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Items: 33

1.

Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.

Markwalder JA, Arnone MR, Benfield PA, Boisclair M, Burton CR, Chang CH, Cox SS, Czerniak PM, Dean CL, Doleniak D, Grafstrom R, Harrison BA, Kaltenbach RF 3rd, Nugiel DA, Rossi KA, Sherk SR, Sisk LM, Stouten P, Trainor GL, Worland P, Seitz SP.

J Med Chem. 2004 Nov 18;47(24):5894-911.

PMID:
15537345
2.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.

Yue EW, DiMeo SV, Higley CA, Markwalder JA, Burton CR, Benfield PA, Grafstrom RH, Cox S, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Trainor GL, Seitz SP.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):343-6.

PMID:
14698155
3.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).

Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Trainor GL.

J Med Chem. 2002 Nov 21;45(24):5233-48.

PMID:
12431051
4.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.

Nugiel DA, Vidwans A, Etzkorn AM, Rossi KA, Benfield PA, Burton CR, Cox S, Doleniak D, Seitz SP.

J Med Chem. 2002 Nov 21;45(24):5224-32.

PMID:
12431050
5.

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors.

Lai Z, Yang T, Kim YB, Sielecki TM, Diamond MA, Strack P, Rolfe M, Caligiuri M, Benfield PA, Auger KR, Copeland RA.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14734-9. Epub 2002 Oct 29.

6.

Identification of selective inhibitors of cyclin dependent kinase 4.

Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2209-11.

PMID:
11514172
7.

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization.

Lai Z, Ferry KV, Diamond MA, Wee KE, Kim YB, Ma J, Yang T, Benfield PA, Copeland RA, Auger KR.

J Biol Chem. 2001 Aug 17;276(33):31357-67. Epub 2001 Jun 7.

8.

Quinazolines as cyclin dependent kinase inhibitors.

Sielecki TM, Johnson TL, Liu J, Muckelbauer JK, Grafstrom RH, Cox S, Boylan J, Burton CR, Chen H, Smallwood A, Chang CH, Boisclair M, Benfield PA, Trainor GL, Seitz SP.

Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60.

PMID:
11354366
9.

Indenopyrazoles as novel cyclin dependent kinase (CDK) inhibitors.

Nugiel DA, Etzkorn AM, Vidwans A, Benfield PA, Boisclair M, Burton CR, Cox S, Czerniak PM, Doleniak D, Seitz SP.

J Med Chem. 2001 Apr 26;44(9):1334-6. No abstract available.

PMID:
11311054
10.

Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation.

Sielecki TM, Boylan JF, Benfield PA, Trainor GL.

J Med Chem. 2000 Jan 13;43(1):1-18. Review. No abstract available.

PMID:
10633033
11.

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.

Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB.

Biochem J. 1998 Dec 1;336 ( Pt 2):471-81.

12.

Construction of linker-scanning mutations using PCR.

Harlow PP, Hobson GM, Benfield PA.

Methods Mol Biol. 1996;57:287-95. Review. No abstract available.

PMID:
8850015
13.

Construction of linker-scanning mutations by oligonucleotide ligation.

Hobson GM, Harlow PP, Benfield PA.

Methods Mol Biol. 1996;57:279-85. Review. No abstract available.

PMID:
8850014
14.
15.

Construction of linker-scanning mutations using the polymerase chain reaction.

Harlow PP, Hobson GM, Benfield PA.

Methods Mol Biol. 1994;31:87-96. Review. No abstract available.

PMID:
7921041
16.

Construction of linker-scanning mutations by oligonucleotide ligation.

Hobson GM, Harlow PP, Benfield PA.

Methods Mol Biol. 1994;31:79-85. Review. No abstract available.

PMID:
7921040
17.

Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.

Fairman R, Beran-Steed RK, Anthony-Cahill SJ, Lear JD, Stafford WF 3rd, DeGrado WF, Benfield PA, Brenner SL.

Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10429-33.

19.

Molecular characterization of helix-loop-helix peptides.

Anthony-Cahill SJ, Benfield PA, Fairman R, Wasserman ZR, Brenner SL, Stafford WF 3rd, Altenbach C, Hubbell WL, DeGrado WF.

Science. 1992 Feb 21;255(5047):979-83.

PMID:
1312255
20.

TATA box-mediated polymerase III transcription in vitro.

Mitchell MT, Hobson GM, Benfield PA.

J Biol Chem. 1992 Jan 25;267(3):1995-2005.

21.

Human cytomegalovirus US3 and UL36-38 immediate-early proteins regulate gene expression.

Colberg-Poley AM, Santomenna LD, Harlow PP, Benfield PA, Tenney DJ.

J Virol. 1992 Jan;66(1):95-105.

22.
23.

Brain and muscle creatine kinase genes contain common TA-rich recognition protein-binding regulatory elements.

Horlick RA, Hobson GM, Patterson JH, Mitchell MT, Benfield PA.

Mol Cell Biol. 1990 Sep;10(9):4826-36.

24.
25.
26.

Identification of a novel TA-rich DNA binding protein that recognizes a TATA sequence within the brain creatine kinase promoter.

Hobson GM, Mitchell MT, Molloy GR, Pearson ML, Benfield PA.

Nucleic Acids Res. 1988 Sep 26;16(18):8925-44.

27.
29.

Isolation and sequence analysis of cDNA clones coding for rat skeletal muscle creatine kinase.

Benfield PA, Zivin RA, Miller LS, Sowder R, Smythers GW, Henderson L, Oroszlan S, Pearson ML.

J Biol Chem. 1984 Dec 10;259(23):14979-84.

30.
31.

Myosin isozymes in avian skeletal muscles. I. Sequential expression of myosin isozymes in developing chicken pectoralis muscles.

Lowey S, Benfield PA, LeBlanc DD, Waller GS.

J Muscle Res Cell Motil. 1983 Dec;4(6):695-716.

PMID:
6230370
32.

Distribution and properties of myosin isozymes in developing avian and mammalian skeletal muscle fibers.

Gauthier GF, Lowey S, Benfield PA, Hobbs AW.

J Cell Biol. 1982 Feb;92(2):471-84.

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