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Items: 22


Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice.

Rauen J, Kreer C, Paillard A, van Duikeren S, Benckhuijsen WE, Camps MG, Valentijn AR, Ossendorp F, Drijfhout JW, Arens R, Burgdorf S.

PLoS One. 2014 Aug 19;9(8):e103755. doi: 10.1371/journal.pone.0103755. eCollection 2014.


The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities.

Assohou-Luty C, Raijmakers R, Benckhuijsen WE, Stammen-Vogelzangs J, de Ru A, van Veelen PA, Franken KL, Drijfhout JW, Pruijn GJ.

Biochim Biophys Acta. 2014 Apr;1844(4):829-36. doi: 10.1016/j.bbapap.2014.02.019. Epub 2014 Mar 2.


Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models.

Stargardt A, Gillis J, Kamphuis W, Wiemhoefer A, Kooijman L, Raspe M, Benckhuijsen W, Drijfhout JW, Hol EM, Reits E.

Aging Cell. 2013 Jun;12(3):499-507. doi: 10.1111/acel.12074. Epub 2013 Apr 23.


Aminopeptidase-resistant peptides are targeted to lysosomes and subsequently degraded.

Gillis JM, Benckhuijsen W, van Veen H, Sanz AS, Drijfhout JW, Reits EA.

Traffic. 2011 Dec;12(12):1897-910. doi: 10.1111/j.1600-0854.2011.01270.x. Epub 2011 Sep 19.


Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.

Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, de Ru A, van Montfoort N, Franken KL, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis II, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJ.

Nat Immunol. 2011 Jan;12(1):45-53. doi: 10.1038/ni.1974. Epub 2010 Dec 12.


Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays.

Geluk A, van der Ploeg-van Schip JJ, van Meijgaarden KE, Commandeur S, Drijfhout JW, Benckhuijsen WE, Franken KL, Naafs B, Ottenhoff TH.

Clin Vaccine Immunol. 2010 Jun;17(6):993-1004. doi: 10.1128/CVI.00046-10. Epub 2010 Apr 28.


Competition-based cellular peptide binding assay for HLA class I.

Kessler JH, Benckhuijsen WE, Mutis T, Melief CJ, van der Burg SH, Drijfhout JW.

Curr Protoc Immunol. 2004 Sep;Chapter 18:Unit 18.12. doi: 10.1002/0471142735.im1812s61. Review.


Expression, purification, and in vitro activity of an arterivirus main proteinase.

van Aken D, Benckhuijsen WE, Drijfhout JW, Wassenaar AL, Gorbalenya AE, Snijder EJ.

Virus Res. 2006 Sep;120(1-2):97-106. Epub 2006 Mar 9.


A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.

Reits E, Neijssen J, Herberts C, Benckhuijsen W, Janssen L, Drijfhout JW, Neefjes J.

Immunity. 2004 Apr;20(4):495-506.


Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides.

Kessler JH, Mommaas B, Mutis T, Huijbers I, Vissers D, Benckhuijsen WE, Schreuder GM, Offringa R, Goulmy E, Melief CJ, van der Burg SH, Drijfhout JW.

Hum Immunol. 2003 Feb;64(2):245-55.


The use of DODT as a non-malodorous scavenger in Fmoc-based peptide synthesis.

Teixeira A, Benckhuijsen WE, de Koning PE, Valentijn AR, Drijfhout JW.

Protein Pept Lett. 2002 Oct;9(5):379-85.


The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.

Vader W, Kooy Y, Van Veelen P, De Ru A, Harris D, Benckhuijsen W, Peña S, Mearin L, Drijfhout JW, Koning F.

Gastroenterology. 2002 Jun;122(7):1729-37.


Specificity of tissue transglutaminase explains cereal toxicity in celiac disease.

Vader LW, de Ru A, van der Wal Y, Kooy YM, Benckhuijsen W, Mearin ML, Drijfhout JW, van Veelen P, Koning F.

J Exp Med. 2002 Mar 4;195(5):643-9.


Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases.

Hiemstra HS, van Veelen PA, Willemen SJ, Benckhuijsen WE, Geluk A, de Vries RR, Roep BO, Drijfhout JW.

Eur J Immunol. 1999 Aug;29(8):2385-91.


Differential binding of viral peptides to HLA-A2 alleles. Implications for human papillomavirus type 16 E7 peptide-based vaccination against cervical carcinoma.

Ressing ME, de Jong JH, Brandt RM, Drijfhout JW, Benckhuijsen WE, Schreuder GM, Offringa R, Kast WM, Melief CJ.

Eur J Immunol. 1999 Apr;29(4):1292-303.


Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.

Hiemstra HS, van Veelen PA, Schloot NC, Geluk A, van Meijgaarden KE, Willemen SJ, Leunissen JA, Benckhuijsen WE, Amons R, de Vries RR, Roep BO, Ottenhoff TH, Drijfhout JW.

J Immunol. 1998 Oct 15;161(8):4078-82.


Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin.

van de Wal Y, Kooy YM, van Veelen PA, Peña SA, Mearin LM, Molberg O, Lundin KE, Sollid LM, Mutis T, Benckhuijsen WE, Drijfhout JW, Koning F.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10050-4.


A new hybrid resin for stepwise screening of peptide libraries combined with single bead Edman sequencing.

Hiemstra HS, Benckhuijsen WE, Amons R, Rapp W, Drijfhout JW.

J Pept Sci. 1998 Jun;4(4):282-8.


The identification of CD4+ T cell epitopes with dedicated synthetic peptide libraries.

Hiemstra HS, Duinkerken G, Benckhuijsen WE, Amons R, de Vries RR, Roep BO, Drijfhout JW.

Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10313-8.


A sensitive fluorometric assay for quantitatively measuring specific peptide binding to HLA class I and class II molecules.

Ottenhoff TH, Geluk A, Toebes M, Benckhuijsen WE, van Meijgaarden KE, Drijfhout JW.

J Immunol Methods. 1997 Jan 15;200(1-2):89-97.


The use of dedicated peptide libraries permits the discovery of high affinity binding peptides.

de Koster HS, Amons R, Benckhuijsen WE, Feijlbrief M, Schellekens GA, Drijfhout JW.

J Immunol Methods. 1995 Nov 16;187(1):179-88.


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