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B cell superantigens in the human intestinal microbiota.

Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A.

Sci Transl Med. 2019 Aug 28;11(507). pii: eaau9356. doi: 10.1126/scitranslmed.aau9356.


IgA Responses to Microbiota.

Bunker JJ, Bendelac A.

Immunity. 2018 Aug 21;49(2):211-224. doi: 10.1016/j.immuni.2018.08.011. Review.


Receptor-Based Artificial Metalloenzymes on Living Human Cells.

Ghattas W, Dubosclard V, Wick A, Bendelac A, Guillot R, Ricoux R, Mahy JP.

J Am Chem Soc. 2018 Jul 18;140(28):8756-8762. doi: 10.1021/jacs.8b04326. Epub 2018 Jul 3.


Diverse developmental pathways of intestinal intraepithelial lymphocytes.

McDonald BD, Jabri B, Bendelac A.

Nat Rev Immunol. 2018 Aug;18(8):514-525. doi: 10.1038/s41577-018-0013-7. Review.


Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.

Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A.

Nat Commun. 2017 Nov 30;8(1):1933. doi: 10.1038/s41467-017-01780-1.


NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma.

McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD.

PLoS One. 2017 Nov 28;12(11):e0188221. doi: 10.1371/journal.pone.0188221. eCollection 2017.


A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.

Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A.

Nat Commun. 2017 Oct 16;8(1):863. doi: 10.1038/s41467-017-00882-0. Erratum in: Nat Commun. 2017 Nov 30;8(1):1933.


Natural polyreactive IgA antibodies coat the intestinal microbiota.

Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A.

Science. 2017 Oct 20;358(6361). pii: eaan6619. doi: 10.1126/science.aan6619. Epub 2017 Sep 28.


Psychosine variants as antigens for natural killer T cells.

Deng S, Kain L, Pereira CS, Mata S, Macedo MF, Bendelac A, Teyton L, Savage PB.

Chem Sci. 2017 Mar 1;8(3):2204-2208. doi: 10.1039/c6sc04218j. Epub 2016 Dec 9.


Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.

Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB.

Inflamm Bowel Dis. 2017 Mar;23(3):366-378. doi: 10.1097/MIB.0000000000001027.


Multiple layers of transcriptional regulation by PLZF in NKT-cell development.

Mao AP, Constantinides MG, Mathew R, Zuo Z, Chen X, Weirauch MT, Bendelac A.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7602-7. doi: 10.1073/pnas.1601504113. Epub 2016 Jun 20.


The Innate Lymphoid Cell Precursor.

Ishizuka IE, Constantinides MG, Gudjonson H, Bendelac A.

Annu Rev Immunol. 2016 May 20;34:299-316. doi: 10.1146/annurev-immunol-041015-055549. Review.


Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage.

Ishizuka IE, Chea S, Gudjonson H, Constantinides MG, Dinner AR, Bendelac A, Golub R.

Nat Immunol. 2016 Mar;17(3):269-76. doi: 10.1038/ni.3344. Epub 2016 Jan 18.


Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice.

Verhoef PA, Constantinides MG, McDonald BD, Urban JF Jr, Sperling AI, Bendelac A.

J Allergy Clin Immunol. 2016 Feb;137(2):591-600.e1. doi: 10.1016/j.jaci.2015.07.050. Epub 2015 Oct 23.


Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection.

McDonald BD, Bunker JJ, Erickson SA, Oh-Hora M, Bendelac A.

Immunity. 2015 Nov 17;43(5):859-69. doi: 10.1016/j.immuni.2015.09.009. Epub 2015 Oct 27.


Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.

Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, Antonopoulos DA, Bendelac A.

Immunity. 2015 Sep 15;43(3):541-53. doi: 10.1016/j.immuni.2015.08.007. Epub 2015 Aug 25.


Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides.

Kain L, Costanzo A, Webb B, Holt M, Bendelac A, Savage PB, Teyton L.

Mol Immunol. 2015 Dec;68(2 Pt A):94-7. doi: 10.1016/j.molimm.2015.06.009. Epub 2015 Jul 2. Review.


PLZF expression maps the early stages of ILC1 lineage development.

Constantinides MG, Gudjonson H, McDonald BD, Ishizuka IE, Verhoef PA, Dinner AR, Bendelac A.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5123-8. doi: 10.1073/pnas.1423244112. Epub 2015 Apr 2.


The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides.

Kain L, Webb B, Anderson BL, Deng S, Holt M, Costanzo A, Zhao M, Self K, Teyton A, Everett C, Kronenberg M, Zajonc DM, Bendelac A, Savage PB, Teyton L.

Immunity. 2014 Oct 16;41(4):543-54. doi: 10.1016/j.immuni.2014.08.017. Erratum in: Immunity. 2014 Nov 20;41(5):867. Constanzo, Anne [corrected to Costanzo, Anne].


Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination.

Tefit JN, Crabé S, Orlandini B, Nell H, Bendelac A, Deng S, Savage PB, Teyton L, Serra V.

Vaccine. 2014 Oct 21;32(46):6138-45. doi: 10.1016/j.vaccine.2014.08.070. Epub 2014 Sep 13.


Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage.

McDonald BD, Bunker JJ, Ishizuka IE, Jabri B, Bendelac A.

Immunity. 2014 Aug 21;41(2):219-29. doi: 10.1016/j.immuni.2014.07.008. Epub 2014 Aug 14.


A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation.

Mathew R, Mao AP, Chiang AH, Bertozzi-Villa C, Bunker JJ, Scanlon ST, McDonald BD, Constantinides MG, Hollister K, Singer JD, Dent AL, Dinner AR, Bendelac A.

J Exp Med. 2014 Jun 2;211(6):1137-51. doi: 10.1084/jem.20132267. Epub 2014 May 26.


A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo.

Deng S, Bai L, Reboulet R, Matthew R, Engler DA, Teyton L, Bendelac A, Savage PB.

Chem Sci. 2014 Apr;5(4):1437-1441.


A committed precursor to innate lymphoid cells.

Constantinides MG, McDonald BD, Verhoef PA, Bendelac A.

Nature. 2014 Apr 17;508(7496):397-401. doi: 10.1038/nature13047. Epub 2014 Feb 9.


Stimulation of natural killer T cells by glycolipids.

Anderson BL, Teyton L, Bendelac A, Savage PB.

Molecules. 2013 Dec 16;18(12):15662-88. doi: 10.3390/molecules181215662. Review.


Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells.

Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ.

Immunity. 2013 Dec 12;39(6):1032-42. doi: 10.1016/j.immuni.2013.11.001. Epub 2013 Nov 14.


Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402.

Casella TM, Eparvier V, Mandavid H, Bendelac A, Odonne G, Dayan L, Duplais C, Espindola LS, Stien D.

Phytochemistry. 2013 Dec;96:370-7. doi: 10.1016/j.phytochem.2013.10.004. Epub 2013 Nov 1.


Polarized effector programs for innate-like thymocytes.

McDonald BD, Constantinides MG, Bendelac A.

Nat Immunol. 2013 Nov;14(11):1110-1. doi: 10.1038/ni.2739. No abstract available.


Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides.

Bai L, Deng S, Reboulet R, Mathew R, Teyton L, Savage PB, Bendelac A.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16097-102. doi: 10.1073/pnas.1303218110. Epub 2013 Sep 16.


Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy.

Zheng Y, Zha Y, Spaapen RM, Mathew R, Barr K, Bendelac A, Gajewski TF.

Mol Immunol. 2013 Oct;55(3-4):283-91. doi: 10.1016/j.molimm.2013.03.006. Epub 2013 Mar 30. Erratum in: Mol Immunol. 2013 Dec;56(4):530.


Transcriptional regulation of the NKT cell lineage.

Constantinides MG, Bendelac A.

Curr Opin Immunol. 2013 Apr;25(2):161-7. doi: 10.1016/j.coi.2013.01.003. Epub 2013 Feb 9. Review.


BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.

Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.

Nature. 2012 Nov 22;491(7425):618-21. doi: 10.1038/nature11548. Epub 2012 Oct 21.


Scavenger receptors target glycolipids for natural killer T cell activation.

Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage PB, Bendelac A, Teyton L.

J Clin Invest. 2012 Nov;122(11):3943-54. doi: 10.1172/JCI62267. Epub 2012 Oct 15.


The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR.

Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A.

Eur J Immunol. 2012 Sep;42(9):2505-10. doi: 10.1002/eji.201242531. Epub 2012 Jul 25.


Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo.

Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A.

J Immunol. 2012 Apr 1;188(7):3053-61. doi: 10.4049/jimmunol.1102414. Epub 2012 Mar 5.


Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.

Seiler MP, Mathew R, Liszewski MK, Spooner CJ, Barr K, Meng F, Singh H, Bendelac A.

Nat Immunol. 2012 Feb 5;13(3):264-71. doi: 10.1038/ni.2230. Erratum in: Nat Immunol. 2013 Apr;14(4):413. Spooner, Chauncey [corrected to Spooner, Chauncey J].


B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-α, perforin).

Kammertoens T, Qin Z, Briesemeister D, Bendelac A, Blankenstein T.

Int J Cancer. 2012 Oct 1;131(7):1499-508. doi: 10.1002/ijc.27411. Epub 2012 Jan 31.


Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation.

Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A.

J Exp Med. 2011 Sep 26;208(10):2113-24. doi: 10.1084/jem.20110522. Epub 2011 Sep 19.


Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids.

Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A, Savage PB.

Org Biomol Chem. 2011 Oct 26;9(22):7659-62. doi: 10.1039/c1ob06276j. Epub 2011 Sep 16.


A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger.

Constantinides MG, Picard D, Savage AK, Bendelac A.

J Immunol. 2011 Jul 1;187(1):309-15. doi: 10.4049/jimmunol.1100761. Epub 2011 Jun 1.


PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.

Thomas SY, Scanlon ST, Griewank KG, Constantinides MG, Savage AK, Barr KA, Meng F, Luster AD, Bendelac A.

J Exp Med. 2011 Jun 6;208(6):1179-88. doi: 10.1084/jem.20102630. Epub 2011 May 30.


Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling.

Savage AK, Constantinides MG, Bendelac A.

J Immunol. 2011 May 15;186(10):5801-6. doi: 10.4049/jimmunol.1100119. Epub 2011 Apr 8.


The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells.

Wang L, Carr T, Xiong Y, Wildt KF, Zhu J, Feigenbaum L, Bendelac A, Bosselut R.

Eur J Immunol. 2010 Sep;40(9):2385-90. doi: 10.1002/eji.201040534.


SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics.

Verykokakis M, Boos MD, Bendelac A, Kee BL.

Immunity. 2010 Aug 27;33(2):203-15. doi: 10.1016/j.immuni.2010.07.013. Epub 2010 Jul 30.


Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice.

Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L.

J Clin Invest. 2010 Jun;120(6):1873-84. doi: 10.1172/JCI40451. Epub 2010 May 17.


Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.

Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL.

PLoS One. 2010 Feb 19;5(2):e9303. doi: 10.1371/journal.pone.0009303.


TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.

Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8. doi: 10.1073/pnas.0903895106. Epub 2009 Jul 15.


Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer.

Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A.

Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10254-9. doi: 10.1073/pnas.0901228106. Epub 2009 Jun 8.


Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.

Dose M, Sleckman BP, Han J, Bredemeyer AL, Bendelac A, Gounari F.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8641-6. doi: 10.1073/pnas.0812255106. Epub 2009 May 7.


Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells.

Yin N, Long X, Goff RD, Zhou D, Cantu C 3rd, Mattner J, Mezard PS, Teyton L, Bendelac A, Savage PB.

ACS Chem Biol. 2009 Mar 20;4(3):199-208. doi: 10.1021/cb800277n.

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