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I BET on anti-FGFR to fight cancer resistance.

Benedetti R, Altucci L.

EMBO Mol Med. 2019 Jan 4. pii: e10116. doi: 10.15252/emmm.201810116. [Epub ahead of print] No abstract available.


Biological interactions of biocompatible and water-dispersed MoS2 nanosheets with bacteria and human cells.

Kaur J, Singh M, Dell'Aversana C, Benedetti R, Giardina P, Rossi M, Valadan M, Vergara A, Cutarelli A, Montone AMI, Altucci L, Corrado F, Nebbioso A, Altucci C.

Sci Rep. 2018 Nov 6;8(1):16386. doi: 10.1038/s41598-018-34679-y.


High-Performance Indirect-Drive Cryogenic Implosions at High Adiabat on the National Ignition Facility.

Baker KL, Thomas CA, Casey DT, Khan S, Spears BK, Nora R, Woods T, Milovich JL, Berger RL, Strozzi D, Clark D, Hohenberger M, Hurricane OA, Callahan DA, Landen OL, Bachmann B, Benedetti R, Bionta R, Celliers PM, Fittinghoff D, Goyon C, Grim G, Hatarik R, Izumi N, Gatu Johnson M, Kyrala G, Ma T, Millot M, Nagel SR, Pak A, Patel PK, Turnbull D, Volegov PL, Yeamans C.

Phys Rev Lett. 2018 Sep 28;121(13):135001. doi: 10.1103/PhysRevLett.121.135001.


Residual vein obstruction in patients diagnosed with acute isolated distal deep vein thrombosis associated with active cancer.

Dentali F, Barco S, Pegoraro S, Di Minno MND, Mastroiacovo D, Pomero F, Lodigiani C, Bagna F, Sartori M, Barillari G, Mumoli N, Napolitano M, Passamonti SM, Benedetti R, Ageno W, Di Nisio M.

J Thromb Thrombolysis. 2018 Oct;46(3):404-408. doi: 10.1007/s11239-018-1708-0.


Breast Cancer Vaccines: New Insights.

Benedetti R, Dell'Aversana C, Giorgio C, Astorri R, Altucci L.

Front Endocrinol (Lausanne). 2017 Oct 13;8:270. doi: 10.3389/fendo.2017.00270. eCollection 2017. Review.


Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses.

Nebbioso A, Benedetti R, Conte M, Carafa V, De Bellis F, Shaik J, Matarese F, Della Ventura B, Gesuele F, Velotta R, Martens JHA, Stunnenberg HG, Altucci C, Altucci L.

Sci Rep. 2017 Sep 15;7(1):11725. doi: 10.1038/s41598-017-12010-5.



Agnelli G, Becattini C, Giustozzi M, Imberti D, Benedetti R, Fontana M.

G Ital Cardiol (Rome). 2017 Sep;18(9):613-617. doi: 10.1714/2741.27942. Italian. No abstract available.


Patient pain during intravitreal injections under topical anesthesia: a systematic review.

Shiroma HF, Takaschima AKK, Farah ME, Höfling-Lima AL, de Luca Canto G, Benedetti RH, Rodrigues EB.

Int J Retina Vitreous. 2017 Jul 3;3:23. doi: 10.1186/s40942-017-0076-9. eCollection 2017.


An association between residual vein thrombosis and subclinical atherosclerosis: Cross-sectional study.

Prandoni P, Ciammaichella M, Mumoli N, Zanatta N, Visonà A, Avruscio G, Camporese G, Bucherini E, Bova C, Imberti D, Benedetti R, Rossetto V, Noventa F, Milan M; Veritas Investigators.

Thromb Res. 2017 Sep;157:16-19. doi: 10.1016/j.thromres.2017.06.036. Epub 2017 Jun 29.


Clinical course of isolated distal deep vein thrombosis in patients with active cancer: a multicenter cohort study.

Dentali F, Pegoraro S, Barco S, di Minno MND, Mastroiacovo D, Pomero F, Lodigiani C, Bagna F, Sartori M, Barillari G, Mumoli N, Napolitano M, Passamonti SM, Benedetti R, Ageno W, Di Nisio M.

J Thromb Haemost. 2017 Sep;15(9):1757-1763. doi: 10.1111/jth.13761. Epub 2017 Jul 18.


A spatially balanced design with probability function proportional to the within sample distance.

Benedetti R, Piersimoni F.

Biom J. 2017 Sep;59(5):1067-1084. doi: 10.1002/bimj.201600194. Epub 2017 May 16.


Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.

Madia VN, Benedetti R, Barreca ML, Ngo L, Pescatori L, Messore A, Pupo G, Saccoliti F, Valente S, Mai A, Scipione L, Zheng YG, Tintori C, Botta M, Cecchetti V, Altucci L, Di Santo R, Costi R.

ChemMedChem. 2017 Aug 22;12(16):1359-1368. doi: 10.1002/cmdc.201700040. Epub 2017 Apr 12.


Ethical and legal duty of anesthesiologists regarding Jehovah's Witness patient: care protocol.

Takaschima AK, Sakae TM, Takaschima AK, Takaschima RD, Lima BJ, Benedetti RH.

Braz J Anesthesiol. 2016 Nov - Dec;66(6):637-641. doi: 10.1016/j.bjane.2015.03.012. Epub 2016 Sep 12. Review.


[Ethical and legal duty of anesthesiologists regarding Jehovah's Witness patient: care protocol].

Takaschima AK, Sakae TM, Takaschima AK, Takaschima RD, de Lima BJ, Benedetti RH.

Rev Bras Anestesiol. 2016 Nov - Dec;66(6):637-641. doi: 10.1016/j.bjan.2015.03.008. Epub 2016 Mar 23. Portuguese.


Safety ad efficacy of direct oral anticoagulants for extended treatment of venous thromboembolism.

Imberti D, Pomero F, Benedetti R, Fenoglio L.

Intern Emerg Med. 2016 Oct;11(7):895-900. doi: 10.1007/s11739-016-1521-8. Epub 2016 Aug 22.


The management of patients with venous thromboembolism in Italy: insights from the PREFER in VTE registry.

Guercini F, Mommi V, Camporese G, Tonello C, Imberti D, Benedetti R, De Bartolomeo G, Di Lecce L, Romeo F, Agnelli G.

Intern Emerg Med. 2016 Dec;11(8):1095-1102. Epub 2016 Jul 22.


c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer.

Nebbioso A, Carafa V, Conte M, Tambaro FP, Abbondanza C, Martens J, Nees M, Benedetti R, Pallavicini I, Minucci S, Garcia-Manero G, Iovino F, Lania G, Ingenito C, Belsito Petrizzi V, Stunnenberg HG, Altucci L.

Clin Cancer Res. 2017 May 15;23(10):2542-2555. doi: 10.1158/1078-0432.CCR-15-2388. Epub 2016 Jun 29.


An rK28-Based Immunoenzymatic Assay for the Diagnosis of Canine Visceral Leishmaniasis in Latin America.

Lauricella MA, Maidana CG, Frias VF, Romagosa CM, Negri V, Benedetti R, Sinagra AJ, Luna C, Tartaglino L, Laucella S, Reed SG, Riarte AR.

Am J Trop Med Hyg. 2016 Jul 6;95(1):92-8. doi: 10.4269/ajtmh.13-0768. Epub 2016 May 9.


OC-01 - Clinical history of cancer patients with isolated distal deep vein thrombosis: a multicenter cohort study.

Dentali F, Pegoraro S, Barco S, di Minno MN, Mastroiacovo D, Pomero F, Lodigiani C, Bagna F, Sartori M, Barillari G, Mumoli N, Napolitano M, Passamonti S, Benedetti R, Ageno W, Nisio MD.

Thromb Res. 2016 Apr;140 Suppl 1:S168. doi: 10.1016/S0049-3848(16)30118-9. Epub 2016 Apr 8.


Primary prophylaxis of VTE in cancer outpatients.

Imberti D, Benedetti R.

Thromb Res. 2016 Apr;140 Suppl 1:S103-8. doi: 10.1016/S0049-3848(16)30108-6. Review.


Epigenetic-based therapy: From single- to multi-target approaches.

Benedetti R, Conte M, Iside C, Altucci L.

Int J Biochem Cell Biol. 2015 Dec;69:121-31. doi: 10.1016/j.biocel.2015.10.016. Epub 2015 Oct 19. Review.


A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons.

Rosato-Siri MD, Zambello E, Mutinelli C, Garbati N, Benedetti R, Aldegheri L, Graziani F, Virginio C, Alvaro G, Large CH.

J Pharmacol Exp Ther. 2015 Sep;354(3):251-60. doi: 10.1124/jpet.115.225748. Epub 2015 Jun 17.


Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia.

Nebbioso A, Benedetti R, Conte M, Iside C, Altucci L.

Expert Opin Ther Targets. 2015;19(9):1187-202. doi: 10.1517/14728222.2015.1051728. Epub 2015 May 30. Review.


Venous Thromboembolism in Patients Undergoing Shoulder Arthroscopy: Findings From the RECOS Registry.

Imberti D, Dentali F, Ivaldo N, Murena L, Paladini P, Castagna A, Barillari G, Guerra E, Tonello C, Castoldi F, Lazzaro F, Benedetti R, Camporese G, Porcellini G; RECOS Investigators.

Clin Appl Thromb Hemost. 2015 Jul;21(5):486-8. doi: 10.1177/1076029614567311. Epub 2015 Jan 23. No abstract available.


HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape.

Conte M, Dell'Aversana C, Benedetti R, Petraglia F, Carissimo A, Petrizzi VB, D'Arco AM, Abbondanza C, Nebbioso A, Altucci L.

Oncotarget. 2015 Jan 20;6(2):886-901.


Analysis of chromatin-nuclear receptor interactions by laser-chromatin immunoprecipitation.

Benedetti R, Conte M, Carafa V, Della Ventura B, Altucci C, Velotta R, Stunnenberg HG, Altucci L, Nebbioso A.

Methods Mol Biol. 2014;1204:25-34. doi: 10.1007/978-1-4939-1346-6_3.


Apixaban versus enoxaparin in elective major orthopedic surgery: a clinical review.

Maniscalco P, Caforio M, Imberti D, Porcellini G, Benedetti R.

Clin Appl Thromb Hemost. 2015 Mar;21(2):115-9. doi: 10.1177/1076029614546328. Epub 2014 Aug 13. Review.


Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells.

Lenoci A, Tomassi S, Conte M, Benedetti R, Rodriguez V, Carradori S, Secci D, Castellano S, Sbardella G, Filetici P, Novellino E, Altucci L, Rotili D, Mai A.

ChemMedChem. 2014 Mar;9(3):542-8. doi: 10.1002/cmdc.201300536. Epub 2014 Feb 6.


Targeting Histone Deacetylases in Diseases: Where Are We?

Benedetti R, Conte M, Altucci L.

Antioxid Redox Signal. 2015 Jul 1;23(1):99-126. doi: 10.1089/ars.2013.5776. Epub 2014 Mar 6. Review.


Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

Rotili D, Tomassi S, Conte M, Benedetti R, Tortorici M, Ciossani G, Valente S, Marrocco B, Labella D, Novellino E, Mattevi A, Altucci L, Tumber A, Yapp C, King ON, Hopkinson RJ, Kawamura A, Schofield CJ, Mai A.

J Med Chem. 2014 Jan 9;57(1):42-55. doi: 10.1021/jm4012802. Epub 2013 Dec 19.


Practical management of rivaroxaban for the treatment of venous thromboembolism.

Imberti D, Benedetti R.

Clin Appl Thromb Hemost. 2015 May;21(4):309-18. doi: 10.1177/1076029613503397. Epub 2013 Sep 19. Review.


Prevention of venous thromboembolism in acutely ill medical patients after the results of recent trials with the new oral anticoagulants.

Imberti D, Benedetti R, Ageno W.

Intern Emerg Med. 2013 Dec;8(8):667-72. doi: 10.1007/s11739-013-0979-x. Epub 2013 Jul 16. Review.


Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells.

Habibi E, Brinkman AB, Arand J, Kroeze LI, Kerstens HH, Matarese F, Lepikhov K, Gut M, Brun-Heath I, Hubner NC, Benedetti R, Altucci L, Jansen JH, Walter J, Gut IG, Marks H, Stunnenberg HG.

Cell Stem Cell. 2013 Sep 5;13(3):360-9. doi: 10.1016/j.stem.2013.06.002. Epub 2013 Jul 11.


tert-Butylcarbamate-containing histone deacetylase inhibitors: apoptosis induction, cytodifferentiation, and antiproliferative activities in cancer cells.

Valente S, Trisciuoglio D, Tardugno M, Benedetti R, Labella D, Secci D, Mercurio C, Boggio R, Tomassi S, Di Maro S, Novellino E, Altucci L, Del Bufalo D, Mai A, Cosconati S.

ChemMedChem. 2013 May;8(5):800-11. doi: 10.1002/cmdc.201300005. Epub 2013 Mar 25.


"There's really no other option": Italian Australians' experiences of caring for a family member with dementia.

Benedetti R, Cohen L, Taylor M.

J Women Aging. 2013;25(2):138-64. doi: 10.1080/08952841.2013.760330.


Trials with 'epigenetic' drugs: an update.

Nebbioso A, Carafa V, Benedetti R, Altucci L.

Mol Oncol. 2012 Dec;6(6):657-82. doi: 10.1016/j.molonc.2012.09.004. Epub 2012 Oct 6. Review.


Emergency reversal of anticoagulation with vitamin K antagonists with 3-factor prothrombin complex concentrates in patients with major bleeding.

Imberti D, Magnacavallo A, Dentali F, Condoleo E, Gallerani M, Benedetti R, Ageno W.

J Thromb Thrombolysis. 2013 Jul;36(1):102-8. doi: 10.1007/s11239-012-0817-4.


Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities.

Pereira R, Benedetti R, Pérez-Rodríguez S, Nebbioso A, García-Rodríguez J, Carafa V, Stuhldreier M, Conte M, Rodríguez-Barrios F, Stunnenberg HG, Gronemeyer H, Altucci L, de Lera AR.

J Med Chem. 2012 Nov 26;55(22):9467-91. doi: 10.1021/jm300618u. Epub 2012 Oct 17.


Assembly of high-areal-density deuterium-tritium fuel from indirectly driven cryogenic implosions.

Mackinnon AJ, Kline JL, Dixit SN, Glenzer SH, Edwards MJ, Callahan DA, Meezan NB, Haan SW, Kilkenny JD, Döppner T, Farley DR, Moody JD, Ralph JE, MacGowan BJ, Landen OL, Robey HF, Boehly TR, Celliers PM, Eggert JH, Krauter K, Frieders G, Ross GF, Hicks DG, Olson RE, Weber SV, Spears BK, Salmonsen JD, Michel P, Divol L, Hammel B, Thomas CA, Clark DS, Jones OS, Springer PT, Cerjan CJ, Collins GW, Glebov VY, Knauer JP, Sangster C, Stoeckl C, McKenty P, McNaney JM, Leeper RJ, Ruiz CL, Cooper GW, Nelson AG, Chandler GG, Hahn KD, Moran MJ, Schneider MB, Palmer NE, Bionta RM, Hartouni EP, LePape S, Patel PK, Izumi N, Tommasini R, Bond EJ, Caggiano JA, Hatarik R, Grim GP, Merrill FE, Fittinghoff DN, Guler N, Drury O, Wilson DC, Herrmann HW, Stoeffl W, Casey DT, Johnson MG, Frenje JA, Petrasso RD, Zylestra A, Rinderknecht H, Kalantar DH, Dzenitis JM, Di Nicola P, Eder DC, Courdin WH, Gururangan G, Burkhart SC, Friedrich S, Blueuel DL, Bernstein LA, Eckart MJ, Munro DH, Hatchett SP, Macphee AG, Edgell DH, Bradley DK, Bell PM, Glenn SM, Simanovskaia N, Barrios MA, Benedetti R, Kyrala GA, Town RP, Dewald EL, Milovich JL, Widmann K, Moore AS, LaCaille G, Regan SP, Suter LJ, Felker B, Ashabranner RC, Jackson MC, Prasad R, Richardson MJ, Kohut TR, Datte PS, Krauter GW, Klingman JJ, Burr RF, Land TA, Hermann MR, Latray DA, Saunders RL, Weaver S, Cohen SJ, Berzins L, Brass SG, Palma ES, Lowe-Webb RR, McHalle GN, Arnold PA, Lagin LJ, Marshall CD, Brunton GK, Mathisen DG, Wood RD, Cox JR, Ehrlich RB, Knittel KM, Bowers MW, Zacharias RA, Young BK, Holder JP, Kimbrough JR, Ma T, La Fortune KN, Widmayer CC, Shaw MJ, Erbert GV, Jancaitis KS, DiNicola JM, Orth C, Heestand G, Kirkwood R, Haynam C, Wegner PJ, Whitman PK, Hamza A, Dzenitis EG, Wallace RJ, Bhandarkar SD, Parham TG, Dylla-Spears R, Mapoles ER, Kozioziemski BJ, Sater JD, Walters CF, Haid BJ, Fair J, Nikroo A, Giraldez E, Moreno K, Vanwonterghem B, Kauffman RL, Batha S, Larson DW, Fortner RJ, Schneider DH, Lindl JD, Patterson RW, Atherton LJ, Moses EI.

Phys Rev Lett. 2012 May 25;108(21):215005. Epub 2012 May 24.


Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study.

Dentali F, Poli D, Scoditti U, Di Minno MN, De Stefano V, Siragusa S, Kostal M, Palareti G, Sartori MT, Grandone E, Vedovati MC, Ageno W; CErebral VEin Thrombosis International Study Investigators, Falanga A, Lerede T, Bianchi M, Testa S, Witt D, McCool K, Bucherini E, Grifoni E, Coalizzo D, Benedetti R, Marietta M, Sessa M, Guaschino C, di Minno G, Tufano A, Barbar S, Malato A, Pini M, Castellini P, Barco S, Barone M, Paciaroni M, Alberti A, Agnelli G, Giorgi Pierfranceschi M, Dulicek P, Silingardi M, Federica L, Ghirarduzzi A, Tiraferri E, di Lazzaro V, Rossi E, Ciminello A, Pasca S, Barillari G, Rezoagli E, Galli M, Squizzato A, Tosetto A.

J Thromb Haemost. 2012 Jul;10(7):1297-302. doi: 10.1111/j.1538-7836.2012.04774.x. Erratum in: J Thromb Haemost. 2013 Feb;11(2):399. Stefano, V D [corrected to De Stefano, V].


Psidium guajava L. anti-neoplastic effects: induction of apoptosis and cell differentiation.

Bontempo P, Doto A, Miceli M, Mita L, Benedetti R, Nebbioso A, Veglione M, Rigano D, Cioffi M, Sica V, Molinari AM, Altucci L.

Cell Prolif. 2012 Feb;45(1):22-31. doi: 10.1111/j.1365-2184.2011.00797.x. Epub 2011 Dec 16.


Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).

Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G.

Bioorg Med Chem. 2011 Jun 15;19(12):3690-701. doi: 10.1016/j.bmc.2011.01.013. Epub 2011 Jan 14.


Epigenetic profiling of the antitumor natural product psammaplin A and its analogues.

García J, Franci G, Pereira R, Benedetti R, Nebbioso A, Rodríguez-Barrios F, Gronemeyer H, Altucci L, de Lera AR.

Bioorg Med Chem. 2011 Jun 15;19(12):3637-49. doi: 10.1016/j.bmc.2010.12.026. Epub 2010 Dec 15.


The identification of novel orally active mGluR5 antagonist GSK2210875.

Pilla M, Andreoli M, Tessari M, Delle-Fratte S, Roth A, Butler S, Brown F, Shah P, Bettini E, Cavallini P, Benedetti R, Minick D, Smith P, Tehan B, D'Alessandro P, Lorthioir O, Ball C, Garzya V, Goodacre C, Watson S.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7521-4. doi: 10.1016/j.bmcl.2010.09.120. Epub 2010 Nov 2.


New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.

Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.

ChemMedChem. 2010 Sep 3;5(9):1530-40. doi: 10.1002/cmdc.201000158.


6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.

Micheli F, Cavanni P, Andreotti D, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Carletti R, Checchia A, Corsi M, Fazzolari E, Fontana S, Marchioro C, Merlo-Pich E, Negri M, Oliosi B, Ratti E, Read KD, Roscic M, Sartori I, Spada S, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L, Di Fabio R.

J Med Chem. 2010 Jul 8;53(13):4989-5001. doi: 10.1021/jm100481d.


1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.

Micheli F, Cavanni P, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Checchia A, Davalli S, Di Fabio R, Fazzolari E, Fontana S, Marchioro C, Minick D, Negri M, Oliosi B, Read KD, Sartori I, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L.

J Med Chem. 2010 Mar 25;53(6):2534-51. doi: 10.1021/jm901818u.


Treatment of altered passive eruption: periodontal plastic surgery of the dentogingival junction.

Rossi R, Benedetti R, Santos-Morales RI.

Eur J Esthet Dent. 2008 Autumn;3(3):212-23.


Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells.

Bontempo P, Mita L, Doto A, Miceli M, Nebbioso A, Lepore I, Franci G, Menafra R, Carafa V, Conte M, De Bellis F, Manzo F, Di Cerbo V, Benedetti R, D'Amato L, Marino M, Bolli A, Del Pozzo G, Diano N, Portaccio M, Mita GD, Vietri MT, Cioffi M, Nola E, Dell'aversana C, Sica V, Molinari AM, Altucci L.

J Transl Med. 2009 Jun 18;7:48. doi: 10.1186/1479-5876-7-48.


An atypical vascular case of Behçet's disease and consequent treatment.

Benedetti R, Brignone A, Incerti Vecchi L, Orlandini F.

Intern Emerg Med. 2009 Apr;4(2):179-80. doi: 10.1007/s11739-008-0210-7. Epub 2008 Dec 12. No abstract available.


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