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Cytomegalovirus Evades TRAIL-Mediated Innate Lymphoid Cell 1 Defenses.

Picarda G, Ghosh R, McDonald B, Verma S, Thiault N, El Morabiti R, Griffith TS, Benedict CA.

J Virol. 2019 Jul 30;93(16). pii: e00617-19. doi: 10.1128/JVI.00617-19. Print 2019 Aug 15.


Structure of human cytomegalovirus UL144, an HVEM orthologue, bound to the B and T cell lymphocyte attenuator.

Bitra A, Nemčovičová I, Picarda G, Doukov T, Wang J, Benedict CA, Zajonc DM.

J Biol Chem. 2019 Jul 5;294(27):10519-10529. doi: 10.1074/jbc.RA119.009199. Epub 2019 May 24.


Restriction of Human Cytomegalovirus Infection by Galectin-9.

Machala EA, Avdic S, Stern L, Zajonc DM, Benedict CA, Blyth E, Gottlieb DJ, Abendroth A, McSharry BP, Slobedman B.

J Virol. 2019 Jan 17;93(3). pii: e01746-18. doi: 10.1128/JVI.01746-18. Print 2019 Feb 1.


Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection.

Seelige R, Saddawi-Konefka R, Adams NM, Picarda G, Sun JC, Benedict CA, Bui JD.

Sci Rep. 2018 Sep 12;8(1):13670. doi: 10.1038/s41598-018-32011-2.


IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence.

Wehrens EJ, Wong KA, Gupta A, Khan A, Benedict CA, Zuniga EI.

PLoS One. 2018 Jul 25;13(7):e0201249. doi: 10.1371/journal.pone.0201249. eCollection 2018.


Cytomegalovirus: Shape-Shifting the Immune System.

Picarda G, Benedict CA.

J Immunol. 2018 Jun 15;200(12):3881-3889. doi: 10.4049/jimmunol.1800171. Review.


Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.

Delpoux A, Michelini RH, Verma S, Lai CY, Omilusik KD, Utzschneider DT, Redwood AJ, Goldrath AW, Benedict CA, Hedrick SM.

J Exp Med. 2018 Feb 5;215(2):575-594. doi: 10.1084/jem.20170697. Epub 2017 Dec 27.


Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.

Bitra A, Doukov T, Wang J, Picarda G, Benedict CA, Croft M, Zajonc DM.

J Biol Chem. 2018 Jan 26;293(4):1317-1329. doi: 10.1074/jbc.M117.814905. Epub 2017 Dec 14.


A noncanonical function of cGAMP in inflammasome priming and activation.

Swanson KV, Junkins RD, Kurkjian CJ, Holley-Guthrie E, Pendse AA, El Morabiti R, Petrucelli A, Barber GN, Benedict CA, Ting JP.

J Exp Med. 2017 Dec 4;214(12):3611-3626. doi: 10.1084/jem.20171749. Epub 2017 Oct 13.


Erratum for Verma et al., "Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection".

Verma S, Weiskopf D, Gupta A, McDonald B, Peters B, Sette A, Benedict CA.

J Virol. 2017 Aug 10;91(17). pii: e00959-17. doi: 10.1128/JVI.00959-17. Print 2017 Sep 1. No abstract available.


CMV immune evasion and manipulation of the immune system with aging.

Jackson SE, Redeker A, Arens R, van Baarle D, van den Berg SPH, Benedict CA, Čičin-Šain L, Hill AB, Wills MR.

Geroscience. 2017 Jun;39(3):273-291. doi: 10.1007/s11357-017-9986-6. Epub 2017 Jun 24.


N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.

Dufour F, Rattier T, Shirley S, Picarda G, Constantinescu AA, Morlé A, Zakaria AB, Marcion G, Causse S, Szegezdi E, Zajonc DM, Seigneuric R, Guichard G, Gharbi T, Picaud F, Herlem G, Garrido C, Schneider P, Benedict CA, Micheau O.

Cell Death Differ. 2017 Mar;24(3):500-510. doi: 10.1038/cdd.2016.150. Epub 2017 Feb 10.


cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection.

Lio CW, McDonald B, Takahashi M, Dhanwani R, Sharma N, Huang J, Pham E, Benedict CA, Sharma S.

J Virol. 2016 Aug 12;90(17):7789-97. doi: 10.1128/JVI.01040-16. Print 2016 Sep 1.


Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection.

Verma S, Weiskopf D, Gupta A, McDonald B, Peters B, Sette A, Benedict CA.

J Virol. 2015 Oct 21;90(2):650-8. doi: 10.1128/JVI.02123-15. Print 2016 Jan 15. Erratum in: J Virol. 2017 Aug 10;91(17 ):.


Cardif (MAVS) Regulates the Maturation of NK Cells.

Haynes LD, Verma S, McDonald B, Wu R, Tacke R, Nowyhed HN, Ekstein J, Feuvrier A, Benedict CA, Hedrick CC.

J Immunol. 2015 Sep 1;195(5):2157-67. doi: 10.4049/jimmunol.1402060. Epub 2015 Jul 31.


Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense.

Verma S, Loewendorf A, Wang Q, McDonald B, Redwood A, Benedict CA.

PLoS Pathog. 2014 Aug 14;10(8):e1004268. doi: 10.1371/journal.ppat.1004268. eCollection 2014 Aug.


Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW, Humphreys IR.

Cell Host Microbe. 2014 Apr 9;15(4):471-83. doi: 10.1016/j.chom.2014.03.003.


Distinct requirements for activation of NKT and NK cells during viral infection.

Tyznik AJ, Verma S, Wang Q, Kronenberg M, Benedict CA.

J Immunol. 2014 Apr 15;192(8):3676-85. doi: 10.4049/jimmunol.1300837. Epub 2014 Mar 14.


A CMV vaccine: TREATing despite the TRICKs.

Benedict CA.

Expert Rev Vaccines. 2013 Nov;12(11):1235-7. doi: 10.1586/14760584.2013.844653. Epub 2013 Oct 4. No abstract available.


CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells.

Šedý JR, Bjordahl RL, Bekiaris V, Macauley MG, Ware BC, Norris PS, Lurain NS, Benedict CA, Ware CF.

J Immunol. 2013 Jul 15;191(2):828-36. doi: 10.4049/jimmunol.1300894. Epub 2013 Jun 12.


CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.

Welten SP, Redeker A, Franken KL, Benedict CA, Yagita H, Wensveen FM, Borst J, Melief CJ, van Lier RA, van Gisbergen KP, Arens R.

J Virol. 2013 Jun;87(12):6851-65. doi: 10.1128/JVI.03305-12. Epub 2013 Apr 10.


Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.

Nemčovičová I, Benedict CA, Zajonc DM.

PLoS Pathog. 2013 Mar;9(3):e1003224. doi: 10.1371/journal.ppat.1003224. Epub 2013 Mar 21.


Lymphoid-tissue stromal cells coordinate innate defense to cytomegalovirus.

Verma S, Wang Q, Chodaczek G, Benedict CA.

J Virol. 2013 Jun;87(11):6201-10. doi: 10.1128/JVI.00113-13. Epub 2013 Mar 27.


Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemčovičová I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA.

Cell Host Microbe. 2013 Mar 13;13(3):324-35. doi: 10.1016/j.chom.2013.02.003.


The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner.

Poole E, Walther A, Raven K, Benedict CA, Mason GM, Sinclair J.

J Virol. 2013 Apr;87(8):4261-71. doi: 10.1128/JVI.03497-12. Epub 2013 Jan 30.


Clinical targeting of the TNF and TNFR superfamilies.

Croft M, Benedict CA, Ware CF.

Nat Rev Drug Discov. 2013 Feb;12(2):147-68. doi: 10.1038/nrd3930. Epub 2013 Jan 21. Review.


TRAIL: not just for tumors anymore?

Benedict CA, Ware CF.

J Exp Med. 2012 Oct 22;209(11):1903-6. doi: 10.1084/jem.20122235. Review.


Dissecting the requirements for maintenance of the CMV-specific memory T-cell pool.

Loewendorf AI, Arens R, Purton JF, Surh CD, Benedict CA.

Viral Immunol. 2011 Aug;24(4):351-5. doi: 10.1089/vim.2010.0140. Epub 2011 Jul 1.


The mouse cytomegalovirus glycoprotein m155 inhibits CD40 expression and restricts CD4 T cell responses.

Loewendorf AI, Steinbrueck L, Peter C, Busche A, Benedict CA, Kay-Jackson PC.

J Virol. 2011 May;85(10):5208-12. doi: 10.1128/JVI.02178-10. Epub 2011 Mar 16.


Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.

Arens R, Loewendorf A, Redeker A, Sierro S, Boon L, Klenerman P, Benedict CA, Schoenberger SP.

J Immunol. 2011 Apr 1;186(7):3874-81. doi: 10.4049/jimmunol.1003231. Epub 2011 Feb 28.


The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50.

Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A.

Sci Signal. 2011 Feb 22;4(161):ra11. doi: 10.1126/scisignal.2001501.


Sources and signals regulating type I interferon production: lessons learned from cytomegalovirus.

Verma S, Benedict CA.

J Interferon Cytokine Res. 2011 Feb;31(2):211-8. doi: 10.1089/jir.2010.0118. Epub 2011 Jan 12. Review.


B7-mediated costimulation of CD4 T cells constrains cytomegalovirus persistence.

Arens R, Loewendorf A, Her MJ, Schneider-Ohrum K, Shellam GR, Janssen E, Ware CF, Schoenberger SP, Benedict CA.

J Virol. 2011 Jan;85(1):390-6. doi: 10.1128/JVI.01839-10. Epub 2010 Oct 27.


Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8(+) T cells.

Humphreys IR, Lee SW, Jones M, Loewendorf A, Gostick E, Price DA, Benedict CA, Ware CF, Croft M.

Eur J Immunol. 2010 Oct;40(10):2762-8. doi: 10.1002/eji.200940256.


Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells.

Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold CN, Blasius AL, Benedict CA, Moresco EM, Xia Y, Beutler B.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9759-64. doi: 10.1073/pnas.1005186107. Epub 2010 May 10.


Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything.

Loewendorf A, Benedict CA.

J Intern Med. 2010 May;267(5):483-501. doi: 10.1111/j.1365-2796.2010.02220.x. Review.


CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection.

Snyder CM, Loewendorf A, Bonnett EL, Croft M, Benedict CA, Hill AB.

J Immunol. 2009 Sep 15;183(6):3932-41. doi: 10.4049/jimmunol.0900227. Epub 2009 Aug 19.


DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.

Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J.

EMBO Rep. 2009 Aug;10(8):916-22. doi: 10.1038/embor.2009.109. Epub 2009 Jul 10.


Cardif-mediated signaling controls the initial innate response to dengue virus in vivo.

Perry ST, Prestwood TR, Lada SM, Benedict CA, Shresta S.

J Virol. 2009 Aug;83(16):8276-81. doi: 10.1128/JVI.00365-09. Epub 2009 Jun 3.


A proviral role for CpG in cytomegalovirus infection.

Iversen AC, Steinkjer B, Nilsen N, Bohnhorst J, Moen SH, Vik R, Stephens P, Thomas DW, Benedict CA, Espevik T.

J Immunol. 2009 May 1;182(9):5672-81. doi: 10.4049/jimmunol.0801268.


Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals.

Tyznik AJ, Tupin E, Nagarajan NA, Her MJ, Benedict CA, Kronenberg M.

J Immunol. 2008 Oct 1;181(7):4452-6.


Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response.

Arens R, Wang P, Sidney J, Loewendorf A, Sette A, Schoenberger SP, Peters B, Benedict CA.

J Immunol. 2008 May 15;180(10):6472-6.


Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway.

Benedict CA, Loewendorf A, Garcia Z, Blazar BR, Janssen EM.

J Immunol. 2008 Apr 1;180(7):4836-47.


Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus.

Schneider K, Loewendorf A, De Trez C, Fulton J, Rhode A, Shumway H, Ha S, Patterson G, Pfeffer K, Nedospasov SA, Ware CF, Benedict CA.

Cell Host Microbe. 2008 Feb 14;3(2):67-76. doi: 10.1016/j.chom.2007.12.008.


The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells.

De Trez C, Schneider K, Potter K, Droin N, Fulton J, Norris PS, Ha SW, Fu YX, Murphy T, Murphy KM, Pfeffer K, Benedict CA, Ware CF.

J Immunol. 2008 Jan 1;180(1):238-48.


Immunosuppression: learning from the masters.

Benedict CA, Janssen EM.

Expert Rev Clin Immunol. 2007 Sep;3(5):659-62. doi: 10.1586/1744666X.3.5.659. No abstract available.


OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism.

Humphreys IR, Loewendorf A, de Trez C, Schneider K, Benedict CA, Munks MW, Ware CF, Croft M.

J Immunol. 2007 Aug 15;179(4):2195-202.


Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands.

Humphreys IR, de Trez C, Kinkade A, Benedict CA, Croft M, Ware CF.

J Exp Med. 2007 May 14;204(5):1217-25. Epub 2007 May 7.


A fourth IkappaB protein within the NF-kappaB signaling module.

Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A.

Cell. 2007 Jan 26;128(2):369-81.


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