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Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle.

Qadota H, Matsunaga Y, Bagchi P, Lange KI, Carrier KJ, Pols WV, Swartzbaugh E, Wilson KJ, Srayko M, Pallas DC, Benian GM.

Mol Biol Cell. 2018 Aug 15;29(17):2084-2097. doi: 10.1091/mbc.E18-03-0192. Epub 2018 Jun 27.


Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase.

Williams RM, Franke B, Wilkinson M, Fleming JR, Rigden DJ, Benian GM, Eyers PA, Mayans O.

J Mol Biol. 2018 Mar 16;430(6):793-805. doi: 10.1016/j.jmb.2018.01.020. Epub 2018 Feb 3.


Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.

Loveless T, Qadota H, Benian GM, Hardin J.

Mol Biol Cell. 2017 Dec 1;28(25):3621-3633. doi: 10.1091/mbc.E16-06-0455. Epub 2017 Oct 4.


High-resolution imaging of muscle attachment structures in Caenorhabditis elegans.

Qadota H, Matsunaga Y, Nguyen KCQ, Mattheyses A, Hall DH, Benian GM.

Cytoskeleton (Hoboken). 2017 Nov;74(11):426-442. doi: 10.1002/cm.21410. Epub 2017 Sep 30.


Indoles from commensal bacteria extend healthspan.

Sonowal R, Swimm A, Sahoo A, Luo L, Matsunaga Y, Wu Z, Bhingarde JA, Ejzak EA, Ranawade A, Qadota H, Powell DN, Capaldo CT, Flacker JM, Jones RM, Benian GM, Kalman D.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7506-E7515. doi: 10.1073/pnas.1706464114. Epub 2017 Aug 21.


Twitchin kinase inhibits muscle activity.

Matsunaga Y, Hwang H, Franke B, Williams R, Penley M, Qadota H, Yi H, Morran LT, Lu H, Mayans O, Benian GM.

Mol Biol Cell. 2017 Jun 15;28(12):1591-1600. doi: 10.1091/mbc.E16-10-0707. Epub 2017 Apr 20.


Development, structure, and maintenance of C. elegans body wall muscle.

Gieseler K, Qadota H, Benian GM.

WormBook. 2017 Apr 13;2017:1-59. doi: 10.1895/wormbook.1.81.2. Review.


The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.

Qadota H, Mayans O, Matsunaga Y, McMurry JL, Wilson KJ, Kwon GE, Stanford R, Deehan K, Tinley TL, Ngwa VM, Benian GM.

Mol Biol Cell. 2016 May 15;27(10):1606-20. doi: 10.1091/mbc.E15-09-0675. Epub 2016 Mar 23.


Diapause is associated with a change in the polarity of secretion of insulin-like peptides.

Matsunaga Y, Honda Y, Honda S, Iwasaki T, Qadota H, Benian GM, Kawano T.

Nat Commun. 2016 Feb 3;7:10573. doi: 10.1038/ncomms10573.


Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.

Hwang H, Barnes DE, Matsunaga Y, Benian GM, Ono S, Lu H.

Sci Rep. 2016 Jan 29;6:19900. doi: 10.1038/srep19900.


Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.

Matsunaga Y, Qadota H, Furukawa M, Choe HH, Benian GM.

Mol Biol Cell. 2015 Jun 1;26(11):2096-111. doi: 10.1091/mbc.E14-05-1009. Epub 2015 Apr 7.


Titin and obscurin: giants holding hands and discovery of a new Ig domain subset.

Benian GM, Mayans O.

J Mol Biol. 2015 Feb 27;427(4):707-714. doi: 10.1016/j.jmb.2014.12.017. Epub 2014 Dec 31. No abstract available.


On-demand optical immobilization of Caenorhabditis elegans for high-resolution imaging and microinjection.

Hwang H, Krajniak J, Matsunaga Y, Benian GM, Lu H.

Lab Chip. 2014 Sep 21;14(18):3498-501. doi: 10.1039/c4lc00697f. Epub 2014 Jul 24.


An approach for exploring interaction between two proteins in vivo.

Qadota H, Benian GM.

Front Physiol. 2014 Apr 29;5:162. doi: 10.3389/fphys.2014.00162. eCollection 2014. Review.


Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin).

Qadota H, Luo Y, Matsunaga Y, Park AS, Gernert KM, Benian GM.

J Biol Chem. 2014 May 16;289(20):14252-62. doi: 10.1074/jbc.M114.556308. Epub 2014 Apr 1.


Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.

Mayans O, Benian GM, Simkovic F, Rigden DJ.

Biochem Soc Trans. 2013 Aug;41(4):1066-71. doi: 10.1042/BST20130085. Review.


ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.

Lecroisey C, Brouilly N, Qadota H, Mariol MC, Rochette NC, Martin E, Benian GM, Ségalat L, Mounier N, Gieseler K.

Mol Biol Cell. 2013 Apr;24(8):1232-49. doi: 10.1091/mbc.E12-09-0679. Epub 2013 Feb 20.


A family of indoles regulate virulence and Shiga toxin production in pathogenic E. coli.

Bommarius B, Anyanful A, Izrayelit Y, Bhatt S, Cartwright E, Wang W, Swimm AI, Benian GM, Schroeder FC, Kalman D.

PLoS One. 2013;8(1):e54456. doi: 10.1371/journal.pone.0054456. Epub 2013 Jan 23.


CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.

Warner A, Xiong G, Qadota H, Rogalski T, Vogl AW, Moerman DG, Benian GM.

Mol Biol Cell. 2013 Mar;24(5):601-16. doi: 10.1091/mbc.E12-06-0478. Epub 2013 Jan 2.


Paradigm shifts in cardiovascular research from Caenorhabditis elegans muscle.

Epstein HF, Benian GM.

Trends Cardiovasc Med. 2012 Nov;22(8):201-9. doi: 10.1016/j.tcm.2012.07.021. Review.


Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.

von Castelmur E, Strümpfer J, Franke B, Bogomolovas J, Barbieri S, Qadota H, Konarev PV, Svergun DI, Labeit S, Benian GM, Schulten K, Mayans O.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13608-13. doi: 10.1073/pnas.1200697109. Epub 2012 Aug 6.


Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.

Spooner PM, Bonner J, Maricq AV, Benian GM, Norman KR.

PLoS One. 2012;7(7):e40182. doi: 10.1371/journal.pone.0040182. Epub 2012 Jul 2.


A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites.

Qadota H, Moerman DG, Benian GM.

J Biol Chem. 2012 Aug 17;287(34):28537-51. doi: 10.1074/jbc.M112.354852. Epub 2012 Jul 3.


UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.

Wilson KJ, Qadota H, Mains PE, Benian GM.

Mol Biol Cell. 2012 Jul;23(14):2623-34. doi: 10.1091/mbc.E12-01-0055. Epub 2012 May 23.


Introduction to methods in invertebrate muscle biology.

Bernstein SI, Benian GM.

Methods. 2012 Jan;56(1):1-2. doi: 10.1016/j.ymeth.2012.02.014. No abstract available.


Immunofluorescent localization of proteins in Caenorhabditis elegans muscle.

Wilson KJ, Qadota H, Benian GM.

Methods Mol Biol. 2012;798:171-81. doi: 10.1007/978-1-61779-343-1_10.


Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components.

Nahabedian JF, Qadota H, Stirman JN, Lu H, Benian GM.

Methods. 2012 Jan;56(1):95-102. doi: 10.1016/j.ymeth.2011.11.005. Epub 2011 Nov 22.


Caenorhabditis elegans muscle: a genetic and molecular model for protein interactions in the heart.

Benian GM, Epstein HF.

Circ Res. 2011 Oct 14;109(9):1082-95. doi: 10.1161/CIRCRESAHA.110.237685. Review.


The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.

Warner A, Qadota H, Benian GM, Vogl AW, Moerman DG.

Mol Biol Cell. 2011 Jul 15;22(14):2551-63. doi: 10.1091/mbc.E10-12-0941. Epub 2011 Jun 1.


PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.

Qadota H, Miyauchi T, Nahabedian JF, Stirman JN, Lu H, Amano M, Benian GM, Kaibuchi K.

J Mol Biol. 2011 Mar 25;407(2):222-31. doi: 10.1016/j.jmb.2011.01.039. Epub 2011 Jan 26.


α-actinin is required for the proper assembly of Z-disk/focal-adhesion-like structures and for efficient locomotion in Caenorhabditis elegans.

Moulder GL, Cremona GH, Duerr J, Stirman JN, Fields SD, Martin W, Qadota H, Benian GM, Lu H, Barstead RJ.

J Mol Biol. 2010 Nov 5;403(4):516-28. doi: 10.1016/j.jmb.2010.08.055. Epub 2010 Sep 17.


Molecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscle.

Qadota H, Benian GM.

J Biomed Biotechnol. 2010;2010:864749. doi: 10.1155/2010/864749. Epub 2010 Apr 19. Review.


Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.

Forbes JG, Flaherty DB, Ma K, Qadota H, Benian GM, Wang K.

J Mol Biol. 2010 May 21;398(5):672-89. doi: 10.1016/j.jmb.2010.03.032. Epub 2010 Mar 25.


CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle.

Miller RK, Qadota H, Stark TJ, Mercer KB, Wortham TS, Anyanful A, Benian GM.

Mol Biol Cell. 2009 Aug;20(15):3608-16. doi: 10.1091/mbc.E09-03-0208. Epub 2009 Jun 17.


Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.

Anyanful A, Easley KA, Benian GM, Kalman D.

Cell Host Microbe. 2009 May 8;5(5):450-62. doi: 10.1016/j.chom.2009.04.012.


A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.

Xiong G, Qadota H, Mercer KB, McGaha LA, Oberhauser AF, Benian GM.

J Mol Biol. 2009 Mar 6;386(4):976-88.


The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.

Qadota H, Blangy A, Xiong G, Benian GM.

J Mol Biol. 2008 Nov 21;383(4):747-52. doi: 10.1016/j.jmb.2008.08.083. Epub 2008 Sep 9.


A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types.

Mercer KB, Szlam SM, Manning E, Gernert KM, Walthall WW, Benian GM, Gutekunst CA.

J Mol Neurosci. 2009 Jan;37(1):37-49. doi: 10.1007/s12031-008-9109-z. Epub 2008 Jul 1.


Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.

Greene DN, Garcia T, Sutton RB, Gernert KM, Benian GM, Oberhauser AF.

Biophys J. 2008 Aug;95(3):1360-70. doi: 10.1529/biophysj.108.130237. Epub 2008 Apr 4.


A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.

Qadota H, McGaha LA, Mercer KB, Stark TJ, Ferrara TM, Benian GM.

Mol Biol Cell. 2008 Jun;19(6):2424-32. doi: 10.1091/mbc.E08-01-0053. Epub 2008 Mar 12.


UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans.

Miller RK, Qadota H, Mercer KB, Gernert KM, Benian GM.

Mol Biol Cell. 2008 Apr;19(4):1529-39. doi: 10.1091/mbc.E07-07-0723. Epub 2008 Feb 6.


unc-94 encodes a tropomodulin in Caenorhabditis elegans.

Stevenson TO, Mercer KB, Cox EA, Szewczyk NJ, Conley CA, Hardin JD, Benian GM.

J Mol Biol. 2007 Dec 7;374(4):936-50. Epub 2007 Oct 10.


Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle.

Qadota H, Mercer KB, Miller RK, Kaibuchi K, Benian GM.

Mol Biol Cell. 2007 Nov;18(11):4317-26. Epub 2007 Aug 29.


UNC-98 links an integrin-associated complex to thick filaments in Caenorhabditis elegans muscle.

Miller RK, Qadota H, Landsverk ML, Mercer KB, Epstein HF, Benian GM.

J Cell Biol. 2006 Dec 18;175(6):853-9. Epub 2006 Dec 11.


Titin/connectin-related proteins in C. elegans: a review and new findings.

Ferrara TM, Flaherty DB, Benian GM.

J Muscle Res Cell Motil. 2005;26(6-8):435-47. Review. No abstract available.


Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.

Zastrow MS, Flaherty DB, Benian GM, Wilson KL.

J Cell Sci. 2006 Jan 15;119(Pt 2):239-49.


Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.

Anyanful A, Dolan-Livengood JM, Lewis T, Sheth S, Dezalia MN, Sherman MA, Kalman LV, Benian GM, Kalman D.

Mol Microbiol. 2005 Aug;57(4):988-1007.


Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.

Small TM, Gernert KM, Flaherty DB, Mercer KB, Borodovsky M, Benian GM.

J Mol Biol. 2004 Sep 3;342(1):91-108.


Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes.

Mercer KB, Flaherty DB, Miller RK, Qadota H, Tinley TL, Moerman DG, Benian GM.

Mol Biol Cell. 2003 Jun;14(6):2492-507. Epub 2003 Mar 7.

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