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Items: 1 to 50 of 91

1.

2-Hydroxylation of Acinetobacter baumannii Lipid A Contributes to Virulence.

Bartholomew TL, Kidd TJ, Sá Pessoa J, Conde Álvarez R, Bengoechea JA.

Infect Immun. 2019 Mar 25;87(4). pii: e00066-19. doi: 10.1128/IAI.00066-19. Print 2019 Apr.

2.

Klebsiella pneumoniae infection biology: living to counteract host defences.

Bengoechea JA, Sa Pessoa J.

FEMS Microbiol Rev. 2019 Mar 1;43(2):123-144. doi: 10.1093/femsre/fuy043. Review.

3.

Nanodelivery strategies for the treatment of multidrug-resistant bacterial infections.

Jiang L, Lin J, Taggart CC, Bengoechea JA, Scott CJ.

J Interdiscip Nanomed. 2018 Sep 4;3(3):111-121. doi: 10.1002/jin2.48. eCollection 2018 Sep. Review.

4.

The intrinsic resistome of Klebsiella pneumoniae.

Bernardini A, Cuesta T, Tomás A, Bengoechea JA, Martínez JL, Sánchez MB.

Int J Antimicrob Agents. 2019 Jan;53(1):29-33. doi: 10.1016/j.ijantimicag.2018.09.012. Epub 2018 Sep 17.

PMID:
30236960
5.

Modulation of Haemophilus influenzae interaction with hydrophobic molecules by the VacJ/MlaA lipoprotein impacts strongly on its interplay with the airways.

Fernández-Calvet A, Rodríguez-Arce I, Almagro G, Moleres J, Euba B, Caballero L, Martí S, Ramos-Vivas J, Bartholomew TL, Morales X, Ortíz-de-Solórzano C, Yuste JE, Bengoechea JA, Conde-Álvarez R, Garmendia J.

Sci Rep. 2018 May 2;8(1):6872. doi: 10.1038/s41598-018-25232-y.

6.

Clearance of intracellular Klebsiella pneumoniae infection using gentamicin-loaded nanoparticles.

Jiang L, Greene MK, Insua JL, Pessoa JS, Small DM, Smyth P, McCann AP, Cogo F, Bengoechea JA, Taggart CC, Scott CJ.

J Control Release. 2018 Jun 10;279:316-325. doi: 10.1016/j.jconrel.2018.04.040. Epub 2018 Apr 25.

PMID:
29704616
7.

Identification of lptA, lpxE, and lpxO, Three Genes Involved in the Remodeling of Brucella Cell Envelope.

Conde-Álvarez R, Palacios-Chaves L, Gil-Ramírez Y, Salvador-Bescós M, Bárcena-Varela M, Aragón-Aranda B, Martínez-Gómez E, Zúñiga-Ripa A, de Miguel MJ, Bartholomew TL, Hanniffy S, Grilló MJ, Vences-Guzmán MÁ, Bengoechea JA, Arce-Gorvel V, Gorvel JP, Moriyón I, Iriarte M.

Front Microbiol. 2018 Jan 10;8:2657. doi: 10.3389/fmicb.2017.02657. eCollection 2017.

8.

Vibrio cholerae amino acids go on the defense.

Bengoechea JA.

J Biol Chem. 2017 Dec 22;292(51):21216-21217. doi: 10.1074/jbc.H117.000868.

9.

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection.

Ivin M, Dumigan A, de Vasconcelos FN, Ebner F, Borroni M, Kavirayani A, Przybyszewska KN, Ingram RJ, Lienenklaus S, Kalinke U, Stoiber D, Bengoechea JA, Kovarik P.

PLoS Pathog. 2017 Nov 7;13(11):e1006696. doi: 10.1371/journal.ppat.1006696. eCollection 2017 Nov.

10.

Investigating intracellular persistence of Staphylococcus aureus within a murine alveolar macrophage cell line.

Lacoma A, Cano V, Moranta D, Regueiro V, Domínguez-Villanueva D, Laabei M, González-Nicolau M, Ausina V, Prat C, Bengoechea JA.

Virulence. 2017 Nov 17;8(8):1761-1775. doi: 10.1080/21505594.2017.1361089. Epub 2017 Sep 12.

11.

Identification and Characterization of Two Klebsiella pneumoniae lpxL Lipid A Late Acyltransferases and Their Role in Virulence.

Mills G, Dumigan A, Kidd T, Hobley L, Bengoechea JA.

Infect Immun. 2017 Aug 18;85(9). pii: e00068-17. doi: 10.1128/IAI.00068-17. Print 2017 Sep.

12.

Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens.

Martínez I, Oliveros JC, Cuesta I, de la Barrera J, Ausina V, Casals C, de Lorenzo A, García E, García-Fojeda B, Garmendia J, González-Nicolau M, Lacoma A, Menéndez M, Moranta D, Nieto A, Ortín J, Pérez-González A, Prat C, Ramos-Sevillano E, Regueiro V, Rodriguez-Frandsen A, Solís D, Yuste J, Bengoechea JA, Melero JA.

Front Microbiol. 2017 Mar 1;8:276. doi: 10.3389/fmicb.2017.00276. eCollection 2017.

13.

A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence.

Kidd TJ, Mills G, Sá-Pessoa J, Dumigan A, Frank CG, Insua JL, Ingram R, Hobley L, Bengoechea JA.

EMBO Mol Med. 2017 Apr;9(4):430-447. doi: 10.15252/emmm.201607336.

14.

Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM.

Leskinen K, Pajunen MI, Varjosalo M, Fernández-Carrasco H, Bengoechea JA, Skurnik M.

Mol Microbiol. 2017 Mar;103(6):1065-1091. doi: 10.1111/mmi.13610. Epub 2017 Jan 23.

15.

Klebsiella sweet deadly kiss.

Bengoechea JA.

Virulence. 2016 Oct 2;7(7):742-4. doi: 10.1080/21505594.2016.1204509. Epub 2016 Jun 22. No abstract available.

16.

Deciphering tissue-induced Klebsiella pneumoniae lipid A structure.

Llobet E, Martínez-Moliner V, Moranta D, Dahlström KM, Regueiro V, Tomás A, Cano V, Pérez-Gutiérrez C, Frank CG, Fernández-Carrasco H, Insua JL, Salminen TA, Garmendia J, Bengoechea JA.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6369-78. doi: 10.1073/pnas.1508820112. Epub 2015 Nov 2.

17.

Significance of tagI and mfd genes in the virulence of non-typeable Haemophilus influenzae.

Spricigo DA, Cortés P, Moranta D, Barbé J, Bengoechea JA, Lagostera M.

Int Microbiol. 2014 Sep;17(3):159-64. doi: 10.2436/20.1501.01.218.

18.

Genome Expression Profiling-Based Identification and Administration Efficacy of Host-Directed Antimicrobial Drugs against Respiratory Infection by Nontypeable Haemophilus influenzae.

Euba B, Moleres J, Segura V, Viadas C, Morey P, Moranta D, Leiva J, de-Torres JP, Bengoechea JA, Garmendia J.

Antimicrob Agents Chemother. 2015 Dec;59(12):7581-92. doi: 10.1128/AAC.01278-15. Epub 2015 Sep 28.

19.

Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes.

Cano V, March C, Insua JL, Aguiló N, Llobet E, Moranta D, Regueiro V, Brennan GP, Millán-Lou MI, Martín C, Garmendia J, Bengoechea JA.

Cell Microbiol. 2015 Nov;17(11):1537-60. doi: 10.1111/cmi.12466. Epub 2015 Jul 17.

PMID:
26045209
20.

Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling.

Tomás A, Lery L, Regueiro V, Pérez-Gutiérrez C, Martínez V, Moranta D, Llobet E, González-Nicolau M, Insua JL, Tomas JM, Sansonetti PJ, Tournebize R, Bengoechea JA.

J Biol Chem. 2015 Jul 3;290(27):16678-97. doi: 10.1074/jbc.M114.621292. Epub 2015 May 13.

21.

Relative Contribution of P5 and Hap Surface Proteins to Nontypable Haemophilus influenzae Interplay with the Host Upper and Lower Airways.

Euba B, Moleres J, Viadas C, Ruiz de los Mozos I, Valle J, Bengoechea JA, Garmendia J.

PLoS One. 2015 Apr 20;10(4):e0123154. doi: 10.1371/journal.pone.0123154. eCollection 2015.

22.

Relationship between azithromycin susceptibility and administration efficacy for nontypeable Haemophilus influenzae respiratory infection.

Euba B, Moleres J, Viadas C, Barberán M, Caballero L, Grilló MJ, Bengoechea JA, de-Torres JP, Liñares J, Leiva J, Garmendia J.

Antimicrob Agents Chemother. 2015 May;59(5):2700-12. doi: 10.1128/AAC.04447-14. Epub 2015 Feb 23.

23.

Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype.

Pérez-Cidoncha M, Killip MJ, Asensio VJ, Fernández Y, Bengoechea JA, Randall RE, Ortín J.

PLoS One. 2014 Jun 2;9(6):e98668. doi: 10.1371/journal.pone.0098668. eCollection 2014.

24.

Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor.

Lery LM, Frangeul L, Tomas A, Passet V, Almeida AS, Bialek-Davenet S, Barbe V, Bengoechea JA, Sansonetti P, Brisse S, Tournebize R.

BMC Biol. 2014 May 29;12:41. doi: 10.1186/1741-7007-12-41.

25.

Characterization of nontypable Haemophilus influenzae isolates recovered from adult patients with underlying chronic lung disease reveals genotypic and phenotypic traits associated with persistent infection.

Garmendia J, Viadas C, Calatayud L, Mell JC, Martí-Lliteras P, Euba B, Llobet E, Gil C, Bengoechea JA, Redfield RJ, Liñares J.

PLoS One. 2014 May 13;9(5):e97020. doi: 10.1371/journal.pone.0097020. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e107686.

26.

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response.

Pérez-Cidoncha M, Killip MJ, Oliveros JC, Asensio VJ, Fernández Y, Bengoechea JA, Randall RE, Ortín J.

J Virol. 2014 May;88(9):4632-46. doi: 10.1128/JVI.00014-14. Epub 2014 Feb 26.

27.

Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis.

Morey P, Viadas C, Euba B, Hood DW, Barberán M, Gil C, Grilló MJ, Bengoechea JA, Garmendia J.

Infect Immun. 2013 Nov;81(11):4100-11. doi: 10.1128/IAI.00492-13. Epub 2013 Aug 26.

28.

Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: adaptation and pathogenesis in the human airways.

Garmendia J, Martí-Lliteras P, Moleres J, Puig C, Bengoechea JA.

Int Microbiol. 2012 Dec;15(4):159-72. Review.

29.

Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella.

Insua JL, Llobet E, Moranta D, Pérez-Gutiérrez C, Tomás A, Garmendia J, Bengoechea JA.

Infect Immun. 2013 Oct;81(10):3552-65. doi: 10.1128/IAI.00391-13. Epub 2013 Jul 8.

30.

Role of bacterial surface structures on the interaction of Klebsiella pneumoniae with phagocytes.

March C, Cano V, Moranta D, Llobet E, Pérez-Gutiérrez C, Tomás JM, Suárez T, Garmendia J, Bengoechea JA.

PLoS One. 2013;8(2):e56847. doi: 10.1371/journal.pone.0056847. Epub 2013 Feb 15.

31.

Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation.

Frank CG, Reguerio V, Rother M, Moranta D, Maeurer AP, Garmendia J, Meyer TF, Bengoechea JA.

Cell Microbiol. 2013 Jul;15(7):1212-33. doi: 10.1111/cmi.12110. Epub 2013 Feb 17.

PMID:
23347154
32.

Deciphering the acylation pattern of Yersinia enterocolitica lipid A.

Reinés M, Llobet E, Dahlström KM, Pérez-Gutiérrez C, Llompart CM, Torrecabota N, Salminen TA, Bengoechea JA.

PLoS Pathog. 2012;8(10):e1002978. doi: 10.1371/journal.ppat.1002978. Epub 2012 Oct 25.

33.

Infection systems biology: from reactive to proactive (P4) medicine.

Bengoechea JA.

Int Microbiol. 2012 Jun;15(2):55-60. Review.

34.

Host cell kinases, α5 and β1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells.

López-Gómez A, Cano V, Moranta D, Morey P, García del Portillo F, Bengoechea JA, Garmendia J.

Microbiology. 2012 Sep;158(Pt 9):2384-98. doi: 10.1099/mic.0.059972-0. Epub 2012 Jun 21. Erratum in: Microbiology. 2012 Nov;158(Pt 11):2886-90.

PMID:
22723286
35.

The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition.

Conde-Álvarez R, Arce-Gorvel V, Iriarte M, Manček-Keber M, Barquero-Calvo E, Palacios-Chaves L, Chacón-Díaz C, Chaves-Olarte E, Martirosyan A, von Bargen K, Grilló MJ, Jerala R, Brandenburg K, Llobet E, Bengoechea JA, Moreno E, Moriyón I, Gorvel JP.

PLoS Pathog. 2012;8(5):e1002675. doi: 10.1371/journal.ppat.1002675. Epub 2012 May 10.

36.

Molecular basis of Yersinia enterocolitica temperature-dependent resistance to antimicrobial peptides.

Reinés M, Llobet E, Llompart CM, Moranta D, Pérez-Gutiérrez C, Bengoechea JA.

J Bacteriol. 2012 Jun;194(12):3173-88. doi: 10.1128/JB.00308-12. Epub 2012 Apr 13.

37.

[Correlation between TLR2 and TLR4 levels and adrenal gland response in trauma patients].

Llompart-Pou JA, Pérez-Bárcena J, Marsé P, Pérez G, Bengoechea JA, Raurich JM.

Med Intensiva. 2012 Nov;36(8):590-2. doi: 10.1016/j.medin.2012.01.012. Epub 2012 Mar 19. Spanish. No abstract available.

38.

Secretory IgA and COPD: a new kid on the block?

Bengoechea JA.

Am J Respir Crit Care Med. 2011 Aug 1;184(3):285-7. doi: 10.1164/rccm.201105-0821ED. No abstract available.

PMID:
21804117
39.

Identification of the lipopolysaccharide core of Yersinia pestis and Yersinia pseudotuberculosis as the receptor for bacteriophage φA1122.

Kiljunen S, Datta N, Dentovskaya SV, Anisimov AP, Knirel YA, Bengoechea JA, Holst O, Skurnik M.

J Bacteriol. 2011 Sep;193(18):4963-72. doi: 10.1128/JB.00339-11. Epub 2011 Jul 15.

40.

Impact of cigarette smoke exposure on host-bacterial pathogen interactions.

Garmendia J, Morey P, Bengoechea JA.

Eur Respir J. 2012 Feb;39(2):467-77. doi: 10.1183/09031936.00061911. Epub 2011 Jul 7. Review.

41.

Analysis of the networks controlling the antimicrobial-peptide-dependent induction of Klebsiella pneumoniae virulence factors.

Llobet E, Campos MA, Giménez P, Moranta D, Bengoechea JA.

Infect Immun. 2011 Sep;79(9):3718-32. doi: 10.1128/IAI.05226-11. Epub 2011 Jun 27.

42.

Nontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates.

Martí-Lliteras P, López-Gómez A, Mauro S, Hood DW, Viadas C, Calatayud L, Morey P, Servin A, Liñares J, Oliver A, Bengoechea JA, Garmendia J.

PLoS One. 2011;6(6):e21133. doi: 10.1371/journal.pone.0021133. Epub 2011 Jun 16.

43.

Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system.

Beceiro A, Llobet E, Aranda J, Bengoechea JA, Doumith M, Hornsey M, Dhanji H, Chart H, Bou G, Livermore DM, Woodford N.

Antimicrob Agents Chemother. 2011 Jul;55(7):3370-9. doi: 10.1128/AAC.00079-11. Epub 2011 May 16.

44.

Efficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter baumannii.

López-Rojas R, Docobo-Pérez F, Pachón-Ibáñez ME, de la Torre BG, Fernández-Reyes M, March C, Bengoechea JA, Andreu D, Rivas L, Pachón J.

Eur J Clin Microbiol Infect Dis. 2011 Nov;30(11):1391-8. doi: 10.1007/s10096-011-1233-y. Epub 2011 Apr 12.

PMID:
21479973
45.

Klebsiella pneumoniae outer membrane protein A is required to prevent the activation of airway epithelial cells.

March C, Moranta D, Regueiro V, Llobet E, Tomás A, Garmendia J, Bengoechea JA.

J Biol Chem. 2011 Mar 25;286(12):9956-67. doi: 10.1074/jbc.M110.181008. Epub 2011 Jan 28.

46.

Chronic obstructive pulmonary disease Th1 cells display impaired response to endotoxin.

Bengoechea JA, Ito K.

Am J Respir Crit Care Med. 2011 Jan 15;183(2):148-50. doi: 10.1164/rccm.201008-1275ED. No abstract available.

PMID:
21242592
47.

Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit.

Pérez-Bárcena J, Crespí C, Regueiro V, Marsé P, Raurich JM, Ibáñez J, García de Lorenzo-Mateos A, Bengoechea JA.

Crit Care. 2010;14(6):R233. doi: 10.1186/cc9388. Epub 2010 Dec 24.

48.

Evidence for a non-replicative intracellular stage of nontypable Haemophilus influenzae in epithelial cells.

Morey P, Cano V, Martí-Lliteras P, López-Gómez A, Regueiro V, Saus C, Bengoechea JA, Garmendia J.

Microbiology. 2011 Jan;157(Pt 1):234-50. doi: 10.1099/mic.0.040451-0. Epub 2010 Oct 7.

PMID:
20929955
49.

Klebsiella pneumoniae subverts the activation of inflammatory responses in a NOD1-dependent manner.

Regueiro V, Moranta D, Frank CG, Larrarte E, Margareto J, March C, Garmendia J, Bengoechea JA.

Cell Microbiol. 2011 Jan;13(1):135-53. doi: 10.1111/j.1462-5822.2010.01526.x. Epub 2010 Oct 14.

PMID:
20846183
50.

Characterization of the six glycosyltransferases involved in the biosynthesis of Yersinia enterocolitica serotype O:3 lipopolysaccharide outer core.

Pinta E, Duda KA, Hanuszkiewicz A, Salminen TA, Bengoechea JA, Hyytiäinen H, Lindner B, Radziejewska-Lebrecht J, Holst O, Skurnik M.

J Biol Chem. 2010 Sep 3;285(36):28333-42. doi: 10.1074/jbc.M110.111336. Epub 2010 Jul 1.

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