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Items: 28


Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes.

Gravotta D, Perez Bay A, Jonker CTH, Zager PJ, Benedicto I, Schreiner R, Caceres PS, Rodriguez-Boulan E.

Mol Biol Cell. 2019 Jul 1;30(14):1716-1728. doi: 10.1091/mbc.E18-12-0811. Epub 2019 May 15.


Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.

Benedicto I, Lehmann GL, Ginsberg M, Nolan DJ, Bareja R, Elemento O, Salfati Z, Alam NM, Prusky GT, Llanos P, Rabbany SY, Maminishkis A, Miller SS, Rafii S, Rodriguez-Boulan E.

Nat Commun. 2017 May 19;8:15374. doi: 10.1038/ncomms15374.


Directional Fluid Transport across Organ-Blood Barriers: Physiology and Cell Biology.

Caceres PS, Benedicto I, Lehmann GL, Rodriguez-Boulan EJ.

Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3). pii: a027847. doi: 10.1101/cshperspect.a027847. Review.


The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells.

Perez Bay AE, Schreiner R, Benedicto I, Paz Marzolo M, Banfelder J, Weinstein AM, Rodriguez-Boulan EJ.

Nat Commun. 2016 May 16;7:11550. doi: 10.1038/ncomms11550.


Apolipoprotein E, but Not Apolipoprotein B, Is Essential for Efficient Cell-to-Cell Transmission of Hepatitis C Virus.

Gondar V, Molina-Jiménez F, Hishiki T, García-Buey L, Koutsoudakis G, Shimotohno K, Benedicto I, Majano PL.

J Virol. 2015 Oct;89(19):9962-73. doi: 10.1128/JVI.00577-15. Epub 2015 Jul 22.


Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis.

Strippoli R, Loureiro J, Moreno V, Benedicto I, Lozano ML, Barreiro O, Pellinen T, Minguet S, Foronda M, Osteso MT, Calvo E, Vázquez J, Cabrera ML, Del Pozo MA.

EMBO Mol Med. 2015 Mar;7(3):357. doi: 10.15252/emmm.201570010. No abstract available.


Basolateral sorting of chloride channel 2 is mediated by interactions between a dileucine motif and the clathrin adaptor AP-1.

de la Fuente-Ortega E, Gravotta D, Perez Bay A, Benedicto I, Carvajal-Gonzalez JM, Lehmann GL, Lagos CF, Rodríguez-Boulan E.

Mol Biol Cell. 2015 May 1;26(9):1728-42. doi: 10.1091/mbc.E15-01-0047. Epub 2015 Mar 4.


Clathrin mediates infectious hepatitis C virus particle egress.

Benedicto I, Gondar V, Molina-Jiménez F, García-Buey L, López-Cabrera M, Gastaminza P, Majano PL.

J Virol. 2015 Apr;89(8):4180-90. doi: 10.1128/JVI.03620-14. Epub 2015 Jan 28.


Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis.

Strippoli R, Loureiro J, Moreno V, Benedicto I, Pérez Lozano ML, Barreiro O, Pellinen T, Minguet S, Foronda M, Osteso MT, Calvo E, Vázquez J, López Cabrera M, del Pozo MA.

EMBO Mol Med. 2015 Jan;7(1):102-23. doi: 10.15252/emmm.201404127. Erratum in: EMBO Mol Med. 2015 Mar;7(3):357.


Galectin-4-mediated transcytosis of transferrin receptor.

Perez Bay AE, Schreiner R, Benedicto I, Rodriguez-Boulan EJ.

J Cell Sci. 2014 Oct 15;127(Pt 20):4457-69. doi: 10.1242/jcs.153437. Epub 2014 Sep 1.


Plasma membrane protein polarity and trafficking in RPE cells: past, present and future.

Lehmann GL, Benedicto I, Philp NJ, Rodriguez-Boulan E.

Exp Eye Res. 2014 Sep;126:5-15. doi: 10.1016/j.exer.2014.04.021. Review.


Role of tight junctions in hepatitis C virus infection.

Benedicto I, Molina-Jiménez F, García-Buey L, Gondar V, López-Cabrera M, Moreno-Otero R, Majano PL.

Rev Esp Enferm Dig. 2012 May;104(5):255-63. Review. No abstract available.


Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication.

García-Mediavilla MV, Pisonero-Vaquero S, Lima-Cabello E, Benedicto I, Majano PL, Jorquera F, González-Gallego J, Sánchez-Campos S.

Lab Invest. 2012 Aug;92(8):1191-202. doi: 10.1038/labinvest.2012.88. Epub 2012 May 28.


Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells.

Strippoli R, Benedicto I, Perez Lozano ML, Pellinen T, Sandoval P, Lopez-Cabrera M, del Pozo MA.

PLoS One. 2012;7(2):e31492. doi: 10.1371/journal.pone.0031492. Epub 2012 Feb 27.


Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle.

Molina-Jimenez F, Benedicto I, Dao Thi VL, Gondar V, Lavillette D, Marin JJ, Briz O, Moreno-Otero R, Aldabe R, Baumert TF, Cosset FL, Lopez-Cabrera M, Majano PL.

Virology. 2012 Mar 30;425(1):31-9. doi: 10.1016/j.virol.2011.12.021. Epub 2012 Jan 24.


Interplay among cellular polarization, lipoprotein metabolism and hepatitis C virus entry.

Benedicto I, Molina-Jiménez F, Moreno-Otero R, López-Cabrera M, Majano PL.

World J Gastroenterol. 2011 Jun 14;17(22):2683-90. doi: 10.3748/wjg.v17.i22.2683.


p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition.

Strippoli R, Benedicto I, Foronda M, Perez-Lozano ML, Sánchez-Perales S, López-Cabrera M, Del Pozo MÁ.

J Cell Sci. 2010 Dec 15;123(Pt 24):4321-31. doi: 10.1242/jcs.071647. Epub 2010 Nov 23.


Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation.

Molina-Jiménez F, Benedicto I, Murata M, Martín-Vílchez S, Seki T, Antonio Pintor-Toro J, Tortolero M, Moreno-Otero R, Okazaki K, Koike K, Barbero JL, Matsuzaki K, Majano PL, López-Cabrera M.

Hepatology. 2010 Mar;51(3):777-87. doi: 10.1002/hep.23468.


Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis.

Figueroa-Vega N, Alfonso-Pérez M, Benedicto I, Sánchez-Madrid F, González-Amaro R, Marazuela M.

J Clin Endocrinol Metab. 2010 Feb;95(2):953-62. doi: 10.1210/jc.2009-1719. Epub 2009 Dec 16.


The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection.

Benedicto I, Molina-Jiménez F, Bartosch B, Cosset FL, Lavillette D, Prieto J, Moreno-Otero R, Valenzuela-Fernández A, Aldabe R, López-Cabrera M, Majano PL.

J Virol. 2009 Aug;83(16):8012-20. doi: 10.1128/JVI.00038-09. Epub 2009 Jun 10.


Hepatitis C virus NS5A and core proteins induce oxidative stress-mediated calcium signalling alterations in hepatocytes.

Dionisio N, Garcia-Mediavilla MV, Sanchez-Campos S, Majano PL, Benedicto I, Rosado JA, Salido GM, Gonzalez-Gallego J.

J Hepatol. 2009 May;50(5):872-82. doi: 10.1016/j.jhep.2008.12.026. Epub 2009 Feb 26.


Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/Snail1 pathway.

Strippoli R, Benedicto I, Pérez Lozano ML, Cerezo A, López-Cabrera M, del Pozo MA.

Dis Model Mech. 2008 Nov-Dec;1(4-5):264-74. doi: 10.1242/dmm.001321. Epub 2008 Oct 28.


Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum.

Benedicto I, Molina-Jiménez F, Barreiro O, Maldonado-Rodríguez A, Prieto J, Moreno-Otero R, Aldabe R, López-Cabrera M, Majano PL.

Hepatology. 2008 Oct;48(4):1044-53. doi: 10.1002/hep.22465.


AM3, a natural glycoconjugate, induces the functional maturation of human dendritic cells.

Martín-Vilchez S, Molina-Jiménez F, Alonso-Lebrero JL, Sanz-Cameno P, Rodríguez-Muñoz Y, Benedicto I, Roda-Navarro P, Trapero M, Aragoneses-Fenoll L, González S, Pivel JP, Corbí AL, López-Cabrera M, Moreno-Otero R, Majano PL.

Br J Pharmacol. 2008 Jun;154(3):698-708. doi: 10.1038/bjp.2008.87. Epub 2008 Apr 14.


A Polypodium leucotomos extract inhibits solar-simulated radiation-induced TNF-alpha and iNOS expression, transcriptional activation and apoptosis.

Jańczyk A, Garcia-Lopez MA, Fernandez-Peñas P, Alonso-Lebrero JL, Benedicto I, López-Cabrera M, Gonzalez S.

Exp Dermatol. 2007 Oct;16(10):823-9.


Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins.

Núñez O, Fernández-Martínez A, Majano PL, Apolinario A, Gómez-Gonzalo M, Benedicto I, López-Cabrera M, Boscá L, Clemente G, García-Monzón C, Martín-Sanz P.

Gut. 2004 Nov;53(11):1665-72.


Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity.

Gómez-Gonzalo M, Benedicto I, Carretero M, Lara-Pezzi E, Maldonado-Rodríguez A, Moreno-Otero R, Lai MM, López-Cabrera M.

Virology. 2004 Oct 10;328(1):120-30.


The hepatitis B virus X protein binds to and activates the NH(2)-terminal trans-activation domain of nuclear factor of activated T cells-1.

Carretero M, Gómez-Gonzalo M, Lara-Pezzi E, Benedicto I, Aramburu J, Martínez-Martínez S, Redondo JM, López-Cabrera M.

Virology. 2002 Aug 1;299(2):288-300.

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