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A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.

Wojnarowicz PM, Lima E Silva R, Ohnaka M, Lee SB, Chin Y, Kulukian A, Chang SH, Desai B, Garcia Escolano M, Shah R, Garcia-Cao M, Xu S, Kadam R, Goldgur Y, Miller MA, Ouerfelli O, Yang G, Arakawa T, Albanese SK, Garland WA, Stoller G, Chaudhary J, Norton L, Soni RK, Philip J, Hendrickson RC, Iavarone A, Dannenberg AJ, Chodera JD, Pavletich N, Lasorella A, Campochiaro PA, Benezra R.

Cell Rep. 2019 Oct 1;29(1):62-75.e7. doi: 10.1016/j.celrep.2019.08.073.


Author Correction: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.

Cook PJ, Thomas R, Kannan R, de Leon ES, Drilon A, Rosenblum MK, Scaltriti M, Benezra R, Ventura A.

Nat Commun. 2018 Mar 13;9:16187. doi: 10.1038/ncomms16187.


Whole chromosome loss and associated breakage-fusion-bridge cycles transform mouse tetraploid cells.

Thomas R, Marks DH, Chin Y, Benezra R.

EMBO J. 2018 Jan 17;37(2):201-218. doi: 10.15252/embj.201797630. Epub 2017 Dec 1.


Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.

Cook PJ, Thomas R, Kannan R, de Leon ES, Drilon A, Rosenblum MK, Scaltriti M, Benezra R, Ventura A.

Nat Commun. 2017 Jul 11;8:15987. doi: 10.1038/ncomms15987. Erratum in: Nat Commun. 2018 Mar 13;9:16187.


Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.

Marks DH, Thomas R, Chin Y, Shah R, Khoo C, Benezra R.

Cell Rep. 2017 May 30;19(9):1832-1845. doi: 10.1016/j.celrep.2017.05.021.


Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden.

Montrose DC, Zhou XK, McNally EM, Sue E, Yantiss RK, Gross SS, Leve ND, Karoly ED, Suen CS, Ling L, Benezra R, Pamer EG, Dannenberg AJ.

Cancer Prev Res (Phila). 2016 Sep;9(9):721-31. doi: 10.1158/1940-6207.CAPR-16-0095. Epub 2016 Jul 18.


TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients.

Comen E, Wojnarowicz P, Seshan VE, Shah R, Coker C, Norton L, Benezra R.

NPJ Breast Cancer. 2016 Apr 20;2:16009. doi: 10.1038/npjbcancer.2016.9. eCollection 2016.


Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma.

Cook PJ, Thomas R, Kingsley PJ, Shimizu F, Montrose DC, Marnett LJ, Tabar VS, Dannenberg AJ, Benezra R.

Neuro Oncol. 2016 Oct;18(10):1379-89. doi: 10.1093/neuonc/now049. Epub 2016 Mar 28.


Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.

Man N, Sun XJ, Tan Y, García-Cao M, Liu F, Cheng G, Hatlen M, Xu H, Shah R, Chastain N, Liu N, Huang G, Zhou Y, Sheng M, Song J, Yang FC, Benezra R, Nimer SD, Wang L.

Blood. 2016 May 12;127(19):2322-6. doi: 10.1182/blood-2015-11-677708. Epub 2016 Mar 4.


Id1 expression in endothelial cells of the colon is required for normal response to injury.

Zhang N, Subbaramaiah K, Yantiss RK, Zhou XK, Chin Y, Scherl EJ, Bosworth BP, Benezra R, Dannenberg AJ.

Am J Pathol. 2015 Nov;185(11):2983-93. doi: 10.1016/j.ajpath.2015.07.005. Epub 2015 Sep 5.


Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.

Wang L, Man N, Sun XJ, Tan Y, García-Cao M, Liu F, Hatlen M, Xu H, Huang G, Mattlin M, Mehta A, Rampersaud E, Benezra R, Nimer SD.

Blood. 2015 Jul 30;126(5):640-50. doi: 10.1182/blood-2015-03-635532. Epub 2015 Jun 17. Erratum in: Blood. 2016 Apr 14;127(15):1941. Cao, Marta Garcia [corrected to Garcia-Cao, Marta]. Blood. 2016 Sep 29;128(13):1778. Blood. 2016 Apr 14;127(15):1941.


Somatic mutations in leukocytes infiltrating primary breast cancers.

Kleppe M, Comen E, Wen HY, Bastian L, Blum B, Rapaport FT, Keller M, Granot Z, Socci N, Viale A, You D, Benezra R, Weigelt B, Brogi E, Berger MF, Reis-Filho JS, Levine RL, Norton L.

NPJ Breast Cancer. 2015 Jun 10;1:15005. doi: 10.1038/npjbcancer.2015.5. eCollection 2015.


Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer.

Zhang N, Subbaramaiah K, Yantiss RK, Zhou XK, Chin Y, Benezra R, Dannenberg AJ.

Cancer Prev Res (Phila). 2015 Apr;8(4):303-11. doi: 10.1158/1940-6207.CAPR-14-0411. Epub 2015 Jan 26.


Id Proteins Contribute to Tumor Development and Metastatic Colonization in a Model of Bladder Carcinogenesis.

Garcia-Cao M, Al-Ahmadie HA, Chin Y, Bochner BH, Benezra R.

Bladder Cancer. 2015 Oct 26;1(2):159-170.


ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury.

Zhang N, Yantiss RK, Nam HS, Chin Y, Zhou XK, Scherl EJ, Bosworth BP, Subbaramaiah K, Dannenberg AJ, Benezra R.

Stem Cell Reports. 2014 Nov 11;3(5):716-24. doi: 10.1016/j.stemcr.2014.09.012. Epub 2014 Oct 23.


The ID proteins: master regulators of cancer stem cells and tumour aggressiveness.

Lasorella A, Benezra R, Iavarone A.

Nat Rev Cancer. 2014 Feb;14(2):77-91. doi: 10.1038/nrc3638. Epub 2014 Jan 20. Review.


TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition.

Stankic M, Pavlovic S, Chin Y, Brogi E, Padua D, Norton L, Massagué J, Benezra R.

Cell Rep. 2013 Dec 12;5(5):1228-42. doi: 10.1016/j.celrep.2013.11.014.


Grant applications: Undo NIH policy to ease effect of cuts.

Benezra R.

Nature. 2013 Jan 24;493(7433):480. doi: 10.1038/493480e. No abstract available.


The cancer biology of whole-chromosome instability.

Duijf PH, Benezra R.

Oncogene. 2013 Oct;32(40):4727-36. doi: 10.1038/onc.2012.616. Epub 2013 Jan 14. Review.


Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.

Niola F, Zhao X, Singh D, Sullivan R, Castano A, Verrico A, Zoppoli P, Friedmann-Morvinski D, Sulman E, Barrett L, Zhuang Y, Verma I, Benezra R, Aldape K, Iavarone A, Lasorella A.

J Clin Invest. 2013 Jan;123(1):405-17. doi: 10.1172/JCI63811. Epub 2012 Dec 17. Erratum in: J Clin Invest. 2014 Sep 2;124(9):4134.


Cancer cells preferentially lose small chromosomes.

Duijf PH, Schultz N, Benezra R.

Int J Cancer. 2013 May 15;132(10):2316-26. doi: 10.1002/ijc.27924. Epub 2012 Nov 26.


Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation.

Wen YH, Ho A, Patil S, Akram M, Catalano J, Eaton A, Norton L, Benezra R, Brogi E.

Breast Cancer Res Treat. 2012 Aug;135(1):93-102. doi: 10.1007/s10549-012-2070-0. Epub 2012 Apr 27.


Id proteins synchronize stemness and anchorage to the niche of neural stem cells.

Niola F, Zhao X, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A.

Nat Cell Biol. 2012 Apr 22;14(5):477-87. doi: 10.1038/ncb2490.


Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle.

Ono Y, Masuda S, Nam HS, Benezra R, Miyagoe-Suzuki Y, Takeda S.

J Cell Sci. 2012 Mar 1;125(Pt 5):1309-17. doi: 10.1242/jcs.096198. Epub 2012 Feb 20.


Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma.

Barrett LE, Granot Z, Coker C, Iavarone A, Hambardzumyan D, Holland EC, Nam HS, Benezra R.

Cancer Cell. 2012 Jan 17;21(1):11-24. doi: 10.1016/j.ccr.2011.11.025.


Id1 maintains embryonic stem cell self-renewal by up-regulation of Nanog and repression of Brachyury expression.

Romero-Lanman EE, Pavlovic S, Amlani B, Chin Y, Benezra R.

Stem Cells Dev. 2012 Feb 10;21(3):384-93. doi: 10.1089/scd.2011.0428. Epub 2011 Dec 1.


Tumor entrained neutrophils inhibit seeding in the premetastatic lung.

Granot Z, Henke E, Comen EA, King TA, Norton L, Benezra R.

Cancer Cell. 2011 Sep 13;20(3):300-14. doi: 10.1016/j.ccr.2011.08.012.


Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.

Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R.

Cancer Cell. 2011 Jun 14;19(6):701-14. doi: 10.1016/j.ccr.2011.04.017.


Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors.

Escorcia FE, Henke E, McDevitt MR, Villa CH, Smith-Jones P, Blasberg RG, Benezra R, Scheinberg DA.

Cancer Res. 2010 Nov 15;70(22):9277-86. doi: 10.1158/0008-5472.CAN-10-2029. Epub 2010 Nov 2.


Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth.

Mellick AS, Plummer PN, Nolan DJ, Gao D, Bambino K, Hahn M, Catena R, Turner V, McDonnell K, Benezra R, Brink R, Swarbrick A, Mittal V.

Cancer Res. 2010 Sep 15;70(18):7273-82. doi: 10.1158/0008-5472.CAN-10-1142. Epub 2010 Aug 31.


Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth.

Penack O, Henke E, Suh D, King CG, Smith OM, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Lu TT, May C, Scheinberg DA, Gao DC, Mittal V, Heller G, Benezra R, van den Brink MR.

J Natl Cancer Inst. 2010 Jun 16;102(12):894-908. doi: 10.1093/jnci/djq172. Epub 2010 May 12.


Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal.

Sotillo R, Schvartzman JM, Socci ND, Benezra R.

Nature. 2010 Mar 18;464(7287):436-40. doi: 10.1038/nature08803. Epub 2010 Feb 21.


Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Schvartzman JM, Sotillo R, Benezra R.

Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781. Review.


Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent.

James D, Nam HS, Seandel M, Nolan D, Janovitz T, Tomishima M, Studer L, Lee G, Lyden D, Benezra R, Zaninovic N, Rosenwaks Z, Rabbany SY, Rafii S.

Nat Biotechnol. 2010 Feb;28(2):161-6. doi: 10.1038/nbt.1605. Epub 2010 Jan 17.


Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.

Sotillo R, Schvartzman JM, Benezra R.

Cancer Cell. 2009 Dec 8;16(6):451-2. doi: 10.1016/j.ccr.2009.11.014.


High levels of Id1 expression define B1 type adult neural stem cells.

Nam HS, Benezra R.

Cell Stem Cell. 2009 Nov 6;5(5):515-26. doi: 10.1016/j.stem.2009.08.017.


Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression.

Gao D, Nolan D, McDonnell K, Vahdat L, Benezra R, Altorki N, Mittal V.

Biochim Biophys Acta. 2009 Aug;1796(1):33-40. doi: 10.1016/j.bbcan.2009.05.001. Epub 2009 May 19. Review.


Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.

Diaz-Rodríguez E, Sotillo R, Schvartzman JM, Benezra R.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16719-24. doi: 10.1073/pnas.0803504105. Epub 2008 Oct 21.


Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription.

Subbaramaiah K, Benezra R, Hudis C, Dannenberg AJ.

J Biol Chem. 2008 Dec 5;283(49):33955-68. doi: 10.1074/jbc.M805490200. Epub 2008 Oct 8.


Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.

Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS.

Cancer Cell. 2008 Sep 9;14(3):263-73. doi: 10.1016/j.ccr.2008.08.001.


Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas.

Kerbel RS, Benezra R, Lyden DC, Hattori K, Heissig B, Nolan DJ, Mittal V, Shaked Y, Dias S, Bertolini F, Rafii S.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):E54; author reply E55. doi: 10.1073/pnas.0804876105. Epub 2008 Aug 20. No abstract available.


Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells.

Miller R, Cirulli V, Diaferia GR, Ninniri S, Hardiman G, Torbett BE, Benezra R, Crisa L.

Diabetes. 2008 Sep;57(9):2402-12. doi: 10.2337/db08-0244. Epub 2008 Jun 2.


Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo.

Henke E, Perk J, Vider J, de Candia P, Chin Y, Solit DB, Ponomarev V, Cartegni L, Manova K, Rosen N, Benezra R.

Nat Biotechnol. 2008 Jan;26(1):91-100. doi: 10.1038/nbt1366. Epub 2008 Jan 6.


Id1 restrains p21 expression to control endothelial progenitor cell formation.

Ciarrocchi A, Jankovic V, Shaked Y, Nolan DJ, Mittal V, Kerbel RS, Nimer SD, Benezra R.

PLoS One. 2007 Dec 19;2(12):e1338.


ID genes mediate tumor reinitiation during breast cancer lung metastasis.

Gupta GP, Perk J, Acharyya S, de Candia P, Mittal V, Todorova-Manova K, Gerald WL, Brogi E, Benezra R, Massagué J.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19506-11. Epub 2007 Nov 28.


Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K.

PLoS One. 2007 Nov 28;2(11):e1165.


Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint.

Koltsova EK, Ciofani M, Benezra R, Miyazaki T, Clipstone N, Zúñiga-Pflücker JC, Wiest DL.

J Immunol. 2007 Oct 1;179(7):4694-703.


Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.

Bai G, Sheng N, Xie Z, Bian W, Yokota Y, Benezra R, Kageyama R, Guillemot F, Jing N.

Dev Cell. 2007 Aug;13(2):283-97.


Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization.

Nolan DJ, Ciarrocchi A, Mellick AS, Jaggi JS, Bambino K, Gupta S, Heikamp E, McDevitt MR, Scheinberg DA, Benezra R, Mittal V.

Genes Dev. 2007 Jun 15;21(12):1546-58.


Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

Singh Jaggi J, Henke E, Seshan SV, Kappel BJ, Chattopadhyay D, May C, McDevitt MR, Nolan D, Mittal V, Benezra R, Scheinberg DA.

PLoS One. 2007 Mar 7;2(3):e267.

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