z.

Protein Eng Des Sel. 2014 Sep;27(9):289-95. doi: 10.1093/protein/gzu034.


Alefacept promotes immunosuppression-free renal allograft survival in nonhuman primates via depletion of recipient memory T cells.

Lee S, Yamada Y, Tonsho M, Boskovic S, Nadazdin O, Schoenfeld D, Cappetta K, Atif M, Smith RN, Cosimi AB, Benichou G, Kawai T.

Am J Transplant. 2013 Dec;13(12):3223-9. doi: 10.1111/ajt.12500. Epub 2013 Oct 24.


Successful tolerance to fully MHC disparate renal allografts via donor hematopoietic mixed chimerism in non-human primates.

Benichou G, Nadazdin O, Cosimi AB, Kawai T.

Am J Transplant. 2013 Sep;13(9):2500. doi: 10.1111/ajt.12366. Epub 2013 Jul 19. No abstract available.


Primary vascularization of allografts governs their immunogenicity and susceptibility to tolerogenesis.

Kant CD, Akiyama Y, Tanaka K, Shea S, Connolly SE, Germana S, Winn HJ, LeGuern C, Tocco G, Benichou G.

J Immunol. 2013 Aug 15;191(4):1948-56. doi: 10.4049/jimmunol.1202092. Epub 2013 Jul 5.


The road to transplant tolerance is paved with good dendritic cells.

Benichou G, Tocco G.

Eur J Immunol. 2013 Mar;43(3):584-8. doi: 10.1002/eji.201343361.


Bidirectional alloreactivity: A proposed microchimerism-based solution to the NIMA paradox.

Burlingham WJ, Benichou G.

Chimerism. 2012 Apr-Jun;3(2):29-36. doi: 10.4161/chim.21668. Epub 2012 Apr 1. Review.


Tolerance induction after organ transplantation, "delayed tolerance," via the mixed chimerism approach: planting flowers in a battle field.

Yamada Y, Benichou G, Cosimi AB, Kawai T.

Chimerism. 2012 Jan-Mar;3(1):24-8. No abstract available.


Low-dose IL-2 for In vivo expansion of CD4+ and CD8+ regulatory T cells in nonhuman primates.

Aoyama A, Klarin D, Yamada Y, Boskovic S, Nadazdin O, Kawai K, Schoenfeld D, Madsen JC, Cosimi AB, Benichou G, Kawai T.

Am J Transplant. 2012 Sep;12(9):2532-7. doi: 10.1111/j.1600-6143.2012.04133.x. Epub 2012 Jun 8.


Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates.

Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T.

J Immunol. 2012 Jun 15;188(12):6063-70. doi: 10.4049/jimmunol.1200656. Epub 2012 May 14.


Innate immunity and resistance to tolerogenesis in allotransplantation.

Benichou G, Tonsho M, Tocco G, Nadazdin O, Madsen JC.

Front Immunol. 2012 Apr 19;3:73. doi: 10.3389/fimmu.2012.00073. eCollection 2012.


Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates.

Millington T, Koulmanda M, Ng C, Boskovic S, Nadazdin OM, Benichou G, Zheng XX, Strom TB, Madsen JC.

J Heart Lung Transplant. 2012 Apr;31(4):427-35. doi: 10.1016/j.healun.2012.01.864. Epub 2012 Feb 24.


Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates.

Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T.

Am J Transplant. 2012 Feb;12(2):330-40. doi: 10.1111/j.1600-6143.2011.03795.x. Epub 2011 Nov 4.


Contributions of direct and indirect alloresponses to chronic rejection of kidney allografts in nonhuman primates.

Nadazdin O, Boskovic S, Wee SL, Sogawa H, Koyama I, Colvin RB, Smith RN, Tocco G, O'Connor DH, Karl JA, Madsen JC, Sachs DH, Kawai T, Cosimi AB, Benichou G.

J Immunol. 2011 Nov 1;187(9):4589-97. doi: 10.4049/jimmunol.1003253. Epub 2011 Sep 28.


B-cell-dependent memory T cells impede nonmyeloablative mixed chimerism induction in presensitized mice.

Levesque V, Bardwell PD, Shimizu I, Haspot F, Benichou G, Yeap BY, Sykes M.

Am J Transplant. 2011 Nov;11(11):2322-31. doi: 10.1111/j.1600-6143.2011.03683.x. Epub 2011 Aug 10.


Immune recognition and rejection of allogeneic skin grafts.

Benichou G, Yamada Y, Yun SH, Lin C, Fray M, Tocco G.

Immunotherapy. 2011 Jun;3(6):757-70. doi: 10.2217/imt.11.2. Review.


Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates.

Nadazdin O, Boskovic S, Murakami T, Tocco G, Smith RN, Colvin RB, Sachs DH, Allan J, Madsen JC, Kawai T, Cosimi AB, Benichou G.

Sci Transl Med. 2011 Jun 8;3(86):86ra51. doi: 10.1126/scitranslmed.3002093.


Dendritic cell maturation occurs through the inhibition of GSK-3β.

Alessandrini A, De Haseth S, Fray M, Miyajima M, Colvin RB, Williams WW, Benedict Cosimi A, Benichou G.

Cell Immunol. 2011;270(2):114-25. doi: 10.1016/j.cellimm.2011.04.007. Epub 2011 Apr 30.


Autoimmune sensitization to cardiac myosin leads to acute rejection of cardiac allografts in miniature swine.

Veillette GR, Sahara H, Meltzer AJ, Weiss MJ, Iwamoto Y, Kim KM, Rosengard BR, Allan JS, Houser SL, Sachs DH, Benichou G, Madsen JC.

Transplantation. 2011 Jun 15;91(11):1187-91. doi: 10.1097/TP.0b013e318218415d.


Early acceptance of renal allografts in mice is dependent on foxp3(+) cells.

Miyajima M, Chase CM, Alessandrini A, Farkash EA, Della Pelle P, Benichou G, Graham JA, Madsen JC, Russell PS, Colvin RB.

Am J Pathol. 2011 Apr;178(4):1635-45. doi: 10.1016/j.ajpath.2010.12.024.


Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model.

Akiyama Y, Caucheteux SM, Vernochet C, Iwamoto Y, Tanaka K, Kanellopoulos-Langevin C, Benichou G.

J Immunol. 2011 Feb 1;186(3):1442-9. doi: 10.4049/jimmunol.1003023. Epub 2010 Dec 22.


Natural killer cells in rejection and tolerance of solid organ allografts.

Benichou G, Yamada Y, Aoyama A, Madsen JC.

Curr Opin Organ Transplant. 2011 Feb;16(1):47-53. doi: 10.1097/MOT.0b013e32834254cf. Review.


Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition.

Graham JA, Fray M, de Haseth S, Lee KM, Lian MM, Chase CM, Madsen JC, Markmann J, Benichou G, Colvin RB, Cosimi AB, Deng S, Kim J, Alessandrini A.

J Biol Chem. 2010 Oct 22;285(43):32852-9. doi: 10.1074/jbc.M110.150904. Epub 2010 Aug 20.


Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys.

Nadazdin O, Boskovic S, Murakami T, O'Connor DH, Wiseman RW, Karl JA, Tuscher JJ, Sachs DH, Madsen JC, Tocco G, Kawai T, Cosimi AB, Benichou G.

Am J Transplant. 2010 Jun;10(6):1375-84. doi: 10.1111/j.1600-6143.2010.03119.x. Epub 2010 May 14.


Intracellular MHC class II controls regulatory tolerance to allogeneic transplants.

LeGuern C, Akiyama Y, Germana S, Tanaka K, Fernandez L, Iwamoto Y, Houser S, Benichou G.

J Immunol. 2010 Mar 1;184(5):2394-400. doi: 10.4049/jimmunol.0803664. Epub 2010 Jan 25.


Dual effects of the alloresponse by Th1 and Th2 cells on acute and chronic rejection of allotransplants.

Illigens BM, Yamada A, Anosova N, Dong VM, Sayegh MH, Benichou G.

Eur J Immunol. 2009 Nov;39(11):3000-9. doi: 10.1002/eji.200838980.


Direct versus indirect allorecognition pathways: on the right track.

Benichou G, Thomson AW.

Am J Transplant. 2009 Apr;9(4):655-6. doi: 10.1111/j.1600-6143.2009.02572.x. No abstract available.


The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts.

Weiss MJ, Guenther DA, Mezrich JD, Sahara H, Ng CY, Meltzer AJ, Sayre JK, Cochrane ME, Pujara AC, Houser SL, Sachs DH, Rosengard BR, Allan JS, Benichou G, Madsen JC.

Am J Transplant. 2009 Jan;9(1):105-13.


Differential roles of direct and indirect allorecognition pathways in the rejection of skin and corneal transplants.

Boisgérault F, Liu Y, Anosova N, Dana R, Benichou G.

Transplantation. 2009 Jan 15;87(1):16-23. doi: 10.1097/TP.0b013e318191b38b.


Induction of autoimmunity after allotransplantation.

Benichou G, Alessandrini A, Charrad RS, Wilkes DS.

Front Biosci. 2007 May 1;12:4362-9. Review.


Induction of allograft tolerance in nonhuman primates and humans.

Ochiai T, Benichou G, Cosimi AB, Kawai T.

Front Biosci. 2007 May 1;12:4248-53. Review.


Modulation of alloreactivity to MHC-derived peptides and transplantation tolerance.

Benichou G, Kant CD, Madsen J, Tocco G.

Front Biosci. 2007 May 1;12:4239-47. Review.


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