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Items: 46


The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors.

Bahjat M, de Wilde G, van Dam T, Maas C, Bloedjes T, Bende RJ, van Noesel CJM, Luijks DM, Eldering E, Kersten MJ, Guikema JEJ.

Cell Cycle. 2019 Sep;18(18):2307-2322. doi: 10.1080/15384101.2019.1646068. Epub 2019 Jul 26.


De novo gene mutations in normal human memory B cells.

Slot LM, Wormhoudt TAM, Kwakkenbos MJ, Wagner K, Ballering A, Jongejan A, van Kampen ACM, Guikema JEJ, Bende RJ, van Noesel CJM.

Leukemia. 2019 May;33(5):1219-1230. doi: 10.1038/s41375-018-0289-4. Epub 2018 Oct 23.


Rheumatoid Factor Reactivity of Expanded CD21-/low B Cells in Patients With Sjögren's Syndrome: Comment on the Article by Glauzy et al.

Bende RJ, van Noesel CJM.

Arthritis Rheumatol. 2019 Jan;71(1):169-170. doi: 10.1002/art.40756. Epub 2018 Nov 21. No abstract available.


Acquisition of N-Glycosylation Sites in Immunoglobulin Heavy Chain Genes During Local Expansion in Parotid Salivary Glands of Primary Sjögren Patients.

Visser A, Doorenspleet ME, de Vries N, Spijkervet FKL, Vissink A, Bende RJ, Bootsma H, Kroese FGM, Bos NA.

Front Immunol. 2018 Mar 12;9:491. doi: 10.3389/fimmu.2018.00491. eCollection 2018.


B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains.

Slot LM, Hoogeboom R, Smit LA, Wormhoudt TA, Biemond BJ, Oud ME, Schilder-Tol EJ, Mulder AB, Jongejan A, van Kampen AH, Kluin PM, Guikema JE, Bende RJ, van Noesel CJ.

Am J Pathol. 2016 Dec;186(12):3273-3284. doi: 10.1016/j.ajpath.2016.07.027. Epub 2016 Oct 15.


The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.

Ochodnicka-Mackovicova K, Bahjat M, Maas C, van der Veen A, Bloedjes TA, de Bruin AM, van Andel H, Schrader CE, Hendriks RW, Verhoeyen E, Bende RJ, van Noesel CJ, Guikema JE.

J Immunol. 2016 Oct 1;197(7):2918-29. doi: 10.4049/jimmunol.1501989. Epub 2016 Aug 24.


Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity.

Bende RJ, Janssen J, Wormhoudt TA, Wagner K, Guikema JE, van Noesel CJ.

Haematologica. 2016 May;101(5):e200-3. doi: 10.3324/haematol.2015.139626. Epub 2016 Feb 8. No abstract available.


NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity.

Ochodnicka-Mackovicova K, Bahjat M, Bloedjes TA, Maas C, de Bruin AM, Bende RJ, van Noesel CJ, Guikema JE.

Blood. 2015 Sep 10;126(11):1324-35. doi: 10.1182/blood-2015-01-621623. Epub 2015 Jul 7.


Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome.

Bende RJ, Slot LM, Hoogeboom R, Wormhoudt TA, Adeoye AO, Guikema JE, van Noesel CJ.

Arthritis Rheumatol. 2015 Apr;67(4):1074-83. doi: 10.1002/art.39002.


In vitro induction of antibody secretion of primary B-cell chronic lymphocytic leukaemia cells.

Hoogeboom R, Reinten RJ, Schot JJ, Guikema JE, Bende RJ, van Noesel CJ.

Leukemia. 2015 Jan;29(1):244-7. doi: 10.1038/leu.2014.266. Epub 2014 Sep 10. No abstract available.


A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi.

Hoogeboom R, van Kessel KP, Hochstenbach F, Wormhoudt TA, Reinten RJ, Wagner K, Kater AP, Guikema JE, Bende RJ, van Noesel CJ.

J Exp Med. 2013 Jan 14;210(1):59-70. doi: 10.1084/jem.20121801. Epub 2013 Jan 7.


A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient.

Hoogeboom R, Wormhoudt TA, Schipperus MR, Langerak AW, Dunn-Walters DK, Guikema JE, Bende RJ, van Noesel CJ.

Leukemia. 2013 Mar;27(3):738-40. doi: 10.1038/leu.2012.238. Epub 2012 Aug 20. No abstract available.


Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased VH4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment.

van Maldegem F, Wormhoudt TA, Mulder MM, Oud ME, Schilder-Tol E, Musler AR, Aten J, Saeed P, Kersten MJ, Pals ST, van Noesel CJ, Bende RJ.

Leukemia. 2012 Jul;26(7):1647-53. doi: 10.1038/leu.2012.28. Epub 2012 Feb 3.


MALT lymphoma-derived rheumatoid factors are nonpolyreactive high-affinity antibodies.

Hoogeboom R, Bende RJ, van Noesel CJ.

Blood. 2010 Sep 9;116(10):1818-9; author reply 1819-20. doi: 10.1182/blood-2010-03-274613. No abstract available.


Activation-induced cytidine deaminase splice variants are defective because of the lack of structural support for the catalytic site.

van Maldegem F, Jibodh RA, van Dijk R, Bende RJ, van Noesel CJ.

J Immunol. 2010 Mar 1;184(5):2487-91. doi: 10.4049/jimmunol.0903102. Epub 2010 Jan 29.


CD20 deficiency in humans results in impaired T cell-independent antibody responses.

Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA.

J Clin Invest. 2010 Jan;120(1):214-22. doi: 10.1172/JCI40231. Epub 2009 Dec 21.


Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas.

Bende RJ, van Maldegem F, van Noesel CJ.

Haematologica. 2009 Aug;94(8):1109-23. doi: 10.3324/haematol.2009.005983. Epub 2009 Jul 16. Review.


AID splice variants lack deaminase activity.

van Maldegem F, Scheeren FA, Aarti Jibodh R, Bende RJ, Jacobs H, van Noesel CJ.

Blood. 2009 Feb 19;113(8):1862-4; author reply 1864. doi: 10.1182/blood-2008-08-175265. No abstract available.


The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment.

van Maldegem F, van Dijk R, Wormhoudt TA, Kluin PM, Willemze R, Cerroni L, van Noesel CJ, Bende RJ.

Blood. 2008 Oct 15;112(8):3355-61. doi: 10.1182/blood-2008-01-132415. Epub 2008 Aug 7.


IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis.

Scheeren FA, Diehl SA, Smit LA, Beaumont T, Naspetti M, Bende RJ, Blom B, Karube K, Ohshima K, van Noesel CJ, Spits H.

Blood. 2008 May 1;111(9):4706-15. doi: 10.1182/blood-2007-08-105643. Epub 2008 Feb 22.


Germinal centers in human lymph nodes contain reactivated memory B cells.

Bende RJ, van Maldegem F, Triesscheijn M, Wormhoudt TA, Guijt R, van Noesel CJ.

J Exp Med. 2007 Oct 29;204(11):2655-65. Epub 2007 Oct 15.


Graft-versus-host-like disease complicating thymoma: lack of AIRE expression as a cause of non-hereditary autoimmunity?

Offerhaus GJ, Schipper ME, Lazenby AJ, Montgomery E, Morsink FH, Bende RJ, Musler AR, van Lier RA, van Noesel CJ.

Immunol Lett. 2007 Nov 30;114(1):31-7. Epub 2007 Sep 29.


Molecular pathways in follicular lymphoma.

Bende RJ, Smit LA, van Noesel CJ.

Leukemia. 2007 Jan;21(1):18-29. Epub 2006 Oct 12. Review.


Antigen receptors and somatic hypermutation in B-cell chronic lymphocytic leukemia with Richter's transformation.

Smit LA, van Maldegem F, Langerak AW, van der Schoot CE, de Wit MJ, Bea S, Campo E, Bende RJ, van Noesel CJ.

Haematologica. 2006 Jul;91(7):903-11.


Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator.

Tjin EP, Bende RJ, Derksen PW, van Huijstee AP, Kataoka H, Spaargaren M, Pals ST.

J Immunol. 2005 Sep 1;175(5):2807-13.


Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity.

Bende RJ, Aarts WM, Riedl RG, de Jong D, Pals ST, van Noesel CJ.

J Exp Med. 2005 Apr 18;201(8):1229-41.


Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients.

Guikema JE, Rosati S, Akkermans K, Bende RJ, van Noesel CJ, van Krieken JH, Hansmann ML, Schuuring E, Kluin PM.

Blood. 2005 Apr 1;105(7):2997-8; discussion 2998-9. No abstract available.


Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype.

Smit LA, Bende RJ, Aten J, Guikema JE, Aarts WM, van Noesel CJ.

Cancer Res. 2003 Jul 15;63(14):3894-8.


The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma.

Derksen PW, de Gorter DJ, Meijer HP, Bende RJ, van Dijk M, Lokhorst HM, Bloem AC, Spaargaren M, Pals ST.

Leukemia. 2003 Apr;17(4):764-74.


Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells.

Bende RJ, Smit LA, Bossenbroek JG, Aarts WM, Spaargaren M, de Leval L, Boeckxstaens GE, Pals ST, van Noesel CJ.

Am J Pathol. 2003 Jan;162(1):105-13.


Biased Iglambda expression in hypermutated IgD multiple myelomas does not result from receptor revision.

van der Burg M, Bende RJ, Aarts WM, Langerak AW, van Dongen JJ, van Noesel CJ.

Leukemia. 2002 Jul;16(7):1358-61.


In situ analysis of the variable heavy chain gene of an IgM/IgG-expressing follicular lymphoma: evidence for interfollicular trafficking of tumor cells.

Aarts WM, Bende RJ, Vaandrager JW, Kluin PM, Langerak AW, Pals ST, van Noesel CJ.

Am J Pathol. 2002 Mar;160(3):883-91.


Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells.

Fenton JA, Vaandrager JW, Aarts WM, Bende RJ, Heering K, van Dijk M, Morgan G, van Noesel CJ, Schuuring E, Kluin PM.

Blood. 2002 Jan 15;99(2):716-8.


Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time.

Aarts WM, Bende RJ, Bossenbroek JG, Pals ST, van Noesel CJ.

Blood. 2001 Jul 1;98(1):238-40.


Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load.

Aarts WM, Bende RJ, Steenbergen EJ, Kluin PM, Ooms EC, Pals ST, van Noesel CJ.

Blood. 2000 May 1;95(9):2922-9.


Analysis of variable heavy and light chain genes in follicular lymphomas of different heavy chain isotype.

Aarts WM, Bende RJ, Pals ST, van Noesel CJ.

Curr Top Microbiol Immunol. 1999;246:217-22; discussion 223-4. No abstract available.


VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching.

Aarts WM, Willemze R, Bende RJ, Meijer CJ, Pals ST, van Noesel CJ.

Blood. 1998 Nov 15;92(10):3857-64.


Expression of connective tissue growth factor in human renal fibrosis.

Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, Goldschmeding R.

Kidney Int. 1998 Apr;53(4):853-61.


Proteins encoded by open reading frames 3 and 4 of the genome of Lelystad virus (Arteriviridae) are structural proteins of the virion.

van Nieuwstadt AP, Meulenberg JJ, van Essen-Zanbergen A, Petersen-den Besten A, Bende RJ, Moormann RJ, Wensvoort G.

J Virol. 1996 Jul;70(7):4767-72.


Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

Klein MR, van Baalen CA, Holwerda AM, Kerkhof Garde SR, Bende RJ, Keet IP, Eeftinck-Schattenkerk JK, Osterhaus AD, Schuitemaker H, Miedema F.

J Exp Med. 1995 Apr 1;181(4):1365-72.


Associations between HLA frequencies and pathogenic features of human immunodeficiency virus type 1 infection in seroconverters from the Amsterdam cohort of homosexual men.

Klein MR, Keet IP, D'Amaro J, Bende RJ, Hekman A, Mesman B, Koot M, de Waal LP, Coutinho RA, Miedema F.

J Infect Dis. 1994 Jun;169(6):1244-9.


Expression of the IL-6 gene induces differentiation of a human monoclonal EBV-transformed B cell line.

Jochems GJ, Bende RJ, Klein MR, Zeijlemaker WP, van Lier RA.

Hum Antibodies Hybridomas. 1993 Jul;4(3):124-33.


Effects of IL-4, IL-5, and IL-6 on growth and immunoglobulin production of Epstein-Barr virus-infected human B cells.

Bende RJ, Jochems GJ, Frame TH, Klein MR, van Eijk RV, van Lier RA, Zeijlemaker WP.

Cell Immunol. 1992 Sep;143(2):310-23.


Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers.

Van Noesel CJ, Brouns GS, van Schijndel GM, Bende RJ, Mason DY, Borst J, van Lier RA.

J Exp Med. 1992 Jun 1;175(6):1511-9.

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